{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T17:01:08Z","timestamp":1788022868760,"version":"build-2784847793"},"reference-count":192,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Natural Science Foundation of Chongqing","award":["CSTB2023NSCQ-MSX0451"],"award-info":[{"award-number":["CSTB2023NSCQ-MSX0451"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Tumor drug resistance, a major cause of treatment failure, involves complex multi-gene networks, remodeling of signaling pathways, and interactions with the tumor microenvironment. Yin Yang 1 (YY1) is a critical oncogene overexpressed in many tumors and mediates multiple tumor-related processes, such as cell proliferation, metabolic reprogramming, immune evasion, and drug resistance. Notably, YY1 drives resistance through multiple mechanisms, such as upregulation of drug efflux, maintenance of cancer stemness, enhancement of DNA repair capacity, modulation of the tumor microenvironment, and epithelial\u2013mesenchymal transition, thereby positioning it as a pivotal regulator of drug resistance. This review examines the pivotal role of YY1 in resistance, elucidating its molecular mechanisms and clinical relevance. We demonstrate that YY1 inhibition could effectively reverse drug resistance and restore therapeutic sensitivity across various treatment modalities. Importantly, we highlight the promising potential of YY1-targeted strategies, particularly combined with anti-tumor agents, to overcome resistance barriers. Furthermore, we discuss critical translational considerations for advancing these combinatorial approaches into clinical practice.<\/jats:p>","DOI":"10.3390\/biom15081069","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T10:28:09Z","timestamp":1753352889000},"page":"1069","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Yin Yang 1 (YY1) as a Central Node in Drug Resistance Pathways: Potential for Combination Strategies in Cancer Therapy"],"prefix":"10.3390","volume":"15","author":[{"given":"Zhiyan","family":"Li","sequence":"first","affiliation":[{"name":"College of Pharmacy and Biological Engineering, Chongqing University of Technology, Chongqing 400054, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Jia","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Biological Engineering, Chongqing University of Technology, Chongqing 400054, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1136-6994","authenticated-orcid":false,"given":"Ian Timothy Sembiring","family":"Meliala","sequence":"additional","affiliation":[{"name":"Centre for Cellular Biology and Signalling, Zhejiang University-University of Edinburgh (ZJU-UoE) Institute, 718 East Haizhou Rd., Haining 314400, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Biological Engineering, Chongqing University of Technology, Chongqing 400054, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9182-8230","authenticated-orcid":false,"given":"Vivi","family":"Kasim","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0092-8674(91)90189-6","article-title":"Transcriptional repression by YY1, a human GLI-Kr\u00fcppel-related protein, and relief of repression by adenovirus E1A protein","volume":"67","author":"Shi","year":"1991","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1038\/sj.onc.1209080","article-title":"Transcription factor YY1: Structure, function, and therapeutic implications in cancer biology","volume":"25","author":"Gordon","year":"2006","journal-title":"Oncogene"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1007\/BF00360552","article-title":"Chromosomal localization of the transcription factor YY1 in the mouse and human","volume":"5","author":"Zhu","year":"1994","journal-title":"Mamm. Genome"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Schug, J., Schuller, W.P., Kappen, C., Salbaum, J.M., Bucan, M., and Stoeckert, C.J. (2005). Promoter features related to tissue specificity as measured by Shannon entropy. Genome Biol., 6.","DOI":"10.1186\/gb-2005-6-4-r33"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/ijc.31255","article-title":"The Yin and Yang of YY1 in tumor growth and suppression","volume":"143","author":"Khachigian","year":"2018","journal-title":"Int. J. Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1158\/0008-5472.CAN-12-0366","article-title":"Transcription factor YY1 contributes to tumor growth by stabilizing hypoxia factor HIF-1\u03b1 in a p53-independent manner","volume":"73","author":"Wu","year":"2013","journal-title":"Cancer Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1158\/0008-5472.CAN-22-2213","article-title":"Cancer-Associated Fibroblast-Derived miR-146a-5p Generates a Niche That Promotes Bladder Cancer Stemness and Chemoresistance","volume":"83","author":"Zhuang","year":"2023","journal-title":"Cancer Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0378-1119(99)00261-9","article-title":"Unlocking the mechanisms of transcription factor YY1: Are chromatin modifying enzymes the key?","volume":"236","author":"Thomas","year":"1999","journal-title":"Gene"},{"key":"ref_9","first-page":"F49","article-title":"Everything you have ever wanted to know about Yin Yang 1","volume":"1332","author":"Shi","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"19296","DOI":"10.1073\/pnas.0603564103","article-title":"Polycomb recruitment to DNA in vivo by the YY1 REPO domain","volume":"103","author":"Wilkinson","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.1038\/s41418-020-0580-6","article-title":"Yin Yang 1 is required for PHD finger protein 20-mediated myogenic differentiation in vitro and in vivo","volume":"27","author":"Lee","year":"2020","journal-title":"Cell Death Differ."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e70296","DOI":"10.1111\/jcmm.70296","article-title":"SE-lncRNAs in Cancer: Classification, Subcellular Localisation, Function and Corresponding TFs","volume":"28","author":"Bao","year":"2024","journal-title":"J. Cell. Mol. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e2501119","DOI":"10.1002\/advs.202501119","article-title":"MAGEA6 Engages a YY1-Dependent Transcription to Dictate Perineural Invasion in Colorectal Cancer","volume":"12","author":"Wang","year":"2025","journal-title":"Adv. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Shimizu, T., Shindo, T., Ogawa, H., Teranaka, K., Watanabe, A., and Takaori-Kondo, A. (2025). Upregulation of YY1\/EZH2 and MLH1 as Therapeutic Targets for Adult T-Cell Leukemia\/Lymphoma. Cancer Sci., 1\u201313.","DOI":"10.1111\/cas.70095"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4183","DOI":"10.7150\/thno.43481","article-title":"The biological implications of Yin Yang 1 in the hallmarks of cancer","volume":"10","author":"Meliala","year":"2020","journal-title":"Theranostics"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.drup.2019.04.001","article-title":"YY1 regulates cancer cell immune resistance by modulating PD-L1 expression","volume":"43","author":"Hays","year":"2019","journal-title":"Drug Resist. Updat."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Li, M., Wei, J., Xue, C., Zhou, X., Chen, S., Zheng, L., Duan, Y., Deng, H., Xiong, W., and Tang, F. (2023). Dissecting the roles and clinical potential of YY1 in the tumor microenvironment. Front. Oncol., 13.","DOI":"10.3389\/fonc.2023.1122110"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e31990","DOI":"10.1097\/MD.0000000000031990","article-title":"Crosstalk between YY1 and lncRNAs in cancer: A review","volume":"101","author":"Wang","year":"2022","journal-title":"Medicine"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/cei.13218","article-title":"Blocking of YY1 reduce neutrophil infiltration by inhibiting IL-8 production via the PI3K-Akt-mTOR signaling pathway in rheumatoid arthritis","volume":"195","author":"Lin","year":"2019","journal-title":"Clin. Exp. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/imm.12990","article-title":"YY1 binds to the E3\u2019 enhancer and inhibits the expression of the immunoglobulin \u03ba gene via epigenetic modifications","volume":"155","author":"Zhou","year":"2018","journal-title":"Immunology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/s41586-019-1730-1","article-title":"A view on drug resistance in cancer","volume":"575","author":"Vasan","year":"2019","journal-title":"Nature"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"102340","DOI":"10.1016\/j.ctrv.2022.102340","article-title":"Treatment-driven tumour heterogeneity and drug resistance: Lessons from solid tumours","volume":"104","author":"Crucitta","year":"2022","journal-title":"Cancer Treat. Rev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1158\/2159-8290.CD-20-1638","article-title":"Overcoming Resistance to Tumor-Targeted and Immune-Targeted Therapies","volume":"11","author":"Aldea","year":"2021","journal-title":"Cancer Discov."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1200\/JCO.21.01845","article-title":"Managing Resistance to Immune Checkpoint Inhibitors in Lung Cancer: Treatment and Novel Strategies","volume":"40","author":"Passaro","year":"2022","journal-title":"J. Clin. Oncol."},{"key":"ref_25","first-page":"e1291","article-title":"Molecular and cellular paradigms of multidrug resistance in cancer","volume":"5","author":"Vaidya","year":"2022","journal-title":"Cancer Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1615\/CritRevOncog.2017020959","article-title":"The Multilayered Regulation of the Oncogenic Protein YY1","volume":"22","author":"Rizkallah","year":"2017","journal-title":"Crit. Rev. Oncog."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"5826741","DOI":"10.1155\/2022\/5826741","article-title":"A Systematic Pan-Cancer Analysis of YY1 Aberrations and their Relationship with Clinical Outcome, Tumor Microenvironment, and Therapeutic Targets","volume":"2022","author":"Fu","year":"2022","journal-title":"J. Immunol. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1615\/CritRevOncog.v16.i3-4.30","article-title":"The oncogenic role of Yin Yang 1","volume":"16","author":"Zhang","year":"2011","journal-title":"Crit. Rev. Oncog."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Hosea, R., Hillary, S., Wu, S., and Kasim, V. (2023). Targeting Transcription Factor YY1 for Cancer Treatment: Current Strategies and Future Directions. Cancers, 15.","DOI":"10.3390\/cancers15133506"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1146\/annurev.med.53.082901.103929","article-title":"Mechanisms of cancer drug resistance","volume":"53","author":"Gottesman","year":"2002","journal-title":"Annu. Rev. Med."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Duan, C., Yu, M., Xu, J., Li, B.Y., Zhao, Y., and Kankala, R.K. (2023). Overcoming Cancer Multi-drug Resistance (MDR): Reasons, mechanisms, nanotherapeutic solutions, and challenges. Biomed. Pharmacother., 162.","DOI":"10.1016\/j.biopha.2023.114643"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s40262-020-00867-1","article-title":"Effect of P-glycoprotein (P-gp) Inducers on Exposure of P-gp Substrates: Review of Clinical Drug-Drug Interaction Studies","volume":"59","author":"Elmeliegy","year":"2020","journal-title":"Clin. Pharmacokinet."},{"key":"ref_33","first-page":"213","article-title":"Establishment and Characteristics of a Novel Mantle Cell Lymphoma-derived Cell Line and a Bendamustine-resistant Subline","volume":"15","author":"Nagoshi","year":"2018","journal-title":"Cancer Genom. Proteom."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1600-0609.2008.01083.x","article-title":"Gene expression profiling of Polycomb, Hox and Meis genes in patients with acute myeloid leukaemia","volume":"81","author":"Grubach","year":"2008","journal-title":"Eur. J. Haematol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Li, J., Luo, X., Wei, M., Li, Z., Li, Y., Zhao, H., Miyagishi, M., Kasim, V., and Wu, S. (2023). YY2\/PHGDH axis suppresses tumorigenesis by inhibiting tumor cell de novo serine biosynthesis. Biomed. Pharmacother., 165.","DOI":"10.1016\/j.biopha.2023.115006"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1080\/10428194.2018.1448083","article-title":"Role of Yin Yang-1 (YY1) in the transcription regulation of the multi-drug resistance (MDR1) gene","volume":"59","author":"Vega","year":"2018","journal-title":"Leuk. Lymphoma"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1038\/s41388-023-02762-y","article-title":"PGC-1\u03b1 promotes colorectal carcinoma metastasis through regulating ABCA1 transcription","volume":"42","author":"Chen","year":"2023","journal-title":"Oncogene"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.ccell.2016.03.004","article-title":"Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA","volume":"29","author":"Qu","year":"2016","journal-title":"Cancer Cell"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.cell.2014.09.051","article-title":"Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways","volume":"159","author":"Boelens","year":"2014","journal-title":"Cell"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.1007\/s11010-025-05222-1","article-title":"Upregulation of YY1 in M2 macrophages promotes secretion of exosomes containing hsa-circ-0000326 via super-enhancers to facilitate prostate cancer progression","volume":"480","author":"Guan","year":"2025","journal-title":"Mol. Cell Biochem."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Navasardyan, I., Zaravinos, A., and Bonavida, B. (2024). Therapeutic Implications of Targeting YY1 in Glioblastoma. Cancers, 16.","DOI":"10.3390\/cancers16112074"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Liu, X., Cao, Z., Liu, N., Gao, G., Du, M., Wang, Y., Cheng, B., Zhu, M., Jia, B., and Pan, L. (2022). Kill two birds with one stone: Engineered exosome-mediated delivery of cholesterol modified YY1-siRNA enhances chemoradiotherapy sensitivity of glioblastoma. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.975291"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Jung, M., Bui, I., and Bonavida, B. (2023). Role of YY1 in the Regulation of Anti-Apoptotic Gene Products in Drug-Resistant Cancer Cells. Cancers, 15.","DOI":"10.3390\/cancers15174267"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Potluri, V., Noothi, S.K., Vallabhapurapu, S.D., Yoon, S.O., Driscoll, J.J., Lawrie, C.H., and Vallabhapurapu, S. (2013). Transcriptional repression of Bim by a novel YY1-RelA complex is essential for the survival and growth of Multiple Myeloma. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0066121"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.3892\/ijo.2014.2511","article-title":"Overexpression of Yin Yang 1 in bone marrow-derived human multiple myeloma and its clinical significance","volume":"45","author":"Liu","year":"2014","journal-title":"Int. J. Oncol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1172\/JCI66553","article-title":"CXCR4 downregulation of let-7a drives chemoresistance in acute myeloid leukemia","volume":"123","author":"Chen","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1615\/CritRevOncog.2014011929","article-title":"RKIP-mediated chemo-immunosensitization of resistant cancer cells via disruption of the NF-\u03baB\/Snail\/YY1\/RKIP resistance-driver loop","volume":"19","author":"Bonavida","year":"2014","journal-title":"Crit. Rev. Oncog."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Ho, M., and Bonavida, B. (2024). Cross-Talks between Raf Kinase Inhibitor Protein and Programmed Cell Death Ligand 1 Expressions in Cancer: Role in Immune Evasion and Therapeutic Implications. Cells, 13.","DOI":"10.3390\/cells13100864"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13046-017-0535-z","article-title":"Overexpression of RKIP and its cross-talk with several regulatory gene products in multiple myeloma","volume":"36","author":"Shvartsur","year":"2017","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"11177","DOI":"10.1002\/cam4.5745","article-title":"The role of transcription factor Yin Yang-1 in colorectal cancer","volume":"12","author":"Shao","year":"2023","journal-title":"Cancer Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.4161\/cc.10.16.16952","article-title":"Mcl-1 and YY1 inhibition and induction of DR5 by the BH3-mimetic Obatoclax (GX15-070) contribute in the sensitization of B-NHL cells to TRAIL apoptosis","volume":"10","author":"Baritaki","year":"2011","journal-title":"Cell Cycle"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.niox.2008.08.001","article-title":"Nitric oxide sensitizes tumor cells to TRAIL-induced apoptosis via inhibition of the DR5 transcription repressor Yin Yang 1","volume":"20","author":"Vega","year":"2009","journal-title":"Nitric Oxide"},{"key":"ref_53","first-page":"685","article-title":"The NO TRAIL to YES TRAIL in cancer therapy (review)","volume":"31","author":"Lee","year":"2007","journal-title":"Int. J. Oncol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/s41419-021-03730-8","article-title":"CXCR4 intracellular protein promotes drug resistance and tumorigenic potential by inversely regulating the expression of Death Receptor 5","volume":"12","author":"Nengroo","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/ijc.31064","article-title":"CRHR2\/Ucn2 signaling is a novel regulator of miR-7\/YY1\/Fas circuitry contributing to reversal of colorectal cancer cell resistance to Fas-mediated apoptosis","volume":"142","author":"Pothoulakis","year":"2018","journal-title":"Int. J. Cancer"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.7150\/thno.50571","article-title":"KDM6A promotes imatinib resistance through YY1-mediated transcriptional upregulation of TRKA independently of its demethylase activity in chronic myelogenous leukemia","volume":"11","author":"Zhang","year":"2021","journal-title":"Theranostics"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"5408","DOI":"10.1038\/s44319-024-00290-8","article-title":"Targeting the transcription factor YY1 is synthetic lethal with loss of the histone demethylase KDM5C","volume":"25","author":"Zheng","year":"2024","journal-title":"EMBO Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s13148-022-01326-3","article-title":"CRNDE acts as an epigenetic modulator of the p300\/YY1 complex to promote HCC progression and therapeutic resistance","volume":"14","author":"Liu","year":"2022","journal-title":"Clin. Epigenetics"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1089\/dna.2021.0059","article-title":"YY1-Induced lncRNA PART1 Enhanced Resistance of Ovarian Cancer Cells to Cisplatin by Regulating miR-512-3p\/CHRAC1 Axis","volume":"40","author":"Yang","year":"2021","journal-title":"DNA Cell Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/s41419-017-0233-y","article-title":"The MiR-135b-BMAL1-YY1 loop disturbs pancreatic clockwork to promote tumourigenesis and chemoresistance","volume":"9","author":"Jiang","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"216935","DOI":"10.1016\/j.canlet.2024.216935","article-title":"CRISPR\/Cas9 screen reveals that targeting TRIM34 enhances ferroptosis sensitivity and augments immunotherapy efficacy in hepatocellular carcinoma","volume":"593","author":"Yao","year":"2024","journal-title":"Cancer Lett."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1021\/acs.chemrestox.4c00208","article-title":"Oxymatrine Inhibits Liver Cancer Progression by Regulating SIRT1\/YY1\/GPX4 Axis-Mediated Ferroptosis","volume":"38","author":"Hu","year":"2025","journal-title":"Chem. Res. Toxicol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e2104836","DOI":"10.1002\/advs.202104836","article-title":"Homeostasis Imbalance of YY2 and YY1 Promotes Tumor Growth by Manipulating Ferroptosis","volume":"9","author":"Li","year":"2022","journal-title":"Adv. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1007\/s10495-025-02088-y","article-title":"Nutrient deficiency-induced downregulation of SNX1 inhibits ferroptosis through PPARs-ACSL1\/4 axis in colorectal cancer","volume":"30","author":"Qian","year":"2025","journal-title":"Apoptosis"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Ramos, A., Sadeghi, S., and Tabatabaeian, H. (2021). Battling Chemoresistance in Cancer: Root Causes and Strategies to Uproot Them. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22179451"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1007\/s10555-024-10177-8","article-title":"Deciphering cellular and molecular mechanism of MUC13 mucin involved in cancer cell plasticity and drug resistance","volume":"43","author":"Malik","year":"2024","journal-title":"Cancer Metastasis Rev."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Sethy, C., and Kundu, C.N. (2021). 5-Fluorouracil (5-FU) resistance and the new strategy to enhance the sensitivity against cancer: Implication of DNA repair inhibition. Biomed. Pharmacother., 137.","DOI":"10.1016\/j.biopha.2021.111285"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Du, B., and Shim, J.S. (2016). Targeting Epithelial-Mesenchymal Transition (EMT) to Overcome Drug Resistance in Cancer. Molecules, 21.","DOI":"10.3390\/molecules21070965"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Liu, H., Han, J., Lv, Y., Zhao, Z., Zheng, S., Sun, Y., and Sun, T. (2023). Isorhamnetin and anti-PD-L1 antibody dual-functional mesoporous silica nanoparticles improve tumor immune microenvironment and inhibit YY1-mediated tumor progression. J. Nanobiotechnol., 21.","DOI":"10.1186\/s12951-023-01967-3"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1101\/gad.261982.115","article-title":"Cancer stem cells in glioblastoma","volume":"29","author":"Lathia","year":"2015","journal-title":"Genes. Dev."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"4301","DOI":"10.7150\/ijbs.66224","article-title":"YY1-induced DLEU1\/miR-149-5p Promotes Malignant Biological Behavior of Cholangiocarcinoma through Upregulating YAP1\/TEAD2\/SOX2","volume":"18","author":"Li","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.stem.2024.06.003","article-title":"Cancer stem cell mimicry for immune evasion and therapeutic resistance","volume":"31","author":"Saw","year":"2024","journal-title":"Cell Stem Cell"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12964-020-00627-5","article-title":"Drug resistance and Cancer stem cells","volume":"19","author":"Li","year":"2021","journal-title":"Cell Commun. Signal."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e13582","DOI":"10.1111\/cpr.13582","article-title":"MET overexpression in ovarian cancer via CD24-induced downregulation of miR-181a: A signalling for cellular quiescence-like state and chemoresistance in ovarian CSCs","volume":"57","author":"Kwon","year":"2024","journal-title":"Cell Prolif."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41420-024-01858-y","article-title":"CD24 induced cellular quiescence-like state and chemoresistance in ovarian cancer cells via miR-130a\/301a-dependent CDK19 downregulation","volume":"10","author":"Jang","year":"2024","journal-title":"Cell Death Discov."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13046-016-0359-2","article-title":"Yin Yang 1 is associated with cancer stem cell transcription factors (SOX2, OCT4, BMI1) and clinical implication","volume":"35","author":"Kaufhold","year":"2016","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1158\/2159-8290.CD-20-1848","article-title":"Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem Cells","volume":"12","author":"Qiu","year":"2022","journal-title":"Cancer Discov."},{"key":"ref_78","first-page":"517","article-title":"miR-186 reverses cisplatin resistance and inhibits the formation of the glioblastoma-initiating cell phenotype by degrading Yin Yang 1 in glioblastoma","volume":"43","author":"Li","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.yexcr.2018.12.016","article-title":"MiR-7-5p suppresses stemness and enhances temozolomide sensitivity of drug-resistant glioblastoma cells by targeting Yin Yang 1","volume":"375","author":"Jia","year":"2019","journal-title":"Exp. Cell Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1016\/j.ccell.2023.11.003","article-title":"Genomic alterations driving precancerous to cancerous lesions in esophageal cancer development","volume":"41","author":"Chang","year":"2023","journal-title":"Cancer Cell"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"368","DOI":"10.20517\/cdr.2021.148","article-title":"DNA damage and metabolic mechanisms of cancer drug resistance","volume":"5","author":"Tiek","year":"2022","journal-title":"Cancer Drug Resist."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.cell.2025.01.005","article-title":"Cellular responses to RNA damage","volume":"188","author":"Cordes","year":"2025","journal-title":"Cell"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"7401","DOI":"10.1093\/nar\/gkae502","article-title":"YY1 is involved in homologous recombination inhibition at guanine quadruplex sites in human cells","volume":"52","author":"Cui","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"101577","DOI":"10.1016\/j.mcp.2020.101577","article-title":"YY1-mediated PTEN dephosphorylation antagonizes IR-induced DNA repair contributing to tongue squamous cell carcinoma radiosensitization","volume":"53","author":"Zhao","year":"2020","journal-title":"Mol. Cell. Probes"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1016\/j.molcel.2021.03.034","article-title":"The dystonia gene THAP1 controls DNA double-strand break repair choice","volume":"81","author":"Shinoda","year":"2021","journal-title":"Mol. Cell"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"7949","DOI":"10.1073\/pnas.1720000115","article-title":"Spatially constrained tandem bromodomain inhibition bolsters sustained repression of BRD4 transcriptional activity for TNBC cell growth","volume":"115","author":"Ren","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Sarnik, J., Pop\u0142awski, T., and Tokarz, P. (2021). BET Proteins as Attractive Targets for Cancer Therapeutics. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222011102"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Duan, B., Zhou, X., Zhang, X., Qiu, F., Zhang, S., Chen, Y., Yang, J., Wang, J., and Tan, W. (2023). BRD4-binding enhancer promotes CRC progression by interacting with YY1 to activate the Wnt pathway through upregulation of TCF7L2. Biochem. Pharmacol., 218.","DOI":"10.1016\/j.bcp.2023.115877"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"4971","DOI":"10.1093\/nar\/gkab252","article-title":"Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2\/4-PFKP during tumorigenesis of advanced prostate cancer","volume":"49","author":"Xu","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1186\/s12967-024-05956-4","article-title":"YY1 drives PARP1 expression essential for PARylation of NONO in mRNA maturation during neuroblastoma progression","volume":"22","author":"Yang","year":"2024","journal-title":"J. Transl. Med."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"155734","DOI":"10.1016\/j.phymed.2024.155734","article-title":"The anti-non-small cell lung cancer effect of Diosbulbin B: Targeting YY1 induced cell cycle arrest and apoptosis","volume":"130","author":"Zhao","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Myadelets, D., Parfenyev, S., Vasileva, J., Shuvalov, O., Petukhov, A., Fedorova, O., Barlev, N., and Daks, A. (2024). Methyltransferase Set7\/9 controls PARP1 expression and regulates cisplatin response of breast cancer cells. Biochem. Biophys. Res. Commun., 691.","DOI":"10.1016\/j.bbrc.2023.149328"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Wang, J., Zhou, L., Li, Z., Zhang, T., Liu, W., Liu, Z., Yuan, Y.C., Su, F., Xu, L., and Wang, Y. (2015). YY1 suppresses FEN1 over-expression and drug resistance in breast cancer. BMC Cancer, 15.","DOI":"10.1186\/s12885-015-1043-1"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/s41388-019-0986-0","article-title":"MicroRNA-140 impedes DNA repair by targeting FEN1 and enhances chemotherapeutic response in breast cancer","volume":"39","author":"Lu","year":"2020","journal-title":"Oncogene"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/s41419-020-02812-3","article-title":"Inhibition of miR-1193 leads to synthetic lethality in glioblastoma multiforme cells deficient of DNA-PKcs","volume":"11","author":"Zhang","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s10238-025-01619-w","article-title":"YY1-induced transcription of AKR1C3 activates the Hedgehog signalling pathway to enhance lenalidomide resistance and glycolytic activity in multiple myeloma cells","volume":"25","author":"Chen","year":"2025","journal-title":"Clin. Exp. Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/ijc.35170","article-title":"Enhanced pharmacological activities of AKR1C3-activated prodrug AST-3424 in cancer cells with defective DNA repair","volume":"156","author":"Meng","year":"2025","journal-title":"Int. J. Cancer"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"e2014195118","DOI":"10.1073\/pnas.2014195118","article-title":"Oncogenic HPV promotes the expression of the long noncoding RNA lnc-FANCI-2 through E7 and YY1","volume":"118","author":"Liu","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s12032-025-02675-8","article-title":"Contribution of tumor microenvironment (TME) to tumor apoptosis, angiogenesis, metastasis, and drug resistance","volume":"42","author":"Xiao","year":"2025","journal-title":"Med. Oncol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/cac2.12416","article-title":"Tumor microenvironment signaling and therapeutics in cancer progression","volume":"43","author":"Goenka","year":"2023","journal-title":"Cancer Commun."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1189\/jlb.0609385","article-title":"Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation","volume":"86","author":"Solinas","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"ref_102","first-page":"120","article-title":"Hypoxia-induced angiogenesis during carcinogenesis","volume":"36","author":"Choi","year":"2003","journal-title":"J. Biochem. Mol. Biol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.1007\/s11033-023-08251-5","article-title":"The role of hypoxia on prostate cancer progression and metastasis","volume":"50","author":"Mohamed","year":"2023","journal-title":"Mol. Biol. Rep."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1158\/0008-5472.CAN-07-5582","article-title":"Deletion of Yin Yang 1 protein in osteosarcoma cells on cell invasion and CXCR4\/angiogenesis and metastasis","volume":"68","author":"Rossiello","year":"2008","journal-title":"Cancer Res."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Meo, C., and de Nigris, F. (2024). Clinical Potential of YY1-Hypoxia Axis for Vascular Normalization and to Improve Immunotherapy. Cancers, 16.","DOI":"10.3390\/cancers16030491"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1158\/1535-7163.MCT-06-0024","article-title":"Tumor pH controls the in vivo efficacy of weak acid and base chemotherapeutics","volume":"5","author":"Gerweck","year":"2006","journal-title":"Mol. Cancer Ther."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ejps.2016.03.025","article-title":"Cancer chemoresistance; biochemical and molecular aspects: A brief overview","volume":"89","author":"Kachalaki","year":"2016","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Li, X., Ma, T.K., Wang, M., Zhang, X.D., Liu, T.Y., Liu, Y., Huang, Z.H., Zhu, Y.H., Zhang, S., and Yin, L. (2023). YY1-induced upregulation of LncRNA-ARAP1-AS2 and ARAP1 promotes diabetic kidney fibrosis via aberrant glycolysis associated with EGFR\/PKM2\/HIF-1\u03b1 pathway. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1069348"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.neo.2020.12.009","article-title":"Glycolysis-induced drug resistance in tumors-A response to danger signals?","volume":"23","author":"Marcucci","year":"2021","journal-title":"Neoplasia"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ccell.2023.02.016","article-title":"The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth","volume":"41","author":"Joyce","year":"2023","journal-title":"Cancer Cell"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1158\/2159-8290.CD-20-1808","article-title":"Therapeutic Targeting of the Tumor Microenvironment","volume":"11","author":"Bejarano","year":"2021","journal-title":"Cancer Discov."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s12943-021-01441-4","article-title":"Role of oncogenic KRAS in the prognosis, diagnosis and treatment of colorectal cancer","volume":"20","author":"Zhu","year":"2021","journal-title":"Mol. Cancer"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Ros, J., Vaghi, C., Baraibar, I., Saoudi Gonz\u00e1lez, N., Rodr\u00edguez-Castells, M., Garc\u00eda, A., Alcaraz, A., Salva, F., Tabernero, J., and Elez, E. (2024). Targeting KRAS G12C Mutation in Colorectal Cancer, A Review: New Arrows in the Quiver. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25063304"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s12041-024-01487-5","article-title":"YY1 as a mediator to enhance the resistance of KRAS mutant colorectal cancer cells to cetuximab","volume":"104","author":"Ma","year":"2025","journal-title":"J. Genet."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Zhao, M., Lu, T., Bi, G., Hu, Z., Liang, J., Bian, Y., Feng, M., and Zhan, C. (2023). PLK1 regulating chemoradiotherapy sensitivity of esophageal squamous cell carcinoma through pentose phosphate pathway\/ferroptosis. Biomed. Pharmacother., 168.","DOI":"10.1016\/j.biopha.2023.115711"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"101059","DOI":"10.1016\/j.drup.2024.101059","article-title":"Single-cell transcriptome analysis reveals the association between histone lactylation and cisplatin resistance in bladder cancer","volume":"73","author":"Li","year":"2024","journal-title":"Drug Resist. Updat."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"4190","DOI":"10.7150\/ijbs.97720","article-title":"The Antitumor and Sorafenib-resistant Reversal Effects of Ursolic Acid on Hepatocellular Carcinoma via Targeting ING5","volume":"20","author":"Fan","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/ijc.20851","article-title":"Implications of galactocerebrosidase and galactosylcerebroside metabolism in cancer cells","volume":"115","author":"Beier","year":"2005","journal-title":"Int. J. Cancer"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1038\/s41388-021-02159-9","article-title":"A low amino acid environment promotes cell macropinocytosis through the YY1-FGD6 axis in Ras-mutant pancreatic ductal adenocarcinoma","volume":"41","author":"Zhang","year":"2022","journal-title":"Oncogene"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"4317","DOI":"10.1016\/j.cell.2022.10.006","article-title":"Systemic vaccination induces CD8(+) T cells and remodels the tumor microenvironment","volume":"185","author":"Baharom","year":"2022","journal-title":"Cell"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Chen, C., Wang, Z., Ding, Y., and Qin, Y. (2023). Tumor microenvironment-mediated immune evasion in hepatocellular carcinoma. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1133308"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Merenstein, A., Obeidat, L., Zaravinos, A., and Bonavida, B. (2024). The Role of YY1 in the Regulation of LAG-3 Expression in CD8 T Cells and Immune Evasion in Cancer: Therapeutic Implications. Cancers, 17.","DOI":"10.3390\/cancers17010019"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/s41408-024-01199-0","article-title":"Single-cell transcriptomic and spatial analysis reveal the immunosuppressive microenvironment in relapsed\/refractory angioimmunoblastic T-cell lymphoma","volume":"14","author":"Zhu","year":"2024","journal-title":"Blood Cancer J."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/08923973.2017.1327962","article-title":"Inhibitory effects of propofol on Th17 cell differentiation","volume":"39","author":"Lin","year":"2017","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Khalaf, K., Hana, D., Chou, J.T., Singh, C., Mackiewicz, A., and Kaczmarek, M. (2021). Aspects of the Tumor Microenvironment Involved in Immune Resistance and Drug Resistance. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.656364"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Baritaki, S., and Zaravinos, A. (2023). Cross-Talks between RKIP and YY1 through a Multilevel Bioinformatics Pan-Cancer Analysis. Cancers, 15.","DOI":"10.20944\/preprints202309.0467.v1"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.immuni.2013.01.004","article-title":"Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy","volume":"38","author":"Liao","year":"2013","journal-title":"Immunity"},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Kwiatkowska, D., Mazur, E., and Reich, A. (2022). YY1 Is a Key Player in Melanoma Immunotherapy\/Targeted Treatment Resistance. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.856963"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"e2405130","DOI":"10.1002\/advs.202405130","article-title":"Pericytes Modulate Third-Generation Tyrosine Kinase Inhibitor Sensitivity in EGFR-Mutated Lung Cancer Cells Through IL32-\u03b25-Integrin Paracrine Signaling","volume":"11","author":"Huang","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Liu, X.C., Lian, W., Zhang, L.J., Feng, X.C., Gao, Y., Li, S.X., Liu, C., Cheng, Y., Yang, L., and Wang, X.J. (2015). Interleukin-18 Down-Regulates Multidrug Resistance-Associated Protein 2 Expression through Farnesoid X Receptor Associated with Nuclear Factor Kappa B and Yin Yang 1 in Human Hepatoma HepG2 Cells. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0136215"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"6261","DOI":"10.1038\/s41467-025-61560-0","article-title":"YY1 enhances HIF-1\u03b1 stability in tumor-associated macrophages to suppress anti-tumor immunity of prostate cancer in mice","volume":"16","author":"Li","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"10789","DOI":"10.1038\/ncomms10789","article-title":"YY1 inhibits differentiation and function of regulatory T cells by blocking Foxp3 expression and activity","volume":"7","author":"Hwang","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Yang, W., Li, Z., Qin, R., Wang, X., An, H., Wang, Y., Zhu, Y., Liu, Y., Cai, S., and Chen, S. (2021). Corrigendum: YY1 Promotes Endothelial Cell-Dependent Tumor Angiogenesis in Hepatocellular Carcinoma by Transcriptionally Activating VEGFA. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.828861"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.3892\/mmr.2016.4836","article-title":"The hypoxia-mimetic agent CoCl2 induces chemotherapy resistance in LOVO colorectal cancer cells","volume":"13","author":"Yang","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1615\/CritRevImmunol.2020033272","article-title":"Involvement of Yin Yang 1 (YY1) Expression in T-Cell Subsets Differentiation and Their Functions: Implications in T Cell-Mediated Diseases","volume":"39","author":"Kosasih","year":"2019","journal-title":"Crit. Rev. Immunol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"5820","DOI":"10.1158\/0008-5472.CAN-08-2819","article-title":"Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer","volume":"69","author":"Arumugam","year":"2009","journal-title":"Cancer Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"840","DOI":"10.3892\/ijo.2015.3084","article-title":"Epithelial-mesenchymal transition and drug resistance in breast cancer (Review)","volume":"47","author":"Huang","year":"2015","journal-title":"Int. J. Oncol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"10697","DOI":"10.18632\/oncotarget.4037","article-title":"EMT, CTCs and CSCs in tumor relapse and drug-resistance","volume":"6","author":"Mitra","year":"2015","journal-title":"Oncotarget"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrclinonc.2017.44","article-title":"EMT, CSCs, and drug resistance: The mechanistic link and clinical implications","volume":"14","author":"Shibue","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Jin, W. (2020). Role of JAK\/STAT3 Signaling in the Regulation of Metastasis, the Transition of Cancer Stem Cells, and Chemoresistance of Cancer by Epithelial-Mesenchymal Transition. Cells, 9.","DOI":"10.3390\/cells9010217"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"e2205873","DOI":"10.1002\/advs.202205873","article-title":"Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability and Oncogenic Functions","volume":"10","author":"Guan","year":"2023","journal-title":"Adv. Sci."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Hashemi, M., Arani, H.Z., Orouei, S., Fallah, S., Ghorbani, A., Khaledabadi, M., Kakavand, A., Tavakolpournegari, A., Saebfar, H., and Heidari, H. (2022). EMT mechanism in breast cancer metastasis and drug resistance: Revisiting molecular interactions and biological functions. Biomed. Pharmacother., 155.","DOI":"10.1016\/j.biopha.2022.113774"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s41586-023-05838-7","article-title":"RHOJ controls EMT-associated resistance to chemotherapy","volume":"616","author":"Debaugnies","year":"2023","journal-title":"Nature"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"963","DOI":"10.2174\/15680096113136660102","article-title":"The Role of Snail in EMT and Tumorigenesis","volume":"13","author":"Wang","year":"2013","journal-title":"Curr. Cancer Drug Targets"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.niox.2010.10.001","article-title":"Dual role of NO donors in the reversal of tumor cell resistance and EMT: Downregulation of the NF-\u03baB\/Snail\/YY1\/RKIP circuitry","volume":"24","author":"Bonavida","year":"2011","journal-title":"Nitric Oxide"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1615\/CritRevOncog.2017020473","article-title":"Targeting the Overexpressed YY1 in Cancer Inhibits EMT and Metastasis","volume":"22","author":"Cho","year":"2017","journal-title":"Crit. Rev. Oncog."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1186\/s12931-019-1223-7","article-title":"YY1 mediates TGF-\u03b21-induced EMT and pro-fibrogenesis in alveolar epithelial cells","volume":"20","author":"Zhang","year":"2019","journal-title":"Respir. Res."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Xuan, W., Zhou, C., and You, G. (2020). LncRNA LINC00668 promotes cell proliferation, migration, invasion ability and EMT process in hepatocellular carcinoma by targeting miR-532-5p\/YY1 axis. Biosci. Rep., 40.","DOI":"10.1042\/BSR20192697"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1158\/1541-7786.MCR-08-0255","article-title":"Yin yang 1 modulates taxane response in epithelial ovarian cancer","volume":"7","author":"Matsumura","year":"2009","journal-title":"Mol. Cancer Res."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"215971","DOI":"10.1016\/j.canlet.2022.215971","article-title":"METTL3-mediated N6-methyladenosine modification and HDAC5\/YY1 promote IFFO1 downregulation in tumor development and chemo-resistance","volume":"553","author":"Zhang","year":"2023","journal-title":"Cancer Lett."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.4103\/IJPM.IJPM_96_20","article-title":"Loss of YY1 expression predicts unfavorable prognosis in stage III colorectal cancer","volume":"64","author":"Kim","year":"2021","journal-title":"Indian J. Pathol. Microbiol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/s41419-023-06321-x","article-title":"YY1 modulates the radiosensitivity of esophageal squamous cell carcinoma through KIF3B-mediated Hippo signaling pathway","volume":"14","author":"Zheng","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Dillen, A., Bui, I., Jung, M., Agioti, S., Zaravinos, A., and Bonavida, B. (2024). Regulation of PD-L1 Expression by YY1 in Cancer: Therapeutic Efficacy of Targeting YY1. Cancers, 16.","DOI":"10.3390\/cancers16061237"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"6370","DOI":"10.7150\/thno.57828","article-title":"Recent progress in nanomedicine for enhanced cancer chemotherapy","volume":"11","author":"Wei","year":"2021","journal-title":"Theranostics"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.biomaterials.2018.04.027","article-title":"Combinational strategy for high-performance cancer chemotherapy","volume":"171","author":"Qin","year":"2018","journal-title":"Biomaterials"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2015.10.019","article-title":"\u201cCombo\u201d nanomedicine: Co-delivery of multi-modal therapeutics for efficient, targeted, and safe cancer therapy","volume":"98","author":"Kemp","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/onc.2011.217","article-title":"Yin Yang 1 positively regulates BRCA1 and inhibits mammary cancer formation","volume":"31","author":"Lee","year":"2012","journal-title":"Oncogene"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.bbrc.2005.08.150","article-title":"Inhibition of the transcription factor Yin Yang 1 activity by S-nitrosation","volume":"336","author":"Hongo","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.niox.2012.12.001","article-title":"Contribution of either YY1 or BclXL-induced inhibition by the NO-donor DETANONOate in the reversal of drug resistance, both in vitro and in vivo","volume":"29","author":"Baritaki","year":"2013","journal-title":"Nitric Oxide"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.drudis.2021.09.020","article-title":"Advances in understanding the role of P-gp in doxorubicin resistance: Molecular pathways, therapeutic strategies, and prospects","volume":"27","author":"Mirzaei","year":"2022","journal-title":"Drug Discov. Today"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1097\/WNR.0000000000001345","article-title":"Involvement of hypoxia-inducible factor-1 alpha in the upregulation of P-glycoprotein in refractory epilepsy","volume":"30","author":"Wang","year":"2019","journal-title":"Neuroreport"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1096\/fj.02-0358fje","article-title":"Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species","volume":"17","author":"Wartenberg","year":"2003","journal-title":"FASEB J."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"105152","DOI":"10.1016\/j.tiv.2021.105152","article-title":"Calcium channel blockers lercanidipine and amlodipine inhibit YY1\/ERK\/TGF-\u03b2 mediated transcription and sensitize the gastric cancer cells to doxorubicin","volume":"74","author":"Panneerpandian","year":"2021","journal-title":"Toxicol. Vitr."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1158\/1535-7163.MCT-11-0635","article-title":"Galiximab signals B-NHL cells and inhibits the activities of NF-\u03baB-induced YY1- and snail-resistant factors: Mechanism of sensitization to apoptosis by chemoimmunotherapeutic drugs","volume":"11","author":"Vega","year":"2012","journal-title":"Mol. Cancer Ther."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"601","DOI":"10.3892\/etm.2022.11538","article-title":"Inhibition of NLRC5 attenuates the malignant growth and enhances the sensitivity of gastric cancer cells to 5-FU chemotherapy by blocking the carcinogenic effect of YY1","volume":"24","author":"Liang","year":"2022","journal-title":"Exp. Ther. Med."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"14843","DOI":"10.18632\/aging.203182","article-title":"TP73-AS1 is induced by YY1 during TMZ treatment and highly expressed in the aging brain","volume":"13","author":"Mazor","year":"2021","journal-title":"Aging"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.4049\/jimmunol.175.4.2174","article-title":"Rituximab-induced inhibition of YY1 and Bcl-xL expression in Ramos non-Hodgkin\u2019s lymphoma cell line via inhibition of NF-kappa B activity: Role of YY1 and Bcl-xL in Fas resistance and chemoresistance, respectively","volume":"175","author":"Vega","year":"2005","journal-title":"J. Immunol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3109\/10428194.2010.531408","article-title":"A potential mechanism of rituximab-induced inhibition of tumor growth through its sensitization to tumor necrosis factor-related apoptosis-inducing ligand-expressing host cytotoxic cells","volume":"52","author":"Vega","year":"2011","journal-title":"Leuk. Lymphoma"},{"key":"ref_169","first-page":"149","article-title":"Combination treatment of malignant B cells using the anti-CD20 antibody rituximab and the anti-malarial artesunate","volume":"35","author":"Sieber","year":"2009","journal-title":"Int. J. Oncol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1021\/acs.chemrev.0c00383","article-title":"Challenges and Opportunities in Cancer Drug Resistance","volume":"121","author":"Ward","year":"2021","journal-title":"Chem. Rev."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1158\/2159-8290.CD-20-1209","article-title":"Development of Immunotherapy Combination Strategies in Cancer","volume":"11","author":"Yap","year":"2021","journal-title":"Cancer Discov."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1158\/0008-5472.CAN-15-2019","article-title":"Forced Activation of Notch in Macrophages Represses Tumor Growth by Upregulating miR-125a and Disabling Tumor-Associated Macrophages","volume":"76","author":"Zhao","year":"2016","journal-title":"Cancer Res."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"100987","DOI":"10.1016\/j.drup.2023.100987","article-title":"Elevated NOX4 promotes tumorigenesis and acquired EGFR-TKIs resistance via enhancing IL-8\/PD-L1 signaling in NSCLC","volume":"70","author":"Liu","year":"2023","journal-title":"Drug Resist. Updat."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"670","DOI":"10.3892\/ijo.2013.1986","article-title":"Galiximab (anti-CD80)-induced growth inhibition and prolongation of survival in vivo of B-NHL tumor xenografts and potentiation by the combination with fludarabine","volume":"43","author":"Hariharan","year":"2013","journal-title":"Int. J. Oncol."},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Cataldo, A., Romero-Cordoba, S., Plantamura, I., Cosentino, G., Hidalgo-Miranda, A., Tagliabue, E., and Iorio, M.V. (2020). MiR-302b as a Combinatorial Therapeutic Approach to Improve Cisplatin Chemotherapy Efficacy in Human Triple-Negative Breast Cancer. Cancers, 12.","DOI":"10.3390\/cancers12082261"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.redox.2015.07.015","article-title":"Dual roles of nitric oxide in the regulation of tumor cell response and resistance to photodynamic therapy","volume":"6","author":"Rapozzi","year":"2015","journal-title":"Redox Biol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.redox.2015.09.037","article-title":"The Role Of Nitric Oxide After Repeated Low Dose Photodynamic Treatments In Prostate Carcinoma Cells","volume":"5","author":"Rapozzi","year":"2015","journal-title":"Redox Biol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.7150\/ijbs.79965","article-title":"YAP1 synergize with YY1 transcriptional co-repress DUSP1 to induce osimertinib resistant by activating the EGFR\/MAPK pathway and abrogating autophagy in non-small cell lung cancer","volume":"19","author":"Ning","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1111\/cas.13662","article-title":"Yin Yang 1 promotes the Warburg effect and tumorigenesis via glucose transporter GLUT3","volume":"109","author":"Wang","year":"2018","journal-title":"Cancer Sci."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1093\/neuonc\/noab288","article-title":"Targeting radiation-tolerant persister cells as a strategy for inhibiting radioresistance and recurrence in glioblastoma","volume":"24","author":"Gu","year":"2022","journal-title":"Neuro Oncol."},{"key":"ref_181","first-page":"721","article-title":"MicroRNA-411-3p motivates methotrexate\u2019s cellular uptake and cytotoxicity via targeting Yin-yang 1 in leukemia cells","volume":"70","author":"Sun","year":"2023","journal-title":"Acta Biochim. Pol."},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Morales-Martinez, M., Vega, G.G., Neri, N., Nambo, M.J., Alvarado, I., Cuadra, I., Duran-Padilla, M.A., Huerta-Yepez, S., and Vega, M.I. (2020). MicroRNA-7 Regulates Migration and Chemoresistance in Non-Hodgkin Lymphoma Cells Through Regulation of KLF4 and YY1. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.588893"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s10637-016-0396-x","article-title":"A photodynamic bifunctional conjugate for prostate cancer: An in vitro mechanistic study","volume":"35","author":"Rapozzi","year":"2017","journal-title":"Investig. New Drugs"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"436","DOI":"10.7150\/thno.90322","article-title":"Vitamin D binding protein (VDBP) hijacks twist1 to inhibit vasculogenic mimicry in hepatocellular carcinoma","volume":"14","author":"Qin","year":"2024","journal-title":"Theranostics"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1080\/10428194.2020.1869960","article-title":"KLF4 inhibition by Kenpaullone induces cytotoxicity and chemo sensitization in B-NHL cell lines via YY1 independent","volume":"62","author":"Vega","year":"2021","journal-title":"Leuk. Lymphoma"},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Sarvagalla, S., Kolapalli, S.P., and Vallabhapurapu, S. (2019). The Two Sides of YY1 in Cancer: A Friend and a Foe. Front. Oncol., 9.","DOI":"10.3389\/fonc.2019.01230"},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Chen, Q., Wang, W.J., Jia, Y.X., Yuan, H., Wu, P.F., Ge, W.L., Meng, L.D., Huang, X.M., Shen, P., and Yang, T.Y. (2021). Effect of the transcription factor YY1 on the development of pancreatic endocrine and exocrine tumors: A narrative review. Cell Biosci., 11.","DOI":"10.1186\/s13578-021-00602-8"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"e220321","DOI":"10.1530\/ERC-22-0321","article-title":"Aggressive versus indolent insulinomas: New clinicopathological insights","volume":"30","author":"Hackeng","year":"2023","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_189","doi-asserted-by":"crossref","unstructured":"Kumari, S., Ponamgi, S.P.D., Chelikani, P., Srilatha, M., Nagaraju, G.P., and Peela, S. (2025). Role of Yin Yang 1 (YY1) on microenvironment, signaling pathways, and epigenetics in lung cancer. Biochim. Biophys. Acta Rev. Cancer, 1880.","DOI":"10.1016\/j.bbcan.2025.189359"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1007\/s12253-019-00785-z","article-title":"Somatic Mutations and Intratumoral Heterogeneity of Cancer-Related Genes NLK, YY1 and PA2G4 in Gastric and Colorectal Cancers","volume":"26","author":"Son","year":"2020","journal-title":"Pathol. Oncol. Res."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.eprac.2021.02.016","article-title":"Mutation and Expression of Gene YY1 in Pancreatic Neuroendocrine Tumors and Its Clinical Significance","volume":"27","author":"Song","year":"2021","journal-title":"Endocr. Pract."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s12964-023-01302-1","article-title":"Unveiling the mechanisms and challenges of cancer drug resistance","volume":"22","author":"Khan","year":"2024","journal-title":"Cell Commun. Signal."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/15\/8\/1069\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:15:13Z","timestamp":1760033713000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/15\/8\/1069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,24]]},"references-count":192,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["biom15081069"],"URL":"https:\/\/doi.org\/10.3390\/biom15081069","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,24]]}}}