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Treatment for cornea-related visual impairment and blindness is, however, often constrained by the global shortage of suitable donor grafts. To alleviate the shortage of corneal donor tissue, new treatment options have been explored in the last decade. The discovery of induced pluripotent stem cells (iPSCs), which has revolutionized regenerative medicine, offers immense potential for corneal repair and regeneration. Using iPSCs can provide a renewable source for generating various corneal cell types, including corneal epithelial cells, stromal keratocytes, and corneal endothelial cells. To document the recent progress towards the clinical application of iPSC-derived corneal cells, this review summarizes the latest advancements in iPSC-derived corneal cell therapies, ranging from differentiation protocols and preclinical studies to the first clinical trials, and discusses the challenges for successful translation to the clinic.<\/jats:p>","DOI":"10.3390\/biom15081139","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T08:33:06Z","timestamp":1754555586000},"page":"1139","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical Applications of Corneal Cells Derived from Induced Pluripotent Stem Cells"],"prefix":"10.3390","volume":"15","author":[{"given":"Yixin","family":"Luan","sequence":"first","affiliation":[{"name":"Ophthalmology Research Group, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel (VUB), 1090 Brussels, Belgium"},{"name":"Department of Ophthalmology, Universitair Ziekenhuis Brussel (UZB), 1090 Jette, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3980-0235","authenticated-orcid":false,"given":"Aytan","family":"Musayeva","sequence":"additional","affiliation":[{"name":"Harvey & Bernice Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1951-7589","authenticated-orcid":false,"given":"Jina","family":"Kim","sequence":"additional","affiliation":[{"name":"Ophthalmology Research Group, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel (VUB), 1090 Brussels, Belgium"},{"name":"Department of Ophthalmology, Universitair Ziekenhuis Brussel (UZB), 1090 Jette, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7014-8682","authenticated-orcid":false,"given":"Debbie","family":"Le Blon","sequence":"additional","affiliation":[{"name":"Antwerp Research Group for Ocular Science (ARGOS), Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Wilrijk, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"van den Bogerd","sequence":"additional","affiliation":[{"name":"Antwerp Research Group for Ocular Science (ARGOS), Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Wilrijk, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mor M.","family":"Dickman","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Utrecht, 3584 CM Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0887-7443","authenticated-orcid":false,"given":"Vanessa L. S.","family":"LaPointe","sequence":"additional","affiliation":[{"name":"Department of Cell Biology\u2013Inspired Tissue Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, 6229 ER Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1115-7834","authenticated-orcid":false,"given":"Sorcha","family":"Ni Dhubhghaill","sequence":"additional","affiliation":[{"name":"Ophthalmology Research Group, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel (VUB), 1090 Brussels, Belgium"},{"name":"Department of Ophthalmology, Universitair Ziekenhuis Brussel (UZB), 1090 Jette, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5703-5971","authenticated-orcid":false,"given":"Silke","family":"Oellerich","sequence":"additional","affiliation":[{"name":"Ophthalmology Research Group, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel (VUB), 1090 Brussels, Belgium"},{"name":"Department of Ophthalmology, Universitair Ziekenhuis Brussel (UZB), 1090 Jette, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1001\/jamaophthalmol.2015.4776","article-title":"Global Survey of Corneal Transplantation and Eye Banking","volume":"134","author":"Gain","year":"2016","journal-title":"JAMA Ophthalmol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/ceo.12330","article-title":"Corneal Blindness: A Global Problem","volume":"42","author":"Robaei","year":"2014","journal-title":"Clin Exp. 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