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Dysfunction of mesenchymal stem cells in psoriatic skin may also be the main reason for the dysregulated inflammatory response. Mesenchymal stem cells, a type of adult stem cells with multidifferentiation potential, are involved in the regulation of multiple links and targets in the pathogenesis of psoriasis. Thus, a detailed exploration of these mechanisms may lead to the development of new therapeutic strategies for the treatment of psoriasis. In this paper, the role of mesenchymal stem cells in skin homeostasis, the pathogenesis of psoriasis, and the multimodal function of using mesenchymal stem cells in the treatment of psoriasis are reviewed.<\/jats:p>","DOI":"10.3390\/biom15050737","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T06:54:28Z","timestamp":1747724068000},"page":"737","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multimodal Function of Mesenchymal Stem Cells in Psoriasis Treatment"],"prefix":"10.3390","volume":"15","author":[{"given":"Jiaxin","family":"Ou","sequence":"first","affiliation":[{"name":"The Second Clinical School of Guangzhou University of Chinese Medicine\/The Second Affiliated Hospital of Guangzhou University of Chinese Medicine\/Guangdong Provincial Hospital of Chinese Medicine\/Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou 510120, China"},{"name":"State Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangzhou 510120, China"},{"name":"Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research and Guangdong Provincial Key Laboratory of Clinical Research on Chinese Medicine Syndrome, Guangzhou 510120, China"},{"name":"National Institute of Stem Cell Clinical Research, Guangdong Hospital of Chinese Medicine, Guangzhou 510120, China"},{"name":"Lab of Stem Cell Biology and Innovative Research of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine\/Guangdong Academy of Chinese Medicine, Guangzhou 510120, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziqing","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Clinical School of Guangzhou University of Chinese Medicine\/The Second Affiliated Hospital of Guangzhou University of Chinese Medicine\/Guangdong Provincial Hospital of Chinese Medicine\/Guangdong Provincial Academy of Chinese Medical Sciences, 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Prevention and Treatment of Refractory Chronic Diseases, Guangzhou 510120, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev-immunol-032713-120225","article-title":"Immunology of psoriasis","volume":"32","author":"Lowes","year":"2014","journal-title":"Annu. 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