{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:28:42Z","timestamp":1791822522096,"version":"4.3.4"},"reference-count":81,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cVictor Babes\u201d University of Medicine and Pharmacy, Timisoara."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Sepsis, a life-threatening condition arising from a dysregulated immune response to infection, is a significant health burden globally. Interleukin-6 (IL-6), an inflammatory cytokine produced by immune cells as a response to infection and tissue damage, plays a key role in the pathogenesis of sepsis. This systematic review and meta-analysis aimed to investigate the association of the baseline plasma levels of IL-6, and the dynamic change in these levels over a timespan of 96 h, with short-term mortality. A systematic literature search was conducted across multiple databases. Studies were included if they assessed the independent prognostic value of IL-6 in adult sepsis patients, used well-defined sepsis criteria, and reported at least one IL-6 measurement. Pooled effect estimates for the association between IL-6 and 28\u201330-day mortality were determined using logistic regression and AUROC analysis. Thirty-one studies, encompassing 4566 patients, were included. While baseline IL-6 levels and 96 h IL-6 clearance were not significantly associated with mortality risk (pooled OR 1.001, 95% CI 0.999\u20131.003 and 1.019, 95% CI 0.925\u20131.112, respectively), AUROC analysis indicated moderate-to-good discriminatory power for both baseline (0.701, 95% CI 0.660\u20130.742) and 96 h IL-6 clearance (0.828, 95% CI 0.736\u20130.919) in predicting 28-day mortality. While not a strong independent predictor, IL-6 demonstrates some discriminatory ability, suggesting its potential value in conjunction with other biomarkers.<\/jats:p>","DOI":"10.3390\/biom15030407","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T04:18:32Z","timestamp":1741839512000},"page":"407","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["IL-6 Baseline Values and Dynamic Changes in Predicting Sepsis Mortality: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0320-6904","authenticated-orcid":false,"given":"Norberth-Istvan","family":"Varga","sequence":"first","affiliation":[{"name":"Department of General Medicine, Doctoral School, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3099-8249","authenticated-orcid":false,"given":"Iulia Cristina","family":"Bagiu","sequence":"additional","affiliation":[{"name":"Department of Microbiology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"},{"name":"Multidisciplinary Research Center on Antimicrobial Resistance (MULTI-REZ), Microbiology Department, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1046-7272","authenticated-orcid":false,"given":"Dan Dumitru","family":"Vulcanescu","sequence":"additional","affiliation":[{"name":"Department of Microbiology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"},{"name":"Multidisciplinary Research Center on Antimicrobial Resistance (MULTI-REZ), Microbiology Department, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Voichita","family":"Lazureanu","sequence":"additional","affiliation":[{"name":"Department XIII, Discipline of Infectious Diseases, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirela","family":"Turaiche","sequence":"additional","affiliation":[{"name":"Department XIII, Discipline of Infectious Diseases, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"},{"name":"Methodological and Infectious Diseases Research Center, Department of Infectious Diseases, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8236-2205","authenticated-orcid":false,"given":"Ovidiu","family":"Rosca","sequence":"additional","affiliation":[{"name":"Department XIII, Discipline of Infectious Diseases, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"},{"name":"Methodological and Infectious Diseases Research Center, Department of Infectious Diseases, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian Vasile","family":"Bota","sequence":"additional","affiliation":[{"name":"Doctoral School, Faculty of Medicine, \u201cVasile Goldis\u201d Western University, Bulevardul Revolutiei 94, 310025 Arad, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6133-0204","authenticated-orcid":false,"given":"Florin George","family":"Horhat","sequence":"additional","affiliation":[{"name":"Department of Microbiology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"},{"name":"Multidisciplinary Research Center on Antimicrobial Resistance (MULTI-REZ), Microbiology Department, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990\u20132017: Analysis for the Global Burden of Disease Study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00281-017-0639-8","article-title":"Cytokine storm and sepsis disease pathogenesis","volume":"39","author":"Chousterman","year":"2017","journal-title":"Semin. Immunopathol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s00281-017-0628-y","article-title":"The meteorology of cytokine storms, and the clinical usefulness of this knowledge","volume":"39","author":"Clark","year":"2017","journal-title":"Semin. Immunopathol."},{"key":"ref_5","first-page":"669","article-title":"Role of cytokines as a double-edged sword in sepsis","volume":"27","author":"Chaudhry","year":"2013","journal-title":"Vivo"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1093\/ajhp\/59.suppl_1.S3","article-title":"Pathophysiology of sepsis","volume":"59","author":"Jacobi","year":"2002","journal-title":"Am. J. Health Pharm."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1189\/jlb.0607373","article-title":"Inflammation, endothelium, and coagulation in sepsis","volume":"83","author":"Schouten","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.thromres.2016.11.007","article-title":"Coagulation and sepsis","volume":"149","author":"Levi","year":"2017","journal-title":"Thromb. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.jaci.2016.06.033","article-title":"Interleukins (from IL-1 to IL-38), interferons, transforming growth factor \u03b2, and TNF-\u03b1: Receptors, functions, and roles in diseases","volume":"138","author":"Akdis","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1159\/000505099","article-title":"Interleukin-6: A Masterplayer in the Cytokine Network","volume":"98","author":"Uciechowski","year":"2020","journal-title":"Oncology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cyto.2014.05.024","article-title":"Interleukin-6 and its receptors: A highly regulated and dynamic system","volume":"70","author":"Wolf","year":"2014","journal-title":"Cytokine"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1042\/CS20110340","article-title":"IL-6\/IL-6 receptor system and its role in physiological and pathological conditions","volume":"122","author":"Mihara","year":"2011","journal-title":"Clin. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.7150\/ijbs.4989","article-title":"IL-6 trans-signaling via the soluble il-6 receptor: Importance for the pro-inflammatory activities of IL-6","volume":"8","year":"2012","journal-title":"Int. J. Biol. Sci."},{"key":"ref_14","first-page":"15238","article-title":"Accuracy of serum interleukin (IL)-6 in sepsis diagnosis: A systematic review and meta-analysis","volume":"8","author":"Hou","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Hayden, J.A., C\u00f4t\u00e9, P., Steenstra, I.A., Bombardier, C., and QUIPS-LBP Working Group (2008). Identifying phases of investigation helps planning, appraising, and applying the results of explanatory prognosis studies. J. Clin. Epidemiol., 61.","DOI":"10.1016\/j.jclinepi.2007.08.005"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"280","DOI":"10.7326\/0003-4819-158-4-201302190-00009","article-title":"Assessing bias in studies of prognostic factors","volume":"158","author":"Hayden","year":"2013","journal-title":"Ann. Intern. Med."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Amancio, R.T., Japiassu, A.M., Gomes, R.N., Mesquita, E.C., Assis, E.F., Medeiros, D.M., Grinsztejn, B., Bozza, P.T., Castro-Faria, H.C., and Bozza, F.A. (2013). The innate immune response in hiv\/aids septic shock patients: A comparative study. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0068730"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/MEJ.0b013e3280ec539b","article-title":"Can emergency physicians identify a high mortality subgroup of patients with sepsis: Role of procalcitonin","volume":"15","author":"Viallon","year":"2008","journal-title":"Eur. J. Emerg. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0002-9343(91)90069-A","article-title":"High circulating levels of interleukin-6 in patients with septic shock: Evolution during sepsis, prognostic value, and interplay with other cytokines","volume":"91","author":"Calandra","year":"1991","journal-title":"Am. J. Med."},{"key":"ref_20","first-page":"UC17","article-title":"Comparative Evaluation of Procalcitonin and Interleukin-6 as Diagnostic and Prognostic Biomarkers for Sepsis","volume":"12","author":"Kandaswamy","year":"2018","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1001\/archinte.167.15.1655","article-title":"Understanding the inflammatory cytokine response in pneumonia and sepsis: Results of the genetic and inflammatory markers of sepsis (GenIMS) study","volume":"167","author":"Kellum","year":"2007","journal-title":"Arch. Intern. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jcrc.2010.04.011","article-title":"Predictive value of procalcitonin, interleukin-6, and C-reactive protein for survival in postoperative patients with severe sepsis","volume":"26","author":"Tschaikowsky","year":"2011","journal-title":"J. Crit. Care"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s00011-003-1239-3","article-title":"Are IL-6, IL-10 and PCT plasma concentrations reliable for outcome prediction in severe sepsis? A comparison with APACHE III and SAPS II","volume":"53","author":"Wunder","year":"2004","journal-title":"Inflamm. Res."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Jahn, M., Rekowski, J., J\u00e1nosi, R.A., Kribben, A., Canbay, A., and Katsounas, A. (2020). Score performance of SAPS 2 and SAPS 3 in combination with biomarkers IL-6, PCT or CRP. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0238587"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Ebihara, T., Matsumoto, H., Matsubara, T., Togami, Y., Nakao, S., Matsuura, H., Kojima, T., Sugihara, F., Okuzaki, D., and Hirata, H. (2022). Cytokine Elevation in Severe COVID-19 From Longitudinal Proteomics Analysis: Comparison with Sepsis. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.798338"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Jekarl, D.W., Kim, J.Y., Ha, J.H., Lee, S., Yoo, J., Kim, M., and Kim, Y. (2019). Diagnosis and Prognosis of Sepsis Based on Use of Cytokines, Chemokines, and Growth Factors. Dis. Markers, 1.","DOI":"10.1155\/2019\/1089107"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Davoudian, S., Piovani, D., Desai, A., Mapelli, S.N., Leone, R., Sironi, M., Valentino, S., Silva-Gomes, R., Stravalaci, M., and Asgari, F. (2022). A cytokine\/PTX3 prognostic index as a predictor of mortality in sepsis. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.979232"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Lorente, L., Mart\u00edn, M.M., P\u00e9rez-Cejas, A., Barrios, Y., Sol\u00e9-Viol\u00e1n, J., Ferreres, J., Labarta, L., D\u00edaz, C., and Jim\u00e9nez, A. (2016). Association between Interleukin-6 Promoter Polymorphism (-174 G\/C), Serum Interleukin-6 Levels and Mortality in Severe Septic Patients. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17111861"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Frimpong, A., Owusu, E.D.A., Amponsah, J.A., Obeng-Aboagye, E., van der Puije, W., Frempong, A.F., Kusi, K.A., and Ofori, M.F. (2022). Cytokines as Potential Biomarkers for Differential Diagnosis of Sepsis and Other Non-Septic Disease Conditions. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.901433"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ymeth.2013.04.024","article-title":"Is there value in plasma cytokine measurements in patients with severe trauma and sepsis?","volume":"61","author":"Gentile","year":"2013","journal-title":"Methods"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1164\/ajrccm.164.3.2009052","article-title":"Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis","volume":"164","author":"Harbarth","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1515\/cclm-2014-0607","article-title":"Diagnosis and evaluation of severity of sepsis via the use of biomarkers and profiles of 13 cytokines: A multiplex analysis","volume":"53","author":"Jekarl","year":"2015","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.cyto.2004.10.010","article-title":"Sequential measurement of IL-6 blood levels in patients with systemic inflammatory response syndrome (SIRS)\/sepsis","volume":"29","author":"Oda","year":"2005","journal-title":"Cytokine"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.cyto.2011.12.002","article-title":"A combined score of pro- and anti-inflammatory interleukins improves mortality prediction in severe sepsis","volume":"57","author":"Bobillo","year":"2012","journal-title":"Cytokine"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Belli, O.E., Campolo, J., Vallerio, P., Musca, F., Moreo, A., Maloberti, A., Parolini, M., Bonacchini, L., Monti, G., and De Gasperi, A. (2022). Biochemical but not imaging parameters are predictive of outcome in septic shock: A pilot study. Cardiovasc. Ultrasound, 20.","DOI":"10.1186\/s12947-022-00276-3"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.medcli.2016.06.001","article-title":"Valor pron\u00f3stico de la interleucina 6 en la mortalidad de pacientes con sepsis","volume":"147","author":"Beneyto","year":"2016","journal-title":"Med. Clin."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.cca.2015.12.009","article-title":"Biochemical and inflammatory aspects in patients with severe sepsis and septic shock: The predictive role of IL-18 in mortality","volume":"453","author":"Eidt","year":"2016","journal-title":"Clin. Chim. Acta"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e493","DOI":"10.1097\/CCM.0000000000002292","article-title":"An Unbalanced Inflammatory Cytokine Response Is Not Associated with Mortality Following Sepsis: A Prospective Cohort Study","volume":"45","author":"Frencken","year":"2017","journal-title":"Crit. Care Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.diagmicrobio.2012.12.011","article-title":"Procalcitonin as a diagnostic marker and IL-6 as a prognostic marker for sepsis","volume":"75","author":"Jekarl","year":"2013","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Jiang, Y., Jiang, F.-Q., Kong, F., An, M.-M., Jin, B.-B., Cao, D., and Gong, P. (2019). Inflammatory anemia-associated parameters are related to 28-day mortality in patients with sepsis admitted to the ICU: A preliminary observational study. Ann. Intensiv. Care, 9.","DOI":"10.1186\/s13613-019-0542-7"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1080\/23744235.2021.1925738","article-title":"Cytokine production and outcome in MDR versus non-MDR gram-negative bacteraemia and sepsis","volume":"53","author":"Karamouzos","year":"2021","journal-title":"Infect. Dis."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.cyto.2019.03.002","article-title":"Circulating eNampt and resistin as a proinflammatory duet predicting independently mortality in critically ill patients with sepsis: A prospective observational study","volume":"119","author":"Karampela","year":"2019","journal-title":"Cytokine"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Liu, S., Wang, X., She, F., Zhang, W., Liu, H., and Zhao, X. (2021). Effects of Neutrophil-to-Lymphocyte Ratio Combined with Interleukin-6 in Predicting 28-Day Mortality in Patients with Sepsis. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.639735"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Liu, J., Bai, C., Li, B., Shan, A., Shi, F., Yao, C., Zhang, Y., Wang, J., Chen, W., and Xie, M. (2021). Mortality prediction using a novel combination of biomarkers in the first day of sepsis in intensive care units. Sci. Rep., 11.","DOI":"10.1038\/s41598-020-79843-5"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Matsumoto, H., Ogura, H., Shimizu, K., Ikeda, M., Hirose, T., Matsuura, H., Kang, S., Takahashi, K., Tanaka, T., and Shimazu, T. (2018). The clinical importance of a cytokine network in the acute phase of sepsis. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-32275-8"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.medin.2012.01.014","article-title":"Prognostic value of the biomarkers procalcitonin, interleukin-6 and C-reactive protein in severe sepsis","volume":"36","year":"2012","journal-title":"Med. Intensiv."},{"key":"ref_47","first-page":"488","article-title":"Plasma cytokine measurements augment prognostic scores as indicators of outcome in patients with severe sepsis","volume":"23","author":"Oberholzer","year":"2005","journal-title":"Shock"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1097\/SHK.0b013e318150716b","article-title":"Lactate, procalcitonin, and amino-terminal pro-b-type natriuretic peptide versus cytokine measurements and clinical severity scores for prognostication in septic shock","volume":"29","author":"Phua","year":"2008","journal-title":"Shock"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"99","DOI":"10.31053\/1853.0605.v74.n2.14608","article-title":"IL-6, MMP 3 and prognosis in previously healthy sepsis patients","volume":"74","author":"Montrull","year":"2017","journal-title":"Rev. Fac. Cien. Med. Univ. Nac. Cordoba"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"R\u00edos-Toro, J.-J., M\u00e1rquez-Coello, M., Garc\u00eda-\u00c1lvarez, J.-M., Mart\u00edn-Aspas, A., Rivera-Fern\u00e1ndez, R., de Benito, A.S., and Gir\u00f3n-Gonz\u00e1lez, J.-A. (2017). Soluble membrane receptors, interleukin 6, procalcitonin and C reactive protein as prognostic markers in patients with severe sepsis and septic shock. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0175254"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"135","DOI":"10.5005\/jp-journals-10071-23136","article-title":"Genetic Polymorphisms and Cytokine Profile of Different Ethnicities in Septic Shock Patients, and their Association with Mortality","volume":"23","author":"Siddiqui","year":"2019","journal-title":"Indian J. Crit. Care Med."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Song, J., Park, D.W., Moon, S., Cho, H.-J., Park, J.H., Seok, H., and Choi, W.S. (2019). Diagnostic and prognostic value of interleukin-6, pentraxin 3, and procalcitonin levels among sepsis and septic shock patients: A prospective controlled study according to the Sepsis-3 definitions. BMC Infect. Dis., 19.","DOI":"10.1186\/s12879-019-4618-7"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/SHK.0000000000000616","article-title":"Interleukin-6 Levels Act as a Diagnostic Marker for Infection and a Prognostic Marker in Patients with Organ Dysfunction in Intensive Care Units","volume":"46","author":"Takahashi","year":"2016","journal-title":"Shock"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Thao, P.T.N., Tra, T.T., Son, N.T., and Wada, K. (2018). Reduction in the IL-6 level at 24 h after admission to the intensive care unit is a survival predictor for Vietnamese patients with sepsis and septic shock: A prospective study. BMC Emerg. Med., 18.","DOI":"10.1186\/s12873-018-0191-4"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Turan, Y.B. (2023). The role of proadrenomedullin, interleukin 6 and CD64 in the diagnosis and prognosis of septic shock. BMC Anesthesiol., 23.","DOI":"10.1186\/s12871-023-02237-3"},{"key":"ref_56","first-page":"224","article-title":"Plasma interleukin-6 levels correlate with survival in patients with bacterial sepsis and septic shock","volume":"11","author":"Vivas","year":"2021","journal-title":"Interv. Med. Appl. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Weidhase, L., Wellh\u00f6fer, D., Schulze, G., Kaiser, T., Drogies, T., Wurst, U., and Petros, S. (2019). Is Interleukin-6 a better predictor of successful antibiotic therapy than procalcitonin and C-reactive protein? A single center study in critically ill adults. BMC Infect. Dis., 19.","DOI":"10.1186\/s12879-019-3800-2"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.jinf.2021.01.019","article-title":"Interleukin-37 as a biomarker of mortality risk in patients with sepsis","volume":"82","author":"Wu","year":"2021","journal-title":"J. Infect."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0929-6646(09)60028-0","article-title":"Plasma transforming growth factor-\u03b21 level in patients with severe community-acquired pneumonia and association with disease severity","volume":"108","author":"Wu","year":"2009","journal-title":"J. Formos. Med. Assoc."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Xie, Y., Li, B., Lin, Y., Shi, F., Chen, W., Wu, W., Zhang, W., Fei, Y., Zou, S., and Yao, C. (2020). Combining Blood-Based Biomarkers to Predict Mortality of Sepsis at Arrival at the Emergency Department. Med Sci. Monit., 27.","DOI":"10.12659\/MSM.929527"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s10096-022-04517-1","article-title":"28-day sepsis mortality prediction model from combined serial interleukin-6, lactate, and procalcitonin measurements: A retrospective cohort study","volume":"42","author":"Xie","year":"2022","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"5557","DOI":"10.2147\/IDR.S384351","article-title":"Diagnostic and Prognostic Value of Interleukin-6 in Emergency Department Sepsis Patients","volume":"ume 15","author":"Yu","year":"2022","journal-title":"Infect. Drug Resist."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1177\/0300060518793791","article-title":"Diagnostic and predictive performance of biomarkers in patients with sepsis in an intensive care unit","volume":"47","author":"Zhang","year":"2018","journal-title":"J. Int. Med. Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.ajem.2013.04.008","article-title":"Evaluation of the Mortality in Emergency Department Sepsis score combined with procalcitonin in septic patients","volume":"31","author":"Zhao","year":"2013","journal-title":"Am. J. Emerg. Med."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Molano-Franco, D., Arevalo-Rodriguez, I., Muriel, A., del Campo-Albendea, L., Fern\u00e1ndez-Garc\u00eda, S., Alvarez-M\u00e9ndez, A., Simancas-Racines, D., Viteri, A., Sanchez, G., and Fernandez-Felix, B. (2023). Basal procalcitonin, C-reactive protein, interleukin-6, and presepsin for prediction of mortality in critically ill septic patients: A systematic review and meta-analysis. Diagn. Progn. Res., 7.","DOI":"10.1186\/s41512-023-00152-2"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Li, X.-Y., Liu, M., Fu, Y.-J., Jiang, Y.-J., and Zhang, Z.-N. (2022). Alterations in levels of cytokine following treatment to predict outcome of sepsis: A meta-analysis. Cytokine, 161.","DOI":"10.1016\/j.cyto.2022.156056"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Charles, P.E., Tinel, C., Barbar, S., Aho, S., Prin, S., Doise, J.M., Olsson, N.O., Blettery, B., and Quenot, J.P. (2009). Procalcitonin kinetics within the first days of sepsis: Relationship with the appropriateness of antibiotic therapy and the outcome. Crit. Care, 13.","DOI":"10.1186\/cc7751"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Karlsson, S., Heikkinen, M., Pettil\u00e4, V., Alila, S., V\u00e4is\u00e4nen, S., Pulkki, K., Kolho, E., Ruokonen, E., and the Finnsepsis Study Group (2010). Predictive value of procalcitonin decrease in patients with severe sepsis: A prospective observational study. Crit. Care, 14.","DOI":"10.1186\/cc9327"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"140","DOI":"10.4103\/0972-5229.152755","article-title":"Procalcitonin kinetics as a prognostic marker in severe sepsis\/septic shock","volume":"19","author":"Aggarwal","year":"2015","journal-title":"Indian J. Crit. Care Med."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Schuetz, P., Maurer, P., Punjabi, V., Desai, A., Amin, D.N., and Gluck, E. (2013). Procalcitonin decrease over 72 hours in US critical care units predicts fatal outcome in sepsis patients. Crit. Care, 17.","DOI":"10.1186\/cc12787"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Shi, Y., Peng, J.-M., Hu, X.-Y., and Wang, Y. (2015). The utility of initial procalcitonin and procalcitonin clearance for prediction of bacterial infection and outcome in critically ill patients with autoimmune diseases: A prospective observational study. BMC Anesthesiol., 15.","DOI":"10.1186\/s12871-015-0122-9"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Nor, M.B.M., and Ralib, A.M. (2014). Procalcitonin clearance for early prediction of survival in critically ill patients with severe sepsis. Crit. Care Res. Pract., 2014.","DOI":"10.1155\/2014\/819034"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"706","DOI":"10.14740\/jocmr2251w","article-title":"Procalcitonin Kinetics in the First 72 Hours Predicts 30-Day Mortality in Severely Ill Septic Patients Admitted to an Intermediate Care Unit","volume":"7","author":"Pieralli","year":"2015","journal-title":"J. Clin. Med. Res."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Lee, M.J., Bae, J., Lee, J.H., Park, Y.J., Lee, H.A.R., Mun, S., Kim, Y.-S., Yune, C.J., Chung, T.N., and Kim, K. (2022). Serial Change of Endotoxin Tolerance in a Polymicrobial Sepsis Model. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23126581"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1097\/01.CCM.0000050454.01978.3B","article-title":"2001 SCCM\/ESICM\/ACCP\/ATS\/SIS International Sepsis Definitions Conference","volume":"31","author":"Levy","year":"2003","journal-title":"Crit. Care Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1146\/annurev.med.51.1.245","article-title":"Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty","volume":"51","author":"Ershler","year":"2000","journal-title":"Annu. Rev. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s41569-018-0064-2","article-title":"Inflammageing: Chronic inflammation in ageing, cardiovascular disease, and frailty","volume":"15","author":"Ferrucci","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Puzianowska-Ku\u017anicka, M., Owczarz, M., Wieczorowska-Tobis, K., Nadrowski, P., Chudek, J., Slusarczyk, P., Skalska, A., Jonas, M., Franek, E., and Mossakowska, M. (2016). Interleukin-6 and C-reactive protein, successful aging, and mortality: The PolSenior study. Immun. Ageing, 13.","DOI":"10.1186\/s12979-016-0076-x"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1007\/s12026-016-8860-4","article-title":"Variants in LTA, TNF, IL1B and IL10 genes associated with the clinical course of sepsis","volume":"64","author":"Jaimes","year":"2016","journal-title":"Immunol. Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1017\/S0950268814000703","article-title":"Association between interleukin-10 polymorphisms and sepsis: A meta-analysis","volume":"143","author":"Pan","year":"2015","journal-title":"Epidemiol. Infect."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Gao, J.-W., Zhang, A.-Q., Pan, W., Yue, C.-L., Zeng, L., Gu, W., and Jiang, J. (2015). Association between IL-6-174G\/C Polymorphism and the Risk of Sepsis and Mortality: A Systematic Review and Meta-Analysis. 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