{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:07:38Z","timestamp":1788995258838,"version":"build-2803163510"},"reference-count":85,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Jiangxi Provincial Natural Science Foundation","award":["20242BAB25547"],"award-info":[{"award-number":["20242BAB25547"]}]},{"name":"the Science and Technology Research Project of the Jiangxi Provincial Department of Education","award":["GJJ2201736"],"award-info":[{"award-number":["GJJ2201736"]}]},{"name":"the Jiangxi College Students Innovation and Entrepreneurship Training Program","award":["X202410417055"],"award-info":[{"award-number":["X202410417055"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Steatotic liver disease (SLD) has become one of the most prevalent chronic liver diseases, representing a significant health burden worldwide. The complex pathogenesis of SLD results in a lack of specific therapeutic targets and effective drug treatment modalities. Copper (Cu) is a trace element that plays a critical role in various physiological processes, particularly hepatic metabolism. Meanwhile, Cu overload can induce cellular toxicity, which is generally explained by its capacity to induce oxidative damage. In 2022, a novel form of programmed cell death, designated as cuproptosis, was identified. In essence, excess Cu ions bind to the lipoylated components of the tricarboxylic acid cycle, resulting in proteotoxic stress and subsequent cell death. The role of cuproptosis in the pathologies of Cu overload-induced diseases has gained considerable attention. However, the association between SLD and Cu overload, particularly cuproptosis, remains to be elucidated. This review provides a concise overview of cuproptosis. The significance of Cu overload in SLD, as well as the potential association between cuproptosis and SLD, is explored. This review aims to offer insights into the potential of cuproptosis as a therapeutic target for SLD.<\/jats:p>","DOI":"10.3390\/biom15111490","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T08:14:04Z","timestamp":1761207244000},"page":"1490","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cuproptosis as a Potential Therapeutic Target for Steatotic Liver Disease"],"prefix":"10.3390","volume":"15","author":[{"given":"Yujie","family":"Pan","sequence":"first","affiliation":[{"name":"School of Basic Medical Sciences, Yichun University, Yichun 336000, China"},{"name":"School of Clinical Medicine, Yichun University, Yichun 336000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2193-3670","authenticated-orcid":false,"given":"Cheng","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Yichun University, Yichun 336000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qitao","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Yichun University, Yichun 336000, China"},{"name":"School of Clinical Medicine, Yichun University, Yichun 336000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifei","family":"Duan","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Yichun University, Yichun 336000, China"},{"name":"School of Pharmaceutical Sciences, Yichun University, Yichun 336000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Yichun University, Yichun 336000, China"},{"name":"School of Clinical Medicine, Yichun University, Yichun 336000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7257-7859","authenticated-orcid":false,"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Yichun University, Yichun 336000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/S0140-6736(24)01811-7","article-title":"Steatotic liver disease","volume":"404","author":"Israelsen","year":"2024","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.jhep.2025.07.019","article-title":"Phosphatidylethanol in steatotic liver disease","volume":"83","author":"Torp","year":"2025","journal-title":"J. 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