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They play critical roles in synapse formation and function, neurotransmitter release and uptake, the production of trophic factors, and energy supply for neuronal survival. In addition to producing proteases for amyloid-\u03b2 degradation, astrocytes express various receptors, transporters, gliotransmitters, and other molecules that enable them to sense and respond to external signals. They are also implicated in amyloid-\u03b2 clearance. In Alzheimer\u2019s disease, excessive accumulation of amyloid-\u03b2 induces the polarization of astrocytes into the A1 phenotype, promoting the release of inflammatory cytokines and mitochondrial reactive oxygen species, leading to alterations in astrocytic functions. Under such conditions, gliotransmitter release, glutamate neurotransmission, AMPA receptor trafficking, and both Hebbian and non-Hebbian forms of synaptic plasticity\u2014biological activities essential for synaptic functions\u2014are compromised. Moreover, astrocytes are essential for learning, memory, and synaptic plasticity, and alterations in their function are associated with memory deficits in Alzheimer\u2019s disease. This review provides an overview of the current understanding of the defects in astrocytes that lead to altered synaptic functions, neuronal structural plasticity, and memory deficits in Alzheimer\u2019s disease.<\/jats:p>","DOI":"10.3390\/biom15070910","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T09:04:49Z","timestamp":1750410289000},"page":"910","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Role of Astrocytes in Synaptic Dysfunction and Memory Deficits in Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"15","author":[{"given":"Cristina A.","family":"Mu\u00f1oz de Le\u00f3n-L\u00f3pez","sequence":"first","affiliation":[{"name":"Laboratory of Neurobiology, CIMES, University of Malaga, Campus Teatinos s\/n, 29010 Malaga, Spain"},{"name":"Department of Medicine, Faculty of Medicine, University of Malaga, Campus Teatinos s\/n, 29010 Malaga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7866-3192","authenticated-orcid":false,"given":"Irene","family":"Navarro-Lobato","sequence":"additional","affiliation":[{"name":"Laboratory of Neurobiology, CIMES, University of Malaga, Campus Teatinos s\/n, 29010 Malaga, Spain"},{"name":"Department of Medicine, Faculty of Medicine, University of Malaga, Campus Teatinos s\/n, 29010 Malaga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0742-399X","authenticated-orcid":false,"given":"Zafar U.","family":"Khan","sequence":"additional","affiliation":[{"name":"Laboratory of Neurobiology, CIMES, University of Malaga, Campus Teatinos s\/n, 29010 Malaga, Spain"},{"name":"Department of Medicine, Faculty of Medicine, University of Malaga, Campus Teatinos s\/n, 29010 Malaga, Spain"},{"name":"CIBERNED, Institute of Health Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1002\/glia.24168","article-title":"A Perspective on Astrocyte Regulation of Neural Circuit Function and Animal Behavior","volume":"70","author":"Hirrlinger","year":"2022","journal-title":"Glia"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1146\/annurev-neuro-070918-050443","article-title":"The Emerging Nature of Astrocyte Diversity","volume":"42","author":"Khakh","year":"2019","journal-title":"Annu. 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