{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:39:12Z","timestamp":1760060352598,"version":"build-2065373602"},"reference-count":84,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Red de Investigaci\u00f3n en Atenci\u00f3n Primaria de Adicciones","award":["RD21\/0009\/0008","PI21\/00488","MCIN\/AEI\/10.13039\/501100011033","MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["RD21\/0009\/0008","PI21\/00488","MCIN\/AEI\/10.13039\/501100011033","MCIN\/AEI\/10.13039\/501100011033"]}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD21\/0009\/0008","PI21\/00488","MCIN\/AEI\/10.13039\/501100011033","MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["RD21\/0009\/0008","PI21\/00488","MCIN\/AEI\/10.13039\/501100011033","MCIN\/AEI\/10.13039\/501100011033"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"&quot;Instituto de Investigaci\u00f3n Biom\u00e9dica y Sanitaria de Alicante&quot; (ISABIAL)","award":["RD21\/0009\/0008","PI21\/00488","MCIN\/AEI\/10.13039\/501100011033","MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["RD21\/0009\/0008","PI21\/00488","MCIN\/AEI\/10.13039\/501100011033","MCIN\/AEI\/10.13039\/501100011033"]}]},{"name":"Instituto de Neurociencias \u201cCentro de Excelencia Severo Ochoa&quot; Grant CEX2021-001165-S","award":["RD21\/0009\/0008","PI21\/00488","MCIN\/AEI\/10.13039\/501100011033","MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["RD21\/0009\/0008","PI21\/00488","MCIN\/AEI\/10.13039\/501100011033","MCIN\/AEI\/10.13039\/501100011033"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Alcohol consumption during pregnancy and lactation remains a significant global issue. Preventive policies have proven insufficient, and consumption rates remain high, mainly due to a lack of awareness, the misconception that only high alcohol intake harms the fetus, inconsistent medical advice, and pre-existing alcohol use disorders. Alcohol consumption is linked to child harm during critical stages of development. Using a recently published model of fetal alcohol spectrum disorder (FASD) developed by our group, we analyzed brain changes in mothers who consumed alcohol during pregnancy and lactation and the behavioral consequences at the emotional-cognitive level and in caring for their offspring. We also considered the previous drinking history, using the paradigm of voluntary pre-gestational alcohol consumption. In addition, from gestational day 7 (GD7) until the day of sacrifice, mothers received a 3 g\/kg dose of alcohol every 12 h via gavage. Our findings revealed deficiencies in maternal care, anxiety and depressive-like behavior, and aversive stimulus learning disturbances. These were associated with changes in gene targets linked to stress-axis regulation, reward circuits, and neuroplasticity. Additionally, we observed increased microgliosis and astrogliosis, indicating neuroinflammation in brain regions involved in cognition and emotional states\u2019 regulation.<\/jats:p>","DOI":"10.3390\/biom15091239","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T09:58:32Z","timestamp":1756288712000},"page":"1239","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Behavioral and Brain Gene and Protein Changes in Female Mice Consuming Ethanol During Pregnancy and Lactation"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3910-3993","authenticated-orcid":false,"given":"Daniela","family":"Navarro","sequence":"first","affiliation":[{"name":"Instituto de Neurociencias, Universidad Miguel Hern\u00e1ndez-CSIC, Avda. de Ram\u00f3n y Cajal s\/n, San Juan de Alicante, 03550 Alicante, Spain"},{"name":"Redes de Investigaci\u00f3n Cooperativa Orientada a Resultados en Salud (RICORS), Red de Investigaci\u00f3n en Atenci\u00f3n Primaria de Adicciones (RIAPAd), Instituto de Salud Carlos III, MICINN and FEDER, 28029 Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria y Biom\u00e9dica de Alicante (ISABIAL), 03010 Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1251-6357","authenticated-orcid":false,"given":"Francisco","family":"Navarrete","sequence":"additional","affiliation":[{"name":"Instituto de Neurociencias, Universidad Miguel Hern\u00e1ndez-CSIC, Avda. de Ram\u00f3n y Cajal s\/n, San Juan de Alicante, 03550 Alicante, Spain"},{"name":"Redes de Investigaci\u00f3n Cooperativa Orientada a Resultados en Salud (RICORS), Red de Investigaci\u00f3n en Atenci\u00f3n Primaria de Adicciones (RIAPAd), Instituto de Salud Carlos III, MICINN and FEDER, 28029 Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria y Biom\u00e9dica de Alicante (ISABIAL), 03010 Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0397-3409","authenticated-orcid":false,"given":"Nerina","family":"Villalba","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda Celular y Neurociencia \u201cProf. E. De Robertis\u201d (IBCN), Universidad de Buenos Aires-CONICET, Buenos Aires C1121ABG, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham B.","family":"Torregrosa","sequence":"additional","affiliation":[{"name":"Instituto de Neurociencias, Universidad Miguel Hern\u00e1ndez-CSIC, Avda. de Ram\u00f3n y Cajal s\/n, San Juan de Alicante, 03550 Alicante, Spain"},{"name":"Redes de Investigaci\u00f3n Cooperativa Orientada a Resultados en Salud (RICORS), Red de Investigaci\u00f3n en Atenci\u00f3n Primaria de Adicciones (RIAPAd), Instituto de Salud Carlos III, MICINN and FEDER, 28029 Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria y Biom\u00e9dica de Alicante (ISABIAL), 03010 Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Caltana","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda Celular y Neurociencia \u201cProf. E. De Robertis\u201d (IBCN), Universidad de Buenos Aires-CONICET, Buenos Aires C1121ABG, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9646-9975","authenticated-orcid":false,"given":"Ani","family":"Gasparyan","sequence":"additional","affiliation":[{"name":"Instituto de Neurociencias, Universidad Miguel Hern\u00e1ndez-CSIC, Avda. de Ram\u00f3n y Cajal s\/n, San Juan de Alicante, 03550 Alicante, Spain"},{"name":"Redes de Investigaci\u00f3n Cooperativa Orientada a Resultados en Salud (RICORS), Red de Investigaci\u00f3n en Atenci\u00f3n Primaria de Adicciones (RIAPAd), Instituto de Salud Carlos III, MICINN and FEDER, 28029 Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria y Biom\u00e9dica de Alicante (ISABIAL), 03010 Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"Brusco","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda Celular y Neurociencia \u201cProf. E. 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