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As a vital steroid hormone, progesterone (P4) plays a crucial role during pregnancy and in regulating various physiological processes. Recent studies have indicated that P4 is not only involved in pregnancy maintenance, but may also be closely related to preeclampsia pathogenesis and prevention. Previous research has suggested that P4 may participate in the mechanism of preeclampsia by regulating vascular function, immune responses, and placental function. Moreover, key enzymes and metabolites involved in the synthesis and metabolism of P4 are also associated with preeclampsia onset. Additionally, the potential value of clinically applying P4 in preventing and treating preeclampsia has been shown; however, the corresponding clinical practices require further validation and optimization. This study aimed to review the physiological effects, pathological functions, and clinical applications of P4 in preeclampsia, providing evidence for future research and clinical practice.<\/jats:p>","DOI":"10.3390\/biom15101458","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T11:57:42Z","timestamp":1760529462000},"page":"1458","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Clinical Implications of Progesterone in Preeclampsia"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8313-3444","authenticated-orcid":false,"given":"Zhenzhen","family":"Liu","sequence":"first","affiliation":[{"name":"Key Lab of Reproduction and Development, Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China"},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2157-0454","authenticated-orcid":false,"given":"Weirong","family":"Gu","sequence":"additional","affiliation":[{"name":"Key Lab of Reproduction and Development, Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1161\/HYPERTENSIONAHA.117.10803","article-title":"Hypertensive Disorders of Pregnancy: ISSHP Classification, Diagnosis, and Management Recommendations for International Practice","volume":"72","author":"Brown","year":"2018","journal-title":"Hypertension"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1161\/CIRCULATIONAHA.115.015721","article-title":"Epidemiology and Mechanisms of De Novo and Persistent Hypertension in the Postpartum Period","volume":"132","author":"Goel","year":"2015","journal-title":"Circulation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1161\/CIRCRESAHA.118.313276","article-title":"Preeclampsia: Pathophysiology, Challenges, and Perspectives","volume":"124","author":"Rana","year":"2019","journal-title":"Circ. 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