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While the link between adipose tissue dysfunction and pathophysiology, including diabetes, chronic inflammation, and infertility, is clear, the molecular mechanisms that underlie these associations have not been fully described. We use Drosophila\u00a0melanogaster as a model to better understand how adipose tissue communicates to the ovary. In this study, we utilized D. melanogaster\u2019s robust genetic toolkit to examine the role of five adipokines known to control larval growth during development, CCHamide-1, CCHamide-2, eiger, Growth-blocking peptide 3, and unpaired 2 in regulating oogenesis. We show that the adult fat body expresses these \u201clarval\u201d adipokines. Our data indicate that ovarian germline stem cell maintenance does not require these adipokines. However, adipocyte-derived CCHamide-1, eiger, Growth-blocking peptide 3, and unpaired 2 influence early and late germline survival as well as ovulation. Thus, this work uncovers several adipokines that mediate fat-to-ovary communication.<\/jats:p>","DOI":"10.3390\/biom15040513","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T11:17:57Z","timestamp":1743506277000},"page":"513","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Adipocyte-Derived CCHamide-1, Eiger, Growth-Blocking Peptide 3, and Unpaired 2 Regulate Drosophila melanogaster Oogenesis"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0657-3771","authenticated-orcid":false,"given":"Chad","family":"Simmons","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, College of Arts and Sciences, University of South Carolina, Columbia, SC 29208, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaiah H.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, College of Arts and Sciences, University of South Carolina, Columbia, SC 29208, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3003-4806","authenticated-orcid":false,"given":"Tancia W.","family":"Bradshaw","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, College of Arts and Sciences, University of South Carolina, Columbia, SC 29208, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8710-2831","authenticated-orcid":false,"given":"Alissa Richmond","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, College of Arts and Sciences, University of South Carolina, Columbia, SC 29208, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"110615","DOI":"10.1016\/j.nut.2019.110615","article-title":"Obesity: A Preventable, Treatable, but Relapsing Disease","volume":"71","author":"Romano","year":"2020","journal-title":"Nutrition"},{"key":"ref_2","first-page":"1","article-title":"Prevalence of Obesity and Severe Obesity Among Adults: United States, 2017\u20132018","volume":"360","author":"Hales","year":"2020","journal-title":"NCHS Data Brief"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.amepre.2022.01.012","article-title":"Obesity Prevalence among U.s. 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