{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T21:36:40Z","timestamp":1788989800581,"version":"build-2803163510"},"reference-count":148,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82460731"],"award-info":[{"award-number":["82460731"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82003836"],"award-info":[{"award-number":["82003836"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Key R&D Plan Project of Ningxia","award":["2024BEG01006"],"award-info":[{"award-number":["2024BEG01006"]}]},{"name":"Key R&D Plan Project of Ningxia","award":["2021BEB04080"],"award-info":[{"award-number":["2021BEB04080"]}]},{"name":"Research Project of Key Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, Ningxia Medical University","award":["KFKT202313"],"award-info":[{"award-number":["KFKT202313"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>The incidence of kidney diseases has been increasing due to changes in modern lifestyles and the ecological environment. The progression of kidney disease is characterized by ongoing renal damage and a gradual decline in renal function, ultimately leading to end-stage renal disease. The limitations of present medications have brought many disadvantages to patients. Consequently, identifying bioactive molecules has emerged as a critical strategy in the development of novel therapies for kidney diseases, particularly those derived from natural medicinal resources. This review presents a comprehensive analysis of renoprotective effects and underlying mechanisms of the medicinal plant Scutellaria baicalensis Georgi based on evidence retrieved from multiple databases, including Web of Science, PubMed, and CNKI. Flavonoids from S. baicalensis have been demonstrated to have good renoprotective properties by mitigating inflammation and oxidative stress, inhibiting cell apoptosis, reducing renal fibrosis, etc. Baicalein, wogonin, baicalin, and wogonoside are considered as the main bioactive components of the renoprotective effect of S. baicalensis. Further research on candidate molecules derived from S. baicalensis represents a promising strategy for the development of novel therapeutic agents targeting kidney diseases.<\/jats:p>","DOI":"10.3390\/biom16010064","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T16:34:23Z","timestamp":1767198863000},"page":"64","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Scutellaria baicalensis Georgi: A Promising Source of Bioactive Molecules for Kidney Disease Therapy"],"prefix":"10.3390","volume":"16","author":[{"given":"Xia","family":"Yang","sequence":"first","affiliation":[{"name":"Key Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, School of Pharmacy, Ningxia Medical University, No. 1160 Shengli Street, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Dou","sequence":"additional","affiliation":[{"name":"School of Medical Care, Sichuan Vocational and Technical College, No. 1 Xuefu North Road, Suining 629000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lang","family":"Hai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, School of Pharmacy, Ningxia Medical University, No. 1160 Shengli Street, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Xiao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, School of Pharmacy, Ningxia Medical University, No. 1160 Shengli Street, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Cui","sequence":"additional","affiliation":[{"name":"Key Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, School of Pharmacy, Ningxia Medical University, No. 1160 Shengli Street, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Cai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, School of Pharmacy, Ningxia Medical University, No. 1160 Shengli Street, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, School of Pharmacy, Ningxia Medical University, No. 1160 Shengli Street, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Ji","sequence":"additional","affiliation":[{"name":"Key Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, School of Pharmacy, Ningxia Medical University, No. 1160 Shengli Street, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalong","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Xianyang Normal University, Xianyang 712000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5564-4610","authenticated-orcid":false,"given":"Hua","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, School of Pharmacy, Ningxia Medical University, No. 1160 Shengli Street, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1542\/pir.2021-005438","article-title":"Acute kidney injury","volume":"44","author":"Menon","year":"2023","journal-title":"Pediatr. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1093\/ndt\/gfz174","article-title":"A single number for advocacy and communication-worldwide more than 850 million individuals have kidney diseases","volume":"34","author":"Jager","year":"2019","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/s41581-024-00823-3","article-title":"Drug stewardship in chronic kidney disease to achieve effective and safe medication use","volume":"20","author":"Hall","year":"2024","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"101690","DOI":"10.1016\/j.xcrm.2024.101690","article-title":"The SGLT2 inhibitor dapagliflozin ameliorates renal fibrosis in hyperuricemic nephropathy","volume":"5","author":"Hu","year":"2024","journal-title":"Cell Rep. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1007\/s11883-023-01172-5","article-title":"Emerging preventive strategies in chronic kidney disease: Recent evidence and gaps in knowledge","volume":"25","author":"Pradhan","year":"2023","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.clnu.2023.01.018","article-title":"Nutritional status and the risk of malnutrition in older adults with chronic kidney disease-implications for low protein intake and nutritional care: A critical review endorsed by ERN-ERA and ESPEN","volume":"42","author":"Piccoli","year":"2023","journal-title":"Clin. Nutr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0140-6736(24)02385-7","article-title":"Acute kidney injury","volume":"405","author":"Ostermann","year":"2025","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1053\/j.ajkd.2020.03.023","article-title":"NSAIDs in CKD: Are they safe?","volume":"76","author":"Baker","year":"2020","journal-title":"Am. J. Kidney Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"i3","DOI":"10.1093\/ndt\/gfae212","article-title":"Combination therapy: An upcoming paradigm to improve kidney and cardiovascular outcomes in chronic kidney disease","volume":"40","author":"Alicic","year":"2025","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1093\/ndt\/gfae037","article-title":"Pros and cons of the use of fluoroquinolone antibiotics in patients with kidney disease","volume":"39","author":"Ahmadi","year":"2024","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1161\/HYPERTENSIONAHA.122.17944","article-title":"Novel drug delivery technologies and targets for renal disease","volume":"79","author":"Chade","year":"2022","journal-title":"Hypertension"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/ndt\/gfv346","article-title":"Multicentre randomized controlled trial of angiotensin-converting enzyme inhibitor\/angiotensin receptor blocker withdrawal in advanced renal disease: The STOP-ACEi trial","volume":"31","author":"Bhandari","year":"2016","journal-title":"Nephrol. Dial. Transpl."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.2215\/CJN.00150118","article-title":"Pharmacology behind common drug nephrotoxicities","volume":"13","author":"Perazella","year":"2018","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nrc1317","article-title":"Microtubules as a target for anticancer drugs","volume":"4","author":"Jordan","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4904","DOI":"10.1021\/ja809842b","article-title":"Total synthesis of vinblastine, vincristine, related natural products, and key structural analogues","volume":"31","author":"Ishikawa","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"920","DOI":"10.2174\/0929867330666230208094828","article-title":"A review on shikonin and its derivatives as potent anticancer agents targeted against topoisomerases","volume":"31","author":"Olatunde","year":"2023","journal-title":"Curr. Med. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/nm.2471","article-title":"The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine","volume":"17","author":"Tu","year":"2011","journal-title":"Nat. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1634\/theoncologist.2009-0104","article-title":"Trabectedin","volume":"14","author":"Chuk","year":"2009","journal-title":"Oncologist"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1007\/s11434-016-1136-5","article-title":"Scutellaria baicalensis, the golden herb from the garden of chinese medicinal plants","volume":"61","author":"Zhao","year":"2016","journal-title":"Sci. Bull."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"154195","DOI":"10.1016\/j.phymed.2022.154195","article-title":"Deciphering the pharmacological mechanisms of Scutellaria baicalensis Georgi on oral leukoplakia by combining network pharmacology, molecular docking and experimental evaluations","volume":"103","author":"Hou","year":"2022","journal-title":"Phytomedicine"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1021\/np9904509","article-title":"Flavonoids as antioxidants","volume":"63","author":"Pietta","year":"2000","journal-title":"J. Nat. Prod."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0163-7258(02)00298-X","article-title":"The biochemistry and medical significance of the flavonoids","volume":"96","author":"Havsteen","year":"2002","journal-title":"Pharmacol. Ther."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0955-2863(02)00208-5","article-title":"Flavonoid antioxidants: Chemistry, metabolism and structure-activity relationships","volume":"13","author":"Heim","year":"2002","journal-title":"J. Nutr. Biochem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1254\/jphs.CRJ04003X","article-title":"Anti-inflammatory plant flavonoids and cellular action mechanisms","volume":"96","author":"Kim","year":"2004","journal-title":"J. Pharmacol. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nature15695","article-title":"Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis","volume":"526","author":"Takasato","year":"2015","journal-title":"Nature"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"c179","DOI":"10.1159\/000339789","article-title":"KDIGO clinical practice guidelines for acute kidney injury","volume":"120","author":"Khwaja","year":"2012","journal-title":"Nephron. Clin. Pract."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.pop.2020.08.008","article-title":"Acute kidney injury","volume":"47","author":"Jacob","year":"2020","journal-title":"Prim. Care"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1056\/NEJM199605303342207","article-title":"Acute renal failure","volume":"334","author":"Thadhani","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"17781","DOI":"10.1038\/s41598-023-45006-5","article-title":"Clinical courses of acute kidney injury in hospitalized patients: A multistate analysis","volume":"13","author":"Adiyeke","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.2215\/CJN.15341121","article-title":"Low-flow acute kidney injury: The pathophysiology of prerenal azotemia, abdominal compartment syndrome, and obstructive uropathy","volume":"17","author":"Molitoris","year":"2022","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1007\/s00134-015-3934-7","article-title":"Epidemiology of acute kidney injury in critically ill patients: The multinational AKI-EPI study","volume":"41","author":"Hoste","year":"2015","journal-title":"Intensive Care Med."},{"key":"ref_32","first-page":"550","article-title":"Drug-induced acute kidney injury: Diverse mechanisms of tubular injury","volume":"25","author":"Perazella","year":"2019","journal-title":"Curr. Opin. Crit. Care"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.2215\/CJN.11290821","article-title":"Drug-induced acute kidney injury","volume":"17","author":"Perazella","year":"2022","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41572-021-00284-z","article-title":"Acute kidney injury","volume":"7","author":"Kellum","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/S0140-6736(16)32064-5","article-title":"Chronic kidney disease","volume":"389","author":"Webster","year":"2017","journal-title":"Lancet"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41371-022-00751-4","article-title":"Hypertension and cardiomyopathy associated with chronic kidney disease: Epidemiology, pathogenesis and treatment considerations","volume":"37","author":"Law","year":"2023","journal-title":"J. Hum. Hypertens."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/ki.2013.243","article-title":"Comments on \u2018kdigo 2012 clinical practice guideline for the evaluation and management of chronic kidney disease\u2019","volume":"84","author":"Andrassy","year":"2013","journal-title":"Kidney Int."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"825","DOI":"10.7326\/0003-4819-158-11-201306040-00007","article-title":"Evaluation and management of chronic kidney disease: Synopsis of the kidney disease: Improving global outcomes 2012 clinical practice guideline","volume":"158","author":"Stevens","year":"2013","journal-title":"Ann. Intern. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.kint.2020.02.010","article-title":"Nomenclature for kidney function and disease: Report of a kidney disease: Improving global outcomes (KDIGO) consensus conference","volume":"97","author":"Levey","year":"2020","journal-title":"Kidney Int."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nrneph.2017.2","article-title":"Acute kidney disease and renal recovery: Consensus report of the acute disease quality initiative (ADQI) 16 workgroup","volume":"13","author":"Chawla","year":"2017","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.ccc.2020.11.013","article-title":"Acute kidney disease to chronic kidney disease","volume":"37","author":"Neyra","year":"2021","journal-title":"Crit. Care Clin."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1056\/NEJMra1214243","article-title":"Acute kidney injury and chronic kidney disease as interconnected syndromes","volume":"371","author":"Chawla","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1080\/13880209.2018.1492620","article-title":"A comprehensive review on phytochemistry, pharmacology, and flavonoid biosynthesis of Scutellaria baicalensis","volume":"56","author":"Wang","year":"2018","journal-title":"Pharm. Biol."},{"key":"ref_44","first-page":"578","article-title":"Flavonoids from Scutellaria baicalensis and their bioactivities","volume":"41","author":"Zhou","year":"2009","journal-title":"J. Peking Univ. Health Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1111\/jphp.13129","article-title":"Scutellaria baicalensis Georgi. (Lamiaceae): A review of its traditional uses, botany, phytochemistry, pharmacology and toxicology","volume":"71","author":"Zhao","year":"2019","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s13020-020-00384-0","article-title":"Applications, phytochemistry, pharmacological effects, pharmacokinetics, toxicity of Scutellaria baicalensis Georgi. and its probably potential therapeutic effects on COVID-19: A review","volume":"15","author":"Song","year":"2020","journal-title":"Chin. Med."},{"key":"ref_47","first-page":"575","article-title":"General situation of chemical constitutions anddrug-processing of Scutellaria baicalensis Georgi","volume":"16","author":"Wen","year":"2004","journal-title":"Nat. Prod. Res. Dev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e36146","DOI":"10.1016\/j.heliyon.2024.e36146","article-title":"Recent advances in Scutellariae radix: A comprehensive review on ethnobotanical uses, processing, phytochemistry, pharmacological effects, quality control and influence factors of biosynthesis","volume":"10","author":"Ma","year":"2024","journal-title":"Heliyon"},{"key":"ref_49","first-page":"131","article-title":"Optimization of extraction process of flavonoids from Scutellaria baicalensis stem and leaf by response surface methodology and its content determination","volume":"23","author":"Yan","year":"2024","journal-title":"Hubei Agric. Sci."},{"key":"ref_50","first-page":"31","article-title":"Preparation and characterization of high-purity baicalein","volume":"25","author":"Jiang","year":"2008","journal-title":"J. Beijing Univ. Chem. Technol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.ijpharm.2017.06.068","article-title":"Enhancement of solubility and dissolution rate of baicalein, wogonin and oroxylin A extracted from Radix scutellariae","volume":"528","author":"Yu","year":"2017","journal-title":"Int. J. Pharm."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"5287","DOI":"10.2147\/IJN.S383182","article-title":"Preparation, characterization, and staphylococcus aureus biofilm elimination effect of baicalein-loaded \u03b2-cyclodextrin-grafted chitosan nanoparticles","volume":"17","author":"Zhang","year":"2022","journal-title":"Int. J. Nanomed."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.colsurfb.2017.10.009","article-title":"Apolipoproteins adsorption and brain-targeting evaluation of baicalin nanocrystals modified by combination of Tween 80 and TPGS","volume":"160","author":"Liu","year":"2017","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"251","DOI":"10.2147\/IJN.S119895","article-title":"Lung-targeting drug delivery system of baicalin-loaded nanoliposomes: Development, biodistribution in rabbits, and pharmacodynamics in nude mice bearing orthotopic human lung cancer","volume":"12","author":"Wei","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1080\/03639045.2017.1391831","article-title":"Formulation optimization and the absorption mechanisms of nanoemulsion in improving baicalin oral exposure","volume":"44","author":"Wu","year":"2018","journal-title":"Drug Dev. Ind. Pharm."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.ejps.2012.07.006","article-title":"Development and optimization of baicalin-loaded solid lipid nanoparticles prepared by coacervation method using central composite design","volume":"47","author":"Hao","year":"2012","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1002\/j.2040-4603.2012.tb00431.x","article-title":"Pathophysiology of acute kidney injury","volume":"2","author":"Basile","year":"2012","journal-title":"Compr. Physiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/s41581-018-0052-0","article-title":"Global epidemiology and outcomes of acute kidney injury","volume":"14","author":"Hoste","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_59","first-page":"69","article-title":"Baicalin attenuates lipopolysaccharide-induced renal tubular epithelial cell injury by inhibiting the TXNIP\/NLRP3 signalling pathway via increasing miR-223-3p expression","volume":"34","author":"Sun","year":"2020","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000492159","article-title":"Enteral baicalin, a flavone glycoside, reduces indicators of cardiac surgery-associated acute kidney injury in rats","volume":"9","author":"Shi","year":"2019","journal-title":"Cardiorenal Med."},{"key":"ref_61","first-page":"1704","article-title":"Propofol\u2019s protective effect enhancement by baicalin mediated activation of Nrf2\/HO-1 pathway on renal ischemia-reperfusion injury rats","volume":"36","author":"Li","year":"2021","journal-title":"Acta Chin. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"12507","DOI":"10.3390\/ijms150712507","article-title":"Baicalin ameliorates H2O2 induced cytotoxicity in HK-2 cells through the inhibition of ER stress and the activation of Nrf2 signaling","volume":"15","author":"Lin","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Wang, Y., Li, X., Yan, C., Xie, L., and Yang, Y. (2023). Baicalin exhibits a protective effect against cisplatin-induced cytotoxic damage in canine renal tubular epithelial cells. Metabolites, 13.","DOI":"10.3390\/metabo13121173"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"108097","DOI":"10.1016\/j.intimp.2021.108097","article-title":"Baicalin protects against zearalenone-induced chicks liver and kidney injury by inhibiting expression of oxidative stress, inflammatory cytokines and caspase signaling pathway","volume":"100","author":"Xu","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Lin, M., Li, L., Li, L., Pokhrel, G., Qi, G., Rong, R., and Zhu, T. (2014). The protective effect of baicalin against renal ischemia-reperfusion injury through inhibition of inflammation and apoptosis. BMC Complement. Altern. Med., 14.","DOI":"10.1186\/1472-6882-14-19"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"20587384211073397","DOI":"10.1177\/20587384211073397","article-title":"Protective effect of baicalin against arsenic trioxide-induced acute hepatic injury in mice through JAK2\/STAT3 signaling pathway","volume":"36","author":"He","year":"2022","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_67","first-page":"1204","article-title":"Study on the mechanism of protective effect of baicalin on acute kidney injury in rats with crush syndrome","volume":"31","author":"Xing","year":"2022","journal-title":"Mod. J. Integr. Tradit. Chin. West. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"372","DOI":"10.24976\/Discov.Med.202335176.38","article-title":"Baicalin reduces renal inflammation in mesangial proliferative glomerulonephritis through activation of Nrf2\/ARE and PI3K\/AKT pathways","volume":"35","author":"Ning","year":"2023","journal-title":"Discov. Med."},{"key":"ref_69","first-page":"469","article-title":"The role of NF-\u03baB in the protective effects of baicalin for septic rats\u2019 kidneys","volume":"18","author":"Xi","year":"2011","journal-title":"Chin. J. Clin. Med."},{"key":"ref_70","first-page":"2465","article-title":"Protective effect and mechanism of baicalin on acute kidney injury in duced by rhabdomyolysis syndrome in rats","volume":"20","author":"Li","year":"2023","journal-title":"Lab. Med. Clin."},{"key":"ref_71","first-page":"432","article-title":"Protective effect of baicalin on acute kidney injury induced by aristolochic acid in mice","volume":"26","author":"Jia","year":"2019","journal-title":"Chin. J. Clin. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"5109","DOI":"10.12659\/MSM.899061","article-title":"Baicalin inhibits renal cell apoptosis and protects against acute kidney injury in pediatric sepsis","volume":"22","author":"Zhu","year":"2016","journal-title":"Med. Sci. Monit."},{"key":"ref_73","first-page":"866","article-title":"Protective effect and mechanism of baicalin on acute kidney injury in septic mice","volume":"33","author":"Le","year":"2021","journal-title":"Chin. Crit. Care Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1016\/j.biopha.2018.09.107","article-title":"A potential role of baicalin to inhibit apoptosis and protect against acute liver and kidney injury in rat preeclampsia model","volume":"108","author":"Wang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.2147\/DDDT.S379629","article-title":"Baicalin alleviates contrast-induced acute kidney injury through ROS\/NLRP3\/Caspase-1\/GSDMD pathway-mediated proptosis in vitro","volume":"16","author":"Li","year":"2022","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Sahu, B.D., Mahesh Kumar, J., and Sistla, R. (2015). Baicalein, a bioflavonoid, prevents cisplatin-induced acute kidney injury by up-regulating antioxidant defenses and down-regulating the MAPKs and NF-\u03baB pathways. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0134139"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"e7476","DOI":"10.1590\/1414-431x20187476","article-title":"Baicalein alleviates tubular-interstitial nephritis in vivo and in vitro by down-regulating NF-\u03baB and MAPK pathways","volume":"51","author":"Chen","year":"2018","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_78","first-page":"181","article-title":"Baicalein, a component of Scutellaria baicalensis, attenuates kidney injury induced by myocardial ischemia and reperfusion","volume":"82","author":"Lai","year":"2016","journal-title":"Planta Med."},{"key":"ref_79","first-page":"121","article-title":"Baicalein intervenes in the Nrf-2\/HO-1 signaling pathway reduces kidney injury in sepsis mice","volume":"45","author":"Hu","year":"2025","journal-title":"Chin. J. Vet. Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1093\/jac\/dkx185","article-title":"Baicalein acts as a nephroprotectant that ameliorates colistin-induced nephrotoxicity by activating the antioxidant defence mechanism of the kidneys and down-regulating the inflammatory response","volume":"72","author":"Dai","year":"2017","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3109\/0886022X.2014.991999","article-title":"Protective effect of baicalein on renal ischemia\/reperfusion injury in the rat","volume":"37","author":"Wu","year":"2015","journal-title":"Ren. Fail."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"110607","DOI":"10.1016\/j.cbi.2023.110607","article-title":"Baicalein ameliorates polymyxin B-induced acute renal injury by inhibiting ferroptosis via regulation of SIRT1\/p53 acetylation","volume":"382","author":"Yu","year":"2023","journal-title":"Chem. Biol. Interact."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"155757","DOI":"10.1016\/j.phymed.2024.155757","article-title":"Baicalein alleviates cisplatin-induced acute kidney injury by inhibiting ALOX12-dependent ferroptosis","volume":"130","author":"Guo","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/labinvest.2017.115","article-title":"Wogonin protects against cisplatin-induced acute kidney injury by targeting RIPK1-mediated necroptosis","volume":"98","author":"Meng","year":"2018","journal-title":"Lab. Invest"},{"key":"ref_85","first-page":"1411","article-title":"Protective effect of wogonin on lipopolysaccharide-induced acute kidney injury in mice","volume":"59","author":"Wang","year":"2024","journal-title":"Acta Univ. Med. Anhui"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Qi, Q., Li, Y., Ding, M., Huang, C., Omar, S.M., Shi, Y., Liu, P., Cai, G., Zheng, Z., and Guo, X. (2024). Wogonin inhibits apoptosis and necroptosis induced by nephropathogenic infectious bronchitis virus in chicken renal tubular epithelial cells. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25158194"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.2215\/CJN.11491116","article-title":"Diabetic kidney disease: Challenges, progress, and possibilities","volume":"12","author":"Alicic","year":"2017","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.mcna.2023.03.004","article-title":"Diabetic kidney disease: An update","volume":"107","author":"Gupta","year":"2023","journal-title":"Med. Clin. N. Am."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"15018","DOI":"10.1038\/nrdp.2015.18","article-title":"Diabetic kidney disease","volume":"1","author":"Thomas","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.2147\/DDDT.S319260","article-title":"Baicalin alleviates oxidative stress and inflammation in diabetic nephropathy via Nrf2 and MAPK signaling pathway","volume":"15","author":"Ma","year":"2021","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.2147\/DMSO.S407177","article-title":"Baicalin exerts a protective effect in diabetic nephropathy by repressing inflammation and oxidative stress through the SphK1\/S1P\/NF-\u03baB signaling pathway","volume":"16","author":"Ren","year":"2023","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_92","first-page":"186","article-title":"Baicalin improves diabetic nephropathy in mice by activating Sirt1\/Nrf2 signal through miR-141 inhibition","volume":"40","author":"Yin","year":"2019","journal-title":"Med. J. Wuhan Univ."},{"key":"ref_93","first-page":"419","article-title":"Baicalin regulate oxidative stress to prevent and treat diabetic nephropathy","volume":"22","author":"Xi","year":"2024","journal-title":"Chin. J. Bioprocess. Eng."},{"key":"ref_94","first-page":"488","article-title":"Effect of baicalin capsules on kidney pathological morphology and protein kinase C in the rats of diabetic nephropath","volume":"11","author":"Zhao","year":"2016","journal-title":"World J. Integr. Tradit. West. Med."},{"key":"ref_95","first-page":"19","article-title":"The research of kidney-protective effects of erigeron breviscapus on diabetic nephropathy in rats","volume":"11","author":"Zhang","year":"2003","journal-title":"Chin. J. Diabetes"},{"key":"ref_96","first-page":"885","article-title":"The protective effect of baicalin on the kidney of STZ induced diabeti crats and its relation to VEGF","volume":"27","author":"Hu","year":"2007","journal-title":"Chin. J. Hosp. Pharm."},{"key":"ref_97","unstructured":"Zhao, B.L. (2015). The effects of baicalin on phosphorylation sites on the Connexin43 gap junction protein in diabetic nephropathy rats kidney. [Master\u2019s Thesis, Guangzhou University]."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"156473","DOI":"10.1016\/j.phymed.2025.156473","article-title":"Baicalin alleviates lipid metabolism disorders in diabetic kidney disease via targeting FKBP51","volume":"139","author":"Li","year":"2025","journal-title":"Phytomedicine"},{"key":"ref_99","first-page":"4659","article-title":"AMPK\u03b1, hs-CRP and Fc\u03b3R in diabetic nephropathy and drug intervention","volume":"15","author":"Sun","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"ref_100","first-page":"555","article-title":"Inhibition of 12\/15-lipoxygenase reduces renal inflammation and injury in streptozotocin-induced diabetic mice","volume":"6","author":"Faulkner","year":"2015","journal-title":"J. Diabetes Metab."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.biochi.2014.08.006","article-title":"Prophylactic effect of baicalein against renal dysfunction in type 2 diabetic rats","volume":"106","author":"Ahad","year":"2014","journal-title":"Biochimie"},{"key":"ref_102","first-page":"5","article-title":"Effects of wogonin on blood glucose and renal tissue TLR4 and NF-\u03baB p65 levels in rats with diabetic nephropathy","volume":"27","author":"Hou","year":"2021","journal-title":"Guid. J. Tradit. Chin. Med. Pharm."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.2147\/DDDT.S310882","article-title":"Wogonin alleviates kidney tubular epithelial injury in diabetic nephropathy by inhibiting PI3K\/Akt\/NF-\u03baB signaling pathways","volume":"15","author":"Lei","year":"2021","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_104","first-page":"1523","article-title":"Effect of wogonoside on KLF4\/NF-\u03baB signal pathway in RAW264.7 macrophages stimulated by high glucose","volume":"57","author":"Xie","year":"2022","journal-title":"Act. Univ. Med. Anhui"},{"key":"ref_105","unstructured":"Xie, S. (2022). Wogonoside interferes with DNM3OS\/KLF4 pathway and regulates macrophage activation in diabetic nephropathy. [Master\u2019s Thesis, Anhui Medical University]."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41401-021-00721-5","article-title":"Wogonin protects glomerular podocytes by targeting Bcl-2-mediated autophagy and apoptosis in diabetic kidney disease","volume":"43","author":"Liu","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_107","unstructured":"Wang, Y. (2020). Protective effect and mechanism of wogonin on diabetic kidney podocyte injury. [Ph.D. Thesis, Anhui Medical University]."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"114481","DOI":"10.1016\/j.intimp.2025.114481","article-title":"Wogonoside ameliorates oxidative damage in tubular epithelial cells of diabetic nephropathy by modulating the HNF4A-NRF2 axis","volume":"152","author":"Li","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41584-018-0004-x","article-title":"An update on the genetics of hyperuricaemia and gout","volume":"14","author":"Major","year":"2018","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.jare.2017.03.003","article-title":"Physiological functions and pathogenic potential of uric acid: A review","volume":"8","author":"Tallima","year":"2017","journal-title":"J. Adv. Res."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Casanova, A.G., Morales, A.I., Vicente-Vicente, L., and L\u00f3pez-Hern\u00e1ndez, F.J. (2024). Effect of uric acid reduction on chronic kidney disease. Systematic review and meta-analysis. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1373258"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"5817348","DOI":"10.1155\/2020\/5817348","article-title":"Research advances in the mechanisms of hyperuricemia-induced renal injury","volume":"2020","author":"Su","year":"2020","journal-title":"BioMed Res. Int."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"e14522","DOI":"10.1111\/cbdd.14522","article-title":"Baicalin inhibits monosodium urate crystal-induced pyroptosis in renal tubular epithelial cell line through Panx-1\/P2X7 pathways: Molecular docking, molecular dynamics, and in vitro experiments","volume":"103","author":"Fu","year":"2024","journal-title":"Chem. Biol. Drug Des."},{"key":"ref_114","unstructured":"Liu, Y.J. (2020). Study on the effect and mechanism of baicalin against hyperuricemia nephropathy. [Master\u2019s Thesis, Wuhan Polytechnic University]."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/nep.14159","article-title":"Baicalin and baicalein attenuate hyperuricemic nephropathy via inhibiting PI3K\/AKT\/NF-\u03baB signalling pathway","volume":"28","author":"Liu","year":"2023","journal-title":"Nephrology"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"115594","DOI":"10.1016\/j.taap.2021.115594","article-title":"Network pharmacology and molecular docking analysis on molecular targets: Mechanisms of baicalin and baicalein against hyperuricemic nephropathy","volume":"424","author":"Xiang","year":"2021","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"40305","DOI":"10.18632\/oncotarget.16928","article-title":"Baicalein decreases uric acid and prevents hyperuricemic nephropathy in mice","volume":"8","author":"Meng","year":"2017","journal-title":"Oncotarget"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"153374","DOI":"10.1016\/j.phymed.2020.153374","article-title":"Baicalein alleviates hyperuricemia by promoting uric acid excretion and inhibiting xanthine oxidase","volume":"80","author":"Chen","year":"2021","journal-title":"Phytomedicine"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"121033","DOI":"10.1016\/j.lfs.2022.121033","article-title":"Advances in energy metabolism in renal fibrosis","volume":"312","author":"Wei","year":"2023","journal-title":"Life Sci."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/nep.13808","article-title":"Advances in understanding the role of adiponectin in renal fibrosis","volume":"26","author":"Zhao","year":"2021","journal-title":"Nephrology"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"F674","DOI":"10.1152\/ajprenal.00196.2020","article-title":"C57BL\/6 mice require a higher dose of cisplatin to induce renal fibrosis and CCL2 correlates with cisplatin-induced kidney injury","volume":"319","author":"Sears","year":"2020","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"154049","DOI":"10.1016\/j.phymed.2022.154049","article-title":"Antifibrotic activities of Scutellariae Radix extracts and flavonoids: Comparative proteomics reveals distinct and shared mechanisms","volume":"100","author":"Zhou","year":"2022","journal-title":"Phytomedicine"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jep.2016.06.014","article-title":"Metabolomics study of renal fibrosis and intervention effects of total aglycone extracts of Scutellaria baicalensis in unilateral ureteral obstruction rats","volume":"192","author":"Fang","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"3074","DOI":"10.3892\/etm.2017.4888","article-title":"Baicalin and baicalein attenuate renal fibrosis in vitro via inhibition of the TGF-\u03b21 signaling pathway","volume":"14","author":"Hu","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/bju.13219","article-title":"Baicalein ameliorates renal interstitial fibrosis by inducing myofibroblast apoptosis in vivo and in vitro","volume":"118","author":"Wang","year":"2016","journal-title":"BJU Int."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s10735-015-9621-8","article-title":"Baicalein attenuates renal fibrosis by inhibiting inflammation via down-regulating NF-\u03baB and MAPK signal pathways","volume":"46","author":"Wang","year":"2015","journal-title":"J. Mol. Histol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"e28954","DOI":"10.1016\/j.heliyon.2024.e28954","article-title":"Baicalein improves renal interstitial fibrosis by inhibiting the ferroptosis in vivo and in vitro","volume":"10","author":"Liang","year":"2024","journal-title":"Heliyon"},{"key":"ref_128","unstructured":"Miao, S.H. (2017). Effects of baicalein on endoplasmic reticulum stresspathway in rats with renal interstitial fibrosis. [Master\u2019s Thesis, Lanzhou University]."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1080\/13880209.2022.2097700","article-title":"Baicalin protects against renal interstitial fibrosis in mice by inhibiting the TGF-\u03b2\/Smad signalling pathway","volume":"60","author":"Wang","year":"2022","journal-title":"Pharm. Biol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.3892\/mmr.2017.6208","article-title":"Baicalin ameliorates renal fibrosis via inhibition of transforming growth factor \u03b21 production and downstream signal transduction","volume":"15","author":"Zheng","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_131","first-page":"864","article-title":"Effect of baicalin on human renal tubular epithelial cell transdifferentiation induced by TGF-\u03b21 in vitro","volume":"12","author":"Liu","year":"2011","journal-title":"Chin. J. Integr. Tradit. West. Nephrol."},{"key":"ref_132","first-page":"365","article-title":"Therapeutic effect of baicalin in treatment of renal interstitial fibrosis in rats with unliateral ureteral obstruction and related mechanisms","volume":"18","author":"Tan","year":"2016","journal-title":"Chin. J. Contemp. Pediatr."},{"key":"ref_133","first-page":"201","article-title":"Effect of baicalin on plasma and renal Ang\u2161 in diabetic nephropathy rats","volume":"20","author":"Su","year":"2009","journal-title":"Tradit. Chin. Drug Res. Clin. Pharmacol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s13105-020-00747-z","article-title":"Baicalin suppresses renal fibrosis through microRNA-124\/TLR4\/NF-\u03baB axis in streptozotocin-induced diabetic nephropathy mice and high glucose-treated human proximal tubule epithelial cells","volume":"76","author":"Zhang","year":"2020","journal-title":"J. Physiol. Biochem."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"155162","DOI":"10.1016\/j.phymed.2023.155162","article-title":"Baicalin ameliorates renal fibrosis by upregulating CPT1\u03b1-mediated fatty acid oxidation in diabetic kidney disease","volume":"122","author":"Hu","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2017.08.003","article-title":"High doses of baicalin induces kidney injury and fibrosis through regulating TGF-\u03b2\/Smad signaling pathway","volume":"333","author":"Cai","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_137","unstructured":"Li, F. (2011). The role of baicalin bai against glomerulosclerosis by regulating CTGF. [Master\u2019s Thesis, Guangzhou University of Chinese Medicine]."},{"key":"ref_138","first-page":"471","article-title":"Effect of baicalin on renal fibrosis in rats with diabetic nephropathy by TGF-\u03b21","volume":"33","author":"Zheng","year":"2020","journal-title":"J. Med. Res. Combat. Trauma. Care"},{"key":"ref_139","first-page":"2261","article-title":"Baicalin improves renal fibrosis in rats with chronic kidney disease by regulating the galectin-3\/Akt\/GSK-3B\/Snail signaling pathway","volume":"46","author":"Liu","year":"2024","journal-title":"Hebei Med. J."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1080\/15384101.2020.1843815","article-title":"Baicalin reversal of DNA hypermethylation-associated Klotho suppression ameliorates renal injury in type 1 diabetic mouse model","volume":"19","author":"Zhang","year":"2020","journal-title":"Cell Cycle"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"117742","DOI":"10.1016\/j.lfs.2020.117742","article-title":"Baicalin attenuates fibrogenic process in human renal proximal tubular cells (HK-2) exposed to diabetic milieu","volume":"254","author":"Nam","year":"2020","journal-title":"Life Sci."},{"key":"ref_142","first-page":"2109","article-title":"Study on the mechanism of wogonoside protecting against renal injury and fibrosis in diabetic rats","volume":"39","author":"Ke","year":"2022","journal-title":"J. Guangzhou Univ. Tradit. Chin. Med."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ejphar.2016.07.014","article-title":"Anti-fibrotic effect of wogonin in renal tubular epithelial cells via Smad3-dependent mechanisms","volume":"789","author":"Meng","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"ref_144","first-page":"1840","article-title":"Effect of baicalin modulation of TLR4\/MAPK\/NF-KB signaling pathway on renal fibrosis in rats with diabetic nephropathy","volume":"39","author":"Zhang","year":"2023","journal-title":"Chin. Pharmacol. Bull."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"176676","DOI":"10.1016\/j.ejphar.2024.176676","article-title":"Wogonin ameliorates ER stress-associated inflammatory response, apoptotic death and renal fibrosis in a unilateral ureteral obstruction mouse model","volume":"977","author":"Kuo","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"ref_146","first-page":"11574","article-title":"Molecular docking and network pharmacological analysis of Scutellaria baicalensis against renal cell carcinoma","volume":"27","author":"Guo","year":"2023","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_147","unstructured":"Wang, Y. (2021). The role of wogonin in the malignant behavior and resistance to targeted drug of renal cell carcinoma. [Ph.D. Thesis, Shandong University]."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Wang, Y., Chen, S., Sun, S., Liu, G., Chen, L., Xia, Y., Cui, J., Wang, W., Jiang, X., and Zhang, L. (2020). Wogonin induces apoptosis and reverses sunitinib resistance of renal cell carcinoma cells via inhibiting CDK4-RB pathway. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.01152"}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/1\/64\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T05:18:23Z","timestamp":1767331103000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/1\/64"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,31]]},"references-count":148,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["biom16010064"],"URL":"https:\/\/doi.org\/10.3390\/biom16010064","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,31]]}}}