{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:41:38Z","timestamp":1791247298499,"version":"4.1.0"},"reference-count":88,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271283"],"award-info":[{"award-number":["82271283"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["7202001"],"award-info":[{"award-number":["7202001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["82271283"],"award-info":[{"award-number":["82271283"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["7202001"],"award-info":[{"award-number":["7202001"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Parkinson\u2019s disease (PD) is a neurodegenerative disease with a high prevalence among the middle-aged and elderly population. The pathogenesis of PD is closely linked to the misfolding and aggregation of \u03b1-synuclein, which contributes to the formation of Lewy bodies. These processes are associated with the degeneration of dopaminergic neurons, a key neuropathological change that underlies the motor symptoms of PD. In addition, genetic susceptibility, mitochondrial dysfunction, oxidative stress and neuroinflammation are involved in the progress of the disease. Previous studies indicated that the dysregulation of epigenetic modifications, including DNA methylation and histone acetylation, may be the key pathophysiological factors in PD. N6-methyladenosine (m6A) is a dynamically reversible modification in eukaryotes RNA, and could regulate mRNA degradation, stability, maturation, and translation. Recently, clinical research has shown that the global m6A level is significantly reduced in PD patients as well as the expression changes in m6A-associated proteins. Moreover, the dysregulation of m6A modification was shown to impact dopamine metabolism and damage dopaminergic neurons, indicating that m6A RNA modification may play a critical role in the pathogenesis of PD. In this review, we summarize recent clinical studies on m6A RNA modification in PD patients and discuss the regulatory role of m6A modification in dopamine metabolism and dopaminergic neurons death. Furthermore, based on the different m6A modification databases and prediction websites, we analyzed the potential m6A modification sites on the mRNA of key PD pathogenic genes (SNCA, PRKN, PINK1, and LRRK2) for the first time, aiming to offer new gene targets and perspectives understanding the pathogenesis of PD.<\/jats:p>","DOI":"10.3390\/biom15050617","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T12:04:33Z","timestamp":1745409873000},"page":"617","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Role of N6-Methyladenosine (m6A) RNA Modification in the Pathogenesis of Parkinson\u2019s Disease"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6989-8918","authenticated-orcid":false,"given":"Yulu","family":"Wang","sequence":"first","affiliation":[{"name":"College of Chemistry and Life Science, Beijing University of Technology, 100 Pingleyuan, Chaoyang District, Beijing 100124, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0425-3690","authenticated-orcid":false,"given":"Tianyuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Chemistry and Life Science, Beijing University of Technology, 100 Pingleyuan, Chaoyang District, Beijing 100124, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0195-0813","authenticated-orcid":false,"given":"Chunsen","family":"Yuan","sequence":"additional","affiliation":[{"name":"College of Chemistry and Life Science, Beijing University of Technology, 100 Pingleyuan, Chaoyang District, Beijing 100124, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8539-451X","authenticated-orcid":false,"given":"Xuechai","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Chemistry and Life Science, Beijing University of Technology, 100 Pingleyuan, Chaoyang District, Beijing 100124, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"key":"ref_1","first-page":"1233","article-title":"Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase","volume":"3","author":"Bokar","year":"1997","journal-title":"Rna"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nrm3785","article-title":"The dynamic epitranscriptome: N6-methyladenosine and gene expression control","volume":"15","author":"Meyer","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nchembio.1432","article-title":"A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation","volume":"10","author":"Liu","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.cell.2017.05.003","article-title":"The U6 snRNA m(6)A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention","volume":"169","author":"Pendleton","year":"2017","journal-title":"Cell"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"7719","DOI":"10.1093\/nar\/gkz619","article-title":"The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112","volume":"47","author":"Ernst","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Mathoux, J., Henshall, D.C., and Brennan, G.P. (2021). Regulatory Mechanisms of the RNA Modification m(6)A and Significance in Brain Function in Health and Disease. Front. Cell Neurosci., 15.","DOI":"10.3389\/fncel.2021.671932"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41392-020-00450-x","article-title":"The role of m6A modification in the biological functions and diseases","volume":"6","author":"Jiang","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nchembio.687","article-title":"N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO","volume":"7","author":"Jia","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.molcel.2012.10.015","article-title":"ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility","volume":"49","author":"Zheng","year":"2013","journal-title":"Mol. Cell"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ccell.2016.11.017","article-title":"FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N(6)-Methyladenosine RNA Demethylase","volume":"31","author":"Li","year":"2017","journal-title":"Cancer Cell"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"E325","DOI":"10.1073\/pnas.1717794115","article-title":"ALKBH5-dependent m6A demethylation controls splicing and stability of long 3\u2032-UTR mRNAs in male germ cells","volume":"115","author":"Tang","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/cr.2017.15","article-title":"YTHDF3 facilitates translation and decay of N(6)-methyladenosine-modified RNA","volume":"27","author":"Shi","year":"2017","journal-title":"Cell Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.molcel.2016.01.012","article-title":"Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing","volume":"61","author":"Xiao","year":"2016","journal-title":"Mol. Cell"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/cr.2017.99","article-title":"Ythdc2 is an N(6)-methyladenosine binding protein that regulates mammalian spermatogenesis","volume":"27","author":"Hsu","year":"2017","journal-title":"Cell Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"17249","DOI":"10.1021\/jacs.7b09213","article-title":"RNA Chemical Proteomics Reveals the N(6)-Methyladenosine (m(6)A)-Regulated Protein-RNA Interactome","volume":"139","author":"Arguello","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Yen, Y.P., and Chen, J.A. (2021). The m(6)A epitranscriptome on neural development and degeneration. J. Biomed. Sci., 28.","DOI":"10.1186\/s12929-021-00734-6"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1038\/npp.2017.31","article-title":"The Role of The RNA Demethylase FTO (Fat Mass and Obesity-Associated) and mRNA Methylation in Hippocampal Memory Formation","volume":"42","author":"Walters","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.neuron.2017.12.036","article-title":"Epitranscriptomic m(6)A Regulation of Axon Regeneration in the Adult Mammalian Nervous System","volume":"97","author":"Weng","year":"2018","journal-title":"Neuron"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.cell.2017.09.003","article-title":"Temporal Control of Mammalian Cortical Neurogenesis by m(6)A Methylation","volume":"171","author":"Yoon","year":"2017","journal-title":"Cell"},{"key":"ref_20","first-page":"3936","article-title":"Fragile X mental retardation protein modulates the stability of its m6A-marked messenger RNA targets","volume":"27","author":"Zhang","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Xia, L., Zhang, F., Li, Y., Mo, Y., Zhang, L., Li, Q., Luo, M., Hou, X., Du, Z., and Deng, J. (2023). A new perspective on Alzheimer\u2019s disease: m6A modification. Front. Genet., 14.","DOI":"10.3389\/fgene.2023.1166831"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1021\/acschemneuro.8b00657","article-title":"Down-Regulation of m6A mRNA Methylation Is Involved in Dopaminergic Neuronal Death","volume":"10","author":"Chen","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"113227","DOI":"10.1016\/j.bbr.2021.113227","article-title":"Role of Fto on CaMKII\/CREB signaling pathway of hippocampus in depressive-like behaviors induced by chronic restraint stress mice","volume":"406","author":"Shen","year":"2021","journal-title":"Behav. Brain Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jad.2015.12.048","article-title":"Meta-analysis indicates that SNP rs9939609 within FTO is not associated with major depressive disorder (MDD) in Asian population","volume":"193","author":"Yao","year":"2016","journal-title":"J. Affect. Disord."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/ana.25809","article-title":"SCN3A-Related Neurodevelopmental Disorder: A Spectrum of Epilepsy and Brain Malformation","volume":"88","author":"Zaman","year":"2020","journal-title":"Ann. Neurol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.amjmed.2019.03.001","article-title":"Parkinson\u2019s Disease and Parkinsonism","volume":"132","author":"Hayes","year":"2019","journal-title":"Am. J. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1093\/brain\/122.8.1437","article-title":"The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson\u2019s disease","volume":"122","author":"Damier","year":"1999","journal-title":"Brain"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","article-title":"Parkinson\u2019s disease","volume":"397","author":"Bloem","year":"2021","journal-title":"Lancet"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1126\/science.276.5321.2045","article-title":"Mutation in the alpha-synuclein gene identified in families with Parkinson\u2019s disease","volume":"276","author":"Polymeropoulos","year":"1997","journal-title":"Science"},{"key":"ref_30","first-page":"25","article-title":"Apoptosis and autophagy in nigral neurons of patients with Parkinson\u2019s disease","volume":"12","author":"Anglade","year":"1997","journal-title":"Histol. Histopathol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.neuron.2016.03.038","article-title":"Understanding Dopaminergic Cell Death Pathways in Parkinson Disease","volume":"90","author":"Michel","year":"2016","journal-title":"Neuron"},{"key":"ref_32","first-page":"1","article-title":"The clinical diagnosis of Parkinson\u2019s disease","volume":"82","author":"Munhoz","year":"2024","journal-title":"Arq. Neuropsiquiatr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1474-4422(05)70285-4","article-title":"The diagnosis of Parkinson\u2019s disease","volume":"5","author":"Tolosa","year":"2006","journal-title":"Lancet Neurol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Emamzadeh, F.N., and Surguchov, A. (2018). Parkinson\u2019s Disease: Biomarkers, Treatment, and Risk Factors. Front. Neurosci., 12.","DOI":"10.3389\/fnins.2018.00612"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s12264-017-0183-5","article-title":"Biomarkers for Parkinson\u2019s Disease: Recent Advancement","volume":"33","author":"Lotankar","year":"2017","journal-title":"Neurosci. Bull."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/jnc.15882","article-title":"METTL14 is decreased and regulates m(6) A modification of \u03b1-synuclein in Parkinson\u2019s disease","volume":"166","author":"He","year":"2023","journal-title":"J. Neurochem."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Martinez De La Cruz, B., Gell, C., Markus, R., Macdonald, I., Fray, R., and Knight, H.M. (2023). m(6) A mRNA methylation in human brain is disrupted in Lewy body disorders. Neuropathol. Appl. Neurobiol., 49.","DOI":"10.1111\/nan.12885"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1186\/s12967-023-04461-4","article-title":"FTO-targeted siRNA delivery by MSC-derived exosomes synergistically alleviates dopaminergic neuronal death in Parkinson\u2019s disease via m6A-dependent regulation of ATM mRNA","volume":"21","author":"Geng","year":"2023","journal-title":"J. Transl. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"135315","DOI":"10.1016\/j.neulet.2020.135315","article-title":"Genome-wide identification of m(6)A-associated single-nucleotide polymorphisms in Parkinson\u2019s disease","volume":"737","author":"Qiu","year":"2020","journal-title":"Neurosci. Lett."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"giy035","DOI":"10.1093\/gigascience\/giy035","article-title":"m6ASNP: A tool for annotating genetic variants by m6A function","volume":"7","author":"Jiang","year":"2018","journal-title":"Gigascience"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1093\/hmg\/ddr026","article-title":"Cyclin-G-associated kinase modifies \u03b1-synuclein expression levels and toxicity in Parkinson\u2019s disease: Results from the GenePD Study","volume":"20","author":"Dumitriu","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.jocn.2014.12.014","article-title":"Quantitative assessment of the association between GAK rs1564282 C\/T polymorphism and the risk of Parkinson\u2019s disease","volume":"22","author":"Ma","year":"2015","journal-title":"J. Clin. Neurosci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.brainresbull.2020.07.018","article-title":"RNA demethylase Alkbh5 is widely expressed in neurons and decreased during brain development","volume":"163","author":"Du","year":"2020","journal-title":"Brain Res. Bull."},{"key":"ref_44","first-page":"9919129","article-title":"Influence of N6-Methyladenosine Modification Gene HNRNPC on Cell Phenotype in Parkinson\u2019s Disease","volume":"2021","author":"Quan","year":"2021","journal-title":"Parkinsons Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"143.e9","DOI":"10.1016\/j.neurobiolaging.2020.03.018","article-title":"Genetic analysis of N6-methyladenosine modification genes in Parkinson\u2019s disease","volume":"93","author":"Qin","year":"2020","journal-title":"Neurobiol. Aging"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1016\/S0021-9258(18)93832-9","article-title":"Tyrosine Hydroxylase. The Initial Step in Norepinephrine Biosynthesis","volume":"239","author":"Nagatsu","year":"1964","journal-title":"J. Biol. Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s40035-023-00378-6","article-title":"Role of dopamine in the pathophysiology of Parkinson\u2019s disease","volume":"12","author":"Zhou","year":"2023","journal-title":"Transl. Neurodegener."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/0003-9861(70)90144-X","article-title":"Preparation and properties of a homogeneous aromatic L-amino acid decarboxylase from hog kidney","volume":"141","author":"Christenson","year":"1970","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/00019052-200312002-00001","article-title":"Dopamine and cognition","volume":"16","author":"Robbins","year":"2003","journal-title":"Curr. Opin. Neurol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1126\/science.1065931","article-title":"Neurobiology. Dopamine\u2019s reversal of fortune","volume":"293","author":"Blakely","year":"2001","journal-title":"Science"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"8567","DOI":"10.1111\/jcmm.16740","article-title":"Conditional deficiency of m6A methyltransferase Mettl14 in substantia nigra alters dopaminergic neuron function","volume":"25","author":"Teng","year":"2021","journal-title":"J. Cell Mol. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"136907","DOI":"10.1016\/j.neulet.2022.136907","article-title":"Analysis of m6A modification regulators in the substantia nigra and striatum of MPTP-induced Parkinson\u2019s disease mice","volume":"791","author":"Yu","year":"2022","journal-title":"Neurosci. Lett."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1124\/pr.110.002642","article-title":"The physiology, signaling, and pharmacology of dopamine receptors","volume":"63","author":"Beaulieu","year":"2011","journal-title":"Pharmacol. Rev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/mds.26177","article-title":"Dopamine signals and physiological origin of cognitive dysfunction in Parkinson\u2019s disease","volume":"30","author":"Matsumoto","year":"2015","journal-title":"Mov. Disord."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/nn.3449","article-title":"The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry","volume":"16","author":"Hess","year":"2013","journal-title":"Nat. Neurosci."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Nguyen, H., Glaaser, I.W., and Slesinger, P.A. (2024). Direct modulation of G protein-gated inwardly rectifying potassium (GIRK) channels. Front. Physiol., 15.","DOI":"10.3389\/fphys.2024.1386645"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Selberg, S., Yu, L.Y., Bondarenko, O., Kankuri, E., Seli, N., Kovaleva, V., Herodes, K., Saarma, M., and Karelson, M. (2021). Small-Molecule Inhibitors of the RNA M6A Demethylases FTO Potently Support the Survival of Dopamine Neurons. Int. J. Mol. Sci., 22.","DOI":"10.1101\/2021.02.23.432419"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/ede.12364","article-title":"A cis-regulatory change underlying the motor neuron-specific loss of Ebf expression in immotile tunicate larvae","volume":"23","author":"Lowe","year":"2021","journal-title":"Evol. Dev."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"111139","DOI":"10.1016\/j.cellsig.2024.111139","article-title":"Early B Cell Factor 3 (EBF3) attenuates Parkinson\u2019s disease through directly regulating contactin-associated protein-like 4 (CNTNAP4) transcription: An experimental study","volume":"118","author":"Hu","year":"2024","journal-title":"Cell Signal"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"He, F., Ru, X., and Wen, T. (2020). NRF2, a Transcription Factor for Stress Response and Beyond. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21134777"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/cbin.12118","article-title":"Knockdown of fat mass and obesity alleviates the ferroptosis in Parkinson\u2019s disease through m6A-NRF2-dependent manner","volume":"48","author":"Pang","year":"2024","journal-title":"Cell Biol. Int."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1021\/acschemneuro.4c00620","article-title":"m6A Demethylase FTO-Mediated Upregulation of BAP1 Induces Neuronal Ferroptosis via the p53\/SLC7A11 Axis in the MPP(+)\/MPTP-Induced Parkinson\u2019s Disease Model","volume":"16","author":"Li","year":"2025","journal-title":"ACS Chem. Neurosci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/toxsci\/kfy172","article-title":"m6A Demethylase FTO Regulates Dopaminergic Neurotransmission Deficits Caused by Arsenite","volume":"165","author":"Bai","year":"2018","journal-title":"Toxicol. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"128099","DOI":"10.1016\/j.jhazmat.2021.128099","article-title":"Protective role of mRNA demethylase FTO on axon guidance molecules of nigro-striatal projection system in manganese-induced parkinsonism","volume":"426","author":"Qi","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0896-6273(00)80886-7","article-title":"Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system","volume":"25","author":"Abeliovich","year":"2000","journal-title":"Neuron"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.2174\/0115665240263859231018110107","article-title":"METTL14 Regulates the m6A Modification of TRAF6 to Suppress Mitochondrial Dysfunction and Ferroptosis in Dopaminergic Neurons via the cGAS-STING Pathway","volume":"24","author":"Shao","year":"2024","journal-title":"Curr. Mol. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1001\/jamaneurol.2016.2742","article-title":"Aberrations in Peripheral Inflammatory Cytokine Levels in Parkinson Disease: A Systematic Review and Meta-analysis","volume":"73","author":"Qin","year":"2016","journal-title":"JAMA Neurol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1089\/ars.2017.7411","article-title":"Critical Roles of Glutaredoxin in Brain Cells-Implications for Parkinson\u2019s Disease","volume":"30","author":"Mieyal","year":"2019","journal-title":"Antioxid. Redox Signal"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e14441","DOI":"10.1111\/cns.14441","article-title":"NRF1 mitigates motor dysfunction and dopamine neuron degeneration in mice with Parkinson\u2019s disease by promoting GLRX m(6) A methylation through upregulation of METTL3 transcription","volume":"30","author":"Gong","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.cell.2009.01.038","article-title":"A Nurr1\/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death","volume":"137","author":"Saijo","year":"2009","journal-title":"Cell"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/s41583-019-0244-z","article-title":"The m(6)A epitranscriptome: Transcriptome plasticity in brain development and function","volume":"21","author":"Livneh","year":"2020","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1042\/EBC20200039","article-title":"Detection methods of epitranscriptomic mark N6-methyladenosine","volume":"64","author":"Wang","year":"2020","journal-title":"Essays Biochem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/978-1-4939-8808-2_20","article-title":"Dot Blot Analysis for Measuring Global N(6)-Methyladenosine Modification of RNA","volume":"1870","author":"Nagarajan","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nature16998","article-title":"The dynamic N(1)-methyladenosine methylome in eukaryotic messenger RNA","volume":"530","author":"Dominissini","year":"2016","journal-title":"Nature"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nature11112","article-title":"Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq","volume":"485","author":"Dominissini","year":"2012","journal-title":"Nature"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nmeth.3453","article-title":"Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome","volume":"12","author":"Linder","year":"2015","journal-title":"Nat. Methods"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"12930","DOI":"10.1039\/C7CC07699A","article-title":"Detection of N(6)-methyladenosine based on the methyl-sensitivity of MazF RNA endonuclease","volume":"53","author":"Imanishi","year":"2017","journal-title":"Chem. Commun."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Deng, S., Zhang, H., Zhu, K., Li, X., Ye, Y., Li, R., Liu, X., Lin, D., Zuo, Z., and Zheng, J. (2021). M6A2Target: A comprehensive database for targets of m6A writers, erasers and readers. Brief. Bioinform., 22.","DOI":"10.1093\/bib\/bbaa055"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"D1405","DOI":"10.1093\/nar\/gkaa811","article-title":"RMVar: An updated database of functional variants involved in RNA modifications","volume":"49","author":"Luo","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"D273","DOI":"10.1093\/nar\/gkad1070","article-title":"RMBase v3.0: Decode the landscape, mechanisms and functions of RNA modifications","volume":"52","author":"Xuan","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"D194","DOI":"10.1093\/nar\/gkad691","article-title":"m6A-Atlas v2.0: Updated resources for unraveling the N6-methyladenosine (m6A) epitranscriptome among multiple species","volume":"52","author":"Liang","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1093\/nar\/gkw104","article-title":"SRAMP: Prediction of mammalian N6-methyladenosine (m6A) sites based on sequence-derived features","volume":"44","author":"Zhou","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Jia, F., Fellner, A., and Kumar, K.R. (2022). Monogenic Parkinson\u2019s Disease: Genotype, Phenotype, Pathophysiology, and Genetic Testing. Genes, 13.","DOI":"10.3390\/genes13030471"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/s41583-024-00812-2","article-title":"Key genes and convergent pathogenic mechanisms in Parkinson disease","volume":"25","author":"Coukos","year":"2024","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1080\/15548627.2019.1586246","article-title":"METTL3 and ALKBH5 oppositely regulate m(6)A modification of TFEB mRNA, which dictates the fate of hypoxia\/reoxygenation-treated cardiomyocytes","volume":"15","author":"Song","year":"2019","journal-title":"Autophagy"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1038\/s41388-021-01820-7","article-title":"N6-methyladenosine demethyltransferase FTO-mediated autophagy in malignant development of oral squamous cell carcinoma","volume":"40","author":"Wang","year":"2021","journal-title":"Oncogene"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"967","DOI":"10.3390\/neurolint15030062","article-title":"In Search of a Function for the N6-Methyladenosine in Epitranscriptome, Autophagy and Neurodegenerative Diseases","volume":"15","author":"Suga","year":"2023","journal-title":"Neurol. Int."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Gao, Z., Zha, X., Li, M., Xia, X., and Wang, S. (2024). Insights into the m(6)A demethylases FTO and ALKBH5: Structural, biological function, and inhibitor development. Cell Biosci., 14.","DOI":"10.1186\/s13578-024-01286-6"}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/15\/5\/617\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:20:27Z","timestamp":1760030427000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/15\/5\/617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,23]]},"references-count":88,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,5]]}},"alternative-id":["biom15050617"],"URL":"https:\/\/doi.org\/10.3390\/biom15050617","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,23]]}}}