{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:18:00Z","timestamp":1789507080454,"version":"build-2803163510"},"reference-count":140,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T00:00:00Z","timestamp":1762041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Nuclear receptors (NRs) are transcription factors regulated by ligands that direct metabolism, development, and immunity. The NR superfamily constitutes a principal category of pharmacological targets for human ailments. Retinoic acid receptor-related orphan receptors (RORs) \u03b1, \u03b2, and \u03b3 are part of the nuclear receptor superfamily. They are nevertheless classified as \u201corphan\u201d receptors due to the contentious nature of identifying their endogenous ligands. ROR\u03b3 nuclear receptor protein further consists of two isoforms, namely ROR\u03b31 and ROR\u03b32 or ROR\u03b3t. ROR\u03b3t is largely found in immune cells and has been primarily associated with chronic inflammatory conditions. The expression of STAT3 is a major driver of Th17 differentiation and induces ROR\u03b3t expression through the JAK-STAT pathway. Type 3 innate lymphoid cells (ILC3s), Th17 cells, and \u03b3\u03b4T cells express ROR\u03b3t, the master transcription regulator for the pro-inflammatory cytokine interleukin IL-17. In chronic inflammatory skin disorders, a significant increase in IL-17 has been observed, which plays a key role in both immune cell recruitment to the site of inflammation and the propagation of tissue damage. In this review, we will discuss how ROR\u03b3t regulates IL-17-driven inflammation and explore potential strategies to target the ROR\u03b3t-IL-17 axis as a viable therapeutic intervention in chronic inflammatory skin disorders.<\/jats:p>","DOI":"10.3390\/biom15111543","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:47:58Z","timestamp":1762177678000},"page":"1543","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Critical Evaluation of the Role of Transcription Factor RAR-Orphan Receptor-\u03b3t in the Development of Chronic Inflammatory Dermatological Diseases: A Promising Therapeutic Target"],"prefix":"10.3390","volume":"15","author":[{"given":"Anik","family":"Pramanik","sequence":"first","affiliation":[{"name":"Department of Zoology, Academic Building II, Sidho Kanho Birsha University, PO: Sainik School, Ranchi Road, Purulia 723104, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8127-7895","authenticated-orcid":false,"given":"Pallabi","family":"Mondal","sequence":"additional","affiliation":[{"name":"Department of Zoology, Academic Building II, Sidho Kanho Birsha University, PO: Sainik School, Ranchi Road, Purulia 723104, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3235-4220","authenticated-orcid":false,"given":"Sankar","family":"Bhattacharyya","sequence":"additional","affiliation":[{"name":"Department of Zoology, Academic Building II, Sidho Kanho Birsha University, PO: Sainik School, Ranchi Road, Purulia 723104, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.str.2024.01.004","article-title":"Structural characterization of the DNA binding mechanism of retinoic acid-related orphan receptor gamma","volume":"32","author":"Jiang","year":"2024","journal-title":"Structure"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1039\/D0NP00047G","article-title":"Natural products as modulators of retinoic acid receptor-related orphan receptors (RORs)","volume":"38","author":"Ladurner","year":"2020","journal-title":"Nat. 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