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Currently lacking a clinical cure, AD presents significant physical and emotional challenges for patients and their families, substantially impacting their quality of life. This underscores significant unmet needs in AD management and highlights the necessity for developing effective therapeutic applications. Recently, several chlorine-containing active substances with promising pharmacological activity have been discovered in soft corals cultivated through coral farming. Among these, brianolide, isolated from the soft coral Briareum stechei, has shown promising potential. This study investigated brianolide\u2019s regulatory effects on the inflammatory response in atopic dermatitis and its underlying mechanisms. Using an in vitro human keratinocyte cell line (HaCaT) stimulated with tumor necrosis factor-\u03b1 (TNF-\u03b1)\/interferon-\u03b3 (IFN-\u03b3) to mimic AD inflammation, brianolide was found to inhibit cytokine and chemokine expression via the mitogen-activated protein kinase (MAPK) and nuclear factor kappa-light-chain-enhancer of activated B cell (NF\u03baB)-signaling pathways. In an in vivo animal model of 2,4-Dinitrochlorobenzene (DNCB)-induced AD, brianolide demonstrated anti-inflammatory effects, reducing transepidermal water loss (TEWL), ear thickness, erythema, and epidermal blood flow. These findings provide new insights into brianolide\u2019s activity against AD-related inflammation, elucidate potential mechanisms, and contribute to understanding the pharmacological potential of natural coral products for AD treatment.<\/jats:p>","DOI":"10.3390\/biom15060871","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T14:03:11Z","timestamp":1750082591000},"page":"871","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Brianolide from Briareum stechei Attenuates Atopic Dermatitis-like Skin Lesions by Regulating the NF\u03baB and MAPK Pathways"],"prefix":"10.3390","volume":"15","author":[{"given":"Chia-Chen","family":"Wang","sequence":"first","affiliation":[{"name":"School of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan"},{"name":"Department of Dermatology, Cardinal Tien Hospital, New Taipei City 23148, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang-Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Metabolism and Endocrinology, Department of Internal Medicine, Taoyuan Armed Forces General Hospital, Taoyuan 32551, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Jou","family":"Hsu","sequence":"additional","affiliation":[{"name":"PhD Program in Pharmaceutical Biotechnology, Fu Jen Catholic University, New Taipei City 24205, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0461-2050","authenticated-orcid":false,"given":"Chao-Hsien","family":"Sung","sequence":"additional","affiliation":[{"name":"PhD Program in Pharmaceutical Biotechnology, Fu Jen Catholic University, New Taipei City 24205, Taiwan"},{"name":"Division of Anesthesiology, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City 24352, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-Jung","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, School of Health and Medical Engineering, Ming Chuan University, Taoyuan 33300, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng-Fang","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6644-9236","authenticated-orcid":false,"given":"Ping-Jyun","family":"Sung","sequence":"additional","affiliation":[{"name":"National Museum of Marine Biology and Aquarium, Pingtung County 94450, Taiwan"},{"name":"Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3478-5451","authenticated-orcid":false,"given":"Chi-Feng","family":"Hung","sequence":"additional","affiliation":[{"name":"School of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan"},{"name":"PhD Program in Pharmaceutical Biotechnology, Fu Jen Catholic University, New Taipei City 24205, Taiwan"},{"name":"School of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.det.2024.04.005","article-title":"Long-Term Impact of Atopic Dermatitis on Quality of Life","volume":"42","author":"Fitzmaurice","year":"2024","journal-title":"Dermatol. 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