{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:42:24Z","timestamp":1793144544408,"version":"4.5.0"},"reference-count":223,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Cannabidiol (CBD), a non-psychoactive phytocannabinoid derived from Cannabis sativa L., has emerged as a promising multifunctional agent in dermatology and cosmetic science. The review provides an updated synthesis of CBD\u2019s topical therapeutic potential, challenges, and evolving regulatory frameworks. CBD exhibits diverse biological effects, including anti-inflammatory, antioxidant, antibacterial, analgesic, lipostatic, antiproliferative, moisturising, and anti-ageing properties through interactions with the skin\u2019s endocannabinoid system (ECS), modulating CB1, CB2, TRPV channels, and PPARs. Preclinical and clinical evidence support its efficacy in managing acne, psoriasis (including scalp psoriasis), atopic and seborrheic dermatitis, and allergic contact dermatitis. CBD also relieves pruritus through neuroimmune modulation and promotes wound healing in conditions such as pyoderma gangrenosum and epidermolysis bullosa. In hair disorders such as androgenetic alopecia, it aids follicular regeneration. CBD shows promise in managing skin cancers (melanoma, squamous cell carcinoma, Kaposi sarcoma) and pigmentation disorders such as melasma and vitiligo. It enhances skin rejuvenation by reducing oxidative stress and boosting collagen and hydration. However, there are challenges regarding CBD\u2019s physicochemical stability, skin penetration, and regulatory standardisation. As consumer demand for natural, multifunctional skincare grows, further research is essential to validate its long-term safety, efficacy, and optimal formulation strategies.<\/jats:p>","DOI":"10.3390\/biom15091219","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:09:32Z","timestamp":1756080572000},"page":"1219","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Cannabidiol in Skin Health: A Comprehensive Review of Topical Applications in Dermatology and Cosmetic Science"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4979-6903","authenticated-orcid":false,"given":"Aura","family":"Rusu","sequence":"first","affiliation":[{"name":"Pharmaceutical and Therapeutic Chemistry Department, Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of T\u00e2rgu Mure\u0219, 540142 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea-Maria","family":"Farca\u0219","sequence":"additional","affiliation":[{"name":"Pharmaceutical and Therapeutic Chemistry Department, Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of T\u00e2rgu Mure\u0219, 540142 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9333-4063","authenticated-orcid":false,"given":"Octavia-Laura","family":"Oancea","sequence":"additional","affiliation":[{"name":"Organic Chemistry Department, Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of T\u00e2rgu Mure\u0219, 540142 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5900-743X","authenticated-orcid":false,"given":"Corneliu","family":"Tanase","sequence":"additional","affiliation":[{"name":"Pharmaceutical Botany Department, Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of T\u00e2rgu Mure\u0219, 540142 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.3897\/pharmacia.70.e114938","article-title":"Regulation and Control of the Use of Cannabis and Cannabidiol in \u201cnovel Foods\u201d","volume":"70","author":"Tsvetkova","year":"2023","journal-title":"Pharmacia"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"R8","DOI":"10.1016\/j.cub.2019.10.039","article-title":"Cannabis\u00a0sativa","volume":"30","author":"Schilling","year":"2020","journal-title":"Curr. Biol."},{"key":"ref_3","unstructured":"Gomes, A.L.P. (2021). Cannabis: The New Trendy Ingredient in Skincare. [Master\u2019s Thesis, Universidade de Lisboa]."},{"key":"ref_4","first-page":"463","article-title":"Cannabidiol-Therapeutic and Legal Aspects","volume":"75","author":"Vlad","year":"2020","journal-title":"Die Pharm.-Int. J. Pharm. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S163","DOI":"10.1038\/sj.bjp.0706406","article-title":"Cannabinoid Pharmacology: The First 66 Years","volume":"147","author":"Pertwee","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"103391","DOI":"10.1016\/j.isci.2021.103391","article-title":"Cannabis sativa Research Trends, Challenges, and New-Age Perspectives","volume":"24","author":"Hussain","year":"2021","journal-title":"Iscience"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Murillo-Rodriguez, E., Pandi-Perumal, S.R., and Monti, J.M. (2021). Constituents of Cannabis sativa. Cannabinoids and Neuropsychiatric Disorders, Springer International Publishing.","DOI":"10.1007\/978-3-030-57369-0"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"927","DOI":"10.2147\/CCID.S286411","article-title":"Therapeutic Potential of Cannabidiol (CBD) for Skin Health and Disorders","volume":"13","author":"Baswan","year":"2020","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1007\/s40257-024-00891-y","article-title":"The Potential Role of Cannabidiol in Cosmetic Dermatology: A Literature Review","volume":"25","author":"Kuzumi","year":"2024","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"G\u0119gotek, A., Atalay, S., Domingues, P., and Skrzydlewska, E. (2019). The Differences in the Proteome Profile of Cannabidiol-Treated Skin Fibroblasts Following UVA or UVB Irradiation in 2D and 3D Cell Cultures. Cells, 8.","DOI":"10.3390\/cells8090995"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-020-01530-y","article-title":"The Antimicrobial Potential of Cannabidiol","volume":"4","author":"Blaskovich","year":"2021","journal-title":"Commun. Biol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Ferreira, I., Lopes, C.M., and Amaral, M.H. (2024). Treatment Advances for Acne Vulgaris: The Scientific Role of Cannabinoids. Cosmetics, 11.","DOI":"10.20944\/preprints202401.1363.v1"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Fava, A.L.M., de Souza, C.M., dos Santos, \u00c9.M., Silv\u00e9rio, L.A.L., Ataide, J.A., Paiva-Santos, A.C., Costa, J.L., de Melo, D.O., and Mazzola, P.G. (2024). Evidence of Cannabidiol Effectiveness Associated or Not with Tetrahydrocannabinol in Topical Administration: A Scope Review. Pharmaceuticals, 17.","DOI":"10.3390\/ph17060748"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1080\/19390211.2020.1795044","article-title":"Cannabis sativa L. and Its Extracts: Regulation of Cannabidiol in the European Union and United Kingdom","volume":"17","author":"Tallon","year":"2020","journal-title":"J. Diet. Suppl."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.nurpra.2020.07.022","article-title":"Cannabidiol Products: Review of the Regulatory and Clinical Considerations","volume":"16","author":"Hawes","year":"2020","journal-title":"J. Nurse Pract."},{"key":"ref_16","unstructured":"(2025, March 20). Office of the Commissioner FDA Regulation of Cannabis and Cannabis-Derived Products, Including Cannabidiol (CBD), Available online: https:\/\/www.fda.gov\/news-events\/public-health-focus\/fda-regulation-cannabis-and-cannabis-derived-products-including-cannabidiol-cbd."},{"key":"ref_17","unstructured":"(2025, March 20). NHS Sativex\u00ae (Use of) in Spasticity Due to Multiple Sclerosis, Neuro Rehabilitation Unit (NRU). Available online: https:\/\/rightdecisions.scot.nhs.uk\/media\/2741\/1083-sativex.pdf."},{"key":"ref_18","unstructured":"(2025, March 20). FDA EPIDIOLEX (Cannabidiol) Oral Solution, Available online: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2018\/210365lbl.pdf."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Jardim, C., and Delgado-Charro, M.B. (2025). The Regulatory Environment Surrounding Cannabis Medicines in the EU, the USA, and Australia. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17050635"},{"key":"ref_20","unstructured":"Syst\u00e8mes, D. (2025, July 21). BIOVIA Draw for Academics Thank You. Available online: https:\/\/discover.3ds.com\/biovia-draw-academic-thank-you."},{"key":"ref_21","unstructured":"(2025, July 21). Marvin-Chemical Drawing Software. Available online: https:\/\/chemaxon.com\/marvin."},{"key":"ref_22","unstructured":"(2025, March 20). PubChem PubChem, Available online: https:\/\/pubchem.ncbi.nlm.nih.gov\/."},{"key":"ref_23","unstructured":"(2025, August 10). Grammarly: Free AI Writing Assistance. Available online: https:\/\/www.grammarly.com\/."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Morales, P., Reggio, P.H., and Jagerovic, N. (2017). An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol. Front. Pharmacol., 8.","DOI":"10.3389\/fphar.2017.00422"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Yoo, E.H., and Lee, J.H. (2023). Cannabinoids and Their Receptors in Skin Diseases. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242216523"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ebiom.2017.01.003","article-title":"Targeting Cutaneous Cannabinoid Signaling in Inflammation-A \u201cHigh\u201d-Way to Heal?","volume":"16","year":"2017","journal-title":"EBioMedicine"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1089\/can.2016.0004","article-title":"On a New Cannabinoid Classification System: A Sight on the Illegal Market of Novel Psychoactive Substances","volume":"1","author":"Shevyrin","year":"2016","journal-title":"Cannabis Cannabinoid Res."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Martins, A.M., Gomes, A.L., Vilas Boas, I., Marto, J., and Ribeiro, H.M. (2022). Cannabis-Based Products for the Treatment of Skin Inflammatory Diseases: A Timely Review. Pharmaceuticals, 15.","DOI":"10.3390\/ph15020210"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Hesami, M., Pepe, M., Baiton, A., and Jones, A.M.P. (2023). Current Status and Future Prospects in Cannabinoid Production through In Vitro Culture and Synthetic Biology. Biotechnol. Adv., 62.","DOI":"10.1016\/j.biotechadv.2022.108074"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Radwan, M.M., Chandra, S., Gul, S., and ElSohly, M.A. (2021). Cannabinoids, Phenolics, Terpenes and Alkaloids of Cannabis. Molecules, 26.","DOI":"10.3390\/molecules26092774"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.smim.2014.04.002","article-title":"What We Know and Do Not Know about the Cannabinoid Receptor 2 (CB2)","volume":"26","author":"Malfitano","year":"2014","journal-title":"Semin. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Jurga, M., Jurga, A., Jurga, K., Ka\u017amierczak, B., Ku\u015bmierczyk, K., and Chabowski, M. (2024). Cannabis-Based Phytocannabinoids: Overview, Mechanism of Action, Therapeutic Application, Production, and Affecting Environmental Factors. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252011258"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Kowalczuk, A., Marycz, K., Kornicka, J., Groborz, S., Meissner, J., and Mularczyk, M. (2023). Tetrahydrocannabivarin (THCV) Protects Adipose-Derived Mesenchymal Stem Cells (ASC) against Endoplasmic Reticulum Stress Development and Reduces Inflammation during Adipogenesis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24087120"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"180","DOI":"10.30574\/gscarr.2024.21.1.0364","article-title":"Phytocannabino\u00efds: Therapeutic Potential, Mechanism of Action, and Regulatory Challenges","volume":"21","author":"Bahloul","year":"2024","journal-title":"GSC Adv. Res. Rev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.1007\/s11033-021-06366-1","article-title":"Endocannabinoid System and Its Modulation of Brain, Gut, Joint and Skin Inflammation","volume":"48","author":"Osafo","year":"2021","journal-title":"Mol. Biol. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/s42255-022-00600-1","article-title":"Metabolic Messengers: Endocannabinoids","volume":"4","author":"Marsicano","year":"2022","journal-title":"Nat. Metab."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/sj.cdd.4401284","article-title":"The Endocannabinoid System, Anandamide and the Regulation of Mammalian Cell Apoptosis","volume":"10","author":"Maccarrone","year":"2003","journal-title":"Cell Death Differ."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.1073\/pnas.061029898","article-title":"2-Arachidonyl Glyceryl Ether, an Endogenous Agonist of the Cannabinoid CB1 Receptor","volume":"98","author":"Fride","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1021\/ja01858a058","article-title":"Structure of Cannabidiol, a Product Isolated from the Marihuana Extract of Minnesota Wild Hemp. I","volume":"62","author":"Adams","year":"1940","journal-title":"J. Am. Chem. Soc."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s12210-020-00956-0","article-title":"The Early History of Cannabinoid Research","volume":"31","author":"Appendino","year":"2020","journal-title":"Rend. Fis. Acc. Lincei."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1016\/0040-4020(63)85022-X","article-title":"Hashish\u2014I: The Structure of Cannabidiol","volume":"19","author":"Mechoulam","year":"1963","journal-title":"Tetrahedron"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/S0040-4039(00)90646-4","article-title":"The Absolute Configuration of \u03941-Tetrahydrocannabinol, the Major Active Constituent of Hashish","volume":"8","author":"Mechoulam","year":"1967","journal-title":"Tetrahedron Lett."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Parker, L., Rock, E.M., and Mechoulam, R. (2022). CBD: What Does the Science Say?, The MIT Press.","DOI":"10.7551\/mitpress\/13686.001.0001"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0009-3084(02)00144-5","article-title":"Cannabidiol: An Overview of Some Chemical and Pharmacological Aspects. Part I: Chemical Aspects","volume":"121","author":"Mechoulam","year":"2002","journal-title":"Chem. Phys. Lipids"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"12137","DOI":"10.1021\/acs.jmedchem.0c00724","article-title":"The Essential Medicinal Chemistry of Cannabidiol (CBD)","volume":"63","author":"Nelson","year":"2020","journal-title":"J. Med. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1107\/S0567740877010577","article-title":"Cannabidiol","volume":"33","author":"Jones","year":"1977","journal-title":"Acta Cryst. B"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"114890","DOI":"10.1016\/j.comptc.2024.114890","article-title":"A Comprehensive Molecular Analysis of Cannabidiol: From Solid State to Antioxidant Potential","volume":"1241","author":"Aguiar","year":"2024","journal-title":"Comput. Theor. Chem."},{"key":"ref_48","unstructured":"(2025, April 09). DRUGBANK online Cannabidiol. Available online: https:\/\/go.drugbank.com\/drugs\/DB09061."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Francke, N.M., Schneider, F., Baumann, K., and Bunjes, H. (2021). Formulation of Cannabidiol in Colloidal Lipid Carriers. Molecules, 26.","DOI":"10.3390\/molecules26051469"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Schwarzenberg, A., Carpenter, H., Wright, C., Bayazeid, O., and Brokl, M. (2022). Characterizing the Degradation of Cannabidiol in an E-Liquid Formulation. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-23910-6"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"100465","DOI":"10.1016\/j.rechem.2022.100465","article-title":"Stability of Cannabidiol (CBD) in Solvents and Formulations: A GC\u2013MS Approach","volume":"4","author":"Franco","year":"2022","journal-title":"Results Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1007\/s43630-024-00589-4","article-title":"Photodegradation of Cannabidiol (CBD) and \u03949-THC in Cannabis Plant Material","volume":"23","author":"Bini","year":"2024","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_53","unstructured":"(2025, April 09). ChemicalBook CANNABIDIOL|13956-29-1. Available online: https:\/\/www.chemicalbook.com\/ChemicalProductProperty_EN_CB7673434.htm."},{"key":"ref_54","unstructured":"(2025, April 09). CHEMBL Compound: CANNABIDIOL (CHEMBL190461). Available online: https:\/\/www.ebi.ac.uk\/explore\/compound\/CHEMBL190461."},{"key":"ref_55","unstructured":"Wong, J.C.M., Sivak, O., Wasan, K., Fischer, P., and Gershkovich, P. (2013, January 24\u201326). Intestinal Absorption of Lipophilic Cannabinoids: The Role of Lymphatic Transport. Proceedings of the 5th World Conference on Drug Absorption, Transport and Delivery, Uppsala, Switzerland."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1021\/acs.jced.3c00105","article-title":"Densities and Viscosities of Cannabis Extracts and Distillates, and Densities, Viscosities, Fusion Enthalpy, and Melting Point of Cannabidiol","volume":"68","author":"Orozco","year":"2023","journal-title":"J. Chem. Eng. Data"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/DER.0000000000000257","article-title":"The Endocannabinoid System and Its Role in Eczematous Dermatoses","volume":"28","author":"Trusler","year":"2017","journal-title":"Dermatitis"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Atalay, S., Jarocka-Karpowicz, I., and Skrzydlewska, E. (2020). Antioxidative and Anti-Inflammatory Properties of Cannabidiol. Antioxidants, 9.","DOI":"10.3390\/antiox9010021"},{"key":"ref_59","first-page":"14083","article-title":"A Molecular Basis for the Anti-Inflammatory and Anti-Fibrosis Properties of Cannabidiol","volume":"34","author":"Sunda","year":"2020","journal-title":"Fed. Am. Soc. Exp. Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e1908","DOI":"10.1002\/hsr2.1908","article-title":"The Effect of Cannabinoids on Wound Healing: A Review","volume":"7","author":"Parikh","year":"2024","journal-title":"Health Sci. Rep."},{"key":"ref_61","first-page":"36","article-title":"The ABCs of CBD: Cannabinoids in Dermatology and Skin Care","volume":"44","year":"2023","journal-title":"Dermatol. Times"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"100095","DOI":"10.1016\/j.xjidi.2022.100095","article-title":"Cannabinoids for the Treatment of Dermatologic Conditions","volume":"2","author":"Sivesind","year":"2022","journal-title":"JID Innov."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4102\/safp.v64i1.5493","article-title":"Topical Cannabidiol (CBD) in Skin Pathology\u2013A Comprehensive Review and Prospects for New Therapeutic Opportunities","volume":"64","author":"Makhakhe","year":"2022","journal-title":"S. Afr. Fam. Pract."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Mlost, J., Bryk, M., and Starowicz, K. (2020). Cannabidiol for Pain Treatment: Focus on Pharmacology and Mechanism of Action. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21228870"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.jpainsymman.2017.06.005","article-title":"Topical Medical Cannabis: A New Treatment for Wound Pain\u2014Three Cases of Pyoderma Gangrenosum","volume":"54","author":"Maida","year":"2017","journal-title":"J. Pain Symptom Manag."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s42238-023-00179-8","article-title":"Topical Cannabidiol Is Well Tolerated in Individuals with a History of Elite Physical Performance and Chronic Lower Extremity Pain","volume":"5","author":"Hall","year":"2023","journal-title":"J. Cannabis Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1089\/can.2024.0012","article-title":"Topical Cannabidiol Application May Not Attenuate Muscle Soreness or Improve Performance: A Randomized, Double-Blinded, Placebo-Controlled Pilot Study","volume":"10","author":"Pastina","year":"2024","journal-title":"Cannabis Cannabinoid Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e1556","DOI":"10.1089\/can.2023.0253","article-title":"Topical Cannabidiol for Established Chemotherapy-Induced Neuropathy: A Pilot Randomized Placebo-Controlled Trial","volume":"9","author":"Novotny","year":"2024","journal-title":"Cannabis Cannabinoid Res."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"C\u00e1sedas, G., de Yarza-Sancho, M., and L\u00f3pez, V. (2024). Cannabidiol (CBD): A Systematic Review of Clinical and Preclinical Evidence in the Treatment of Pain. Pharmaceuticals, 17.","DOI":"10.3390\/ph17111438"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Galletta, M., Reekie, T.A., Nagalingam, G., Bottomley, A.L., Harry, E.J., Kassiou, M., and Triccas, J.A. (2020). Rapid Antibacterial Activity of Cannabichromenic Acid against Methicillin-Resistant Staphylococcus Aureus. Antibiotics, 9.","DOI":"10.3390\/antibiotics9080523"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Niyangoda, D., Aung, M.L., Qader, M., Tesfaye, W., Bushell, M., Chiong, F., Tsai, D., Ahmad, D., Samarawickrema, I., and Sinnollareddy, M. (2024). Cannabinoids as Antibacterial Agents: A Systematic and Critical Review of In Vitro Efficacy Against Streptococcus and Staphylococcus. Antibiotics, 13.","DOI":"10.3390\/antibiotics13111023"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1021\/np8002673","article-title":"Antibacterial Cannabinoids from: A Structure\u2212Activity Study","volume":"71","author":"Appendino","year":"2008","journal-title":"J. Nat. Prod."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Gildea, L., Ayariga, J.A., Ajayi, O.S., Xu, J., Villafane, R., and Samuel-Foo, M. (2022). Cannabis sativa CBD Extract Shows Promising Antibacterial Activity against Salmonella Typhimurium and S. Newington. Molecules, 27.","DOI":"10.3390\/molecules27092669"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1039\/D3SM01466E","article-title":"Stability, Biofunctional, and Antimicrobial Characteristics of Cannabidiol Isolate for the Design of Topical Formulations","volume":"20","author":"Pillai","year":"2024","journal-title":"Soft Matter"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Hong, H., Sloan, L., Saxena, D., and Scott, D.A. (2022). The Antimicrobial Properties of Cannabis and Cannabis-Derived Compounds and Relevance to CB2-Targeted Neurodegenerative Therapeutics. Biomedicines, 10.","DOI":"10.3390\/biomedicines10081959"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Saleemi, M.A., Yahaya, N., Zain, N.N.M., Raoov, M., Yong, Y.K., Noor, N.S., and Lim, V. (2022). Antimicrobial and Cytotoxic Effects of Cannabinoids: An Updated Review with Future Perspectives and Current Challenges. Pharmaceuticals, 15.","DOI":"10.3390\/ph15101228"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1089\/can.2020.0105","article-title":"The Effects of Cannabinoids on Pro- and Anti-Inflammatory Cytokines: A Systematic Review of In Vivo Studies","volume":"6","author":"Henshaw","year":"2021","journal-title":"Cannabis Cannabinoid Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1089\/can.2016.0034","article-title":"An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies","volume":"2","author":"Iffland","year":"2017","journal-title":"Cannabis Cannabinoid Res."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Rybarczyk, A., Majchrzak-Celi\u0144ska, A., and Krajka-Ku\u017aniak, V. (2023). Targeting Nrf2 Signaling Pathway in Cancer Prevention and Treatment: The Role of Cannabis Compounds. Antioxidants, 12.","DOI":"10.3390\/antiox12122052"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.jaad.2024.06.088","article-title":"Topical Nanoencapsulated Cannabidiol Cream as an Innovative Strategy Combating UV-A\u2013Induced Nuclear and Mitochondrial DNA Injury: A Pilot Randomized Clinical Study","volume":"91","author":"McCormick","year":"2024","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1089\/can.2023.0070","article-title":"Analgesic and Anti-Inflammatory Effects of 1% Topical Cannabidiol Gel in Animal Models","volume":"9","author":"Bunman","year":"2024","journal-title":"Cannabis Cannabinoid Res."},{"key":"ref_82","unstructured":"Boas, V., and da Silva, I. (2020). Cannabis-Based Skin Products: Where Are We at?. [Master\u2019s Thesis, Universidade de Lisboa]. Available online: https:\/\/repositorio.ulisboa.pt\/handle\/10451\/52678."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"12663","DOI":"10.3390\/molecules181012663","article-title":"Understanding the Molecular Aspects of Tetrahydrocannabinol and Cannabidiol as Antioxidants","volume":"18","author":"Borges","year":"2013","journal-title":"Molecules"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"104915","DOI":"10.1016\/j.fitote.2021.104915","article-title":"CBG, CBD, \u03949-THC, CBN, CBGA, CBDA and \u03949-THCA as Antioxidant Agents and Their Intervention Abilities in Antioxidant Action","volume":"152","author":"Dawidowicz","year":"2021","journal-title":"Fitoterapia"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Mashabela, M.D., and Kappo, A.P. (2024). Anti-Cancer and Anti-Proliferative Potential of Cannabidiol: A Cellular and Molecular Perspective. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25115659"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Pagano, C., Navarra, G., Coppola, L., Avilia, G., Bifulco, M., and Laezza, C. (2022). Cannabinoids: Therapeutic Use in Clinical Practice. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23063344"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1089\/acm.2017.0016","article-title":"A Review of the Therapeutic Antitumor Potential of Cannabinoids","volume":"23","year":"2017","journal-title":"J. Altern. Complement. Med."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Lyu, P., Li, H., Wan, J., Chen, Y., Zhang, Z., Wu, P., Wan, Y., Seeram, N.P., Chamcheu, J.C., and Liu, C. (2024). Bipiperidinyl Derivatives of Cannabidiol Enhance Its Antiproliferative Effects in Melanoma Cells. Antioxidants, 13.","DOI":"10.3390\/antiox13040478"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Le, T.Q., Meesiripan, N., Sanggrajang, S., Suwanpidokkul, N., Prayakprom, P., Bodhibukkana, C., Khaowroongrueng, V., Suriyachan, K., Thanasitthichai, S., and Srisubat, A. (2024). Anti-Proliferative and Apoptotic Effect of Cannabinoids on Human Pancreatic Ductal Adenocarcinoma Xenograft in BALB\/c Nude Mice Model. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-55307-y"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Sainz-Cort, A., M\u00fcller-S\u00e1nchez, C., and Espel, E. (2020). Anti-Proliferative and Cytotoxic Effect of Cannabidiol on Human Cancer Cell Lines in Presence of Serum. BMC Res. Notes, 13.","DOI":"10.1186\/s13104-020-05229-5"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"108865","DOI":"10.1016\/j.intimp.2022.108865","article-title":"Cannabidiol Exerts Anti-Proliferative Activity via a Cannabinoid Receptor 2-Dependent Mechanism in Human Colorectal Cancer Cells","volume":"108","author":"Lee","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"D\u2019Aloia, A., Ceriani, M., Tisi, R., Stucchi, S., Sacco, E., and Costa, B. (2022). Cannabidiol Antiproliferative Effect in Triple-Negative Breast Cancer MDA-MB-231 Cells Is Modulated by Its Physical State and by IGF-1. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23137145"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Chen, Y., Li, H., Liu, J., Ni, J., Deng, Q., He, H., Wu, P., Wan, Y., Seeram, N.P., and Liu, C. (2024). Cytotoxicity of Natural and Synthetic Cannabinoids and Their Synergistic Antiproliferative Effects with Cisplatin in Human Ovarian Cancer Cells. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1496131"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Abassi-Rana, G., Calle-Patino, Y., and Molina-Holgado, F. (2024). Differential Antiproliferative Effects of Cannabidiol (Cbd) in the Core and Infiltrative Boundary of Human Glioblastoma Cells. bioRxiv, Available online: https:\/\/www.biorxiv.org\/content\/10.1101\/2024.09.17.613445v1.","DOI":"10.1101\/2024.09.17.613445"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.1172\/JCI64628","article-title":"Cannabidiol Exerts Sebostatic and Antiinflammatory Effects on Human Sebocytes","volume":"124","author":"Sugawara","year":"2014","journal-title":"J. Clin. Investig."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1111\/exd.13042","article-title":"Differential Effectiveness of Selected Non-Psychotropic Phytocannabinoids on Human Sebocyte Functions Implicates Their Introduction in Dry\/Seborrhoeic Skin and Acne Treatment","volume":"25","author":"Markovics","year":"2016","journal-title":"Exp. Dermatol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s11101-023-09860-5","article-title":"Skin Applications of Cannabidiol: Sources, Effects, Delivery Systems, Marketed Formulations and Safety","volume":"22","author":"Ferreira","year":"2023","journal-title":"Phytochem. Rev."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1111\/ced.14749","article-title":"Tolerability Profile of Topical Cannabidiol and Palmitoylethanolamide: A Compilation of Single-centre Randomized Evaluator-blinded Clinical and In Vitro Studies in Normal Skin","volume":"46","author":"Maghfour","year":"2021","journal-title":"Clin. Exp. Derm."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cbi.2017.06.005","article-title":"Cannabidiol Upregulates Melanogenesis through CB1 Dependent Pathway by Activating P38 MAPK and P42\/44 MAPK","volume":"273","author":"Hwang","year":"2017","journal-title":"Chem. -Biol. Interact."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Gawe\u0142-B\u0119ben, K., Czech, K., and Luca, S.V. (2023). Cannabidiol and Minor Phytocannabinoids: A Preliminary Study to Assess Their Anti-Melanoma, Anti-Melanogenic, and Anti-Tyrosinase Properties. Pharmaceuticals, 16.","DOI":"10.3390\/ph16050648"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3390\/jox12020012","article-title":"Comparative Study of \u03949-Tetrahydrocannabinol and Cannabidiol on Melanogenesis in Human Epidermal Melanocytes from Different Pigmentation Phototypes: A Pilot Study","volume":"12","author":"Goenka","year":"2022","journal-title":"J. Xenobiotics"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"250","DOI":"10.48022\/mbl.2303.03012","article-title":"Anti-Melanogenic Effect of Cannabis sativa Stem Extracts Fermented with Weissella Paramesenteroides","volume":"51","author":"Kim","year":"2023","journal-title":"Microbiol. Biotechnol. Lett."},{"key":"ref_103","first-page":"2023919","article-title":"Chayanee Thammarat; Khongkow, P. Safety and Potential Effects of Cannabidiol on Skin Cells|Tassaneesuwan|Journal of Health Science and Medical Research","volume":"41","author":"Tassaneesuwan","year":"2023","journal-title":"J. Health Sci. Med. Res."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Ikarashi, N., Shiseki, M., Yoshida, R., Tabata, K., Kimura, R., Watanabe, T., Kon, R., Sakai, H., and Kamei, J. (2021). Cannabidiol Application Increases Cutaneous Aquaporin-3 and Exerts a Skin Moisturizing Effect. Pharmaceuticals, 14.","DOI":"10.3390\/ph14090879"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jdermsci.2023.01.008","article-title":"-ram; Mok, B.R.; Son, S.J.; Ryu, J.; Son, W.S.; Yun, S.K.; Kang, S.; Kim, H.J.; et al. Cannabidiol Mediates Epidermal Terminal Differentiation and Redox Homeostasis through Aryl Hydrocarbon Receptor (AhR)-Dependent Signaling","volume":"109","author":"Jeong","year":"2023","journal-title":"J. Dermatol. Sci."},{"key":"ref_106","first-page":"e93","article-title":"A Therapeutic Effect of Cbd-Enriched Ointment in Inflammatory Skin Diseases and Cutaneous Scars","volume":"170","author":"Palmieri","year":"2019","journal-title":"La Clin. Ter."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"121540","DOI":"10.1016\/j.ijpharm.2022.121540","article-title":"In Vitro Percutaneous Absorption Studies of Cannabidiol Using Human Skin: Exploring the Effect of Drug Concentration, Chemical Enhancers, and Essential Oils","volume":"616","author":"Junaid","year":"2022","journal-title":"Int. J. Pharm."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Lapteva, M., Faro Barros, J., and Kalia, Y.N. (2024). Cutaneous Delivery and Biodistribution of Cannabidiol in Human Skin after Topical Application of Colloidal Formulations. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16020202"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Filipiuc, S.-I., Neagu, A.-N., Uritu, C.M., Tamba, B.-I., Filipiuc, L.-E., Tudorancea, I.M., Boca, A.N., H\u00e2ncu, M.F., Porumb, V., and Bild, W. (2023). The Skin and Natural Cannabinoids\u2013Topical and Transdermal Applications. Pharmaceuticals, 16.","DOI":"10.3390\/ph16071049"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1007\/s11101-024-10001-9","article-title":"A Comprehensive Update on Cannabidiol, Its Formulations and Drug Delivery Systems","volume":"24","author":"Banerjee","year":"2024","journal-title":"Phytochem. Rev."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Ahmed, B., Kaur, S., Naryal, S., Devi, A., Kathpalia, M., Shah, R.M., and Kaur, I.P. (2025). Nanoformulated Cannabidiol for Skin Disorders: A GRADE-Based Systematic Review of Therapeutic Evidence and Efficacy. Eur. J. Pharm. Biopharm., 214.","DOI":"10.1016\/j.ejpb.2025.114784"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Calienni, M.N., Scavone, M.A., Sanguinetti, A.P., Corleto, M., Di Meglio, M.R., Raies, P., Cristos, D.S., Maffia, P.C., and Montanari, J. (2024). Lipid Nanoparticle Formulations for the Skin Delivery of Cannabidiol. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16121490"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"F1000 Faculty Rev-1953","DOI":"10.12688\/f1000research.15659.1","article-title":"Recent Advances in Understanding Propionibacterium Acnes (Cutibacterium acnes) in Acne","volume":"7","author":"Platsidaki","year":"2018","journal-title":"F1000Research"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"4573","DOI":"10.2147\/JIR.S374692","article-title":"Cannabidiol Inhibits Inflammation Induced by Cutibacterium Acnes-Derived Extracellular Vesicles via Activation of CB2 Receptor in Keratinocytes","volume":"15","author":"Jiang","year":"2022","journal-title":"J. Inflamm. Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"4474255","DOI":"10.1155\/2023\/4474255","article-title":"Development of an Effective Acne Treatment Based on CBD and Herbal Extracts: Preliminary In Vitro, Ex Vivo, and Clinical Evaluation","volume":"2023","author":"Cohen","year":"2023","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"S180","DOI":"10.1016\/j.jid.2018.03.1074","article-title":"The Safety of Topical Cannabidiol (CBD) for the Treatment of Acne","volume":"138","author":"Spleman","year":"2018","journal-title":"J. Investig. Dermatol."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Woli\u0144ska, R., Zalewska, M., Pozna\u0144ski, P., Nawrocka, A., Kowalczyk, A., Sacharczuk, M., and Bujalska-Zadro\u017cny, M. (2025). Anti-Inflammatory Activity of Cannabis sativa L. Extract in 2,4-Dinitrochlorobenzene-Induced Dermatitis in Rats. Pharmaceuticals, 18.","DOI":"10.3390\/ph18030370"},{"key":"ref_118","first-page":"86","article-title":"CBD: A Potential Lead against Hair Loss, Alopecia, and Its Potential Mechanisms","volume":"21","author":"Wal","year":"2023","journal-title":"Curr. Drug Discov. Technol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"53","DOI":"10.26828\/cannabis\/2021.01.003","article-title":"Hair Regrowth with Cannabidiol (CBD)-Rich Hemp Extract\u2013A Case Series","volume":"4","author":"Smith","year":"2021","journal-title":"Cannabis"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"6653","DOI":"10.1111\/jocd.15427","article-title":"A Cannabinoid Hairy-Tale: Hair Loss or Hair Gain?","volume":"21","author":"Gupta","year":"2022","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4103\/ijt.ijt_34_22","article-title":"Hair Regrowth with Novel Hemp Extract: A Case Series","volume":"15","author":"Smith","year":"2023","journal-title":"Int. J. Trichology"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Afshari, M., Kolackova, M., Rosecka, M., \u010celakovsk\u00e1, J., and Krejsek, J. (2024). Unraveling the Skin; a Comprehensive Review of Atopic Dermatitis, Current Understanding, and Approaches. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1361005"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.36849\/JDD.2020.5464","article-title":"An Observational Study of the Application of a Topical Cannabinoid Gel on Sensitive Dry Skin","volume":"19","author":"Maghfour","year":"2020","journal-title":"J. Drugs Dermatol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/s41401-019-0210-3","article-title":"Cannabis, Cannabinoid Receptors, and Endocannabinoid System: Yesterday, Today, and Tomorrow","volume":"40","author":"Wu","year":"2019","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nrd2553","article-title":"Targeting the Endocannabinoid System: To Enhance or Reduce?","volume":"7","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"329-e77","DOI":"10.1111\/vde.13077","article-title":"The Effect of a Mixed Cannabidiol and Cannabidiolic Acid Based Oil on Client-Owned Dogs with Atopic Dermatitis","volume":"33","author":"Loewinger","year":"2022","journal-title":"Vet. Dermatol."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Bizarro, A.F., Schmidt, V.M., Fernandes, B., Pinto, M., Pereira, H., Marto, J., and Louren\u00e7o, A.M. (2025). The Potential of Cannabidiol for Treating Canine Atopic Dermatitis. Vet. Sci., 12.","DOI":"10.3390\/vetsci12020159"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"e14419","DOI":"10.1111\/dth.14419","article-title":"Promoting Wound Healing of Uremic Calciphylaxis Leg Ulcers Using Topical Cannabis-Based Medicines","volume":"33","author":"Maida","year":"2020","journal-title":"Dermatol. Ther."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1111\/iwj.13484","article-title":"Topical Cannabis-Based Medicines\u2013A Novel Paradigm and Treatment for Non-Uremic Calciphylaxis Leg Ulcers: An Open Label Trial","volume":"17","author":"Maida","year":"2020","journal-title":"Int. Wound J."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"e224","DOI":"10.1111\/pde.13545","article-title":"Self-Initiated Use of Topical Cannabidiol Oil for Epidermolysis Bullosa","volume":"35","author":"Chelliah","year":"2018","journal-title":"Pediatr. Dermatol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/bjd.17341","article-title":"Combined Tetrahydrocannabinol and Cannabidiol to Treat Pain in Epidermolysis Bullosa: A Report of Three Cases","volume":"180","author":"Duipmans","year":"2019","journal-title":"Br. J. Dermatol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"551","DOI":"10.25259\/IJDVL_71_2021","article-title":"Purified Oral Cannabidiol for Pain Management in Severe Recessive Dystrophic Epidermolysis Bullosa","volume":"88","author":"Welponer","year":"2022","journal-title":"Indian. J. Dermatol. Venereol. Leprol."},{"key":"ref_133","unstructured":"(2025, July 03). Assistance Publique-H\u00f4pitaux de Paris Evaluation of the Efficacy of Cannabidiol on the Pruritus in Children With Hereditary Epidermolysis Bullosa, Available online: https:\/\/clinicaltrials.gov\/study\/NCT05651607."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Song, J., Xian, D., Yang, L., Xiong, X., Lai, R., and Zhong, J. (2018). Pruritus: Progress toward Pathogenesis and Treatment. Biomed. Res. Int., 2018.","DOI":"10.1155\/2018\/9625936"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.jaad.2020.01.036","article-title":"Cannabinoids for the Treatment of Chronic Pruritus: A Review","volume":"82","author":"Avila","year":"2020","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.jid.2022.10.014","article-title":"Role of Type I Cannabinoid Receptor in Sensory Neurons in Psoriasiform Skin Inflammation and Pruritus","volume":"143","author":"Liu","year":"2023","journal-title":"J. Investig. Dermatol."},{"key":"ref_137","first-page":"97","article-title":"Efficacy and Tolerance of the Cream Containing Structured Physiological Lipids with Endocannabinoids in the Treatment of Uremic Pruritus: A Preliminary Study","volume":"13","author":"Szepietowski","year":"2005","journal-title":"Acta Dermatovenerol. Croat."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1177\/02692163211045314","article-title":"Cannabinoids for the Treatment of Refractory Neuropathic Pruritus in Amyotrophic Lateral Sclerosis: A Case Report","volume":"36","author":"Lou","year":"2022","journal-title":"Palliat. Med."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"100894","DOI":"10.1016\/j.xkme.2024.100894","article-title":"Cannabis-Containing Cream for CKD-Associated Pruritus: A Double-Blind, Placebo Controlled Trial","volume":"6","author":"Anumas","year":"2024","journal-title":"Kidney Med."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1186\/s13023-021-02010-0","article-title":"Cannabinoid Use and Effects in Patients with Epidermolysis Bullosa: An International Cross-Sectional Survey Study","volume":"16","author":"Gorell","year":"2021","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41572-025-00630-5","article-title":"Psoriasis","volume":"11","author":"Armstrong","year":"2025","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Kim, M.-S., Lee, J.-H., Kim, S.-W., and Bang, C.-H. (2024). Cannabidiol Alleviates Imiquimod-Induced Psoriasis by Inhibiting JAK2\u2013STAT3 in a Mouse Model. Biomedicines, 12.","DOI":"10.3390\/biomedicines12092084"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"52","DOI":"10.53582\/AMJ255152f","article-title":"Therapeutic Effect of Cannabidiol (CBD) in Plaque Psoriasis","volume":"5","author":"Filipovik","year":"2025","journal-title":"Acad. Med. J."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41392-023-01655-6","article-title":"Signaling Pathways and Targeted Therapies for Psoriasis","volume":"8","author":"Guo","year":"2023","journal-title":"Sig Transduct. Target. Ther."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1002\/ptr.6400","article-title":"Cannabis sativa L. Extract and Cannabidiol Inhibit In Vitro Mediators of Skin Inflammation and Wound Injury","volume":"33","author":"Sangiovanni","year":"2019","journal-title":"Phytother. Res."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41419-022-04523-3","article-title":"Advances in the Pathogenesis of Psoriasis: From Keratinocyte Perspective","volume":"13","author":"Zhou","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1038\/d41586-019-02524-5","article-title":"The Reality behind Cannabidiol\u2019s Medical Hype","volume":"572","author":"Eisenstein","year":"2019","journal-title":"Nature"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1159\/000510896","article-title":"Efficacy and Tolerability of a Shampoo Containing Broad-Spectrum Cannabidiol in the Treatment of Scalp Inflammation in Patients with Mild to Moderate Scalp Psoriasis or Seborrheic Dermatitis","volume":"6","author":"Vincenzi","year":"2020","journal-title":"Ski. Appendage Disord."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1001\/jamadermatol.2014.1307","article-title":"Pyoderma Gangrenosum","volume":"150","author":"Okhovat","year":"2014","journal-title":"JAMA Dermatol."},{"key":"ref_150","unstructured":"Tucker, D., and Masood, S. (2025). Seborrheic Dermatitis. StatPearls, StatPearls Publishing."},{"key":"ref_151","first-page":"1389","article-title":"The Safety and Efficacy of 3% Cannabis Seeds Extract Cream for Reduction of Human Cheek Skin Sebum and Erythema Content","volume":"28","author":"Ali","year":"2015","journal-title":"Pak. J. Pharm. Sci."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"e49965","DOI":"10.2196\/49965","article-title":"Oral Cannabidiol for Seborrheic Dermatitis in Patients With Parkinson Disease: Randomized Clinical Trial","volume":"7","author":"Weber","year":"2024","journal-title":"JMIR Dermatol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1159\/000512189","article-title":"A Review of the Current Evidence Connecting Seborrheic Dermatitis and Parkinson\u2019s Disease and the Potential Role of Oral Cannabinoids","volume":"237","author":"Rietcheck","year":"2020","journal-title":"Dermatology"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Ramer, R., Wendt, F., Wittig, F., Sch\u00e4fer, M., Boeckmann, L., Emmert, S., and Hinz, B. (2022). Impact of Cannabinoid Compounds on Skin Cancer. Cancers, 14.","DOI":"10.3390\/cancers14071769"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41416-022-01727-4","article-title":"Cannabinoids as Anticancer Drugs: Current Status of Preclinical Research","volume":"127","author":"Hinz","year":"2022","journal-title":"Br. J. Cancer"},{"key":"ref_156","first-page":"2633","article-title":"Cannabinoid Receptors as Novel Targets for the Treatment of melanomaCannabinoid Receptors as Novel Targets for the Treatment of Melanoma","volume":"20","author":"Carracedo","year":"2006","journal-title":"Fed. Am. Soc. Exp. Biol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.tiv.2017.01.018","article-title":"Tumor-Promoting Effects of Cannabinoid Receptor Type 1 in Human Melanoma Cells","volume":"40","author":"Carpi","year":"2017","journal-title":"Toxicol. Vitr."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"e1633","DOI":"10.1002\/wsbm.1633","article-title":"Rationalizing a Prospective Coupling Effect of Cannabinoids with the Current Pharmacotherapy for Melanoma Treatment","volume":"16","author":"Bachari","year":"2024","journal-title":"WIREs Mech. Dis."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Richtig, G., Kienzl, M., Rittchen, S., Roula, D., Eberle, J., Sarif, Z., Pichler, M., Hoefler, G., and Heinemann, A. (2023). Cannabinoids Reduce Melanoma Cell Viability and Do Not Interfere with Commonly Used Targeted Therapy in Metastatic Melanoma In Vivo and In Vitro. Biology, 12.","DOI":"10.3390\/biology12050706"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1172\/JCI200316116","article-title":"Inhibition of Skin Tumor Growth and Angiogenesis in Vivo by Activation of Cannabinoid Receptors","volume":"111","author":"Casanova","year":"2003","journal-title":"J. Clin. Investig."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jss.2018.08.055","article-title":"Cannabinoids as a Potential New and Novel Treatment for Melanoma: A Pilot Study in a Murine Model","volume":"235","author":"Simmerman","year":"2019","journal-title":"J. Surg. Res."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1038\/jid.2015.45","article-title":"Exploiting Cannabinoid-Induced Cytotoxic Autophagy to Drive Melanoma Cell Death","volume":"135","author":"Armstrong","year":"2015","journal-title":"J. Investig. Dermatol."},{"key":"ref_163","unstructured":"Thamert, R. (2021). A Comparative Study on Cannabidiol in Melanoma Migration and Invasion: Charlotte\u2019s Web vs. Purified CBD, 2020\u20132021. [Master\u2019s Thesis, Jacksonville State UniversityJacksonville State University]."},{"key":"ref_164","first-page":"e23850","article-title":"Cutaneous Squamous Cell Carcinoma and Lichen Simplex Chronicus Successfully Treated with Topical Cannabinoid Oil: A Case Report and Summary of Cannabinoids in Dermatology","volume":"14","author":"Laborada","year":"2022","journal-title":"Cureus"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ejphar.2009.06.004","article-title":"The CB1\/CB2 Receptor Agonist WIN-55,212-2 Reduces Viability of Human Kaposi\u2019s Sarcoma Cells In Vitro","volume":"616","author":"Luca","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1177\/1947601912466556","article-title":"Cannabidiol Inhibits Growth and Induces Programmed Cell Death in Kaposi Sarcoma\u2013Associated Herpesvirus-Infected Endothelium","volume":"3","author":"Maor","year":"2012","journal-title":"Genes. Cancer"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"7230","DOI":"10.1158\/0008-5472.CAN-07-0960","article-title":"Cannabinoid Modulation of Kaposi\u2019s Sarcoma\u2013Associated Herpesvirus Infection and Transformation","volume":"67","author":"Zhang","year":"2007","journal-title":"Cancer Res."},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Shah, P., Holmes, K., Chibane, F., Wang, P., Chagas, P., Salles, E., Jones, M., Palines, P., Masoumy, M., and Baban, B. (2024). Cutaneous Wound Healing and the Effects of Cannabidiol. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25137137"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Monou, P.K., Mamaligka, A.M., Tzimtzimis, E.K., Tzetzis, D., Vergkizi-Nikolakaki, S., Vizirianakis, I.S., Andriotis, E.G., Eleftheriadis, G.K., and Fatouros, D.G. (2022). Fabrication and Preliminary In Vitro Evaluation of 3D-Printed Alginate Films with Cannabidiol (CBD) and Cannabigerol (CBG) Nanoparticles for Potential Wound-Healing Applications. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14081637"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"123202","DOI":"10.1016\/j.ijpharm.2023.123202","article-title":"Cannabidiol Nanoemulsion for Eye Treatment\u2013Anti-Inflammatory, Wound Healing Activity and Its Bioavailability Using In Vitro Human Corneal Substitute","volume":"643","author":"Tran","year":"2023","journal-title":"Int. J. Pharm."},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Klinsang, T., Charoensit, P., Phimnuan, P., Luangpraditkun, K., Ross, G.M., Viennet, C., Ross, S., and Viyoch, J. (2023). In Vitro Wound Healing Potential of a Fibroin Film Incorporating a Cannabidiol\/2-Hydroxypropyl-\u03b2-Cyclodextrin Complex. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15122682"},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Lapmanee, S., Bhubhanil, S., Charoenphon, N., Inchan, A., Bunwatcharaphansakun, P., Khongkow, M., and Namdee, K. (2024). Cannabidiol-Loaded Lipid Nanoparticles Incorporated in Polyvinyl Alcohol and Sodium Alginate Hydrogel Scaffold for Enhancing Cell Migration and Accelerating Wound Healing. Gels, 10.","DOI":"10.3390\/gels10120843"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1111\/exd.14395","article-title":"Topical Cannabis-Based Medicines\u2013A Novel Adjuvant Treatment for Venous Leg Ulcers: An Open-Label Trial","volume":"30","author":"Maida","year":"2021","journal-title":"Exp. Dermatol."},{"key":"ref_174","unstructured":"(2025, June 27). University of Oklahoma The Effects of Topical Cannabidiol on Paramedian Forehead Flap Scar Healing: A Split Scar Study, Available online: https:\/\/clinicaltrials.gov\/study\/NCT05650697."},{"key":"ref_175","first-page":"45","article-title":"Therapeutic and Cosmetic Uses of Cannabis: Cannabinoids for Acne Treatment and Skin -Rejuvenation","volume":"19","author":"Cohen","year":"2021","journal-title":"Skinmed"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"200.e11","DOI":"10.1016\/j.neurobiolaging.2010.07.009","article-title":"Early Onset of Aging-like Changes Is Restricted to Cognitive Abilities and Skin Structure in Cnr1\u2212\/\u2212Mice","volume":"33","author":"Drews","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"111528","DOI":"10.1016\/j.exger.2021.111528","article-title":"Diabetes and Cannabinoid CB1 Receptor Deficiency Promote Similar Early Onset Aging-like Changes in the Skin","volume":"154","author":"Leal","year":"2021","journal-title":"Exp. Gerontol."},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Casares, L., Garc\u00eda, V., Garrido-Rodr\u00edguez, M., Mill\u00e1n, E., Collado, J.A., Garc\u00eda-Mart\u00edn, A., Pe\u00f1arando, J., Calzado, M.A., de la Vega, L., and Mu\u00f1oz, E. (2020). Cannabidiol Induces Antioxidant Pathways in Keratinocytes by Targeting BACH1. Redox Biol., 28.","DOI":"10.1016\/j.redox.2019.101321"},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Gerasymchuk, M., Robinson, G.I., Groves, A., Haselhorst, L., Nandakumar, S., Stahl, C., Kovalchuk, O., and Kovalchuk, I. (2022). Phytocannabinoids Stimulate Rejuvenation and Prevent Cellular Senescence in Human Dermal Fibroblasts. Cells, 11.","DOI":"10.3390\/cells11233939"},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Luangpraditkun, K., Pimjuk, P., Phimnuan, P., Wisanwattana, W., Wisespongpand, C., Waranuch, N., and Viyoch, J. (2024). Anti-Aging Properties of Cannabis sativa Leaf Extract against UVA Irradiation. Cosmetics, 11.","DOI":"10.3390\/cosmetics11020045"},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Tassaneesuwan, N., Khongkow, M., Jansrinual, S., and Khongkow, P. (2025). Discovering the Potential of Cannabidiol for Cosmeceutical Development at the Cellular Level. Pharmaceuticals, 18.","DOI":"10.3390\/ph18020202"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"ojac002","DOI":"10.1093\/asjof\/ojac002","article-title":"A Single-Center Study Evaluating the Effects of a Novel Retinol and Cannabidiol Combination Topical on Facial Skin","volume":"4","author":"Few","year":"2022","journal-title":"Aesthet. Surg. J. Open Forum"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1111\/jocd.15815","article-title":"In Vitro, Ex Vivo, and Clinical Evaluation of Anti-Aging Gel Containing EPA and CBD","volume":"22","author":"Cohen","year":"2023","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"David, C., Elizalde-Hern\u00e1ndez, A., Barboza, A.S., Cardoso, G.C., Santos, M.B.F., and Moraes, R.R. (2022). Cannabidiol in Dentistry: A Scoping Review. Dent. J., 10.","DOI":"10.3390\/dj10100193"},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Bellocchio, L., Patano, A., Inchingolo, A.D., Inchingolo, F., Dipalma, G., Isacco, C.G., de Ruvo, E., Rapone, B., Mancini, A., and Lorusso, F. (2023). Cannabidiol for Oral Health: A New Promising Therapeutical Tool in Dentistry. Int. J. Mol. Sci., 24.","DOI":"10.20944\/preprints202305.0360.v1"},{"key":"ref_186","first-page":"250","article-title":"The Role of THC and CBD in Dentistry\u2013a Review of Impacts on Oral Health","volume":"18","author":"Suski","year":"2024","journal-title":"J. Pre Clin. Clin. Res."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.jobcr.2024.09.001","article-title":"Unleashing the Therapeutic Role of Cannabidiol in Dentistry","volume":"14","author":"Mulla","year":"2024","journal-title":"J. Oral. Biol. Craniofacial Res."},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Hu, Z., Qin, Z., Xie, J., Qu, Y., and Yin, L. (2024). Cannabidiol and Its Application in the Treatment of Oral Diseases: Therapeutic Potentials, Routes of Administration and Prospects. Biomed. Pharmacother., 176.","DOI":"10.1016\/j.biopha.2024.116271"},{"key":"ref_189","doi-asserted-by":"crossref","unstructured":"Carmona Rend\u00f3n, Y., Garz\u00f3n, H.S., Bueno-Silva, B., Arce, R.M., and Su\u00e1rez, L.J. (2023). Cannabinoids in Periodontology: Where Are We Now?. Antibiotics, 12.","DOI":"10.3390\/antibiotics12121687"},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Avraham, M., Steinberg, D., Barak, T., Shalish, M., Feldman, M., and Sionov, R.V. (2023). Improved Anti-Biofilm Effect against the Oral Cariogenic Streptococcus Mutans by Combined Triclosan\/CBD Treatment. Biomedicines, 11.","DOI":"10.3390\/biomedicines11020521"},{"key":"ref_191","doi-asserted-by":"crossref","unstructured":"Ferraz, M.P. (2025). The Potential of Cannabidiol in the Management of Oral Infections. Appl. Sci., 15.","DOI":"10.3390\/app15105736"},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Kie\u0142bratowski, M., Ku\u015bka-Kie\u0142bratowska, A., Mertas, A., Bobela, E., Wiench, R., K\u0119pa, M., Trzcionka, A., Korkosz, R., and Tanasiewicz, M. (2025). Evaluation of the Effectiveness of a Mouthwash Containing Spilanthol and Cannabidiol on Improving Oral Health in Patients with Gingivitis\u2014Clinical Trial. J. Clin. Med., 14.","DOI":"10.3390\/jcm14051641"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/01.ASW.0000891856.08360.61","article-title":"Topical Cannabidiol in the Treatment of Digital Ulcers in Patients with Scleroderma: Comparative Analysis and Literature Review","volume":"36","author":"Spinella","year":"2023","journal-title":"Adv. Ski. Wound Care"},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Liu, J.-K. (2022). Natural Products in Cosmetics. Nat. Prod. Bioprospect., 12.","DOI":"10.1007\/s13659-022-00363-y"},{"key":"ref_195","unstructured":"(2025, July 10). Fortune Business Insights CBD Skincare Market Size, Share, Trends|Growth Report. Available online: https:\/\/www.fortunebusinessinsights.com\/cbd-skincare-products-market-107940."},{"key":"ref_196","unstructured":"(2025, July 10). Allied Market Research https:\/\/www.alliedmarketresearch.com CBD Skin Care Market Size & Share, Industry Report-2033. Available online: https:\/\/www.alliedmarketresearch.com\/cbd-skin-care-market."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"103463","DOI":"10.1016\/j.cis.2025.103463","article-title":"The Challenges Faced by Multifunctional Ingredients: A Critical Review from Sourcing to Cosmetic Applications","volume":"340","author":"Rischard","year":"2025","journal-title":"Adv. Colloid. Interface Sci."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"25148","DOI":"10.1007\/s11356-021-17567-3","article-title":"Biocosmetics: Technological Advances and Future Outlook","volume":"30","author":"Goyal","year":"2023","journal-title":"Env. Sci. Pollut. Res."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.clindermatol.2018.11.002","article-title":"The Growing Trend of Cannabidiol in Skincare Products","volume":"37","author":"Jhawar","year":"2019","journal-title":"Clin. Dermatol."},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Geigert, J. (2023). The Challenge of CMC Regulatory Compliance for Biopharmaceuticals, Springer. [4th ed.].","DOI":"10.1007\/978-3-031-31909-9"},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Kirch, W. (2008). Encyclopedia of Public Health, Springer.","DOI":"10.1007\/978-1-4020-5614-7"},{"key":"ref_202","unstructured":"(2025, August 22). Testing and Calibration Laboratories. Available online: https:\/\/www.iso.org\/ISO-IEC-17025-testing-and-calibration-laboratories.html."},{"key":"ref_203","unstructured":"(2025, August 22). Cosmetics \u2014 Good Manufacturing Practices (GMP) \u2014 Guidelines on Good Manufacturing Practices. Available online: https:\/\/www.iso.org\/standard\/36437.html."},{"key":"ref_204","doi-asserted-by":"crossref","unstructured":"Ni, B., Liu, Y., Dai, M., Zhao, J., Liang, Y., Yang, X., Han, B., and Jiang, M. (2023). The Role of Cannabidiol in Aging. Biomed. Pharmacother., 165.","DOI":"10.1016\/j.biopha.2023.115074"},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Kim, A.L., Yun, Y.J., Choi, H.W., Hong, C.-H., Shim, H.J., Lee, J.H., and Kim, Y.-C. (2022). Profiling Cannabinoid Contents and Expression Levels of Corresponding Biosynthetic Genes in Commercial Cannabis (Cannabis sativa L.) Cultivars. Plants, 11.","DOI":"10.3390\/plants11223088"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/s10722-024-02015-1","article-title":"Exploring Cannabidiol Variations, Investigation of Genetic Diversity, Population Structure and Unveiling Male-Specific Genetic Marker in Industrial Hemp (Cannabis sativa L.)","volume":"72","author":"Alsaleh","year":"2025","journal-title":"Genet. Resour. Crop Evol."},{"key":"ref_207","doi-asserted-by":"crossref","unstructured":"Thu, M.S., Campbell, B.J., Hirankarn, N., Nopsopon, T., Ondee, T., Hall, S.R., Jagota, A., Fothergill, J.L., and Pongpirul, K. (2025). Cannabis and Cannabinoid-Microbiome Interactions in Varied Clinical Contexts: A Comprehensive Systematic Review. Biomed. Pharmacother., 182.","DOI":"10.1016\/j.biopha.2024.117764"},{"key":"ref_208","doi-asserted-by":"crossref","unstructured":"Kaminski, K.P., Hoeng, J., Goffman, F., Schlage, W.K., and Latino, D. (2024). Opportunities, Challenges, and Scientific Progress in Hemp Crops. Molecules, 29.","DOI":"10.3390\/molecules29102397"},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"Aftab, N., Gupta, A., Prasad, P., Kushwaha, H.K., Kishor, R., Singh, V., Chandra, S., Venkatesha, K.T., Kumar, D., and Kumar, N. (2024). Exploring Genetic Diversity for High CBD Content in Cannabis Accessions in Tropical and Subtropical Regions of India. Biochem. Genet., 1\u201331.","DOI":"10.1007\/s10528-024-10914-2"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s44187-025-00303-y","article-title":"A Comprehensive Overview of Biodegradable Packaging Films: Part I\u2014Sources, Additives, and Preparation Methods","volume":"5","author":"Singh","year":"2025","journal-title":"Discov. Food"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"8387","DOI":"10.1007\/s11356-023-31689-w","article-title":"Biobased, Biodegradable and Compostable Plastics: Chemical Nature, Biodegradation Pathways and Environmental Strategy","volume":"31","author":"Nizamuddin","year":"2024","journal-title":"Env. Sci. Pollut. Res."},{"key":"ref_212","doi-asserted-by":"crossref","unstructured":"Prakash, C., Kesari, K.K., and Negi, A. (2025). Role of Green Chemistry in Producing Biodegradable Plastic and Its Role in Sustainable Development. Sustainable Development Goals Towards Environmental Toxicity and Green Chemistry: Environment and Sustainability, Springer Nature.","DOI":"10.1007\/978-3-031-77327-3"},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"Mogaji, E. (2021). Ethical Branding. Brand Management: An Introduction through Storytelling, Springer International Publishing.","DOI":"10.1007\/978-3-030-66119-9"},{"key":"ref_214","doi-asserted-by":"crossref","unstructured":"Mutum, D.S., and Ghazali, E.M. (2023). Ethical Marketing. Consumers, Society and Marketing: A Sustainability Perspective, Springer Nature Switzerland.","DOI":"10.1007\/978-3-031-39359-4"},{"key":"ref_215","unstructured":"Harris, J. (2023). Mastering CBD Marketing: Navigating Legal, Ethical and Industry Guidelines for Success, Springbig."},{"key":"ref_216","unstructured":"Clark, G. (2023). 21st Century Snake Oil: FDA Regulation and Advertising Ethics of CBD Products and Their Derivatives. [Ph.D. Thesis, The University of Texas at Austin]."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1177\/0018578719873870","article-title":"CBD: Considerations for Use Within the Health System","volume":"55","author":"Dill","year":"2020","journal-title":"Hosp. Pharm."},{"key":"ref_218","doi-asserted-by":"crossref","unstructured":"Zbrzezny, A.M., and Krzywicki, T. (2025). Artificial Intelligence in Dermatology: A Review of Methods, Clinical Applications, and Perspectives. Appl. Sci., 15.","DOI":"10.3390\/app15147856"},{"key":"ref_219","doi-asserted-by":"crossref","unstructured":"Grech, V.S., Kefala, V., and Rallis, E. (2024). Cosmetology in the Era of Artificial Intelligence. Cosmetics, 11.","DOI":"10.3390\/cosmetics11040135"},{"key":"ref_220","doi-asserted-by":"crossref","unstructured":"Soleymanpour, M., Saderholm, S., and Kavuluru, R. (2021, January 9\u201312). Therapeutic Claims in Cannabidiol (CBD) Marketing Messages on Twitter. Proceedings of the 2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), Houston, TX, USA.","DOI":"10.1109\/BIBM52615.2021.9669404"},{"key":"ref_221","unstructured":"Zenone, M. (2020). Cannabidiol (CBD) Marketing and Decision-Making: Examining 164 Crowdfunding Campaigns and 2165 CBD Products for Sale Online in Canada. [Master\u2019 Thesis, Simon Fraser University]."},{"key":"ref_222","doi-asserted-by":"crossref","unstructured":"Chen, B., Tang, H., Liu, Z., Qiao, K., Chen, X., Liu, S., Pan, N., Chen, T., and Liu, Z. (2024). Mechanisms of Sensitive Skin and the Soothing Effects of Active Compounds: A Review. Cosmetics, 11.","DOI":"10.3390\/cosmetics11060190"},{"key":"ref_223","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-Mart\u00edn, M.-E., Tarazona, J.V., Hern\u00e1ndez-Cano, N., and Mayor Ibarguren, A. (2025). The Importance of Cosmetics in Oncological Patients. Survey of Tolerance of Routine Cosmetic Care in Oncological Patients. Cosmetics, 12.","DOI":"10.3390\/cosmetics12040137"}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/15\/9\/1219\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:34:55Z","timestamp":1760034895000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/15\/9\/1219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,23]]},"references-count":223,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["biom15091219"],"URL":"https:\/\/doi.org\/10.3390\/biom15091219","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,23]]}}}