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Cerebral A\u03b2 accumulation initiates a noxious cascade that leads to irreversible neuronal degeneration and memory impairment in older adults. Recent advances in A\u03b2 seeding studies offer a promising avenue for exploring the mechanisms underlying amyloid deposition and the complex pathological features of AD. However, the extent to which inoculated A\u03b2 seeds can induce reproducible and reliable pathological manifestations remains unclear due to significant variability across studies. In this review, we will discuss several factors that contribute to the induction or acceleration of amyloid deposition and consequent pathologies. Specifically, we focus on the diversity of host animals, sources and recipe of A\u03b2 seeds, and inoculating strategies. By integrating these key aspects, this review aims to offer a comprehensive perspective on A\u03b2 seeding in AD and provide guidance for modeling AD pathogenesis through the exogenous introduction of A\u03b2 seeds.<\/jats:p>","DOI":"10.3390\/biom15040571","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T07:42:01Z","timestamp":1744616521000},"page":"571","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["In Vivo Seeding of Amyloid-\u03b2 Protein and Implications in Modeling Alzheimer\u2019s Disease Pathology"],"prefix":"10.3390","volume":"15","author":[{"given":"Qianmin","family":"Liu","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences, Hunan University, Changsha 410082, China"},{"name":"Shenzhen Key Laboratory of Neuroimmunomodulation for Neurological Diseases, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simin","family":"Song","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Neuroimmunomodulation for Neurological Diseases, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China"},{"name":"Department of Chinese Medicine, The University of Hong Kong-Shenzhen Hospital (HKU-SZH), Shenzhen 518055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, Hunan University, Changsha 410082, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7410-4679","authenticated-orcid":false,"given":"Wei","family":"Hong","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Neuroimmunomodulation for Neurological Diseases, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"108171","DOI":"10.1016\/j.pharmthera.2022.108171","article-title":"Enhancing autophagy in Alzheimer\u2019s disease through drug repositioning","volume":"237","author":"Eshraghi","year":"2022","journal-title":"Pharmacol. 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