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Catechol-o-methyl-transferase (COMT) gene variants modify the environmental sensitivity associated with the risk of aggression. This study evaluated the association of COMT rs4680 and rs4818 polymorphisms with aggressive behavior in 341 male adolescents living inside and outside a correctional facility, with or without a diagnosis of CD. Aggression was assessed using the Hare Psychopathy Checklist: Youth Version (PCL-YV), Modified Overt Aggression Scale (MOAS) and Swanson, Nolan and Pelham Questionnaire. COMT rs4680 and rs4818 polymorphisms were genotyped using TaqMan SNP Genotyping Assays. A similar prevalence of the COMT genotypes or haplotypes was found between adolescents with or without CD, suicidal behavior, or detention in correctional facility. In youth with CD, the COMT rs4680 A allele was associated with higher MOAS verbal aggression, aggression toward objects, irritability (subjective and open), and PCL-YV interpersonal domain scores compared with carriers of the COMT rs4680 G allele. COMT rs4818 GC carriers with CD had higher scores on the MOAS subjective irritability than GG heterozygotes. These novel findings revealed the association of lower COMT rs4680 and rs4818 activity alleles with aggression in detained male adolescents with CD.<\/jats:p>","DOI":"10.3390\/biom15040554","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T12:05:56Z","timestamp":1744200356000},"page":"554","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of Lower COMT Activity Alleles with Aggressive Traits in Male Youth with Conduct Disorder Living in a Correctional Facility"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9125-406X","authenticated-orcid":false,"given":"Lucija","family":"Tudor","sequence":"first","affiliation":[{"name":"Rudjer Boskovic Institute, Division of Molecular Medicine, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9997-3707","authenticated-orcid":false,"given":"Josip","family":"Podobnik","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychiatric Hospital for Children and Youth Zagreb, 10000 Zagreb, Croatia"},{"name":"Juvenile Correctional Facility Ivanec, 42240 Ivanec, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0787-9340","authenticated-orcid":false,"given":"Gordana","family":"Nedic Erjavec","sequence":"additional","affiliation":[{"name":"Rudjer Boskovic Institute, Division of Molecular Medicine, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3113-0778","authenticated-orcid":false,"given":"Matea","family":"Nikolac Perkovic","sequence":"additional","affiliation":[{"name":"Rudjer Boskovic Institute, Division of Molecular Medicine, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4484-2096","authenticated-orcid":false,"given":"Jaanus","family":"Harro","sequence":"additional","affiliation":[{"name":"Neuropsychopharmacology, Institute of Chemistry, University of Tartu, 50411 Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3326-5297","authenticated-orcid":false,"given":"Margus","family":"Kanarik","sequence":"additional","affiliation":[{"name":"Neuropsychopharmacology, Institute of Chemistry, University of Tartu, 50411 Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darko","family":"Marcinko","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Clinical Hospital Center Zagreb, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6200-2405","authenticated-orcid":false,"given":"Dubravka","family":"Svob Strac","sequence":"additional","affiliation":[{"name":"Rudjer Boskovic Institute, Division of Molecular Medicine, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melita","family":"Cusek","sequence":"additional","affiliation":[{"name":"Juvenile Correctional Facility Ivanec, 42240 Ivanec, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vlatka","family":"Kovac","sequence":"additional","affiliation":[{"name":"Department for Child and Adolescent Psychiatry, Clinical Hospital Center Osijek, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nela","family":"Pivac","sequence":"additional","affiliation":[{"name":"Rudjer Boskovic Institute, Division of Molecular Medicine, 10000 Zagreb, Croatia"},{"name":"University of Applied Sciences Hrvatsko Zagorje Krapina, 49000 Krapina, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.cpr.2007.02.001","article-title":"Sex Differences in Child-Onset, Life-Course-Persistent Conduct Disorder. 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