{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:38:56Z","timestamp":1791401936342,"version":"4.3.3"},"reference-count":130,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fondo de Investigaci\u00f3n Sanitaria, Instituto de Salud Carlos III, Madrid, Spain","award":["PI24\/01358"],"award-info":[{"award-number":["PI24\/01358"]}]},{"name":"Fondo de Investigaci\u00f3n Sanitaria, Instituto de Salud Carlos III, Madrid, Spain","award":["PI21\/01683"],"award-info":[{"award-number":["PI21\/01683"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Although the pathogenesis of the neurodegenerative phenomena of Huntington\u2019s disease (HD) is not well known, in the last 30 years, numerous data have been published that suggest a possible role of oxidative stress. The majority of studies regarding this issue were performed in different experimental models of this disease (neurotoxic models such as intraperitoneal injection of 3-nitropropionic acid or intrastriatal injection of quinolinic acid, transgenic animal models for HD, and cell cultures) and, less frequently, in samples of brain tissue, plasma\/serum, blood cells, and other tissues from patients with a genetic\u2013molecular diagnosis of presymptomatic and symptomatic HD compared to healthy controls. In this narrative review, we have summarized the data from the main studies in which oxidative stress parameters have been measured both in patients with HD and in experimental models of the same disease, as well as the few studies on gene variants involved in oxidative stress in patients with HD. Most studies addressing this issue in experimental models of HD have shown an increase in markers or oxidative stress, a decrease in antioxidant substances, or both. However, the results of studies on patients with HD have not been conclusive as few studies have been published on the matter. However, a meta-analysis of blood studies on HD patients (including a pool of serum and blood cell studies) has shown an increase in lipid peroxidation markers, OH8dG concentrations, and GPx activity and a decrease in GSH levels. Future prospective and multicenter studies with a long-term follow-up period involving a large number of HD patients and healthy controls are needed to address this topic.<\/jats:p>","DOI":"10.3390\/biom15040527","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T14:59:57Z","timestamp":1743778797000},"page":"527","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Oxidative Stress in Huntington\u2019s Disease"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7558-7323","authenticated-orcid":false,"given":"F\u00e9lix Javier","family":"Jim\u00e9nez-Jim\u00e9nez","sequence":"first","affiliation":[{"name":"Section of Neurology, Hospital Universitario del Sureste, Arganda del Rey, 28500 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8644-2210","authenticated-orcid":false,"given":"Hortensia","family":"Alonso-Navarro","sequence":"additional","affiliation":[{"name":"Section of Neurology, Hospital Universitario del Sureste, Arganda del Rey, 28500 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8094-046X","authenticated-orcid":false,"given":"Elena","family":"Garc\u00eda-Mart\u00edn","sequence":"additional","affiliation":[{"name":"University Institute of Molecular Pathology Biomarkers, Universidad de Extremadura, 10071 C\u00e1ceres, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9928-6293","authenticated-orcid":false,"given":"Alba","family":"C\u00e1rcamo-Fonfr\u00eda","sequence":"additional","affiliation":[{"name":"Section of Neurology, Hospital Universitario del Sureste, Arganda del Rey, 28500 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda del Mar","family":"Caballero-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Section of Neurology, Hospital Universitario del Sureste, Arganda del Rey, 28500 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6895-9160","authenticated-orcid":false,"given":"Jos\u00e9 A. G.","family":"Ag\u00fandez","sequence":"additional","affiliation":[{"name":"University Institute of Molecular Pathology Biomarkers, Universidad de Extremadura, 10071 C\u00e1ceres, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0140-6736(07)60111-1","article-title":"Huntington\u2019s Disease","volume":"369","author":"Walker","year":"2007","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1750-1172-5-40","article-title":"Huntington\u2019s Disease: A Clinical Review","volume":"5","author":"Roos","year":"2010","journal-title":"Orphanet J. 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