{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:10:03Z","timestamp":1760058603100,"version":"build-2065373602"},"reference-count":77,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005009","name":"Assar Gabrielssons Fond","doi-asserted-by":"publisher","award":["FB20-96"],"award-info":[{"award-number":["FB20-96"]}],"id":[{"id":"10.13039\/501100005009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Laboratory and animal studies indicate that melatonin exerts a negative impact on breast cancer progression and metastasis. These actions are both receptor-dependent and -independent. Of the two transmembrane melatonin receptors identified in humans, breast cancer expresses only MT1. The aim of this study was to investigate the expression of MT1 in hormone-receptor-positive, HER2-negative invasive ductal breast carcinoma in postmenopausal women and its possible correlations with clinicopathological parameters and survival. A total of 118 patients with luminal A\/B primary breast cancer with or without axillary metastases were identified. The MT1 receptor expression was immunohistochemically assessed as a percentage of stained cells and a weighted index (WI) (percentage multiplied by staining intensity). Most tumor samples (84.7%) and metastasized lymph nodes (96%) stained positive for MT1, with varying intensity. No statistically significant correlations were found between the MT1 expression or the WI in the primary tumor and the patient and tumor characteristics, or the MT1 and WI in the metastasized lymph nodes. The survival analysis did not reveal a significant effect of MT1 expression or the WI on the risk of recurrence or survival.<\/jats:p>","DOI":"10.3390\/biom15040581","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T08:11:39Z","timestamp":1744704699000},"page":"581","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Melatonin MT1 Receptor Expression in Luminal Invasive Ductal Breast Carcinoma in Postmenopausal Women"],"prefix":"10.3390","volume":"15","author":[{"given":"Leda","family":"Pistiolis","sequence":"first","affiliation":[{"name":"Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 41390 Gothenburg, Sweden"},{"name":"Department of Surgery, Sahlgrenska University Hospital Gothenburg, 41345 Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahar","family":"Alawieh","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Sahlgrenska University Hospital Gothenburg, 41345 Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thorhildur","family":"Halldorsdottir","sequence":"additional","affiliation":[{"name":"Landspitali University Hospital, 105 Reykjavik, Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7711-4418","authenticated-orcid":false,"given":"Anik\u00f3","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Sahlgrenska University Hospital Gothenburg, 41345 Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5795-0355","authenticated-orcid":false,"given":"Roger","family":"Olofsson Bagge","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 41390 Gothenburg, Sweden"},{"name":"Department of Surgery, Sahlgrenska University Hospital Gothenburg, 41345 Gothenburg, Sweden"},{"name":"Wallenberg Center of Translational Medicine, University of Gothenburg, 41345 Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/j.1469-185X.2009.00118.x","article-title":"The changing biological roles of melatonin during evolution: From an antioxidant to signals of darkness, sexual selection and fitness","volume":"85","author":"Tan","year":"2010","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Zhao, D., Yu, Y., Shen, Y., Liu, Q., Zhao, Z., Sharma, R., and Reiter, R.J. (2019). Melatonin Synthesis and Function: Evolutionary History in Animals and Plants. Front. Endocrinol., 10.","DOI":"10.3389\/fendo.2019.00249"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1152\/physiol.00011.2014","article-title":"Melatonin: Exceeding expectations","volume":"29","author":"Reiter","year":"2014","journal-title":"Physiology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1007\/s00018-014-1579-2","article-title":"Extrapineal melatonin: Sources, regulation, and potential functions","volume":"71","author":"Escames","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1007\/s00432-020-03292-w","article-title":"Melatonin: An endogenous miraculous indolamine, fights against cancer progression","volume":"146","author":"Samanta","year":"2020","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Ma, H., Kang, J., Fan, W., He, H., and Huang, F. (2021). ROR: Nuclear Receptor for Melatonin or Not?. Molecules, 26.","DOI":"10.3390\/molecules26092693"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1124\/pr.110.002832","article-title":"International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors","volume":"62","author":"Dubocovich","year":"2010","journal-title":"Pharmacol. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1111\/bph.13536","article-title":"Update on melatonin receptors: IUPHAR Review 20","volume":"173","author":"Jockers","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"ref_9","first-page":"135","article-title":"The melatonin hypothesis: Electric power and breast cancer","volume":"104","author":"Stevens","year":"1996","journal-title":"Environ. Health Perspect."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1093\/jnci\/93.20.1563","article-title":"Rotating night shifts and risk of breast cancer in women participating in the nurses\u2019 health study","volume":"93","author":"Schernhammer","year":"2001","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Manouchehri, E., Taghipour, A., Ghavami, V., Ebadi, A., Homaei, F., and Latifnejad Roudsari, R. (2021). Night-shift work duration and breast cancer risk: An updated systematic review and meta-analysis. BMC Women\u2019s Health, 21.","DOI":"10.1186\/s12905-021-01233-4"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1600-079X.2009.00665.x","article-title":"Defining chronodisruption","volume":"46","author":"Erren","year":"2009","journal-title":"J. Pineal Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e12926","DOI":"10.1111\/jpi.12926","article-title":"Melatonin facts: Lack of evidence that melatonin is a radical scavenger in living systems","volume":"76","author":"Boutin","year":"2024","journal-title":"J. Pineal Res."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Boutin, J.A., Kennaway, D.J., and Jockers, R. (2023). Melatonin: Facts, Extrapolations and Clinical Trials. Biomolecules, 13.","DOI":"10.3390\/biom13060943"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e12657","DOI":"10.1111\/jpi.12657","article-title":"Measuring melatonin by immunoassay","volume":"69","author":"Kennaway","year":"2020","journal-title":"J. Pineal Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.biochi.2024.03.010","article-title":"Melatonin facts: Melatonin lacks immuno-inflammation boosting capacities at the molecular and cellular levels","volume":"222","author":"Boutin","year":"2024","journal-title":"Biochimie"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e12906","DOI":"10.1111\/jpi.12906","article-title":"The mammalian gastro-intestinal tract is a NOT a major extra-pineal source of melatonin","volume":"75","author":"Kennaway","year":"2023","journal-title":"J. Pineal Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s11892-017-0957-1","article-title":"Disentangling the Role of Melatonin and its Receptor MTNR1B in Type 2 Diabetes: Still a Long Way to Go?","volume":"17","author":"Bonnefond","year":"2017","journal-title":"Curr. Diabetes Rep."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Nikolaev, G., Robeva, R., and Konakchieva, R. (2021). Membrane Melatonin Receptors Activated Cell Signaling in Physiology and Disease. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23010471"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1517\/14728222.2013.834890","article-title":"Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: A review","volume":"17","author":"Bizzarri","year":"2013","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Chu, L.W., John, E.M., Yang, B., Kurian, A.W., Zia, Y., Yu, K., Ingles, S.A., Stanczyk, F.Z., and Hsing, A.W. (2018). Measuring serum melatonin in postmenopausal women: Implications for epidemiologic studies and breast cancer studies. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0195666"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e12702","DOI":"10.1111\/jpi.12702","article-title":"Melatonin controversies, an update","volume":"70","author":"Boutin","year":"2021","journal-title":"J. Pineal Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s00228-015-1873-4","article-title":"Clinical pharmacokinetics of melatonin: A systematic review","volume":"71","author":"Harpsoe","year":"2015","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1007\/s40262-016-0386-3","article-title":"Pharmacokinetics of Melatonin: The Missing Link in Clinical Efficacy?","volume":"55","author":"Andersen","year":"2016","journal-title":"Clin. Pharmacokinet."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0303-7207(02)00029-1","article-title":"MT(1) melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells","volume":"192","author":"Yuan","year":"2002","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/jpi.12032","article-title":"Expression of melatonin receptor MT1 in cells of human invasive ductal breast carcinoma","volume":"54","author":"Jablonska","year":"2013","journal-title":"J. Pineal Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1097\/PAI.0000000000000788","article-title":"Role of Melatonin in Breast Carcinoma: Correlation of Expression Patterns of Melatonin-1 Receptor With Estrogen, Progesterone, and HER2 Receptors","volume":"28","author":"Goyal","year":"2019","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1309\/1T4V-CT1G-UBJP-3EHP","article-title":"Differential expression of high-affinity melatonin receptors (MT1) in normal and malignant human breast tissue","volume":"118","author":"Dillon","year":"2002","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s10549-008-0220-1","article-title":"Alteration of the MT1 melatonin receptor gene and its expression in primary human breast tumors and breast cancer cell lines","volume":"118","author":"Lai","year":"2009","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s10549-012-2371-3","article-title":"Expression of melatonin receptors in triple negative breast cancer (TNBC) in African American and Caucasian women: Relation to survival","volume":"137","author":"Haus","year":"2013","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/S0140-6736(78)92591-6","article-title":"Role of pineal gland in aetiology and treatment of breast cancer","volume":"2","author":"Cohen","year":"1978","journal-title":"Lancet"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1126\/science.7079745","article-title":"Decreased nocturnal plasma melatonin peak in patients with estrogen receptor positive breast cancer","volume":"216","author":"Tamarkin","year":"1982","journal-title":"Science"},{"key":"ref_33","first-page":"2135","article-title":"Age-related decreases in melatonin secretion--clinical consequences","volume":"85","author":"Wurtman","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12253-008-9067-3","article-title":"The Nottingham prognostic index for invasive carcinoma of the breast","volume":"14","author":"Lee","year":"2008","journal-title":"Pathol. Oncol. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s12020-018-1624-2","article-title":"Evaluation of melatonin and AFMK levels in women with breast cancer","volume":"62","year":"2018","journal-title":"Endocrine"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1200\/JCO.1985.3.7.941","article-title":"Plasma melatonin and the hormone-dependency of human breast cancer","volume":"3","author":"Danforth","year":"1985","journal-title":"J. Clin. Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1600-079X.1986.tb00760.x","article-title":"Human melatonin production decreases with age","volume":"3","author":"Sack","year":"1986","journal-title":"J. Pineal Res."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Tan, D.X., Xu, B., Zhou, X., and Reiter, R.J. (2018). Pineal Calcification, Melatonin Production, Aging, Associated Health Consequences and Rejuvenation of the Pineal Gland. Molecules, 23.","DOI":"10.3390\/molecules23020301"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e12677","DOI":"10.1111\/jpi.12677","article-title":"Switching diseased cells from cytosolic aerobic glycolysis to mitochondrial oxidative phosphorylation: A metabolic rhythm regulated by melatonin?","volume":"70","author":"Reiter","year":"2021","journal-title":"J. Pineal Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1159\/000346475","article-title":"Correlation between Ki67 and breast cancer prognosis","volume":"84","author":"Kontzoglou","year":"2013","journal-title":"Oncology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.breast.2011.07.008","article-title":"Characteristics and outcomes according to molecular subtypes of breast cancer as classified by a panel of four biomarkers using immunohistochemistry","volume":"21","author":"Park","year":"2012","journal-title":"Breast"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1200\/JCO.2015.62.3504","article-title":"Annual Hazard Rates of Recurrence for Breast Cancer During 24 Years of Follow-Up: Results From the International Breast Cancer Study Group Trials I to V","volume":"34","author":"Colleoni","year":"2016","journal-title":"J. Clin. Oncol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/sj.bjc.6602787","article-title":"Clinical characteristics of different histologic types of breast cancer","volume":"93","author":"Li","year":"2005","journal-title":"Br. J. Cancer"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Reiter, R.J., Sharma, R., Tan, D.X., Chuffa, L.G.A., da Silva, D.G.H., Slominski, A.T., Steinbrink, K., and Kleszczynski, K. (2024). Dual sources of melatonin and evidence for different primary functions. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1414463"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Bonmati-Carrion, M.A., and Tomas-Loba, A. (2021). Melatonin and Cancer: A Polyhedral Network Where the Source Matters. Antioxidants, 10.","DOI":"10.3390\/antiox10020210"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"E7997","DOI":"10.1073\/pnas.1705768114","article-title":"Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release","volume":"114","author":"Suofu","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"18886","DOI":"10.3390\/molecules201018886","article-title":"Melatonin as a Potent and Inducible Endogenous Antioxidant: Synthesis and Metabolism","volume":"20","author":"Tan","year":"2015","journal-title":"Molecules"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","article-title":"Understanding the Warburg effect: The metabolic requirements of cell proliferation","volume":"324","author":"Cantley","year":"2009","journal-title":"Science"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"335","DOI":"10.4155\/fmc-2020-0326","article-title":"Melatonin synthesis in and uptake by mitochondria: Implications for diseased cells with dysfunctional mitochondria","volume":"13","author":"Reiter","year":"2021","journal-title":"Future Med. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Franco, P.I.R., do Carmo Neto, J.R., Milhomem, A.C., Machado, J.R., and Miguel, M.P. (2022). Antitumor effect of melatonin on breast cancer in experimental models: A systematic review. Biochim. Biophys. Acta Rev. Cancer, 1878.","DOI":"10.1016\/j.bbcan.2022.188838"},{"key":"ref_51","first-page":"11","article-title":"Medical implications of melatonin: Receptor-mediated and receptor-independent actions","volume":"52","author":"Reiter","year":"2007","journal-title":"Adv. Med. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"d1093","DOI":"10.2741\/1089","article-title":"Molecular pharmacology, regulation and function of mammalian melatonin receptors","volume":"8","author":"Dubocovich","year":"2003","journal-title":"Front. Biosci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s00280-017-3441-3","article-title":"Participation of MT3 melatonin receptors in the synergistic effect of melatonin on cytotoxic and apoptotic actions evoked by chemotherapeutics","volume":"80","author":"Pariente","year":"2017","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biochi.2022.05.008","article-title":"Oncostatic activities of melatonin: Roles in cell cycle, apoptosis, and autophagy [Biochimie 200 (2022) 44\u201359]","volume":"200","author":"Targhazeh","year":"2022","journal-title":"Biochimie"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1517\/14728222.2016.1091882","article-title":"Quinone reductase 2 as a promising target of melatonin therapeutic actions","volume":"20","author":"Boutin","year":"2016","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Jin, Y., Choi, Y.J., Heo, K., and Park, S.J. (2021). Melatonin as an Oncostatic Molecule Based on Its Anti-Aromatase Role in Breast Cancer. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010438"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1600-079X.2004.00207.x","article-title":"Melatonin-estrogen interactions in breast cancer","volume":"38","author":"Cos","year":"2005","journal-title":"J. Pineal Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.cdp.2006.03.002","article-title":"Estrogen-signaling pathway: A link between breast cancer and melatonin oncostatic actions","volume":"30","author":"Cos","year":"2006","journal-title":"Cancer Detect. Prev."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1600-079X.2005.00258.x","article-title":"Melatonin in the treatment of cancer: A systematic review of randomized controlled trials and meta-analysis","volume":"39","author":"Mills","year":"2005","journal-title":"J. Pineal Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1007\/s00280-012-1828-8","article-title":"The efficacy and safety of melatonin in concurrent chemotherapy or radiotherapy for solid tumors: A meta-analysis of randomized controlled trials","volume":"69","author":"Wang","year":"2012","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_61","first-page":"871","article-title":"A randomized study of tamoxifen alone versus tamoxifen plus melatonin in estrogen receptor-negative heavily pretreated metastatic breast-cancer patients","volume":"2","author":"Lissoni","year":"1995","journal-title":"Oncol. Rep."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/bjc.1995.164","article-title":"Modulation of cancer endocrine therapy by melatonin: A phase II study of tamoxifen plus melatonin in metastatic breast cancer patients progressing under tamoxifen alone","volume":"71","author":"Lissoni","year":"1995","journal-title":"Br. J. Cancer"},{"key":"ref_63","first-page":"560","article-title":"Melatonin enhances the apoptotic effects and modulates the changes in gene expression induced by docetaxel in MCF7 human breast cancer cells","volume":"52","author":"Gonzalez","year":"2018","journal-title":"Int. J. Oncol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1002\/jcp.27259","article-title":"Adjuvant chemotherapy with melatonin for targeting human cancers: A review","volume":"234","author":"Najafi","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/jpi.12205","article-title":"Melatonin sensitizes human breast cancer cells to ionizing radiation by downregulating proteins involved in double-strand DNA break repair","volume":"58","author":"Gonzalez","year":"2015","journal-title":"J. Pineal Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.canlet.2015.10.015","article-title":"Melatonin enhancement of the radiosensitivity of human breast cancer cells is associated with the modulation of proteins involved in estrogen biosynthesis","volume":"370","author":"Gonzalez","year":"2016","journal-title":"Cancer Lett."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Reiter, R.J., Rosales-Corral, S.A., Tan, D.X., Acuna-Castroviejo, D., Qin, L., Yang, S.F., and Xu, K. (2017). Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18040843"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1600-079X.2010.00781.x","article-title":"In Vitro and In Vivo antitumor activity of melatonin receptor agonists","volume":"49","author":"Mao","year":"2010","journal-title":"J. Pineal Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1124\/mol.119.116202","article-title":"Pharmacological, Mechanistic, and Pharmacokinetic Assessment of Novel Melatonin-Tamoxifen Drug Conjugates as Breast Cancer Drugs","volume":"96","author":"Hasan","year":"2019","journal-title":"Mol. Pharmacol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ctim.2018.11.003","article-title":"Adverse events associated with oral administration of melatonin: A critical systematic review of clinical evidence","volume":"42","author":"Foley","year":"2019","journal-title":"Complement. Ther. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1007\/s40263-019-00680-w","article-title":"Adverse Events Associated with Melatonin for the Treatment of Primary or Secondary Sleep Disorders: A Systematic Review","volume":"33","author":"Besag","year":"2019","journal-title":"CNS Drugs"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/03007995.2021.2000714","article-title":"What do we really know about the safety and efficacy of melatonin for sleep disorders?","volume":"38","author":"Kennaway","year":"2022","journal-title":"Curr. Med. Res. Opin."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s40261-015-0368-5","article-title":"The Safety of Melatonin in Humans","volume":"36","author":"Andersen","year":"2016","journal-title":"Clin. Drug Investig."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.biochi.2022.03.005","article-title":"Molecular and cellular mechanisms of melatonin in breast cancer","volume":"202","author":"Sadoughi","year":"2022","journal-title":"Biochimie"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12967-023-04015-8","article-title":"Valproic acid inhibits cell growth in both MCF-7 and MDA-MB231 cells by triggering different responses in a cell type-specific manner","volume":"21","author":"Giordano","year":"2023","journal-title":"J. Transl. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ejphar.2007.01.022","article-title":"Human melatonin MT1 receptor induction by valproic acid and its effects in combination with melatonin on MCF-7 breast cancer cell proliferation","volume":"560","author":"Jawed","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/s13063-023-07245-9","article-title":"Adjuvant melatonin for uveal melanoma (AMUM): Protocol for a randomized open-label phase III study","volume":"24","author":"Hagstrom","year":"2023","journal-title":"Trials"}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/15\/4\/581\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:14:40Z","timestamp":1760030080000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/15\/4\/581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,15]]},"references-count":77,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["biom15040581"],"URL":"https:\/\/doi.org\/10.3390\/biom15040581","relation":{},"ISSN":["2218-273X"],"issn-type":[{"type":"electronic","value":"2218-273X"}],"subject":[],"published":{"date-parts":[[2025,4,15]]}}}