{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:30:19Z","timestamp":1760059819098,"version":"build-2065373602"},"reference-count":283,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chongqing Science and Health Joint Medical Research Sprint, Key Projects, and Major Projects","award":["2025DBXM002","CQEIC2024MDAD-050","CSTB2024TIAD-KPX0031","CSTB2024NSCQ-KJFZMSX0077","2022CDJYGRH-001"],"award-info":[{"award-number":["2025DBXM002","CQEIC2024MDAD-050","CSTB2024TIAD-KPX0031","CSTB2024NSCQ-KJFZMSX0077","2022CDJYGRH-001"]}]},{"name":"Chongqing Innovative Medical Device Application Demonstration Project","award":["2025DBXM002","CQEIC2024MDAD-050","CSTB2024TIAD-KPX0031","CSTB2024NSCQ-KJFZMSX0077","2022CDJYGRH-001"],"award-info":[{"award-number":["2025DBXM002","CQEIC2024MDAD-050","CSTB2024TIAD-KPX0031","CSTB2024NSCQ-KJFZMSX0077","2022CDJYGRH-001"]}]},{"name":"Key Project of Chongqing Technology Innovation and Application Development Special Project","award":["2025DBXM002","CQEIC2024MDAD-050","CSTB2024TIAD-KPX0031","CSTB2024NSCQ-KJFZMSX0077","2022CDJYGRH-001"],"award-info":[{"award-number":["2025DBXM002","CQEIC2024MDAD-050","CSTB2024TIAD-KPX0031","CSTB2024NSCQ-KJFZMSX0077","2022CDJYGRH-001"]}]},{"name":"Natural Science Foundation of Chongqing, China","award":["2025DBXM002","CQEIC2024MDAD-050","CSTB2024TIAD-KPX0031","CSTB2024NSCQ-KJFZMSX0077","2022CDJYGRH-001"],"award-info":[{"award-number":["2025DBXM002","CQEIC2024MDAD-050","CSTB2024TIAD-KPX0031","CSTB2024NSCQ-KJFZMSX0077","2022CDJYGRH-001"]}]},{"name":"Fundamental Research Funds for the Central Universities","award":["2025DBXM002","CQEIC2024MDAD-050","CSTB2024TIAD-KPX0031","CSTB2024NSCQ-KJFZMSX0077","2022CDJYGRH-001"],"award-info":[{"award-number":["2025DBXM002","CQEIC2024MDAD-050","CSTB2024TIAD-KPX0031","CSTB2024NSCQ-KJFZMSX0077","2022CDJYGRH-001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>HIV-associated lymphoma (HAL) is a heterogeneous and highly aggressive group of malignancies. Although antiretroviral therapy (ART) has significantly prolonged the survival of people living with HIV (PLWH), the risk of malignancy secondary to HIV infection remains higher than in HIV-negative individuals, with HAL being among the most frequent. The pathogenesis of HAL is complex, involving multifactorial interactions. In current clinical practice, HAL faces a double challenge: the lack of effective biological risk warning systems and the lack of precise prognostic stratification tools. In recent years, the construction of multidimensional biomarker systems has shown critical value in the comprehensive management of HAL. This review aims to systematically summarize recent advances in circulating biomarkers for HAL, focusing on the potential applications of immune environment indicators, such as inflammatory cytokine profiles and microbial translocation markers, as well as serum protein profiles, lymphocyte subsets, extracellular vesicles (EVs), circulating microRNAs (miRNAs), and viral biomarkers. These biomarkers offer promising avenues for early risk prediction, therapeutic monitoring, and prognostic evaluation. Developing an assessment system based on multidimensional biomarkers will optimize early risk stratification, enable precise prognostic classification, and support personalized therapeutic strategies, thereby providing a novel theoretical basis and practical direction for the clinical management of HAL.<\/jats:p>","DOI":"10.3390\/biom15070993","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T15:19:31Z","timestamp":1752247171000},"page":"993","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Circulating Biomarker Panorama in HIV-Associated Lymphoma: A Bridge from Early Risk Warning to Prognostic Stratification"],"prefix":"10.3390","volume":"15","author":[{"given":"Xuejiao","family":"Shu","sequence":"first","affiliation":[{"name":"School of Medicine, Chongqing University, Chongqing 400030, China"},{"name":"Chongqing Key Laboratory for the Mechanism and Intervention of Cancer Metastasis, Department of Hematology-Oncology, Chongqing University Cancer Hospital, Chongqing 400030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Xiao","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory for the Mechanism and Intervention of Cancer Metastasis, Department of Hematology-Oncology, Chongqing University Cancer Hospital, Chongqing 400030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Medicine, Chongqing University, Chongqing 400030, China"},{"name":"Chongqing Key Laboratory for the Mechanism and Intervention of Cancer Metastasis, Department of Hematology-Oncology, Chongqing University Cancer Hospital, Chongqing 400030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya","family":"Li","sequence":"additional","affiliation":[{"name":"School of Medicine, Chongqing University, Chongqing 400030, China"},{"name":"Chongqing Key Laboratory for the Mechanism and Intervention of Cancer Metastasis, Department of Hematology-Oncology, Chongqing University Cancer Hospital, Chongqing 400030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqing","family":"Xie","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory for the Mechanism and Intervention of Cancer Metastasis, Department of Hematology-Oncology, Chongqing University Cancer Hospital, Chongqing 400030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanxiu","family":"He","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory for the Mechanism and Intervention of Cancer Metastasis, Department of Hematology-Oncology, Chongqing University Cancer Hospital, Chongqing 400030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory for the Mechanism and Intervention of Cancer Metastasis, Department of Hematology-Oncology, Chongqing University Cancer Hospital, Chongqing 400030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory for the Mechanism and Intervention of Cancer Metastasis, Department of Hematology-Oncology, Chongqing University Cancer Hospital, Chongqing 400030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1782-7322","authenticated-orcid":false,"given":"Yao","family":"Liu","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory for the Mechanism and Intervention of Cancer Metastasis, Department of Hematology-Oncology, Chongqing University Cancer Hospital, Chongqing 400030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"key":"ref_1","unstructured":"UNAIDS Global HIV & AIDS Statistics\u2014Fact Sheet. 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