{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:58:39Z","timestamp":1792789119977,"version":"4.5.0"},"reference-count":56,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Innovation and Entrepreneurship Plan of Science and Technology Talent of Dalian","award":["2022RG09"],"award-info":[{"award-number":["2022RG09"]}]},{"name":"Innovation and Entrepreneurship Plan of Science and Technology Talent of Dalian","award":["2024JH2\/102400054"],"award-info":[{"award-number":["2024JH2\/102400054"]}]},{"name":"Liaoning Provincial Key Research and Development Program\u2014Industrial Technology Innovation Project","award":["2022RG09"],"award-info":[{"award-number":["2022RG09"]}]},{"name":"Liaoning Provincial Key Research and Development Program\u2014Industrial Technology Innovation Project","award":["2024JH2\/102400054"],"award-info":[{"award-number":["2024JH2\/102400054"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Temporal lobe epilepsy (TLE) is a common drug-resistant form of epilepsy, often accompanied by cognitive and emotional disturbances, highlighting the urgent need for novel therapies. Scorpion Venom Heat-Resistant Synthetic Peptide (SVHRSP), isolated and synthetically derived from scorpion venom, has shown anti-epileptic and neuroprotective potential. This study evaluated the anti-epileptic effects of SVHRSP in a kainic acid (KA)-induced TLE rat model. Our results demonstrated that SVHRSP (0.81 mg\/kg\/day) reduced the frequency and severity of spontaneous seizures. Behavioral tests showed improved cognitive performance in the novel object recognition, object location, and T-maze tasks, as well as reduced anxiety-like behavior in the open-field test. Moreover, SVHRSP mitigated hippocampal neuronal loss and glial activation. Transcriptomic analysis indicated that SVHRSP upregulates genes involved in adhesion molecule-triggered and axon guidance pathways. Western blotting and immunofluorescence further confirmed that SVHRSP restored dendritic (MAP2), axonal (NFL), and synaptic (PSD95) marker expression, elevated the functionally important L1CAM fragment (L1-70), and increased myelin basic protein-induced serine protease activity responsible for L1-70 generation. Blockade of L1CAM expression diminished the neuroprotective effects of SVHRSP, suggesting a critical role for L1CAM-mediated synapse functions. This study is the first to reveal the therapeutic potential of SVHRSP in TLE via L1CAM-associated mechanisms.<\/jats:p>","DOI":"10.3390\/biom15071032","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T10:33:47Z","timestamp":1752748427000},"page":"1032","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Upregulation of L1CAM by SVHRSP Mitigates Neuron Damage, Spontaneous Seizures, and Cognitive Dysfunction in a Kainic Acid-Induced Rat Model of Epilepsy"],"prefix":"10.3390","volume":"15","author":[{"given":"Zhen","family":"Li","sequence":"first","affiliation":[{"name":"National-Local Joint Engineering Research Center for Drug Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biying","family":"Ge","sequence":"additional","affiliation":[{"name":"National-Local Joint Engineering Research Center for Drug Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China"},{"name":"Functional Laboratory, College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoqi","family":"Li","sequence":"additional","affiliation":[{"name":"National-Local Joint Engineering Research Center for Drug Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyao","family":"Huang","sequence":"additional","affiliation":[{"name":"National-Local Joint Engineering Research Center for Drug Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhan","family":"Ji","sequence":"additional","affiliation":[{"name":"National-Local Joint Engineering Research Center for Drug Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melitta","family":"Schachner","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Neuroscience, Keck Center for Collaborative Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengming","family":"Yin","sequence":"additional","affiliation":[{"name":"National-Local Joint Engineering Research Center for Drug Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China"},{"name":"Liaoning Provincial Key Laboratory of Cerebral Diseases, Department of Physiology, College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Li","sequence":"additional","affiliation":[{"name":"National-Local Joint Engineering Research Center for Drug Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China"},{"name":"Department of Biochemistry, School of Basic Medical Science, Dalian Medical University, Dalian 116044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhao","sequence":"additional","affiliation":[{"name":"National-Local Joint Engineering Research Center for Drug Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China"},{"name":"Liaoning Provincial Key Laboratory of Cerebral Diseases, Department of Physiology, College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1001\/jamaneurol.2017.3949","article-title":"Treatment Outcomes in Patients With Newly Diagnosed Epilepsy Treated With Established and New Antiepileptic Drugs: A 30-Year Longitudinal Cohort Study","volume":"75","author":"Chen","year":"2018","journal-title":"JAMA Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1111\/epi.12220","article-title":"International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: A Task Force report from the ILAE Commission on Diagnostic Methods","volume":"54","author":"Blumcke","year":"2013","journal-title":"Epilepsia"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"6301","DOI":"10.1523\/JNEUROSCI.15-10-06301.1995","article-title":"Preferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy","volume":"15","author":"Du","year":"1995","journal-title":"J. Neurosci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1046\/j.1528-1157.2003.32701.x","article-title":"A retrospective analysis of hippocampal pathology in human temporal lobe epilepsy: Evidence for distinctive patient subcategories","volume":"44","author":"Kim","year":"2003","journal-title":"Epilepsia"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.tins.2012.11.008","article-title":"Glia and epilepsy: Excitability and inflammation","volume":"36","author":"Devinsky","year":"2013","journal-title":"Trends Neurosci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"109229","DOI":"10.1016\/j.celrep.2021.109229","article-title":"Sublayer- and cell-type-specific neurodegenerative transcriptional trajectories in hippocampal sclerosis","volume":"35","author":"Cid","year":"2021","journal-title":"Cell Rep."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/S1474-4422(20)30035-1","article-title":"30 years of second-generation antiseizure medications: Impact and future perspectives","volume":"19","author":"Perucca","year":"2020","journal-title":"Lancet Neurol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"107702","DOI":"10.1016\/j.neuropharm.2019.107702","article-title":"The path from scientific discovery to cures for epilepsy","volume":"167","author":"Carvill","year":"2020","journal-title":"Neuropharmacology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1111\/jnc.14107","article-title":"The malleable brain: Plasticity of neural circuits and behavior\u2014A review from students to students","volume":"142","author":"Schaefer","year":"2017","journal-title":"J. Neurochem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0955-0674(03)00107-8","article-title":"Synaptic adhesion molecules","volume":"15","author":"Yamagata","year":"2003","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Duncan, B.W., Murphy, K.E., and Maness, P.F. (2021). Molecular Mechanisms of L1 and NCAM Adhesion Molecules in Synaptic Pruning, Plasticity, and Stabilization. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.625340"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.tips.2015.08.004","article-title":"L1-CAM and N-CAM: From Adhesion Proteins to Pharmacological Targets","volume":"36","author":"Colombo","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Stoyanova, I.I., and Lutz, D. (2022). Functional Diversity of Neuronal Cell Adhesion and Recognition Molecule L1CAM through Proteolytic Cleavage. Cells, 11.","DOI":"10.3390\/cells11193085"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"7727","DOI":"10.1523\/JNEUROSCI.23-21-07727.2003","article-title":"NMDA-dependent proteolysis of presynaptic adhesion molecule L1 in the hippocampus by neuropsin","volume":"23","author":"Ninomiya","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1084\/jem.20150951","article-title":"Conditional deletion of L1CAM in human neurons impairs both axonal and dendritic arborization and action potential generation","volume":"213","author":"Patzke","year":"2016","journal-title":"J. Exp. Med."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Lin, J., Chooi, W.H., Ong, W., Zhang, N., Bechler, M.E., Ffrench-Constant, C., and Chew, S.Y. (2021). Oriented and sustained protein expression on biomimicking electrospun fibers for evaluating functionality of cells. Mater. Sci. Eng. C Mater. Biol. Appl., 118.","DOI":"10.1016\/j.msec.2020.111407"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.neuron.2019.02.009","article-title":"Axo-axonic Innervation of Neocortical Pyramidal Neurons by GABAergic Chandelier Cells Requires AnkyrinG-Associated L1CAM","volume":"102","author":"Tai","year":"2019","journal-title":"Neuron"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Yan, Z., Chu, L., Jia, X., Lin, L., and Cheng, S. (2021). Myelin basic protein enhances axonal regeneration from neural progenitor cells. Cell Biosci., 11.","DOI":"10.1186\/s13578-021-00584-7"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.peptides.2019.02.009","article-title":"Peptides with therapeutic potential in the venom of the scorpion Buthus martensii Karsch","volume":"115","author":"Li","year":"2019","journal-title":"Peptides"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Ahmadi, S., Knerr, J.M., Argemi, L., Bordon, K.C.F., Pucca, M.B., Cerni, F.A., Arantes, E.C., Caliskan, F., and Laustsen, A.H. (2020). Scorpion Venom: Detriments and Benefits. Biomedicines, 8.","DOI":"10.3390\/biomedicines8050118"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"714","DOI":"10.2174\/1389200219666171227205009","article-title":"Structure Activity Relationship of Venom Toxins Targeting Potassium Channels","volume":"19","author":"Batool","year":"2018","journal-title":"Curr. Drug Metab."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/15216540500058899","article-title":"Scorpion venom peptides without disulfide bridges","volume":"57","author":"Zeng","year":"2005","journal-title":"IUBMB Life"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"176704","DOI":"10.1016\/j.ejphar.2024.176704","article-title":"Scorpion venom heat-resistant synthesized peptide ameliorates epileptic seizures and imparts neuroprotection in rats mediated by NMDA receptors","volume":"978","author":"Sui","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1111\/bph.15502","article-title":"Scorpion venom heat-resistant synthesized peptide ameliorates 6-OHDA-induced neurotoxicity and neuroinflammation: Likely role of Na(v) 1.6 inhibition in microglia","volume":"178","author":"Li","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.1111\/bph.15193","article-title":"The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research","volume":"177","author":"Hurst","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Sharma, S., Puttachary, S., Thippeswamy, A., Kanthasamy, A.G., and Thippeswamy, T. (2018). Status Epilepticus: Behavioral and Electroencephalography Seizure Correlates in Kainate Experimental Models. Front. Neurol., 9.","DOI":"10.3389\/fneur.2018.00007"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Hakataya, S., Katsu, N., Okanoya, K., and Toya, G. (2023). An exploratory study of behavioral traits and the establishment of social relationships in female laboratory rats. PLoS ONE, 18.","DOI":"10.1101\/2023.06.09.543342"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nprot.2006.2","article-title":"T-maze alternation in the rodent","volume":"1","author":"Deacon","year":"2006","journal-title":"Nat. Protoc."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"d\u2019Isa, R., Comi, G., and Leocani, L. (2021). Apparatus design and behavioural testing protocol for the evaluation of spatial working memory in mice through the spontaneous alternation T-maze. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-00402-7"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Nagaraj, V., Mikhail, M., Baronio, M., Gatto, A., Nayak, A., Theis, T., Cavallaro, U., and Schachner, M. (2022). Antagonistic L1 Adhesion Molecule Mimetic Compounds Inhibit Glioblastoma Cell Migration In Vitro. Biomolecules, 12.","DOI":"10.3390\/biom12030439"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ebcr.2013.08.005","article-title":"The patient had a normal magnetic resonance imaging and temporal lobe epilepsy secondary to a porencephalic cyst but showed structural lesions (hippocampal sclerosis)","volume":"1","author":"Matsubara","year":"2013","journal-title":"Epilepsy Behav. Case Rep."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Park, H.R., and Cai, M. (2024). Antiseizure effects of Lilii Bulbus on pentylenetetrazol kindling-induced seizures in mice: Involvement of Reelin, Netrin-1, and semaphorin. Biomed. Pharmacother., 173.","DOI":"10.1016\/j.biopha.2024.116385"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"dev151415","DOI":"10.1242\/dev.151415","article-title":"Understanding axon guidance: Are we nearly there yet?","volume":"145","author":"Stoeckli","year":"2018","journal-title":"Development"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1523\/JNEUROSCI.5255-04.2005","article-title":"Secreted semaphorins modulate synaptic transmission in the adult hippocampus","volume":"25","author":"Sahay","year":"2005","journal-title":"J. Neurosci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.4103\/NRR.NRR-D-23-01620","article-title":"The role of axon guidance molecules in the pathogenesis of epilepsy","volume":"20","author":"Liu","year":"2025","journal-title":"Neural Regen. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"6817","DOI":"10.1007\/s12035-022-02995-0","article-title":"Neuropilin-2 Signaling Modulates Mossy Fiber Sprouting by Regulating Axon Collateral Formation Through CRMP2 in a Rat Model of Epilepsy","volume":"59","author":"Li","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Gorlewicz, A., and Kaczmarek, L. (2018). Pathophysiology of Trans-Synaptic Adhesion Molecules: Implications for Epilepsy. Front. Cell Dev. Biol., 6.","DOI":"10.3389\/fcell.2018.00119"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1080\/17425255.2021.1959912","article-title":"Understanding mechanisms of drug resistance in epilepsy and strategies for overcoming it","volume":"17","author":"Lukawski","year":"2021","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Tang, F., Hartz, A.M.S., and Bauer, B. (2017). Drug-Resistant Epilepsy: Multiple Hypotheses, Few Answers. Front. Neurol., 8.","DOI":"10.3389\/fneur.2017.00301"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s12035-014-8999-8","article-title":"Neuroligin-1 Knockdown Suppresses Seizure Activity by Regulating Neuronal Hyperexcitability","volume":"53","author":"Fang","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.neuron.2007.04.012","article-title":"Extracellular interactions between GluR2 and N-cadherin in spine regulation","volume":"54","author":"Saglietti","year":"2007","journal-title":"Neuron"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1126\/science.1069081","article-title":"Trans-synaptic Eph receptor-ephrin signaling in hippocampal mossy fiber LTP","volume":"296","author":"Contractor","year":"2002","journal-title":"Science"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.cell.2013.08.059","article-title":"An extracellular adhesion molecule complex patterns dendritic branching and morphogenesis","volume":"155","author":"Dong","year":"2013","journal-title":"Cell"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s41419-021-04348-6","article-title":"A fragment of cell adhesion molecule L1 reduces amyloid-beta plaques in a mouse model of Alzheimer\u2019s disease","volume":"13","author":"Hu","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"jcs210500","DOI":"10.1242\/jcs.210500","article-title":"A fragment of adhesion molecule L1 is imported into mitochondria, and regulates mitochondrial metabolism and trafficking","volume":"131","author":"Kraus","year":"2018","journal-title":"J. Cell Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"17442","DOI":"10.1074\/jbc.RA118.004240","article-title":"An ankyrin-binding motif regulates nuclear levels of L1-type neuroglian and expression of the oncogene Myc in Drosophila neurons","volume":"293","author":"Kakad","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"11274","DOI":"10.1523\/JNEUROSCI.1774-14.2014","article-title":"Neural cell adhesion molecule NrCAM regulates Semaphorin 3F-induced dendritic spine remodeling","volume":"34","author":"Demyanenko","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Singh, R., Rai, S., Bharti, P.S., Zehra, S., Gorai, P.K., Modi, G.P., Rani, N., Dev, K., Inampudi, K.K., and Y, V.V. (2024). Circulating small extracellular vesicles in Alzheimer\u2019s disease: A case-control study of neuro-inflammation and synaptic dysfunction. BMC Med., 22.","DOI":"10.1186\/s12916-024-03475-z"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1440-1819.2008.01893.x","article-title":"Association between neuronal cell adhesion molecule (NRCAM) single nucleotide polymorphisms and schizophrenia in a Korean population","volume":"63","author":"Kim","year":"2009","journal-title":"Psychiatry Clin. Neurosci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/mp.2012.37","article-title":"Convergent functional genomics of schizophrenia: From comprehensive understanding to genetic risk prediction","volume":"17","author":"Ayalew","year":"2012","journal-title":"Mol. Psychiatry"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.tins.2017.03.003","article-title":"Neural Cell Adhesion Molecules of the Immunoglobulin Superfamily Regulate Synapse Formation, Maintenance, and Function","volume":"40","author":"Sytnyk","year":"2017","journal-title":"Trends Neurosci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nrn.2018.16","article-title":"Dendritic structural plasticity and neuropsychiatric disease","volume":"19","author":"Forrest","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Lukawski, K., and Czuczwar, S.J. (2023). Oxidative Stress and Neurodegeneration in Animal Models of Seizures and Epilepsy. Antioxidants, 12.","DOI":"10.3390\/antiox12051049"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.3233\/JAD-201074","article-title":"Hypoxia, Oxidative Stress, and Inflammation: Three Faces of Neurodegenerative Diseases","volume":"82","author":"Merelli","year":"2021","journal-title":"J. Alzheimers Dis."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.neuroscience.2024.06.021","article-title":"Unraveling the Triad: Hypoxia, Oxidative Stress and Inflammation in Neurodegenerative Disorders","volume":"552","author":"Choudhary","year":"2024","journal-title":"Neuroscience"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.actbio.2022.06.038","article-title":"Effects of neuronal cell adhesion molecule L1 and nanoparticle surface modification on microglia","volume":"149","author":"Kushwah","year":"2022","journal-title":"Acta Biomater."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/15\/7\/1032\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:11:02Z","timestamp":1760033462000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/15\/7\/1032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,17]]},"references-count":56,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["biom15071032"],"URL":"https:\/\/doi.org\/10.3390\/biom15071032","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,17]]}}}