{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:16:33Z","timestamp":1792293393618,"version":"4.4.0"},"reference-count":224,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Guizhou Provincial Basic Research Program (Natural Science)","award":["QKH-JC-ZK [2021] ZD018"],"award-info":[{"award-number":["QKH-JC-ZK [2021] ZD018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Breast cancer is the most prevalent malignant tumor in women. However, its clinical management is severely hindered by three interconnected challenges that limit long-term survival: treatment resistance, metastatic dissemination, and immunological evasion. Ferroptosis, an iron-dependent form of regulated cell death, is emerging as a novel strategy to overcome these obstacles. Furthermore, it demonstrates significant potential in inhibiting tumor metastasis and modifying the anti-tumor immune microenvironment, which provides a novel approach to address the core dilemma of breast cancer. Natural products have emerged as significant sources of ferroptosis inducers owing to their distinctive chemical variety, multi-target regulatory capabilities, and acceptable safety profile. Data increasingly indicates that several natural compounds can function as effective inducers or sensitizers of ferroptosis cell death. This review provides a thorough evaluation of current progress in harnessing natural ingredients to trigger ferroptosis for breast cancer treatment. It also elucidates the fundamental molecular mechanisms. Furthermore, it encapsulates therapeutic efficacy in preclinical models. Ultimately, it rigorously evaluates existing constraints and delineates potential and barriers for clinical translation.<\/jats:p>","DOI":"10.3390\/biom15091308","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T10:50:04Z","timestamp":1757587804000},"page":"1308","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Natural Compounds as Modulators of Ferroptosis: Mechanistic Insights and Therapeutic Prospects in Breast Cancer"],"prefix":"10.3390","volume":"15","author":[{"given":"Haotong","family":"He","sequence":"first","affiliation":[{"name":"Basic Teaching Department, Zhuhai Campus of Zunyi Medical University, Zhuhai 519041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyang","family":"Yu","sequence":"additional","affiliation":[{"name":"Basic Teaching Department, Zhuhai Campus of Zunyi Medical University, Zhuhai 519041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hefeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Zhuhai Campus of Zunyi Medical University, Zhuhai 519041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7639-2456","authenticated-orcid":false,"given":"Guozhen","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Zhuhai Campus of Zunyi Medical University, Zhuhai 519041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Zhuhai Campus of Zunyi Medical University, Zhuhai 519041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s10549-020-06003-8","article-title":"International Variation in Breast Cancer Incidence and Mortality in Young Women","volume":"186","author":"Sopik","year":"2021","journal-title":"Breast Cancer Res. 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