{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:45:30Z","timestamp":1760060730919,"version":"build-2065373602"},"reference-count":40,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MICIU\/AEI\/10.13039\/501100011033","award":["PID2020-115121GB-I00","PID2023-147266NB-I00"],"award-info":[{"award-number":["PID2020-115121GB-I00","PID2023-147266NB-I00"]}]},{"DOI":"10.13039\/501100011033","name":"ERDF\/EU","doi-asserted-by":"publisher","award":["PID2020-115121GB-I00","PID2023-147266NB-I00"],"award-info":[{"award-number":["PID2020-115121GB-I00","PID2023-147266NB-I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Given the central role of neurogenesis in building a functional nervous system, we recently developed a zebrafish-based drug-screening protocol to uncover molecules and signalling pathways regulating spinal cord neurogenesis. In this study, we have expanded this drug screen and discovered a previously unknown role of deacetylase sirtuin 2 (SIRT2) in promoting the generation of serotonergic interneurons in the spinal cord. Treatments with specific SIRT2 inhibitors reduced the generation of serotonergic neurons in the spinal cord, which led to locomotor deficits. Our data suggest that SIRT2 regulates mitotic activity in progenitor cells to promote the generation of serotonergic neurons in developing animals. Together, our results uncover SIRT2 as a key regulator of spinal cord neurogenesis and position it as a promising target for strategies aimed at neural repair in spinal cord disorders.<\/jats:p>","DOI":"10.3390\/biom15101359","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T07:46:49Z","timestamp":1758786409000},"page":"1359","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An In Vivo Drug Screen Reveals That Sirtuin 2 Activity Promotes Spinal Cord Neurogenesis in Developing Zebrafish"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6664-8980","authenticated-orcid":false,"given":"Laura","family":"Gonz\u00e1lez-Llera","sequence":"first","affiliation":[{"name":"Departamento de Biolox\u00eda Funcional, Facultade de Biolox\u00eda, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain"},{"name":"Aquatic One Health Research Center (ARCUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9857-3469","authenticated-orcid":false,"given":"\u00c1lvaro J.","family":"Arana","sequence":"additional","affiliation":[{"name":"Department of Zoology, Genetics and Physical Anthropology, Faculty of Veterinary Science, Universidade de Santiago de Compostela, 27002 Lugo, Spain"},{"name":"Preclinical Animal Models Group, Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7927-5303","authenticated-orcid":false,"given":"Laura","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Zoology, Genetics and Physical Anthropology, Faculty of Veterinary Science, Universidade de Santiago de Compostela, 27002 Lugo, Spain"},{"name":"Preclinical Animal Models Group, Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7507-080X","authenticated-orcid":false,"given":"Ant\u00f3n","family":"Barreiro-Iglesias","sequence":"additional","affiliation":[{"name":"Departamento de Biolox\u00eda Funcional, Facultade de Biolox\u00eda, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain"},{"name":"Aquatic One Health Research Center (ARCUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1152\/jn.00238.2024","article-title":"The mammalian locomotor CPG: Revealing the contents of the black box","volume":"133","author":"Gosgnach","year":"2025","journal-title":"J. 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