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Emerging evidence suggests a bidirectional interplay between them, mediated by shared pathophysiological pathways. This narrative review explores the mechanisms Ilinking obesity to IBD development and progression, focusing on the role of adipose tissue dysfunction. Both diseases exhibit intestinal dysbiosis, low-grade systemic inflammation, and impaired epithelial barrier integrity, contributing to immune activation. Visceral adiposity, particularly mesenteric fat, acts as an immunometabolic organ producing cytokines and adipokines that may exacerbate intestinal inflammation. In Crohn\u2019s disease, mesenteric fat expansion, or \u201ccreeping fat\u201d, is associated with transmural inflammation, fibrosis, and luminal narrowing. Epidemiological data on obesity as a risk factor for IBD remain inconsistent due to methodological heterogeneity and confounders. Similarly, the impact of obesity on IBD outcomes, including disease activity, phenotype, and the need for surgery, is debated. While mesenteric surgical approaches like Kono-S anastomosis showed initial promise in reducing recurrence, recent randomized trials offer conflicting results. Finally, metabolic drugs such as statins, metformin, and GLP-1 receptor agonists have demonstrated anti-inflammatory properties with potential utility in IBD management. Prospective studies are warranted to elucidate the clinical significance of obesity and metabolic dysfunction in IBD and evaluate targeted therapeutic strategies.<\/jats:p>","DOI":"10.3390\/biom15081185","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T13:28:22Z","timestamp":1755523702000},"page":"1185","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Obesity-Mediated Inflammation and Its Influence on Inflammatory Bowel Disease: Pathophysiology, Clinical Impact, and Therapeutic Implications"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6883-8940","authenticated-orcid":false,"given":"Diego","family":"Casas-Deza","sequence":"first","affiliation":[{"name":"Gastroenterology Department, Miguel Servet University Hospital, 50009 Zaragoza, Spain"},{"name":"Health Investigation Institute Arag\u00f3n (IIS-A), 50009 Zaragoza, Spain"},{"name":"Adipocyte and Fat Biology Laboratory (AdipoFat), Translational Research Unit, Miguel Servet University Hospital, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3970-5457","authenticated-orcid":false,"given":"Santiago","family":"Garc\u00eda-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Miguel Servet University Hospital, 50009 Zaragoza, Spain"},{"name":"Health Investigation Institute Arag\u00f3n (IIS-A), 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanesa","family":"Bernal-Monterde","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Miguel Servet University Hospital, 50009 Zaragoza, Spain"},{"name":"Health Investigation Institute Arag\u00f3n (IIS-A), 50009 Zaragoza, Spain"},{"name":"Adipocyte and Fat Biology Laboratory (AdipoFat), Translational Research Unit, Miguel Servet University Hospital, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Polo-Cuadro","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Miguel Servet University Hospital, 50009 Zaragoza, Spain"},{"name":"Health Investigation Institute Arag\u00f3n (IIS-A), 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7771-6197","authenticated-orcid":false,"given":"Carmen","family":"Yag\u00fce-Caballero","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Miguel Servet University Hospital, 50009 Zaragoza, Spain"},{"name":"Health Investigation Institute Arag\u00f3n (IIS-A), 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8982-3737","authenticated-orcid":false,"given":"Jos\u00e9 M.","family":"Arbones-Mainar","sequence":"additional","affiliation":[{"name":"Health 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