{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T05:12:21Z","timestamp":1776921141289,"version":"3.51.2"},"reference-count":64,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sociedad Espa\u00f1ola de Columna Vertebral","award":["beca de investigaci\u00f3n GEER 2019"],"award-info":[{"award-number":["beca de investigaci\u00f3n GEER 2019"]}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Background: The limited self-repair capacity of nerve tissue requires a new therapeutic approach. Mesenchymal stem cells from the uterine cervix, hUCESC, have shown anti-inflammatory, regenerative, and anti-oxidative stress effects through their secretome, which makes them candidates to evaluate their potential in the context of neuronal damage. In this study, we aimed to determine whether secretome or conditioned medium of hUCESC (hUCESC-CM) has beneficial action in the treatment of PC-12 and HMC3 cells in vitro under conditions of oxidative stress and inflammation. Methods: Differentiated PC-12 cells and HMC3 cells were subjected to oxidative stress and inflammatory conditions in the presence of hUCESC-CM. The expression of factors related to both processes was evaluated by q-RT-PCR. Results: PC-12 cells treated with hUCESC-CM showed a significant increase in the expression of anti-oxidative stress factors (HO-1 and Nrf2) and a significant decrease in the expression of pro-inflammatory factors (IL1\u03b2, IL6 and TNF\u03b1). In addition, the treatment of HMC3 cells with hUCESC-CM significantly decreased the expression of IL6 and TNF\u03b1 and enhanced the expression of neuroprotective factors such as BDNF and GDNF. Conclusions: Considering that both oxidative stress and inflammation are interrelated and implicated in several nerve injuries and neurodegenerative disorders, the effects of hUCESC-CM on neuronal cells are very promising.<\/jats:p>","DOI":"10.3390\/biom15101402","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T08:20:28Z","timestamp":1759393228000},"page":"1402","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Secretome from Uterine Cervical Mesenchymal Stem Cells as a Protector of Neuronal Cells Against Oxidative Stress and Inflammation"],"prefix":"10.3390","volume":"15","author":[{"given":"Javier","family":"Mateo","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery and Traumatology, Hospital Universitario Cabue\u00f1es, 33394 Gij\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel \u00c1ngel","family":"Su\u00e1rez-Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and Traumatology, Hospital Universitario Cabue\u00f1es, 33394 Gij\u00f3n, Spain"},{"name":"Department of Medicine, University of Oviedo, 33006 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0092-7805","authenticated-orcid":false,"given":"Maria","family":"Fraile","sequence":"additional","affiliation":[{"name":"Research Unit, Fundaci\u00f3n Hospital de Jove, 33290 Gij\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngel Ram\u00f3n","family":"Pi\u00f1era-Parrilla","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and Traumatology, Hospital Universitario Cabue\u00f1es, 33394 Gij\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2827-5511","authenticated-orcid":false,"given":"Francisco J.","family":"Vizoso","sequence":"additional","affiliation":[{"name":"Research Unit, Fundaci\u00f3n Hospital de Jove, 33290 Gij\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5840-4807","authenticated-orcid":false,"given":"Noemi","family":"Eiro","sequence":"additional","affiliation":[{"name":"Research Unit, Fundaci\u00f3n Hospital de Jove, 33290 Gij\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1016\/S0140-6736(06)68700-X","article-title":"Persistent postsurgical pain: Risk factors and prevention","volume":"367","author":"Kehlet","year":"2006","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1093\/brain\/awq252","article-title":"Post-surgical inflammatory neuropathy","volume":"133","author":"Staff","year":"2010","journal-title":"Brain"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1750-1326-6-11","article-title":"Pathophysiology, treatment, and animal and cellular models of human ischemic stroke","volume":"6","author":"Woodruff","year":"2011","journal-title":"Mol. 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