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Recent studies have underscored the significance of Fli-1 in modulating inflammation and autoimmune diseases via the regulation of inflammatory responses. Specifically, Fli-1 exerts control over inflammatory processes, influencing key effectors and signaling pathways associated with conditions such as systemic lupus erythematosus, scleroderma, cancer, and sepsis. This review aims to summarize the emerging roles of Fli-1 in inflammation and autoimmune diseases, with a focus on elucidating the underlying molecular mechanisms and exploring the potential therapeutic implications.<\/jats:p>","DOI":"10.3390\/biom15040480","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T12:18:52Z","timestamp":1742905132000},"page":"480","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Role of Transcription Factor Fli-1 in Inflammation and Autoimmune Diseases"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5711-1367","authenticated-orcid":false,"given":"Xuan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of General Practice, Xiangya Hospital Central South University, and International Joint Research Center for Medical Metabolomics of Xiangya Hospital, Changsha 410008, China"},{"name":"Department of Medicine, Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC 29403, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian K.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC 29403, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"ref_1","first-page":"S102","article-title":"The contribution of Rudolf Virchow to the concept of inflammation: What is still of importance?","volume":"19","author":"Heidland","year":"2006","journal-title":"J. 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