{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:06:46Z","timestamp":1791223606279,"version":"4.1.0"},"reference-count":106,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"JSPS KAKENHI","award":["JP19K16655"],"award-info":[{"award-number":["JP19K16655"]}]},{"name":"JSPS KAKENHI","award":["JP23K06552"],"award-info":[{"award-number":["JP23K06552"]}]},{"name":"JSPS KAKENHI","award":["JP17K08842"],"award-info":[{"award-number":["JP17K08842"]}]},{"name":"JSPS KAKENHI","award":["JP23H04429"],"award-info":[{"award-number":["JP23H04429"]}]},{"name":"JSPS KAKENHI","award":["JP23K05701"],"award-info":[{"award-number":["JP23K05701"]}]},{"name":"JSPS KAKENHI","award":["JP24K10207"],"award-info":[{"award-number":["JP24K10207"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>The motility and chemotaxis of Vibrio cholerae, the bacterial pathogen responsible for cholera, play crucial roles in both environmental survival and infection. Understanding their molecular mechanisms is therefore essential not only for fundamental biology but also for infection control and therapeutic development. The bacterium\u2019s sheathed, polar flagellum\u2014its motility organelle\u2014is powered by a sodium-driven motor. This motor\u2019s rotation is regulated by the chemotaxis (Che) signaling system, with a histidine kinase, CheA, and a response regulator, CheY, serving as the central processing unit. However, V. cholerae possesses two additional, parallel Che signaling systems whose physiological functions remain unclear. Furthermore, the bacterium harbors over 40 receptors\/transducers that interact with CheA homologs, forming a complex regulatory network likely adapted to diverse environmental cues. Despite significant progress, many aspects of these systems remain to be elucidated. Here, we summarize the current understanding to facilitate future research.<\/jats:p>","DOI":"10.3390\/biom15030434","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T07:20:00Z","timestamp":1742282400000},"page":"434","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Chemotaxis and Related Signaling Systems in Vibrio cholerae"],"prefix":"10.3390","volume":"15","author":[{"given":"Fuga","family":"Omori","sequence":"first","affiliation":[{"name":"Department of Frontier Bioscience, Hosei University, 3-7-2 Kajino-cho, Koganei City, Tokyo 184-8584, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Tajima","sequence":"additional","affiliation":[{"name":"Department of Frontier Bioscience, Hosei University, 3-7-2 Kajino-cho, Koganei City, Tokyo 184-8584, Japan"},{"name":"Research Center for Micro-Nano Technology, Hosei University, 3-11-15 Midori-cho, Koganei City, Tokyo 184-0003, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotaro","family":"Asaoka","sequence":"additional","affiliation":[{"name":"Department of Frontier Bioscience, Hosei University, 3-7-2 Kajino-cho, Koganei City, Tokyo 184-8584, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So-ichiro","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"Faculty of Applied Life Science, Niigata University of Pharmacy and Medical and Life Sciences, 265-1 Higashijima, Akiha-ku, Niigata City, Niigata 956-8603, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1691-2018","authenticated-orcid":false,"given":"Yoshiyuki","family":"Sowa","sequence":"additional","affiliation":[{"name":"Department of Frontier Bioscience, Hosei University, 3-7-2 Kajino-cho, Koganei City, Tokyo 184-8584, Japan"},{"name":"Research Center for Micro-Nano Technology, Hosei University, 3-11-15 Midori-cho, Koganei City, Tokyo 184-0003, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuro","family":"Kawagishi","sequence":"additional","affiliation":[{"name":"Department of Frontier Bioscience, Hosei University, 3-7-2 Kajino-cho, Koganei City, Tokyo 184-8584, Japan"},{"name":"Research Center for Micro-Nano Technology, Hosei University, 3-11-15 Midori-cho, Koganei City, Tokyo 184-0003, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1128\/microbiolspec.VMBF-0015-2015","article-title":"Staying Alive: Vibrio cholerae\u2019s Cycle of Environmental Survival, Transmission, and Dissemination","volume":"4","author":"Conner","year":"2016","journal-title":"Microbiol. 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