{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:46:25Z","timestamp":1784641585163,"version":"3.55.0"},"reference-count":75,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Young Scientists Fund of National Natural Science Foundation of China","award":["82402921"],"award-info":[{"award-number":["82402921"]}]},{"name":"Natural Science Foundation of Tibet Autonomous Region-General Project","award":["XZ202401ZR0111"],"award-info":[{"award-number":["XZ202401ZR0111"]}]},{"name":"Science and Technology Innovation Enhancement Project of Army Medical University","award":["2023XQN43"],"award-info":[{"award-number":["2023XQN43"]}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing","doi-asserted-by":"publisher","award":["CSTB2024NSCQ-MSX0018"],"award-info":[{"award-number":["CSTB2024NSCQ-MSX0018"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Protein S-palmitoylation is a pivotal yet poorly integrated research field in dermatology. This reversible post-translational lipid modification primarily occurs on cysteine residues and is principally catalyzed by zinc finger and Asp-His-His-Cys DHHC-domain containing proteins (zDHHCs). The S-palmitoylation\/depalmitoylation cycle directly affects protein localization, trafficking, stability, and protein\u2013protein interaction, thereby regulating a variety of signaling pathways, including those mediating inflammation and immune reaction. Accumulating evidence has indicated that S-palmitoylation regulates various skin biological functions, including skin inflammation, skin barrier function, hair growth, and melanin synthesis, and is ultimately implicated in the initiation and development of massive dermatoses, such as alopecia and psoriasis. The recent development of new research tools, coupled with S-palmitoylation\u2019s therapeutic potential, makes the timely synthesis of its role in skin pathophysiology both critical and opportune. Here, we summarize recent advances in understanding the mechanistic roles of S-palmitoylation in dermatological conditions and evaluate its potential as a therapeutic target for innovative treatment strategies.<\/jats:p>","DOI":"10.3390\/biom16010053","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T16:34:23Z","timestamp":1767198863000},"page":"53","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Protein S-Palmitoylation as Potential Therapeutic Target for Dermatoses"],"prefix":"10.3390","volume":"16","author":[{"given":"Yanhai","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Dermatology, Daping Hospital, Army Medical University, Chongqing 400042, China"},{"name":"Army 953 Hospital, Shigatse Branch of Xinqiao Hospital, Army Medical University, Shigatse 857000, China"},{"name":"Research Center for Skin Tissue Engineering of Chongqing Higher Education Institutions, Daping Hospital, Army Medical University, Chongqing 400042, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Daping Hospital, Army Medical University, Chongqing 400042, China"},{"name":"Research Center for Skin Tissue Engineering of Chongqing Higher Education Institutions, Daping Hospital, Army Medical University, Chongqing 400042, China"},{"name":"Air Force Hospital of Chinese PLA Central Theater Command, 589 Yunzhong Road, Pingcheng District, Datong 037006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Daping Hospital, Army Medical University, Chongqing 400042, China"},{"name":"Research Center for Skin Tissue Engineering of Chongqing Higher Education Institutions, Daping Hospital, Army Medical University, Chongqing 400042, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Daping Hospital, Army Medical University, Chongqing 400042, China"},{"name":"Research Center for Skin Tissue Engineering of Chongqing Higher Education Institutions, Daping Hospital, Army Medical University, Chongqing 400042, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglin","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Daping Hospital, Army Medical University, Chongqing 400042, China"},{"name":"Research Center for Skin Tissue Engineering of Chongqing Higher Education Institutions, Daping Hospital, Army Medical University, Chongqing 400042, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Daping Hospital, Army Medical University, Chongqing 400042, China"},{"name":"Research Center for Skin Tissue Engineering of Chongqing Higher Education Institutions, Daping Hospital, Army Medical University, Chongqing 400042, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenglin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Daping Hospital, Army Medical University, Chongqing 400042, China"},{"name":"Research Center for Skin Tissue Engineering of Chongqing Higher Education Institutions, Daping Hospital, Army Medical University, Chongqing 400042, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingbo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Daping Hospital, Army Medical University, Chongqing 400042, China"},{"name":"Research Center for Skin Tissue Engineering of Chongqing Higher Education Institutions, Daping Hospital, Army Medical University, Chongqing 400042, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingfei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Daping Hospital, Army Medical University, Chongqing 400042, China"},{"name":"Research Center for Skin Tissue Engineering of Chongqing Higher Education Institutions, Daping Hospital, Army Medical University, Chongqing 400042, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Daping Hospital, Army Medical University, Chongqing 400042, China"},{"name":"Research Center for Skin Tissue Engineering of Chongqing Higher Education Institutions, Daping Hospital, Army Medical University, Chongqing 400042, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1002\/msb.201304521","article-title":"Evolution and functional cross-talk of protein post-translational modifications","volume":"9","author":"Beltrao","year":"2013","journal-title":"Mol. 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