{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:34:51Z","timestamp":1787027691034,"version":"build-2736575974"},"reference-count":62,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T00:00:00Z","timestamp":1759622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012996","name":"University of Cyprus","doi-asserted-by":"publisher","award":["6950\/2022"],"award-info":[{"award-number":["6950\/2022"]}],"id":[{"id":"10.13039\/100012996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Type 2 diabetes mellitus (T2DM) is associated with increased cardiovascular risk characterized by low-grade inflammation. The aim of this systematic review and meta-analysis was to assess the effects of resistance exercise training (RET) predominantly on cytokines, along with changes in glucose profile and body composition in T2DM patients. The present systematic review and meta-analysis was conducted utilizing PubMed, Web of Science, Embase, and the Cochrane Library databases from their inception up to July 2024 (PROSPERO; registration number CRD420251149352). We screened only for randomized controlled trials investigating the effects of systematic, supervised RET on C-reactive protein (CRP) and adipokines: adiponectin, interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-\u03b1), along with changes in anthropometric indices and glycemic control in adult T2DM patients. Pooled post-exercise weighted mean differences (WMDs) with 95% confidence intervals (CIs) were calculated for all outcomes of interest between exercise-treated patients and controls. Sixteen studies involving a total of 668 T2DM patients were retrieved from the databases for meta-analysis. We used the GRADE framework for assessing the certainty of evidence. Cochran Q-score (I2) was used to estimate heterogeneity among studies (level of significance p &lt; 0.10) and risk of bias analysis was also performed. The cumulative results showed that post-RET inflammatory markers were lower in exercise-treated patients compared to controls regarding CRP (mg\/L) (WMD: \u22120.63; 95%CIs: \u22121.05, \u22120.20; p &lt; 0.001); adiponectin (\u03bcg\/mL) (WMD: \u22120.94; 95%CIs: \u22121.49, \u22120.38; p &lt; 0.001). The results from adiponectin are quite conflicting since they derived from only three studies, where one of them had the greater impact. In parallel, we noticed significant amelioration of fasting glucose and HbA1c (p &lt; 0.001), while body weight remained unaltered. Our meta-analysis demonstrated non-significantly lower levels of IL-6 and TNF-\u03b1 in RET vs. control group. RET can merely reduce the inflammatory burden in T2DM patients by ameliorating the circulating levels of CRP and adiponectin, while in the rest of the biomarkers, non-significant results were obtained. Hence, the overall clinical impact of those anti-inflammatory effects of RET needs to be determined.<\/jats:p>","DOI":"10.3390\/biom15101417","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T08:10:51Z","timestamp":1759738251000},"page":"1417","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Anti-Inflammatory Effects of Resistance Training in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7830-3488","authenticated-orcid":false,"given":"Nikolaos P. E.","family":"Kadoglou","sequence":"first","affiliation":[{"name":"Medical School, University of Cyprus, Nicosia 2029, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3503-7288","authenticated-orcid":false,"given":"Chrysostomos","family":"Georgiou","sequence":"additional","affiliation":[{"name":"Medical School, University of Cyprus, Nicosia 2029, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Balaskas","sequence":"additional","affiliation":[{"name":"Medical School, University of Cyprus, Nicosia 2029, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrystalla","family":"Panayiotou","sequence":"additional","affiliation":[{"name":"Medical School, University of Cyprus, Nicosia 2029, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1306-0817","authenticated-orcid":false,"given":"Michail","family":"Vardas","sequence":"additional","affiliation":[{"name":"Medical School, University of Cyprus, Nicosia 2029, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0286-7762","authenticated-orcid":false,"given":"Andreas","family":"Mitsis","sequence":"additional","affiliation":[{"name":"Department of Cardiology, General Hospital of Nicosia, Strovolos 2031, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0696-695X","authenticated-orcid":false,"given":"Constantine N.","family":"Antonopoulos","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Attikon University Hospital, National and Kapodistrian University of Athens, 124 62 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S139","DOI":"10.1016\/j.molmet.2019.06.016","article-title":"Biomarkers for type 2 diabetes","volume":"27","author":"Laakso","year":"2019","journal-title":"Mol. Metab."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12933-018-0728-6","article-title":"Prevalence of cardiovascular disease in type 2 diabetes: A systematic literature review of scientific evidence from across the world in 2007\u20132017","volume":"17","author":"Einarson","year":"2018","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"357","DOI":"10.7326\/0003-4819-147-6-200709180-00005","article-title":"Effects of Aerobic Training, Resistance Training, or Both on Glycemic Control in Type 2 Diabetes: A Randomized Trial","volume":"147","author":"Sigal","year":"2007","journal-title":"Ann. Intern. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"a029694","DOI":"10.1101\/cshperspect.a029694","article-title":"Health Benefits of Exercise","volume":"8","author":"Ruegsegger","year":"2018","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1111\/dme.12055","article-title":"The differential anti-inflammatory effects of exercise modalities and their association with early carotid atherosclerosis progression in patients with Type 2 diabetes","volume":"30","author":"Kadoglou","year":"2013","journal-title":"Diabet. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"166","DOI":"10.2337\/dc12-0702","article-title":"Inflammatory Markers and Risk of Type 2 Diabetes","volume":"36","author":"Wang","year":"2013","journal-title":"Diabetes Care"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"155698","DOI":"10.1016\/j.cyto.2021.155698","article-title":"The interplay between statins and adipokines is this another explanation of statins\u2019 \u2018pleiotropic\u2019 effects?","volume":"148","author":"Kadoglou","year":"2021","journal-title":"Cytokine"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.diabres.2014.04.006","article-title":"Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes","volume":"105","author":"Esser","year":"2014","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nri2921","article-title":"Adipokines in inflammation and metabolic disease","volume":"11","author":"Ouchi","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/s00018-022-04286-2","article-title":"Adipokines, adiposity, and atherosclerosis","volume":"79","author":"Liu","year":"2022","journal-title":"Cell Mol. Life Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"155364","DOI":"10.1016\/j.cyto.2020.155364","article-title":"Omentin-1 and vaspin serum levels in patients with pre-clinical carotid atherosclerosis and the effect of statin therapy on them","volume":"138","author":"Kadoglou","year":"2021","journal-title":"Cytokine"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"156157","DOI":"10.1016\/j.cyto.2023.156157","article-title":"The anti-inflammatory effects of aerobic exercise training in patients with type 2 diabetes: A systematic review and meta-analysis","volume":"164","author":"Papagianni","year":"2023","journal-title":"Cytokine"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4093\/dmj.2022.0007","article-title":"Effectiveness of Resistance Exercise on Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Systematic Review with Meta-Analysis","volume":"47","author":"Mesas","year":"2023","journal-title":"Diabetes Metab. J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.jamda.2022.01.055","article-title":"Effect of Aerobic and Resistant Exercise Intervention on Inflammaging of Type 2 Diabetes Mellitus in Middle-Aged and Older Adults: A Systematic Review and Meta-Analysis","volume":"23","author":"Xing","year":"2022","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1001\/jama.2017.19163","article-title":"Preferred Reporting Items for a Systematic Review and Meta-analysis of Diagnostic Test Accuracy Studies: The PRISMA-DTA Statement","volume":"319","author":"McInnes","year":"2018","journal-title":"JAMA"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Higgins, J.P.T., Thomas, J., Chandler, J., Cumpston, M., Li, T., Page, M.J., and Welch, V.A. (2019). Cochrane Handbook for Systematic Reviews of Interventions, John Wiley & Sons. [2nd ed.].","DOI":"10.1002\/9781119536604"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"102778","DOI":"10.1016\/j.dsx.2023.102778","article-title":"Progressive resistance training ameliorates deteriorating cardiac autonomic dysfunction, subclinical inflammation and endothelial dysfunction in type 2 diabetes mellitus: A randomized control trial","volume":"17","author":"Bhati","year":"2023","journal-title":"Diabetes Metab. Syndr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"19","DOI":"10.7150\/ijms.4.19","article-title":"Strength training improves muscle quality and insulin sensitivity in Hispanic older adults with type 2 diabetes","volume":"4","author":"Brooks","year":"2007","journal-title":"Int. J. Med. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s40200-019-00416-z","article-title":"Anti-inflammatory effects of vitamin D and resistance training in men with type 2 diabetes mellitus and vitamin D deficiency: A randomized, double-blinded, placebo-controlled clinical trial","volume":"18","author":"Dadrass","year":"2019","journal-title":"J. Diabetes Metab. Disord."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1007\/s00421-022-04980-w","article-title":"Effect of performing high-intensity interval training and resistance training on the same day vs. different days in women with type 2 diabetes","volume":"122","author":"Ghodrat","year":"2022","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_21","first-page":"913","article-title":"Effects of resistance training and nigella sativa on type 2 diabetes: Implications for metabolic markers, low grade inflammation and liver enzyme production","volume":"129","author":"Dastgheib","year":"2021","journal-title":"Arch. Physiol. Biochem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.metabol.2011.01.006","article-title":"The effects of aerobic, resistance, and combined exercise on metabolic control, inflammatory markers, adipocytokines, and muscle insulin signaling in patients with type 2 diabetes mellitus","volume":"60","author":"Jorge","year":"2011","journal-title":"Metabolism"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s12020-012-9650-y","article-title":"The effects of resistance training on ApoB\/ApoA-I ratio, Lp(a) and inflammatory markers in patients with type 2 diabetes","volume":"42","author":"Kadoglou","year":"2012","journal-title":"Endocrine"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1177\/147323001003800305","article-title":"Resistance Exercise Did Not Alter Intramuscular Adipose Tissue but Reduced Retinol-binding Protein-4 Concentration in Individuals with Type 2 Diabetes Mellitus","volume":"38","author":"Ku","year":"2010","journal-title":"J. Int. Med. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s12933-020-01136-y","article-title":"Impact of combined training with different exercise intensities on inflammatory and lipid markers in type 2 diabetes: A secondary analysis from a 1-year randomized controlled trial","volume":"19","author":"Santos","year":"2020","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s13539-014-0134-1","article-title":"Reductions in C-reactive protein in older adults with type 2 diabetes are related to improvements in body composition following a randomized controlled trial of resistance training","volume":"5","author":"Mavros","year":"2014","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1007\/s00421-017-3657-2","article-title":"Effects of progressive resistance training and weight loss versus weight loss alone on inflammatory and endothelial biomarkers in older adults with type 2 diabetes","volume":"117","author":"Miller","year":"2017","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.exger.2019.01.003","article-title":"Effects of short-term resistance training on endothelial function and inflammation markers in elderly patients with type 2 diabetes: A randomized controlled trial","volume":"118","author":"Rech","year":"2019","journal-title":"Exp. Gerontol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"5291","DOI":"10.1007\/s11033-021-06539-y","article-title":"Inflammatory, antioxidant and glycemic status to different mode of high-intensity training in type 2 diabetes mellitus","volume":"48","author":"Sabouri","year":"2021","journal-title":"Mol. Biol. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1249\/MSS.0b013e31824526cc","article-title":"Effect of Exercise Training Modality on C-Reactive Protein in Type 2 Diabetes","volume":"44","author":"Swift","year":"2012","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"969","DOI":"10.2337\/dc09-1974","article-title":"A High-Protein Diet With Resistance Exercise Training Improves Weight Loss and Body Composition in Overweight and Obese Patients With Type 2 Diabetes","volume":"33","author":"Wycherley","year":"2010","journal-title":"Diabetes Care"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Ha\u00df, U., Heider, S., Kochlik, B., Herpich, C., Pivovarova-Ramich, O., and Norman, K. (2023). Effects of Exercise and Omega-3-Supplemented, High-Protein Diet on Inflammatory Markers in Serum, on Gene Expression Levels in PBMC, and after Ex Vivo Whole-Blood LPS Stimulation in Old Adults. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24020928"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"112410","DOI":"10.1016\/j.exger.2024.112410","article-title":"The effect of a combined lifestyle intervention with and without protein drink on inflammation in older adults with obesity and type 2 diabetes","volume":"190","author":"Memelink","year":"2024","journal-title":"Exp. Gerontol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1249\/MSS.0b013e3182059eda","article-title":"Sixteen Weeks of Exercise Reduces C-Reactive Protein Levels in Young Women","volume":"43","author":"Arikawa","year":"2011","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12966-018-0703-3","article-title":"Exercise training modalities in patients with type 2 diabetes mellitus: A systematic review and network meta-analysis","volume":"15","author":"Pan","year":"2018","journal-title":"Int. J. Behav. Nutr. Phys. Act."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jesf.2021.08.002","article-title":"Effects of resistance training on insulin sensitivity in the elderly: A meta-analysis of randomized controlled trials","volume":"19","author":"Li","year":"2021","journal-title":"J. Exerc. Sci. Fit."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"112079","DOI":"10.1016\/j.diabres.2025.112079","article-title":"The efficacy of resistance exercise training on metabolic health, body composition, and muscle strength in older adults with type 2 diabetes: A systematic review and Meta-Analysis","volume":"222","author":"Feng","year":"2025","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jphys.2016.08.003","article-title":"Exercise improves glycaemic control in women diagnosed with gestational diabetes mellitus: A systematic review","volume":"62","author":"Harrison","year":"2016","journal-title":"J. Physiother."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.jsams.2024.03.007","article-title":"Comparative efficacy of different exercise types on inflammatory markers in women with overweight and obesity: A systematic review and network meta-analysis of randomized controlled trials","volume":"27","author":"Tan","year":"2024","journal-title":"J. Sci. Med. Sport."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1249\/MSS.0b013e3181b117ca","article-title":"Effects of Resistance or Aerobic Exercise Training on Interleukin-6, C-Reactive Protein, and Body Composition","volume":"42","author":"Donges","year":"2010","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Henein, M.Y., Vancheri, S., Longo, G., and Vancheri, F. (2022). The Role of Inflammation in Cardiovascular Disease. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232112906"},{"key":"ref_42","first-page":"345","article-title":"Effects of exercise training on inflammatory and cardiometabolic health markers in overweight and obese adults: A systematic review and meta-analysis of randomized controlled trials","volume":"63","author":"Hejazi","year":"2023","journal-title":"J. Sports Med. Phys. Fit."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1177\/10998004221132841","article-title":"Effects of Exercise Training on Inflammatory and Cardiometabolic Risk Biomarkers in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","volume":"25","author":"Hejazi","year":"2023","journal-title":"Biol. Res. Nurs."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1002\/jcsm.13257","article-title":"Physical exercise attenuates age-related muscle atrophy and exhibits anti-ageing effects via the adiponectin receptor 1 signalling","volume":"14","author":"Chen","year":"2023","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.numecd.2016.02.011","article-title":"Association between serum adiponectin levels and muscular fitness in Portuguese adolescents: LabMed Physical Activity Study","volume":"26","author":"Santos","year":"2016","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1002\/j.2040-4603.2018.tb00036.x","article-title":"Adiponectin Regulation and Function","volume":"8","author":"Fang","year":"2018","journal-title":"Compr. Physiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"98","DOI":"10.14341\/probl12827","article-title":"Adiponectin: A pleiotropic hormone with multifaceted roles","volume":"67","author":"Shklyaev","year":"2021","journal-title":"Probl. Endokrinol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1253\/circj.CJ-17-0458","article-title":"Role of Adipokines in Cardiovascular Disease","volume":"81","author":"Lau","year":"2017","journal-title":"Circ. J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s10741-010-9159-5","article-title":"Is adiponectin a bystander or a mediator in heart failure? The tangled thread of a good-natured adipokine in aging and cardiovascular disease","volume":"15","author":"Shinmura","year":"2010","journal-title":"Heart Fail. Rev."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Makiel, K., Suder, A., Targosz, A., Maciejczyk, M., and Haim, A. (2023). Exercise-Induced Alternations of Adiponectin, Interleukin-8 and Indicators of Carbohydrate Metabolism in Males with Metabolic Syndrome. Biomolecules, 13.","DOI":"10.3390\/biom13050852"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3915","DOI":"10.1002\/jmv.26654","article-title":"Defining IL-6 levels in healthy individuals: A meta-analysis","volume":"93","author":"Said","year":"2021","journal-title":"J. Med. Virol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1042\/CS20110340","article-title":"IL-6\/IL-6 receptor system and its role in physiological and pathological conditions","volume":"122","author":"Mihara","year":"2012","journal-title":"Clin. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.bbamcr.2011.01.034","article-title":"The pro- and anti-inflammatory properties of the cytokine interleukin-6","volume":"1813","author":"Scheller","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e12996","DOI":"10.1111\/anec.12996","article-title":"The effects of aerobic exercise combined with resistance training on inflammatory factors and heart rate variability in middle-aged and elderly women with type 2 diabetes mellitus","volume":"27","author":"Su","year":"2022","journal-title":"Ann. Noninvasive Electrocardiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1007\/s11154-021-09657-x","article-title":"Physical activity and adipokine levels in individuals with type 2 diabetes: A literature review and practical applications","volume":"22","author":"Zouhal","year":"2021","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.bbi.2018.02.013","article-title":"Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters","volume":"70","author":"Gangestad","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1152\/physrev.2000.80.3.1055","article-title":"Exercise and the immune system: Regulation, integration, and adaptation","volume":"80","author":"Pedersen","year":"2000","journal-title":"Physiol. Rev."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1249\/MSS.0b013e318229d2e9","article-title":"Effect of Resistance, Endurance, and Concurrent Training on TNF-\u03b1, IL-6, and CRP","volume":"44","author":"Libardi","year":"2012","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/jcb.26174","article-title":"Tumor Necrosis Factor-Alpha: Role in Development of Insulin Resistance and Pathogenesis of Type 2 Diabetes Mellitus","volume":"119","author":"Akash","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"ref_60","first-page":"7742","article-title":"Effect of resistance exercise on peripheral inflammatory biomarkers in healthy adults: A meta-analysis of randomized controlled trials","volume":"26","author":"Wang","year":"2022","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.pcad.2023.04.008","article-title":"Exercise and cardiovascular health: A state-of-the-art review","volume":"79","author":"Isath","year":"2023","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1186\/s10020-024-01019-y","article-title":"The interplay of factors in metabolic syndrome: Understanding its roots and complexity","volume":"30","author":"Islam","year":"2024","journal-title":"Mol. Med."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/15\/10\/1417\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T08:30:27Z","timestamp":1759998627000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/15\/10\/1417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,5]]},"references-count":62,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["biom15101417"],"URL":"https:\/\/doi.org\/10.3390\/biom15101417","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,5]]}}}