{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:36:15Z","timestamp":1787027775924,"version":"build-2736575974"},"reference-count":59,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T00:00:00Z","timestamp":1749340800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["T1EDK\u201401504"],"award-info":[{"award-number":["T1EDK\u201401504"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["9578"],"award-info":[{"award-number":["9578"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Hellenic Foundation for Research and Innovation (H.F.R.I.)","award":["T1EDK\u201401504"],"award-info":[{"award-number":["T1EDK\u201401504"]}]},{"name":"the Hellenic Foundation for Research and Innovation (H.F.R.I.)","award":["9578"],"award-info":[{"award-number":["9578"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>One major public health issue is cancer chemotherapy; despite constant progress in the area, administration of anticancer drugs to patients is often associated with serious side effects. It is therefore imperative to develop vehicles for encapsulation and controlled delivery of such drugs. Anticancer drugs include small peptide drugs, such as Bortezomib (BTZ). Self-assembling peptides have been recently reported as promising drug delivery agents. The research reported here proposes the encapsulation of BTZ into peptide hydrogels formed by the self-assembling FmocFF dipeptide as delivery vehicle. We selected FmocFF as an encapsulation vehicle based on our previous simulation study on the complexation propensity of Bortezomib (BTZ) with various peptide gelators. Herein we undertook additional computational studies that highlight the benefits of FmocFF as a potential effective nanocarrier for BTZ combined with experiments of encapsulation and evaluation of BTZ release. Based on these computational and experimental results, we propose the Fmoc-FF dipeptide hydrogel as a promising matrix for the controlled delivery of BTZ.<\/jats:p>","DOI":"10.3390\/biom15060839","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T09:13:01Z","timestamp":1749460381000},"page":"839","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["FmocFF Peptide Hydrogel Is a Promising Matrix for Encapsulation and Controlled Release of the Anticancer Peptide Drug Bortezomib"],"prefix":"10.3390","volume":"15","author":[{"given":"Peter","family":"Divanach","sequence":"first","affiliation":[{"name":"Department of Materials Science and Engineering, University of Crete, Voutes Campus, GR-70013 Heraklion, Greece"},{"name":"Institute of Electronic Structure and Laser, Foundation for Research and Technology-Hellas (FORTH), Nikolaou Plastira 100, Vassilika Vouton, GR-70013 Heraklion, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antzela","family":"Noti","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, University of Crete, Voutes Campus, GR-70013 Heraklion, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Vouvopoulos","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, University of Crete, Voutes Campus, GR-70013 Heraklion, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5106-5184","authenticated-orcid":false,"given":"Thanasis","family":"Athanasiou","sequence":"additional","affiliation":[{"name":"Institute of Electronic Structure and Laser, Foundation for Research and Technology-Hellas (FORTH), Nikolaou Plastira 100, Vassilika Vouton, GR-70013 Heraklion, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0200-7866","authenticated-orcid":false,"given":"Nikos","family":"Kountourakis","sequence":"additional","affiliation":[{"name":"Proteomics Facility, Institute of Molecular Biology & Biotechnology, Foundation for Research and Technology-Hellas (FORTH), Nikolaou Plastira 100, GR-70013 Heraklion, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9613-7639","authenticated-orcid":false,"given":"Vagelis","family":"Harmandaris","sequence":"additional","affiliation":[{"name":"Institute of Applied and Computational Mathematics (IACM), Foundation for Research and Technology-Hellas (FORTH), GR-71110 Heraklion, Greece"},{"name":"Department of Mathematics and Applied Mathematics, University of Crete, GR-71409 Heraklion, Greece"},{"name":"Computation-Based Science and Technology Research Center, The Cyprus Institute, Nicosia 2121, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1393-7639","authenticated-orcid":false,"given":"Anastassia N.","family":"Rissanou","sequence":"additional","affiliation":[{"name":"Theoretical & Physical Chemistry Institute, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, GR-11635 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Mitraki","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, University of Crete, Voutes Campus, GR-70013 Heraklion, Greece"},{"name":"Institute of Electronic Structure and Laser, Foundation for Research and Technology-Hellas (FORTH), Nikolaou Plastira 100, Vassilika Vouton, GR-70013 Heraklion, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.addr.2015.10.022","article-title":"Recent advances of cocktail chemotherapy by combination drug delivery systems","volume":"98","author":"Hu","year":"2016","journal-title":"Adv. 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