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Although early-stage prostate cancer (PCa) has a high cure rate, advanced disease often becomes difficult to manage due to resistance to standard therapies such as androgen deprivation therapy (ADT). Therefore, a deep understanding of the interaction mechanisms between CAFs and PCa cells is essential for developing novel therapeutic strategies targeting resistant advanced PCa. This review systematically summarizes key signaling pathways and molecular mechanisms through which CAFs promote PCa progression, as recently discovered, evaluates the potential of CAFs as prognostic biomarkers, and discusses novel CAF-based therapeutic targets and intervention strategies for PCa.<\/jats:p>","DOI":"10.3390\/biom15101369","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T13:30:03Z","timestamp":1758893403000},"page":"1369","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Research Advances in Cancer-Associated Fibroblasts in Prostate Cancer Progression"],"prefix":"10.3390","volume":"15","author":[{"given":"Zhonghao","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Urology, Affiliated Hospital of Jiangnan University, 1000 Hefeng Road, Wuxi 214122, China"},{"name":"Wuxi School of Medicine, Jiangnan University, 1800 Lihudadao, Wuxi 214122, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Urology, Affiliated Hospital of Jiangnan University, 1000 Hefeng Road, Wuxi 214122, China"},{"name":"Wuxi School of Medicine, Jiangnan University, 1800 Lihudadao, Wuxi 214122, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenwei","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Urology, Affiliated Hospital of Jiangnan University, 1000 Hefeng Road, Wuxi 214122, China"},{"name":"Wuxi School of Medicine, Jiangnan University, 1800 Lihudadao, Wuxi 214122, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sixin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology, Affiliated Hospital of Jiangnan University, 1000 Hefeng Road, Wuxi 214122, China"},{"name":"Wuxi School of Medicine, Jiangnan University, 1800 Lihudadao, Wuxi 214122, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Affiliated Hospital of Jiangnan University, 1000 Hefeng Road, Wuxi 214122, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3456-523X","authenticated-orcid":false,"given":"Yuanyuan","family":"Mi","sequence":"additional","affiliation":[{"name":"Department of Urology, Affiliated Hospital of Jiangnan University, 1000 Hefeng Road, Wuxi 214122, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.eururo.2024.11.013","article-title":"Recent Patterns and Trends in Global Prostate Cancer Incidence and Mortality: An Update","volume":"87","author":"Schafer","year":"2025","journal-title":"Eur. 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