{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:18:35Z","timestamp":1793121515446,"version":"4.5.0"},"reference-count":191,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of the People\u2019s Republic of China","award":["82374218"],"award-info":[{"award-number":["82374218"]}]},{"name":"National Natural Science Foundation of the People\u2019s Republic of China","award":["82405310"],"award-info":[{"award-number":["82405310"]}]},{"name":"The First Batch of Joint Research Projects of the China Association of Traditional Chinese Medicine","award":["2023DYPLHGG-09"],"award-info":[{"award-number":["2023DYPLHGG-09"]}]},{"name":"Jiangsu Province Traditional Chinese Medicine Science and Technology Development Project","award":["MS2021002"],"award-info":[{"award-number":["MS2021002"]}]},{"name":"Natural Science Foundation of the Jiangsu Higher Education Institutions of China","award":["1020241792"],"award-info":[{"award-number":["1020241792"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>The microbiota\u2013gut\u2013organ axis is widely recognized as a pivotal mediator of systemic health, primarily through gut-derived immune, metabolic, and inflammatory signaling. Fucoidans, a class of fucose-containing sulfated polysaccharides predominantly composed of L-fucose and exclusively found in brown seaweeds, have been demonstrated to modulate gut microbiota composition and function, resulting in the enrichment of beneficial bacteria and the suppression of harmful species. They enhance the production of beneficial metabolites, such as short-chain fatty acids and specific bile acids, while suppressing harmful metabolites, including lipopolysaccharide, thereby ameliorating organ damage via key mechanisms such as the mitigation of oxidative stress and inhibition of inflammatory responses. Furthermore, fucoidan supplementation was found to restore intestinal barrier integrity. Using disease models including Parkinson\u2019s disease, alcoholic liver disease, diabetic kidney disease, and obesity, the mechanisms through which fucoidans ameliorate extraintestinal diseases via the microbiota\u2013gut\u2013organ axis were elucidated. Microbiota-dependent mechanisms have been confirmed via experimental approaches such as fecal microbiota transplantation and specific bacterial strain supplementation. Fucoidans represent promising prebiotic agents for the restoration of microbial ecology and the treatment of extraintestinal diseases, highlighting the need for further clinical investigation.<\/jats:p>","DOI":"10.3390\/biom15121750","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T13:45:07Z","timestamp":1766065507000},"page":"1750","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Fucoidan Therapy for Extraintestinal Diseases: Targeting the Microbiota\u2013Gut\u2013Organ Axes"],"prefix":"10.3390","volume":"15","author":[{"given":"Xian","family":"Sun","sequence":"first","affiliation":[{"name":"School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[{"name":"No. 1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoduan","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sifan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.3390\/life13102023","article-title":"The gut-organ axis within the human body: Gut dysbiosis and the role of prebiotics","volume":"13","author":"Saxami","year":"2023","journal-title":"Life"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Guo, Y., Chen, X., Gong, P., Li, G., Yao, W., and Yang, W. 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