{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:46:02Z","timestamp":1792856762739,"version":"4.5.0"},"reference-count":147,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["82104178"],"award-info":[{"award-number":["82104178"]}]},{"name":"National Natural Science Foundation of China","award":["2024AH030040"],"award-info":[{"award-number":["2024AH030040"]}]},{"name":"National Natural Science Foundation of China","award":["JNFX2023029"],"award-info":[{"award-number":["JNFX2023029"]}]},{"name":"National Natural Science Foundation of China","award":["LH250103005"],"award-info":[{"award-number":["LH250103005"]}]},{"name":"the Natural Science Research Project of Anhui Educational Committee","award":["82104178"],"award-info":[{"award-number":["82104178"]}]},{"name":"the Natural Science Research Project of Anhui Educational Committee","award":["2024AH030040"],"award-info":[{"award-number":["2024AH030040"]}]},{"name":"the Natural Science Research Project of Anhui Educational Committee","award":["JNFX2023029"],"award-info":[{"award-number":["JNFX2023029"]}]},{"name":"the Natural Science Research Project of Anhui Educational Committee","award":["LH250103005"],"award-info":[{"award-number":["LH250103005"]}]},{"name":"Young and Middle-aged Teacher Development Program of Anhui Educational Committee","award":["82104178"],"award-info":[{"award-number":["82104178"]}]},{"name":"Young and Middle-aged Teacher Development Program of Anhui Educational Committee","award":["2024AH030040"],"award-info":[{"award-number":["2024AH030040"]}]},{"name":"Young and Middle-aged Teacher Development Program of Anhui Educational Committee","award":["JNFX2023029"],"award-info":[{"award-number":["JNFX2023029"]}]},{"name":"Young and Middle-aged Teacher Development Program of Anhui Educational Committee","award":["LH250103005"],"award-info":[{"award-number":["LH250103005"]}]},{"name":"Longhu Talent Project of Bengbu Medical University","award":["82104178"],"award-info":[{"award-number":["82104178"]}]},{"name":"Longhu Talent Project of Bengbu Medical University","award":["2024AH030040"],"award-info":[{"award-number":["2024AH030040"]}]},{"name":"Longhu Talent Project of Bengbu Medical University","award":["JNFX2023029"],"award-info":[{"award-number":["JNFX2023029"]}]},{"name":"Longhu Talent Project of Bengbu Medical University","award":["LH250103005"],"award-info":[{"award-number":["LH250103005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Focal adhesion kinase (FAK) is a crucial protein component of focal adhesions (FAs) and belongs to the cytoplasmic non-receptor protein tyrosine kinase family. FAK primarily regulates adhesion signaling and cell migration and is highly expressed in various tumors, including lung, liver, gastric, and colorectal cancers, as well as in conditions such as acute lung injury (ALI) and pulmonary fibrosis (PF). Recent research on FAK and its small-molecule inhibitors has revealed that targeting FAK provides a novel approach for treating various lung diseases. FAK inhibitors can obstruct signaling pathways, demonstrating anti-tumor, anti-inflammatory, and anti-fibrotic effects. In lung cancer, FAK inhibitors suppress tumor growth and metastasis; in ALI, they exert protective effects by alleviating inflammatory responses and oxidative stress; and in pulmonary fibrosis, FAK inhibitors reduce fibroblast activation and inhibit collagen deposition. The findings demonstrate promising efficacy and an acceptable safety profile in preclinical models. However, these early-stage results require further validation through clinical studies. Additionally, the underlying mechanisms, as well as the toxic effects and side effects, necessitate further in-depth investigation. Some have progressed to clinical trials (Defactinib (Phase II), PF-562271 (Phase I), CEP-37440 (Phase I), PND-1186 (Phase I), GSK-2256098 (Phase II), BI-853520 (Phase I)), offering potential therapeutic targets for lung diseases. Collectively, these findings establish a foundational basis for the advancement of FAK inhibitor discovery. Emerging methodologies, such as PROTAC degraders and combination regimens, demonstrate significant potential for future research. Based on a comprehensive analysis of the relevant literature from 2015 to the present, this review briefly introduces the structure and function of FAK and discusses recent research advancements regarding FAK and its inhibitors in the context of pulmonary diseases.<\/jats:p>","DOI":"10.3390\/biom15091233","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T14:18:49Z","timestamp":1756217929000},"page":"1233","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Targeting Focal Adhesion Kinase in Lung Diseases: Current Progress and Future Directions"],"prefix":"10.3390","volume":"15","author":[{"given":"Ziyu","family":"Wan","sequence":"first","affiliation":[{"name":"Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Department of Biochemistry and Molecular Biology, Bengbu Medical University, Bengbu 233030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zefeng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Department of Biochemistry and Molecular Biology, Bengbu Medical University, Bengbu 233030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengbin","family":"Wang","sequence":"additional","affiliation":[{"name":"Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Department of Biochemistry and Molecular Biology, Bengbu Medical University, Bengbu 233030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Department of Biochemistry and Molecular Biology, Bengbu Medical University, Bengbu 233030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhao","family":"Ma","sequence":"additional","affiliation":[{"name":"Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Department of Biochemistry and Molecular Biology, Bengbu Medical University, Bengbu 233030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huari","family":"Li","sequence":"additional","affiliation":[{"name":"Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Department of Biochemistry and Molecular Biology, Bengbu Medical University, Bengbu 233030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lexing","family":"Li","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology, Wuhan University of Bioengineering, Wuhan 430415, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Qian","sequence":"additional","affiliation":[{"name":"Shanghai Frontiers Science Center of Drug Target Identification and Delivery, Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, School of Pharmaceutical Sciences, National Key Laboratory of Innovative Immunotherapy, Shanghai Jiao Tong University, Shanghai 200240, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4421-2326","authenticated-orcid":false,"given":"Wei","family":"Gu","sequence":"additional","affiliation":[{"name":"Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Department of Biochemistry and Molecular Biology, Bengbu Medical University, Bengbu 233030, China"},{"name":"Shanghai Frontiers Science Center of Drug Target Identification and Delivery, Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, School of Pharmaceutical Sciences, National Key Laboratory of Innovative Immunotherapy, Shanghai Jiao Tong University, Shanghai 200240, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"ref_1","first-page":"10","article-title":"Cancer statistics, 2025","volume":"75","author":"Siegel","year":"2025","journal-title":"CA A Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.annonc.2024.10.006","article-title":"Lung cancer research and treatment: Global perspectives and strategic calls to action","volume":"35","author":"Meyer","year":"2024","journal-title":"Ann. Oncol. Off. J. Eur. Soc. Med. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.molmed.2023.08.010","article-title":"Pulmonary fibrosis: From pathogenesis to clinical decision-making","volume":"29","author":"Koudstaal","year":"2023","journal-title":"Trends Mol. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1186\/s12967-025-06514-2","article-title":"Pulmonary fibrosis: From mechanisms to therapies","volume":"23","author":"Jiang","year":"2025","journal-title":"J. Transl. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0140-6736(24)01029-8","article-title":"New promises and challenges in the treatment of advanced non-small-cell lung cancer","volume":"404","author":"Meyer","year":"2024","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1164\/rccm.201411-2044ED","article-title":"Nintedanib and pirfenidone. New antifibrotic treatments indicated for idiopathic pulmonary fibrosis offer hopes and raises questions","volume":"191","author":"Raghu","year":"2015","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e29266","DOI":"10.1016\/j.heliyon.2024.e29266","article-title":"Bibliometric analysis of the pirfenidone and nintedanib in interstitial lung diseases","volume":"10","author":"Liu","year":"2024","journal-title":"Heliyon"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Chianese, M., Screm, G., Salton, F., Confalonieri, P., Trotta, L., Barbieri, M., Ruggero, L., Mari, M., Reccardini, N., and Geri, P. (2024). Pirfenidone and Nintedanib in Pulmonary Fibrosis: Lights and Shadows. Pharmaceuticals, 17.","DOI":"10.3390\/ph17060709"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1091\/mbc.2.11.951","article-title":"Fibronectin\/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein","volume":"2","author":"Guan","year":"1991","journal-title":"Cell Regul."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Tapial Mart\u00ednez, P., L\u00f3pez Navajas, P., and Lietha, D. (2020). FAK Structure and Regulation by Membrane Interactions and Force in Focal Adhesions. Biomolecules, 10.","DOI":"10.3390\/biom10020179"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1517\/14728222.11.10.1315","article-title":"Focal adhesion kinase: A promising target for anticancer therapy","volume":"11","author":"Chatzizacharias","year":"2007","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Spallarossa, A., Tasso, B., Russo, E., Villa, C., and Brullo, C. (2022). The Development of FAK Inhibitors: A Five-Year Update. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23126381"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1080\/13543784.2024.2417762","article-title":"Targeting a key FAK-tor: The therapeutic potential of combining focal adhesion kinase (FAK) inhibitors and chemotherapy for chemoresistant non-small cell lung cancer","volume":"33","author":"Geijerman","year":"2024","journal-title":"Expert Opin. Investig. Drugs"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s40259-012-0003-4","article-title":"Targeting focal adhesion kinase in fibrotic diseases","volume":"27","author":"Lagares","year":"2013","journal-title":"BioDrugs"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.lungcan.2019.10.033","article-title":"Phase 2 study of the focal adhesion kinase inhibitor defactinib (VS-6063) in previously treated advanced KRAS mutant non-small cell lung cancer","volume":"139","author":"Gerber","year":"2020","journal-title":"Lung Cancer"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1002\/art.33482","article-title":"Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation","volume":"64","author":"Lagares","year":"2012","journal-title":"Arthritis Rheum."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/s41416-019-0452-3","article-title":"A phase Ib dose-finding, pharmacokinetic study of the focal adhesion kinase inhibitor GSK2256098 and trametinib in patients with advanced solid tumours","volume":"120","author":"Mak","year":"2019","journal-title":"Br. J. Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"29220","DOI":"10.18632\/oncotarget.16352","article-title":"Kinomic profiling identifies focal adhesion kinase 1 as a therapeutic target in advanced clear cell renal cell carcinoma","volume":"8","author":"Ghosh","year":"2017","journal-title":"Oncotarget"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1158\/1535-7163.MCT-14-1077","article-title":"PTEN Expression as a Predictor of Response to Focal Adhesion Kinase Inhibition in Uterine Cancer","volume":"14","author":"Thanapprapasr","year":"2015","journal-title":"Mol. Cancer Ther."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1124\/jpet.113.203042","article-title":"Focal adhesion kinase regulates collagen I-induced airway smooth muscle phenotype switching","volume":"346","author":"Dekkers","year":"2013","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_21","unstructured":"Wang, H., Zhang, H., and Yuan, W. (2024). PTP1B Attenuates the Progression of COPD by Suppressing the SHP-2\/Src\/ERK1\/2\/NLRP3 Signaling Pathway. Altern. Ther. Health Med., ahead of print."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nrm1549","article-title":"Focal adhesion kinase: In command and control of cell motility","volume":"6","author":"Mitra","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"jcs259089","DOI":"10.1242\/jcs.259089","article-title":"New insights into FAK structure and function in focal adhesions","volume":"135","author":"Lietha","year":"2022","journal-title":"J. Cell Sci."},{"key":"ref_24","first-page":"1680","article-title":"Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src","volume":"14","author":"Schaller","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1083\/jcb.151.7.1549","article-title":"Activated R-ras, Rac1, PI 3-kinase and PKCepsilon can each restore cell spreading inhibited by isolated integrin beta1 cytoplasmic domains","volume":"151","author":"Berrier","year":"2000","journal-title":"J. Cell Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1128\/MCB.23.3.933-949.2003","article-title":"R-Ras promotes focal adhesion formation through focal adhesion kinase and p130(Cas) by a novel mechanism that differs from integrins","volume":"23","author":"Kwong","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1128\/MCB.15.2.954","article-title":"Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: A role for Src family kinases","volume":"15","author":"Calalb","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0969-2126(02)00717-7","article-title":"The structural basis of localization and signaling by the focal adhesion targeting domain","volume":"10","author":"Arold","year":"2002","journal-title":"Structure"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1083\/jcb.140.1.211","article-title":"Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration","volume":"140","author":"Cary","year":"1998","journal-title":"J. Cell Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1083\/jcb.140.4.961","article-title":"CAS\/Crk coupling serves as a \u201cmolecular switch\u201d for induction of cell migration","volume":"140","author":"Klemke","year":"1998","journal-title":"J. Cell Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"4806","DOI":"10.1128\/MCB.19.7.4806","article-title":"Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2","volume":"19","author":"Owen","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1242\/jcs.112.16.2677","article-title":"Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration","volume":"112","author":"Sieg","year":"1999","journal-title":"J. Cell Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1128\/MCB.16.6.2606","article-title":"Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: A role for Src family kinases","volume":"16","author":"Vuori","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"ref_34","first-page":"23","article-title":"14, 15-EET induces breast cancer cell EMT and cisplatin resistance by up-regulating integrin \u03b1v\u03b23 and activating FAK\/PI3K\/AKT signaling","volume":"37","author":"Luo","year":"2018","journal-title":"J. Exp. Clin. Cancer Res. CR"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/s41419-022-05307-5","article-title":"PLEKHH2 binds \u03b2-arrestin1 through its FERM domain, activates FAK\/PI3K\/AKT phosphorylation, and promotes the malignant phenotype of non-small cell lung cancer","volume":"13","author":"Wang","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13045-015-0117-5","article-title":"Alpha-enolase promotes cell glycolysis, growth, migration, and invasion in non-small cell lung cancer through FAK-mediated PI3K\/AKT pathway","volume":"8","author":"Fu","year":"2015","journal-title":"J. Hematol. Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e12453","DOI":"10.1111\/cpr.12453","article-title":"Fak-Mapk, Hippo and Wnt signalling pathway expression and regulation in distraction osteogenesis","volume":"51","author":"Song","year":"2018","journal-title":"Cell Prolif."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Llin\u00e0s-Arias, P., and Esteller, M. (2017). Epigenetic inactivation of tumour suppressor coding and non-coding genes in human cancer: An update. Open Biol., 7.","DOI":"10.1098\/rsob.170152"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/s41392-023-01705-z","article-title":"Targeting the RAS\/RAF\/MAPK pathway for cancer therapy: From mechanism to clinical studies","volume":"8","author":"Bahar","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"25008","DOI":"10.1074\/jbc.M414172200","article-title":"Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53","volume":"280","author":"Golubovskaya","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"429","DOI":"10.4161\/cc.3.4.821","article-title":"Cytoplasmic p53: Bax and forward","volume":"3","author":"Chipuk","year":"2004","journal-title":"Cell Cycle"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1006\/bbrc.2000.3547","article-title":"Nuclear localization and apoptotic regulation of an amino-terminal domain focal adhesion kinase fragment in endothelial cells","volume":"276","author":"Lobo","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0006-291X(02)02547-0","article-title":"The focal adhesion kinase amino-terminal domain localises to nuclei and intercellular junctions in HEK 293 and MDCK cells independently of tyrosine 397 and the carboxy-terminal domain","volume":"299","author":"Stewart","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1042\/bj20021846","article-title":"Focal adhesion kinase N-terminus in breast carcinoma cells induces rounding, detachment and apoptosis","volume":"373","author":"Beviglia","year":"2003","journal-title":"Biochem. J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.bbrc.2003.12.055","article-title":"Nuclear import of N-terminal FAK by activation of the FcepsilonRI receptor in RBL-2H3 cells","volume":"314","author":"Jones","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1111\/cbdd.13808","article-title":"Focal adhesion kinase-An emerging viable target in cancer and development of focal adhesion kinase inhibitors","volume":"97","author":"Chauhan","year":"2021","journal-title":"Chem. Biol. Drug Des."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.4155\/fmc-2021-0015","article-title":"FAK inhibitors as promising anticancer targets: Present and future directions","volume":"13","author":"Mustafa","year":"2021","journal-title":"Future Med. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"638","DOI":"10.2174\/187152011796817628","article-title":"Development of focal adhesion kinase inhibitors in cancer therapy","volume":"11","author":"Ma","year":"2011","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/13543776.2018.1414183","article-title":"FAK inhibitors in Cancer, a patent review","volume":"28","author":"Lv","year":"2018","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.2174\/0929867327666201103162239","article-title":"New Insights on Fak and Fak Inhibitors","volume":"28","author":"Brullo","year":"2021","journal-title":"Curr. Med. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/nrc3792","article-title":"FAK in cancer: Mechanistic findings and clinical applications","volume":"14","author":"Sulzmaier","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Tai, Y.L., Chen, L.C., and Shen, T.L. (2015). Emerging roles of focal adhesion kinase in cancer. Biomed. Res. Int., 2015.","DOI":"10.1155\/2015\/690690"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s13045-020-01009-7","article-title":"Abnormally activated OPN\/integrin \u03b1V\u03b23\/FAK signalling is responsible for EGFR-TKI resistance in EGFR mutant non-small-cell lung cancer","volume":"13","author":"Fu","year":"2020","journal-title":"J. Hematol. Oncol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.bbrc.2009.08.132","article-title":"Characterization of a novel focal adhesion kinase inhibitor in human platelets","volume":"389","author":"Jones","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"14845","DOI":"10.1074\/jbc.M606695200","article-title":"Cellular characterization of a novel focal adhesion kinase inhibitor","volume":"282","author":"Martin","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1189\/jlb.1A0217-063R","article-title":"The nonreceptor protein tyrosine kinase Pyk2 promotes the turnover of monocytes at steady state","volume":"102","author":"Llewellyn","year":"2017","journal-title":"J. Leukoc. Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s12026-014-8527-y","article-title":"Functions of the FAK family kinases in T cells: Beyond actin cytoskeletal rearrangement","volume":"59","author":"Chapman","year":"2014","journal-title":"Immunol. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/76882","article-title":"Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response","volume":"1","author":"Guinamard","year":"2000","journal-title":"Nat. Immunol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41575-020-0300-1","article-title":"Pancreatic cancer stroma: An update on therapeutic targeting strategies","volume":"17","author":"Hosein","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/pros.23476","article-title":"Effect of FAK inhibitor VS-6063 (defactinib) on docetaxel efficacy in prostate cancer","volume":"78","author":"Lin","year":"2018","journal-title":"Prostate"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1158\/1535-7163.MCT-11-0261","article-title":"Inhibition of focal adhesion kinase by PF-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment","volume":"10","author":"Stokes","year":"2011","journal-title":"Mol. Cancer Ther."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1080\/13543784.2020.1740680","article-title":"FAK-targeted and combination therapies for the treatment of cancer: An overview of phase I and II clinical trials","volume":"29","author":"Mohanty","year":"2020","journal-title":"Expert Opin. Investig. Drugs"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"856","DOI":"10.4161\/cbt.8.9.8246","article-title":"Sunitinib and PF-562,271 (FAK\/Pyk2 inhibitor) effectively block growth and recovery of human hepatocellular carcinoma in a rat xenograft model","volume":"8","author":"Bagi","year":"2009","journal-title":"Cancer Biol. Ther."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1200\/JCO.2011.38.9346","article-title":"Safety, pharmacokinetic, and pharmacodynamic phase I dose-escalation trial of PF-00562271, an inhibitor of focal adhesion kinase, in advanced solid tumors","volume":"30","author":"Infante","year":"2012","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1158\/0008-5472.CAN-07-5155","article-title":"Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271","volume":"68","author":"Roberts","year":"2008","journal-title":"Cancer Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s12032-023-02092-9","article-title":"FAK inhibitor PF-562271 inhibits the migration and proliferation of high-grade serous ovarian cancer cells through FAK and FAK mediated cell cycle arrest","volume":"40","author":"Pan","year":"2023","journal-title":"Med. Oncol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2249909","DOI":"10.1155\/2022\/2249909","article-title":"Breast Cancer Prognosis Prediction and Immune Pathway Molecular Analysis Based on Mitochondria-Related Genes","volume":"2022","author":"Luo","year":"2022","journal-title":"Genet. Res."},{"key":"ref_68","first-page":"6617","article-title":"Attenuation of Transfusion-Related Acute Lung Injury by FAK Inhibitor PF-562271","volume":"37","author":"Bai","year":"2023","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"111535","DOI":"10.1016\/j.intimp.2024.111535","article-title":"ACE2 improves endothelial cell function and reduces acute lung injury by downregulating FAK expression","volume":"128","author":"He","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"ref_70","first-page":"429","article-title":"ALK inhibitors in non-small cell lung cancer: Crizotinib and beyond","volume":"12","author":"Awad","year":"2014","journal-title":"Clin. Adv. Hematol. Oncol. H O"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12943-018-0810-4","article-title":"The function and therapeutic targeting of anaplastic lymphoma kinase (ALK) in non-small cell lung cancer (NSCLC)","volume":"17","author":"Golding","year":"2018","journal-title":"Mol. Cancer"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"7478","DOI":"10.1021\/acs.jmedchem.6b00487","article-title":"Discovery of Clinical Candidate CEP-37440, a Selective Inhibitor of Focal Adhesion Kinase (FAK) and Anaplastic Lymphoma Kinase (ALK)","volume":"59","author":"Ott","year":"2016","journal-title":"J. Med. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Attwa, M.W., AlRabiah, H., Abdelhameed, A.S., and Kadi, A.A. (2024). Assessment of the in vitro metabolic stability of CEP-37440, a selective FAK\/ALK inhibitor, in HLMs using fast UPLC-MS\/MS method: In silico metabolic lability and DEREK alerts screening. Front. Chem., 12.","DOI":"10.3389\/fchem.2024.1323738"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"764","DOI":"10.4161\/cbt.9.10.11434","article-title":"PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments","volume":"9","author":"Tanjoni","year":"2010","journal-title":"Cancer Biol. Ther."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Hu, H.H., Wang, S.Q., Shang, H.L., Lv, H.F., Chen, B.B., Gao, S.G., and Chen, X.B. (2024). Roles and inhibitors of FAK in cancer: Current advances and future directions. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1274209"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s11523-018-00617-1","article-title":"Phase I Study of BI 853520, an Inhibitor of Focal Adhesion Kinase, in Patients with Advanced or Metastatic Nonhematologic Malignancies","volume":"14","author":"Steeghs","year":"2019","journal-title":"Target. Oncol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1007\/s10637-015-0282-y","article-title":"A phase I study of VS-6063, a second-generation focal adhesion kinase inhibitor, in patients with advanced solid tumors","volume":"33","author":"Jones","year":"2015","journal-title":"Investig. New Drugs"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1007\/s00280-016-3010-1","article-title":"A first-in-Asian phase 1 study to evaluate safety, pharmacokinetics and clinical activity of VS-6063, a focal adhesion kinase (FAK) inhibitor in Japanese patients with advanced solid tumors","volume":"77","author":"Shimizu","year":"2016","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ejmech.2019.05.048","article-title":"Discovery of 2,4-diarylaminopyrimidine derivatives bearing dithiocarbamate moiety as novel FAK inhibitors with antitumor and anti-angiogenesis activities","volume":"177","author":"Su","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1517\/13543776.2014.948845","article-title":"Focal adhesion kinase inhibitors in the treatment of metastatic cancer: A patent review","volume":"24","author":"Shanthi","year":"2014","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41389-018-0032-z","article-title":"Efficacy of the highly selective focal adhesion kinase inhibitor BI 853520 in adenocarcinoma xenograft models is linked to a mesenchymal tumor phenotype","volume":"7","author":"Hirt","year":"2018","journal-title":"Oncogenesis"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"108789","DOI":"10.1016\/j.jmgm.2024.108789","article-title":"Computational insights into allosteric inhibition of focal adhesion kinase: A combined pharmacophore modeling and molecular dynamics approach","volume":"130","author":"Kumar","year":"2024","journal-title":"J. Mol. Graph. Model."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.drudis.2007.06.008","article-title":"A new paradigm for protein kinase inhibition: Blocking phosphorylation without directly targeting ATP binding","volume":"12","author":"Bogoyevitch","year":"2007","journal-title":"Drug Discov. Today"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.3390\/md12042282","article-title":"The marine-derived sipholenol A-4-O-3\u2032,4\u2032-dichlorobenzoate inhibits breast cancer growth and motility in vitro and in vivo through the suppression of Brk and FAK signaling","volume":"12","author":"Akl","year":"2014","journal-title":"Mar. Drugs"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"7405","DOI":"10.1021\/jm800483v","article-title":"A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth","volume":"51","author":"Golubovskaya","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/1940-6207.CAPR-24-0147","article-title":"Lung Microbiome in Lung Cancer: A New Horizon in Cancer Study","volume":"17","author":"Kashyap","year":"2024","journal-title":"Cancer Prev. Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"4539","DOI":"10.1200\/JCO.2005.04.4859","article-title":"Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: Analysis of the surveillance, epidemiologic, and end results database","volume":"24","author":"Govindan","year":"2006","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1093\/ajcp\/aqaa163","article-title":"Robbins and Cotran Pathologic Basis of Disease","volume":"154","author":"Hoda","year":"2020","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/S0025-6196(11)60735-0","article-title":"Non-small cell lung cancer: Epidemiology, risk factors, treatment, and survivorship","volume":"83","author":"Molina","year":"2008","journal-title":"Mayo Clin. Proc."},{"key":"ref_90","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA A Cancer J. Clin."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"5646","DOI":"10.1038\/sj.onc.1202957","article-title":"Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells","volume":"18","author":"Agochiya","year":"1999","journal-title":"Oncogene"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.lungcan.2006.06.001","article-title":"Up-regulation of focal adhesion kinase in non-small cell lung cancer","volume":"53","author":"Carelli","year":"2006","journal-title":"Lung Cancer"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41416-024-02727-2","article-title":"Epithelial-mesenchymal transition status is a remarkable biomarker for the combination treatment with avutometinib and defactinib in KRAS-mutated non-small cell lung cancer","volume":"131","author":"Yoshimura","year":"2024","journal-title":"Br. J. Cancer"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1158\/1535-7163.MCT-16-0282","article-title":"CT-707, a Novel FAK Inhibitor, Synergizes with Cabozantinib to Suppress Hepatocellular Carcinoma by Blocking Cabozantinib-Induced FAK Activation","volume":"15","author":"Wang","year":"2016","journal-title":"Mol. Cancer Ther."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Xing, P., Zhao, Q., Zhang, L., Wang, H., Huang, D., Hu, P., Sun, Y., and Shi, Y. (2022). Conteltinib (CT-707) in patients with advanced ALK-positive non-small cell lung cancer: A multicenter, open-label, first-in-human phase 1 study. BMC Med., 20.","DOI":"10.1186\/s12916-022-02646-0"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Fang, D.D., Tao, R., Wang, G., Li, Y., Zhang, K., Xu, C., Zhai, G., Wang, Q., Wang, J., and Tang, C. (2022). Discovery of a novel ALK\/ROS1\/FAK inhibitor, APG-2449, in preclinical non-small cell lung cancer and ovarian cancer models. BMC Cancer, 22.","DOI":"10.1186\/s12885-022-09799-4"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.cell.2007.05.041","article-title":"Structural basis for the autoinhibition of focal adhesion kinase","volume":"129","author":"Lietha","year":"2007","journal-title":"Cell"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/12013","article-title":"SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27","volume":"1","author":"Carrano","year":"1999","journal-title":"Nat. Cell. Biol."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Lei, M., Huang, H., Li, J., Zhang, J., Yu, G., Jin, X., Liu, J., Kang, F., and Liu, Z. (2025). Design, synthesis and biological evaluation of coumarin-containing 2,4-diphenylpyrimidine derivatives as novel focal adhesion kinase inhibitors for treatment of non-small cell lung cancer. Bioorganic Med. Chem. Lett., 123.","DOI":"10.1016\/j.bmcl.2025.130240"},{"key":"ref_100","first-page":"156135","article-title":"Diosmin reduces the stability of Snail and Cyclin D1 by targeting FAK to inhibit NSCLC progression","volume":"135","author":"Ma","year":"2024","journal-title":"Phytomedicine Int. J. Phytother. Phytopharm."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1056\/NEJM200005043421806","article-title":"The acute respiratory distress syndrome","volume":"342","author":"Ware","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Zheng, J., Li, Y., Kong, X., and Guo, J. (2024). Exploring immune-related pathogenesis in lung injury: Providing new insights Into ALI\/ARDS. Biomed. Pharmacother. Biomed. Pharmacother., 175.","DOI":"10.1016\/j.biopha.2024.116773"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1152\/japplphysiol.00690.2002","article-title":"S1P induces FA remodeling in human pulmonary endothelial cells: Role of Rac, GIT1, FAK, and paxillin","volume":"94","author":"Shikata","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"L999","DOI":"10.1152\/ajplung.00211.2005","article-title":"Regulation of reactive oxygen species-induced endothelial cell-cell and cell-matrix contacts by focal adhesion kinase and adherens junction proteins","volume":"289","author":"Usatyuk","year":"2005","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"35554","DOI":"10.1074\/jbc.M607305200","article-title":"Redox regulation of 4-hydroxy-2-nonenal-mediated endothelial barrier dysfunction by focal adhesion, adherens, and tight junction proteins","volume":"281","author":"Usatyuk","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.phrs.2014.03.002","article-title":"The pharmacology of statins","volume":"88","author":"Sirtori","year":"2014","journal-title":"Pharmacol. Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.tcm.2019.01.001","article-title":"Effect of statins on atherosclerotic plaque","volume":"29","author":"Almeida","year":"2019","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1165\/rcmb.2003-0267OC","article-title":"Cytoskeletal activation and altered gene expression in endothelial barrier regulation by simvastatin","volume":"30","author":"Jacobson","year":"2004","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_109","first-page":"252","article-title":"Protective effect of FAK inhibitor PF-562271 against human umbilical vein endothelial cell injury induced by aging platelets","volume":"44","author":"Bai","year":"2024","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Alves, G.F., Aimaretti, E., Einaudi, G., Mastrocola, R., de Oliveira, J.G., Collotta, D., Porchietto, E., Aragno, M., Cifani, C., and Sordi, R. (2022). Pharmacological Inhibition of FAK-Pyk2 Pathway Protects Against Organ Damage and Prolongs the Survival of Septic Mice. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.837180"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.vph.2018.06.017","article-title":"Attenuation of murine acute lung injury by PF-573,228, an inhibitor of focal adhesion kinase","volume":"110","author":"Lederer","year":"2018","journal-title":"Vasc. Pharmacol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/s41419-022-05046-7","article-title":"FAK mediates LPS-induced inflammatory lung injury through interacting TAK1 and activating TAK1-NF\u03baB pathway","volume":"13","author":"Chen","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.toxlet.2018.04.009","article-title":"CpG-oligodeoxynucleotides may be effective for preventing ionizing radiation induced pulmonary fibrosis","volume":"292","author":"Zhang","year":"2018","journal-title":"Toxicol. Lett."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1164\/rccm.201908-1535ED","article-title":"Estrogen Signaling and MicroRNAs in Lung Fibrosis. Sex, Hormones, and Rock Scars","volume":"200","author":"Tzouvelekis","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1164\/rccm.201809-1650OC","article-title":"Lung Microbiota Contribute to Pulmonary Inflammation and Disease Progression in Pulmonary Fibrosis","volume":"199","author":"Ashley","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1165\/rcmb.2020-0373PS","article-title":"The Interplay of the Genetic Architecture, Aging, and Environmental Factors in the Pathogenesis of Idiopathic Pulmonary Fibrosis","volume":"64","author":"Pardo","year":"2021","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1172\/JCI60323","article-title":"Pulmonary fibrosis: Patterns and perpetrators","volume":"122","author":"Noble","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3390\/arm90050052","article-title":"Guidelines of the Polish Respiratory Society on the Diagnosis and Treatment of Progressive Fibrosing Interstitial Lung Diseases Other than Idiopathic Pulmonary Fibrosis","volume":"90","author":"Piotrowski","year":"2022","journal-title":"Adv. Respir. Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1164\/rccm.201006-0894CI","article-title":"Clinical course and prediction of survival in idiopathic pulmonary fibrosis","volume":"183","author":"Ley","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1183\/09031936.00131912","article-title":"Prevalence and prognosis of unclassifiable interstitial lung disease","volume":"42","author":"Ryerson","year":"2013","journal-title":"Eur. Respir. J."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1186\/s12931-023-02582-4","article-title":"PTK2-associated gene signature could predict the prognosis of IPF","volume":"24","author":"Feng","year":"2023","journal-title":"Respir. Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1111\/j.0022-202X.2005.23701.x","article-title":"Constitutive phosphorylation of focal adhesion kinase is involved in the myofibroblast differentiation of scleroderma fibroblasts","volume":"124","author":"Mimura","year":"2005","journal-title":"J. Investig. Dermatol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1083\/jcb.142.3.873","article-title":"The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-beta1","volume":"142","author":"Serini","year":"1998","journal-title":"J. Cell Biol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"12384","DOI":"10.1074\/jbc.M208544200","article-title":"Myofibroblast differentiation by transforming growth factor-beta1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase","volume":"278","author":"Thannickal","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/377539a0","article-title":"Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice","volume":"377","author":"Furuta","year":"1995","journal-title":"Nature"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/nm.2574","article-title":"Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling","volume":"18","author":"Wong","year":"2011","journal-title":"Nat. Med."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1091\/mbc.e06-12-1121","article-title":"FAK is required for TGFbeta-induced JNK phosphorylation in fibroblasts: Implications for acquisition of a matrix-remodeling phenotype","volume":"18","author":"Liu","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1089\/wound.2021.0077","article-title":"Inhibiting Fibroblast Mechanotransduction Modulates Severity of Idiopathic Pulmonary Fibrosis","volume":"11","author":"Trotsyuk","year":"2022","journal-title":"Adv. Wound Care"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1165\/rcmb.2012-0277OC","article-title":"Antifibrotic effects of focal adhesion kinase inhibitor in bleomycin-induced pulmonary fibrosis in mice","volume":"49","author":"Kinoshita","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1901105","DOI":"10.1183\/13993003.01105-2019","article-title":"The importance of interventional timing in the bleomycin model of pulmonary fibrosis","volume":"55","author":"Kolb","year":"2020","journal-title":"Eur. Respir. J."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev-pathol-042220-015902","article-title":"The Pathology of Asthma: What Is Obstructing Our View?","volume":"18","author":"Aegerter","year":"2023","journal-title":"Annu. Rev. Pathol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.chest.2019.10.009","article-title":"Recent Advances in Severe Asthma: From Phenotypes to Personalized Medicine","volume":"157","author":"Schoettler","year":"2020","journal-title":"Chest"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Hough, K.P., Curtiss, M.L., Blain, T.J., Liu, R.M., Trevor, J., Deshane, J.S., and Thannickal, V.J. (2020). Airway Remodeling in Asthma. Front. Med., 7.","DOI":"10.3389\/fmed.2020.00191"},{"key":"ref_134","first-page":"598","article-title":"YKL-40 is elevated in cerebrospinal fluid from patients with purulent meningitis","volume":"9","author":"Johansen","year":"2002","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.jaip.2017.01.027","article-title":"Cluster Analysis on Longitudinal Data of Patients with Adult-Onset Asthma","volume":"5","author":"Ilmarinen","year":"2017","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1183\/09031936.05.00034805","article-title":"Standardisation of spirometry","volume":"26","author":"Miller","year":"2005","journal-title":"Eur. Respir. J."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jaip.2018.06.015","article-title":"Combined Assessment of Serum Periostin and YKL-40 May Identify Asthma-COPD Overlap","volume":"7","author":"Shirai","year":"2019","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1080\/15384101.2020.1750811","article-title":"YKL-40 mediates airway remodeling in asthma via activating FAK and MAPK signaling pathway","volume":"19","author":"Sun","year":"2020","journal-title":"Cell Cycle"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1111\/jcmm.13174","article-title":"Cyclic peptide *CRRETAWAC* attenuates fibronectin-induced cytokine secretion of human airway smooth muscle cells by inhibiting FAK and p38 MAPK","volume":"21","author":"Chu","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1183\/09031936.00192109","article-title":"Signalling pathway of isophorone diisocyanate-responsive interleukin-8 in airway smooth muscle cells","volume":"37","author":"Kuo","year":"2011","journal-title":"Eur. Respir. J."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.mvr.2011.05.003","article-title":"Focal adhesion kinase and endothelial cell apoptosis","volume":"83","author":"Lu","year":"2012","journal-title":"Microvasc. Res."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.mvr.2014.05.003","article-title":"Cigarette smoke-induced lung endothelial apoptosis and emphysema are associated with impairment of FAK and eIF2\u03b1","volume":"94","author":"Sakhatskyy","year":"2014","journal-title":"Microvasc. Res."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1186\/s12931-022-02193-5","article-title":"Fibroblast growth factor 10 attenuates chronic obstructive pulmonary disease by protecting against glycocalyx impairment and endothelial apoptosis","volume":"23","author":"Jiang","year":"2022","journal-title":"Respir. Res."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1038\/s44321-024-00138-7","article-title":"ERK5 suppression overcomes FAK inhibitor resistance in mutant KRAS-driven non-small cell lung cancer","volume":"16","author":"Pozzato","year":"2024","journal-title":"EMBO Mol. Med."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1038\/s41401-024-01266-z","article-title":"Tumor-targeted PROTAC prodrug nanoplatform enables precise protein degradation and combination cancer therapy","volume":"45","author":"Zou","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"112868","DOI":"10.1016\/j.yexcr.2021.112868","article-title":"FAK-targeting PROTAC demonstrates enhanced antitumor activity against KRAS mutant non-small cell lung cancer","volume":"408","author":"Liu","year":"2021","journal-title":"Exp. Cell Res."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"114373","DOI":"10.1016\/j.ejmech.2022.114373","article-title":"Identification of novel and potent PROTACs targeting FAK for non-small cell lung cancer: Design, synthesis, and biological study","volume":"237","author":"Sun","year":"2022","journal-title":"Eur. J. Med. Chem."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/15\/9\/1233\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:33:12Z","timestamp":1760034792000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/15\/9\/1233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,26]]},"references-count":147,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["biom15091233"],"URL":"https:\/\/doi.org\/10.3390\/biom15091233","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,26]]}}}