{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T19:39:36Z","timestamp":1767641976185,"version":"3.48.0"},"reference-count":185,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Griffith University Postgraduate Research Scholarship"},{"name":"Griffith University International Postgraduate Research Scholarship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Spinal cord injury (SCI) is a debilitating condition resulting in a range of neurological impairments up to complete loss of function below the level of injury. With current clinical management limited to decompression and stabilisation of the injury, there is urgent need to develop effective restorative treatments. In animal models, cell transplantation therapies are being tested that utilise different cell types including olfactory ensheathing cells (OECs), a type of glial cell, to support and promote regeneration. While OECs have a unique combination of properties highly suitable for SCI repair, their efficacy and consistency need to be improved. Evidence suggests a combinational approach using growth factors or compounds alongside OECs may stimulate their innate properties and alter the internal milieu of an injury site in favour of neural repair. Naturally, there is intricate interplay between various growth factors and OECs during development of the olfactory system, and in injury and repair events, which regulate their migration, phagocytosis, and proliferation. Therefore, exploiting different growth factors to selectively enhance OECs\u2019 therapeutic potential could lead to restorative treatment of SCI. While some studies have already explored using growth factors to treat SCI in animal models, an optimal \u2018cocktail\u2019 has yet to be identified. In seeking to identify such a cocktail, this review presents the current understanding of SCI and the therapeutic potential of OECs and explores combined use of growth factors and OECs to improve treatment outcomes.<\/jats:p>","DOI":"10.3390\/biom16010086","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T16:07:07Z","timestamp":1767629227000},"page":"86","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Scent of a Therapy for Spinal Cord Injury: Growth Factors and Their Potential to Modulate Olfactory Ensheathing Cells"],"prefix":"10.3390","volume":"16","author":[{"given":"Tobias S. G.","family":"Seeberger","sequence":"first","affiliation":[{"name":"Clem Jones Centre for Neurobiology and Stem Cell Research, Institute for Biomedicine and Glycomics, Griffith University, Parklands Drive, Gold Coast, QLD 4222, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7087-3809","authenticated-orcid":false,"given":"Mariyam","family":"Murtaza","sequence":"additional","affiliation":[{"name":"Clem Jones Centre for Neurobiology and Stem Cell Research, Institute for Biomedicine and Glycomics, Griffith University, Parklands Drive, Gold Coast, QLD 4222, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Rayfield","sequence":"additional","affiliation":[{"name":"Clem Jones Centre for Neurobiology and Stem Cell Research, Institute for Biomedicine and Glycomics, Griffith University, Parklands Drive, Gold Coast, QLD 4222, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7536-3381","authenticated-orcid":false,"given":"James A.","family":"St John","sequence":"additional","affiliation":[{"name":"Clem Jones Centre for Neurobiology and Stem Cell Research, Institute for Biomedicine and Glycomics, Griffith University, Parklands Drive, Gold Coast, QLD 4222, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2000-4282","authenticated-orcid":false,"given":"Ronak","family":"Reshamwala","sequence":"additional","affiliation":[{"name":"Clem Jones Centre for Neurobiology and Stem Cell Research, Institute for Biomedicine and Glycomics, Griffith University, Parklands Drive, Gold Coast, QLD 4222, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"ref_1","unstructured":"SpinalCure Australia (2020). Spinal Cord Injury in Australia: The Case for Investing in New Treatments, SpinalCure Australia."},{"key":"ref_2","unstructured":"Atlee, J.L. (2007). Chapter 183\u2014Spinal Cord Injury. Complications in Anesthesia, W.B. Saunders. [2nd ed.]."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s11910-019-0984-1","article-title":"Modern Medical Management of Spinal Cord Injury","volume":"19","author":"Karsy","year":"2019","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/B978-0-444-52137-8.00003-6","article-title":"Chapter 3\u2014Clinical diagnosis and prognosis following spinal cord injury","volume":"Volume 109","author":"Verhaagen","year":"2012","journal-title":"Handbook of Clinical Neurology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"175S","DOI":"10.1177\/2192568217703084","article-title":"Type and Timing of Rehabilitation Following Acute and Subacute Spinal Cord Injury: A Systematic Review","volume":"7","author":"Burns","year":"2017","journal-title":"Glob. Spine J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1016\/j.apmr.2008.04.024","article-title":"A Prospective Study on Physical Activity Levels After Spinal Cord Injury During Inpatient Rehabilitation and the Year After Discharge","volume":"89","author":"Bussmann","year":"2008","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1089\/neu.2004.21.1355","article-title":"A Global Perspective on Spinal Cord Injury Epidemiology","volume":"21","author":"Ackery","year":"2004","journal-title":"J. Neurotrauma"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1750-1326-7-6","article-title":"Spinal cord trauma and the molecular point of no return","volume":"7","author":"Yip","year":"2012","journal-title":"Mol. Neurodegener."},{"key":"ref_9","first-page":"546","article-title":"The fate of neurons after traumatic spinal cord injury in rats: A systematic review","volume":"21","author":"Hassannejad","year":"2018","journal-title":"Iran. J. Basic Med. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1186\/s12974-021-02337-2","article-title":"Inflammation after spinal cord injury: A review of the critical timeline of signaling cues and cellular infiltration","volume":"18","author":"Hellenbrand","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/S0306-4522(99)00278-X","article-title":"Neurotoxicity of glutamate at the concentration released upon spinal cord injury","volume":"93","author":"Liu","year":"1999","journal-title":"Neuroscience"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/ana.410270115","article-title":"Alteration in extracellular amino acids after traumatic spinal cord injury","volume":"27","author":"Panter","year":"1990","journal-title":"Ann. Neurol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.expneurol.2004.01.029","article-title":"Concentrations of glutamate released following spinal cord injury kill oligodendrocytes in the spinal cord","volume":"187","author":"Xu","year":"2004","journal-title":"Exp. Neurol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.neulet.2005.04.100","article-title":"Administration of glutamate into the spinal cord at extracellular concentrations reached post-injury causes functional impairments","volume":"384","author":"Xu","year":"2005","journal-title":"Neurosci. Lett."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Belov Kirdajova, D., Kriska, J., Tureckova, J., and Anderova, M. (2020). Ischemia-Triggered Glutamate Excitotoxicity From the Perspective of Glial Cells. Front. Cell. Neurosci., 14.","DOI":"10.3389\/fncel.2020.00051"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/35002090","article-title":"Glutamate release in severe brain ischaemia is mainly by reversed uptake","volume":"403","author":"Rossi","year":"2000","journal-title":"Nature"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Gruenbaum, B.F., Zlotnik, A., Fleidervish, I., Frenkel, A., and Boyko, M. (2022). Glutamate Neurotoxicity and Destruction of the Blood\u2013Brain Barrier: Key Pathways for the Development of Neuropsychiatric Consequences of TBI and Their Potential Treatment Strategies. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23179628"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1089\/neu.2020.7413","article-title":"Blood\u2013Spinal Cord Barrier in Spinal Cord Injury: A Review","volume":"38","author":"Jin","year":"2020","journal-title":"J. Neurotrauma"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/(SICI)1096-9861(19970120)377:3<443::AID-CNE10>3.0.CO;2-S","article-title":"Cellular inflammatory response after spinal cord injury in sprague-dawley and lewis rats","volume":"377","author":"Popovich","year":"1997","journal-title":"J. Comp. Neurol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1093\/brain\/awl296","article-title":"The cellular inflammatory response in human spinal cords after injury","volume":"129","author":"Fleming","year":"2006","journal-title":"Brain"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/j.1750-3639.2011.00488.x","article-title":"Non-Resolving Aspects of Acute Inflammation after Spinal Cord Injury (SCI): Indices and Resolution Plateau","volume":"21","author":"Kopp","year":"2011","journal-title":"Brain Pathol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Feng, Z., Min, L., Liang, L., Chen, B., Chen, H., Zhou, Y., Deng, W., Liu, H., and Hou, J. (2021). Neutrophil Extracellular Traps Exacerbate Secondary Injury via Promoting Neuroinflammation and Blood\u2013Spinal Cord Barrier Disruption in Spinal Cord Injury. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.698249"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Sterner, R.C., and Sterner, R.M. (2023). Immune response following traumatic spinal cord injury: Pathophysiology and therapies. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1084101"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4670","DOI":"10.1038\/s41467-018-07036-w","article-title":"Dynamic control of proinflammatory cytokines Il-1\u03b2 and Tnf-\u03b1 by macrophages in zebrafish spinal cord regeneration","volume":"9","author":"Tsarouchas","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4111","DOI":"10.1007\/s00018-015-1995-y","article-title":"Macrophage polarization in pathology","volume":"72","author":"Sica","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Italiani, P., and Boraschi, D. (2014). From Monocytes to M1\/M2 Macrophages: Phenotypical vs. Functional Differentiation. Front. Immunol., 5.","DOI":"10.3389\/fimmu.2014.00514"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern Recognition Receptors and Inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.immuni.2010.05.007","article-title":"Alternative Activation of Macrophages: Mechanism and Functions","volume":"32","author":"Gordon","year":"2010","journal-title":"Immunity"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s12031-019-01361-5","article-title":"TGF-\u03b2 Secretion by M2 Macrophages Induces Glial Scar Formation by Activating Astrocytes In Vitro","volume":"69","author":"Song","year":"2019","journal-title":"J. Mol. Neurosci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1007\/s12035-019-01851-y","article-title":"Polarization of Reactive Astrocytes in Response to Spinal Cord Injury is Enhanced by M2 Macrophage\u2013Mediated Activation of Wnt\/\u03b2-Catenin Pathway","volume":"57","author":"Sonn","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.4103\/1673-5374.143423","article-title":"Function of microglia and macrophages in secondary damage after spinal cord injury","volume":"9","author":"Zhou","year":"2014","journal-title":"Neural Regen. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/brain\/awp322","article-title":"Quantitative analysis of cellular inflammation after traumatic spinal cord injury: Evidence for a multiphasic inflammatory response in the acute to chronic environment","volume":"133","author":"Beck","year":"2010","journal-title":"Brain"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"13435","DOI":"10.1523\/JNEUROSCI.3257-09.2009","article-title":"Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord","volume":"29","author":"Kigerl","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Shechter, R., Raposo, C., London, A., Sagi, I., and Schwartz, M. (2011). The Glial Scar-Monocyte Interplay: A Pivotal Resolution Phase in Spinal Cord Repair. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0027969"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1042\/CS20220531","article-title":"M1\/M2 macrophages and their overlaps\u2014Myth or reality?","volume":"137","author":"Strizova","year":"2023","journal-title":"Clin. Sci."},{"key":"ref_36","unstructured":"Caplan, L.R., Biller, J., Leary, M.C., Lo, E.H., Thomas, A.J., Yenari, M., and Zhang, J.H. (2017). Chapter 9\u2014Development and Maintenance of the Blood\u2013Brain Barrier. Primer on Cerebrovascular Diseases, Academic Press. [2nd ed.]."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev-immunol-051116-052358","article-title":"Microglia Function in the Central Nervous System During Health and Neurodegeneration","volume":"35","author":"Colonna","year":"2017","journal-title":"Annu. Rev. Immunol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Gattlen, C., Clarke, C.B., Piller, N., Kirschmann, G., Pertin, M., Decosterd, I., Gosselin, R.-D., and Suter, M.R. (2016). Spinal Cord T-Cell Infiltration in the Rat Spared Nerve Injury Model: A Time Course Study. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17030352"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1016\/j.jaci.2009.09.017","article-title":"Adaptive immunity","volume":"125","author":"Bonilla","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13223-018-0278-1","article-title":"An introduction to immunology and immunopathology","volume":"14","author":"Marshall","year":"2018","journal-title":"Allergy Asthma Clin. Immunol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"S197","DOI":"10.1186\/ar557","article-title":"Studies of T-cell activation in chronic inflammation","volume":"4","author":"Cope","year":"2002","journal-title":"Arthritis Res. Ther."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1097\/NEN.0b013e3181ae0236","article-title":"Enhanced Microglial Clearance of Myelin Debris in T Cell-Infiltrated Central Nervous System","volume":"68","author":"Nielsen","year":"2009","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Wang, J., He, W., and Zhang, J. (2023). A richer and more diverse future for microglia phenotypes. Heliyon, 9.","DOI":"10.1016\/j.heliyon.2023.e14713"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"7231","DOI":"10.1523\/JNEUROSCI.1709-08.2008","article-title":"STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury","volume":"28","author":"Herrmann","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1177\/1073858411423441","article-title":"Structural Remodeling of Astrocytes in the Injured CNS","volume":"18","author":"Sun","year":"2011","journal-title":"Neuroscientist"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Perez, J.-C., Gerber, Y.N., and Perrin, F.E. (2021). Dynamic Diversity of Glial Response Among Species in Spinal Cord Injury. Front. Aging Neurosci., 13.","DOI":"10.3389\/fnagi.2021.769548"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"12870","DOI":"10.1523\/JNEUROSCI.2121-13.2013","article-title":"Glial scar borders are formed by newly proliferated, elongated astrocytes that interact to corral inflammatory and fibrotic cells via STAT3-dependent mechanisms after spinal cord injury","volume":"33","author":"Wanner","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1089\/neu.2014.3703","article-title":"Fibronectin Matrix Assembly after Spinal Cord Injury","volume":"32","author":"Zhu","year":"2014","journal-title":"J. Neurotrauma"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Reshamwala, R., Murtaza, M., Chen, M., Shah, M., Ekberg, J., Palipana, D., Vial, M.-L., McMonagle, B., and St John, J. (2022). Designing a Clinical Trial with Olfactory Ensheathing Cell Transplantation-Based Therapy for Spinal Cord Injury: A Position Paper. Biomedicines, 10.","DOI":"10.3390\/biomedicines10123153"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Cofano, F., Boido, M., Monticelli, M., Zenga, F., Ducati, A., Vercelli, A., and Garbossa, D. (2019). Mesenchymal Stem Cells for Spinal Cord Injury: Current Options, Limitations, and Future of Cell Therapy. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20112698"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"21907","DOI":"10.1038\/s41598-021-01490-1","article-title":"Transplantation of rat cranial bone-derived mesenchymal stem cells promotes functional recovery in rats with spinal cord injury","volume":"11","author":"Maeda","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.injury.2011.09.013","article-title":"Transplantation of oligodendrocyte precursor cells improves myelination and promotes functional recovery after spinal cord injury","volume":"43","author":"Wu","year":"2012","journal-title":"Injury"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1089\/neu.2017.5606","article-title":"Efficacy of Oligodendrocyte Progenitor Cell Transplantation in Rat Models with Traumatic Thoracic Spinal Cord Injury: A Systematic Review and Meta-Analysis","volume":"35","author":"Fu","year":"2018","journal-title":"J. Neurotrauma"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1002\/sctm.19-0135","article-title":"The leading edge: Emerging neuroprotective and neuroregenerative cell-based therapies for spinal cord injury","volume":"9","author":"Ahuja","year":"2020","journal-title":"Stem Cells Transl. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"6269","DOI":"10.1523\/JNEUROSCI.0085-16.2016","article-title":"Olfactory Ensheathing Cell Transplantation after a Complete Spinal Cord Transection Mediates Neuroprotective and Immunomodulatory Mechanisms to Facilitate Regeneration","volume":"36","author":"Khankan","year":"2016","journal-title":"J. Neurosci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"132S","DOI":"10.1177\/0963689719883823","article-title":"Survival and Integration of Transplanted Olfactory Ensheathing Cells are Crucial for Spinal Cord Injury Repair: Insights from the Last 10 Years of Animal Model Studies","volume":"28","author":"Reshamwala","year":"2019","journal-title":"Cell Transplant."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"765","DOI":"10.4103\/1673-5374.295347","article-title":"Exogenous platelet-derived growth factor improves neurovascular unit recovery after spinal cord injury","volume":"16","author":"Ye","year":"2021","journal-title":"Neural Regen. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/jcmm.13353","article-title":"Fibroblast growth factors in the management of spinal cord injury","volume":"22","author":"Zhou","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1089\/neu.2022.0009","article-title":"Management of Acute Spinal Cord Injury: Where Have We Been? Where Are We Now? Where Are We Going?","volume":"39","author":"Fehlings","year":"2022","journal-title":"J. Neurotrauma"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1089\/neu.2019.6939","article-title":"Optimizing Olfactory Ensheathing Cell Transplantation for Spinal Cord Injury Repair","volume":"37","author":"Gilmour","year":"2020","journal-title":"J. Neurotrauma"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s11033-025-10785-9","article-title":"Pathophysiology of spinal cord injury and advanced therapeutic approaches","volume":"52","author":"Yadav","year":"2025","journal-title":"Mol. Biol. Rep."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1093\/brain\/awn173","article-title":"Autologous olfactory ensheathing cell transplantation in human paraplegia: A 3-year clinical trial","volume":"131","author":"Cochrane","year":"2008","journal-title":"Brain"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.3727\/096368912X663532","article-title":"Transplantation of Autologous Olfactory Ensheathing Cells in Complete Human Spinal Cord Injury","volume":"22","author":"Tabakow","year":"2013","journal-title":"Cell Transplant."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.4103\/1673-5374.282218","article-title":"Reliable cell purification and determination of cell purity: Crucial aspects of olfactory ensheathing cell transplantation for spinal cord repair","volume":"15","author":"Reshamwala","year":"2020","journal-title":"Neural Regen. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/s41598-020-57793-2","article-title":"The plant natural product 2-methoxy-1,4-naphthoquinone stimulates therapeutic neural repair properties of olfactory ensheathing cells","volume":"10","author":"Chen","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"10240","DOI":"10.1038\/s41598-018-28551-2","article-title":"The serrulatane diterpenoid natural products RAD288 and RAD289 stimulate properties of olfactory ensheathing cells useful for neural repair therapies","volume":"8","author":"Chen","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1089\/neu.2017.5273","article-title":"Partial Recovery of Proprioception in Rats with Dorsal Root Injury after Human Olfactory Bulb Cell Transplantation","volume":"35","author":"Collins","year":"2017","journal-title":"J. Neurotrauma"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000471828","article-title":"Improved Neural Regeneration with Olfactory Ensheathing Cell Inoculated PLGA Scaffolds in Spinal Cord Injury Adult Rats","volume":"25","author":"Wang","year":"2017","journal-title":"Neurosignals"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"111819","DOI":"10.1016\/j.biopha.2021.111819","article-title":"Liraglutide modulates olfactory ensheathing cell migration with activation of ERK and alteration of the extracellular matrix","volume":"141","author":"Tseng","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Basu, S., Choudhury, I.N., Lee, J.Y.P., Chacko, A., Ekberg, J.A.K., and St John, J.A. (2022). Macrophages Treated with VEGF and PDGF Exert Paracrine Effects on Olfactory Ensheathing Cell Function. Cells, 11.","DOI":"10.3390\/cells11152408"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.neuint.2006.10.004","article-title":"BDNF production by olfactory ensheathing cells contributes to axonal regeneration of cultured adult CNS neurons","volume":"50","author":"Pastrana","year":"2007","journal-title":"Neurochem. Int."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Harvey, J.D., and Heinbockel, T. (2018). Neuromodulation of Synaptic Transmission in the Main Olfactory Bulb. Int. J. Environ. Res. Public Health, 15.","DOI":"10.3390\/ijerph15102194"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Lankford, C.K., Laird, J.G., Inamdar, S.M., and Baker, S.A. (2020). A Comparison of the Primary Sensory Neurons Used in Olfaction and Vision. Front. Cell. Neurosci., 14.","DOI":"10.3389\/fncel.2020.595523"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Brann, D.H., Tsukahara, T., Weinreb, C., Lipovsek, M., Van den Berge, K., Gong, B., Chance, R., Macaulay, I.C., Chou, H.-J., and Fletcher, R.B. (2020). Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia. Sci. Adv., 6.","DOI":"10.1126\/sciadv.abc5801"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1099\/0022-1317-83-9-2109","article-title":"Olfactory receptor neurons prevent dissemination of neurovirulent influenza A virus into the brain by undergoing virus-induced apoptosis","volume":"83","author":"Mori","year":"2002","journal-title":"J. Gen. Virol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"12428","DOI":"10.1073\/pnas.1900083116","article-title":"Olfactory sensory neurons mediate ultrarapid antiviral immune responses in a TrkA-dependent manner","volume":"116","author":"Sepahi","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1523\/JNEUROSCI.11-04-00979.1991","article-title":"Cell dynamics in the adult mouse olfactory epithelium: A quantitative autoradiographic study","volume":"11","author":"Kittel","year":"1991","journal-title":"J. Neurosci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/B978-0-444-62627-1.00016-0","article-title":"Chapter 17\u2014Neurotoxic exposure and impairment of the chemical senses of taste and smell","volume":"Volume 131","author":"Lotti","year":"2015","journal-title":"Handbook of Clinical Neurology"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"15686","DOI":"10.1523\/JNEUROSCI.4316-10.2010","article-title":"Regeneration of New Neurons Is Preserved in Aged Vomeronasal Epithelia","volume":"30","author":"Brann","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1002\/cne.22316","article-title":"Age-related changes in cell dynamics of the postnatal mouse olfactory neuroepithelium: Cell proliferation, neuronal differentiation, and cell death","volume":"518","author":"Kondo","year":"2010","journal-title":"J. Comp. Neurol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0165-3806(96)00091-0","article-title":"Ultrastructural study of ensheathing cells in early development of olfactory axons","volume":"95","author":"Tennent","year":"1996","journal-title":"Dev. Brain Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.mcn.2010.07.002","article-title":"Olfactory glia enhance neonatal axon regeneration","volume":"45","author":"Chehrehasa","year":"2010","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1023\/B:NEUR.0000010089.37032.48","article-title":"Ensheathment of the olfactory nerves in the adult rat","volume":"32","author":"Field","year":"2003","journal-title":"J. Neurocytol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0014-4886(02)00058-4","article-title":"Neurotrophic properties of olfactory ensheathing glia","volume":"180","author":"Lipson","year":"2003","journal-title":"Exp. Neurol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.mcn.2015.03.005","article-title":"Differing phagocytic capacities of accessory and main olfactory ensheathing cells and the implication for olfactory glia transplantation therapies","volume":"65","author":"Nazareth","year":"2015","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/cne.23694","article-title":"Olfactory ensheathing cells are the main phagocytic cells that remove axon debris during early development of the olfactory system","volume":"523","author":"Nazareth","year":"2015","journal-title":"J. Comp. Neurol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"103450","DOI":"10.1016\/j.mcn.2019.103450","article-title":"Macrophage migration inhibitory factor and its binding partner HTRA1 are expressed by olfactory ensheathing cells","volume":"102","author":"Wright","year":"2020","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.expneurol.2010.08.020","article-title":"The culture of olfactory ensheathing cells (OECs)\u2014A distinct glial cell type","volume":"229","author":"Higginson","year":"2011","journal-title":"Exp. Neurol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"10514","DOI":"10.1523\/JNEUROSCI.18-24-10514.1998","article-title":"Regeneration of Adult Rat Corticospinal Axons Induced by Transplanted Olfactory Ensheathing Cells","volume":"18","author":"Li","year":"1998","journal-title":"J. Neurosci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/nrn2099","article-title":"Repair of neural pathways by olfactory ensheathing cells","volume":"8","author":"Raisman","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.neulet.2005.11.063","article-title":"Neurite outgrowth promoting effects of enriched and mixed OEC\/ONF cultures","volume":"397","author":"Deumens","year":"2006","journal-title":"Neurosci. Lett."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"18936","DOI":"10.1038\/s41598-020-75850-8","article-title":"Key differences between olfactory ensheathing cells and Schwann cells regarding phagocytosis of necrotic cells: Implications for transplantation therapies","volume":"10","author":"Nazareth","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.3727\/096368914X685131","article-title":"Functional Regeneration of Supraspinal Connections in a Patient with Transected Spinal Cord following Transplantation of Bulbar Olfactory Ensheathing Cells with Peripheral Nerve Bridging","volume":"23","author":"Tabakow","year":"2014","journal-title":"Cell Transplant."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/cne.10664","article-title":"Olfactory bulb core is a rich source of neural progenitor and stem cells in adult rodent and human","volume":"459","author":"Liu","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1002\/stem.3393","article-title":"Neural stem cells in the adult olfactory bulb core generate mature neurons in\u2009vivo","volume":"39","author":"Crespo","year":"2021","journal-title":"Stem Cells"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Sipione, R., Liaudet, N., Rousset, F., Landis, B.N., Hsieh, J.W., and Senn, P. (2023). Axonal Regrowth of Olfactory Sensory Neurons In Vitro. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241612863"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/alr.21711","article-title":"Office-based olfactory mucosa biopsies","volume":"6","author":"Holbrook","year":"2016","journal-title":"Int. Forum Allergy Rhinol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/s41598-017-18754-4","article-title":"Transplantation of olfactory ensheathing cells on functional recovery and neuropathic pain after spinal cord injury; systematic review and meta-analysis","volume":"8","author":"Yousefifard","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.4103\/1673-5374.280310","article-title":"The link between olfactory ensheathing cell survival and spinal cord injury repair: A commentary on common limitations of contemporary research","volume":"15","author":"Reshamwala","year":"2020","journal-title":"Neural Regen. Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"RP95629","DOI":"10.7554\/eLife.95629.4","article-title":"Olfactory ensheathing cells from adult female rats are hybrid glia that promote neural repair","volume":"13","author":"Phelps","year":"2024","journal-title":"eLife"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1007\/s00018-010-0280-3","article-title":"Lamellipodia mediate the heterogeneity of central olfactory ensheathing cell interactions","volume":"67","author":"Windus","year":"2010","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"94","DOI":"10.26599\/JNR.2021.9040008","article-title":"Olfactory ensheathing cell transplantation for chronic spinal cord injury: A long-term follow-up study","volume":"9","author":"Kuang","year":"2021","journal-title":"J. Neurorestoratology"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0169-328X(01)00044-4","article-title":"Cultured olfactory ensheathing cells express nerve growth factor, brain-derived neurotrophic factor, glia cell line-derived neurotrophic factor and their receptors","volume":"88","author":"Woodhall","year":"2001","journal-title":"Mol. Brain Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"17306","DOI":"10.1523\/JNEUROSCI.1522-12.2012","article-title":"Critical role of GFR\u03b11 in the development and function of the main olfactory system","volume":"32","author":"Marks","year":"2012","journal-title":"J. Neurosci."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Denaro, S., D\u2019Aprile, S., Alberghina, C., Pavone, A.M., Torrisi, F., Giallongo, S., Longhitano, L., Mannino, G., Lo Furno, D., and Zappal\u00e0, A. (2022). Neurotrophic and immunomodulatory effects of olfactory ensheathing cells as a strategy for neuroprotection and regeneration. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1098212"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1177\/0963689718759472","article-title":"Enhancing the Therapeutic Potential of Olfactory Ensheathing Cells in Spinal Cord Repair Using Neurotrophins","volume":"27","author":"Wright","year":"2018","journal-title":"Cell Transplant."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/glia.10044","article-title":"Identification of growth factors that promote long-term proliferation of olfactory ensheathing cells and modulate their antigenic phenotype","volume":"37","author":"Alexander","year":"2002","journal-title":"Glia"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1002\/glia.20511","article-title":"Olfactory ensheathing cells promote migration of Schwann cells by secreted nerve growth factor","volume":"55","author":"Cao","year":"2007","journal-title":"Glia"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1007\/s00018-004-4026-y","article-title":"Olfactory ensheathing cells promote neurite sprouting of injured axons in vitro by direct cellular contact and secretion of soluble factors","volume":"61","author":"Chung","year":"2004","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/glia.440030602","article-title":"Glial influences on axonal growth in the primary olfactory system","volume":"3","author":"Doucette","year":"1990","journal-title":"Glia"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.expneurol.2015.03.025","article-title":"Olfactory ensheathing cell\u2013neurite alignment enhances neurite outgrowth in scar-like cultures","volume":"269","author":"Khankan","year":"2015","journal-title":"Exp. Neurol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1002\/glia.20403","article-title":"Glial cell line-derived neurotrophic factor promotes olfactory ensheathing cells migration","volume":"54","author":"Cao","year":"2006","journal-title":"Glia"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/cne.903440303","article-title":"Localization and regulation of low affinity nerve growth factor receptor expression in the rat olfactory system during development and regeneration","volume":"344","author":"Gong","year":"1994","journal-title":"J. Comp. Neurol."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Raucci, F., Tiong, J.D., and Wray, S. (2013). P75 nerve growth factor receptors modulate development of GnRH neurons and olfactory ensheating cells. Front. Neurosci., 7.","DOI":"10.3389\/fnins.2013.00262"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.mcn.2018.06.004","article-title":"Semaphorin 3A as an inhibitive factor for migration of olfactory ensheathing cells through cofilin activation is involved in formation of olfactory nerve layer","volume":"92","author":"Wang","year":"2018","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/glia.22455","article-title":"Olfactory ensheathing cells form the microenvironment of migrating GnRH-1 neurons during mouse development","volume":"61","author":"Geller","year":"2013","journal-title":"Glia"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s11481-013-9479-z","article-title":"The roles of PDGF in development and during neurogenesis in the normal and diseased nervous system","volume":"9","author":"Funa","year":"2014","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1161\/01.STR.28.3.564","article-title":"A Putative Role for Platelet-Derived Growth Factor in Angiogenesis and Neuroprotection After Ischemic Stroke in Humans","volume":"28","author":"Krupinski","year":"1997","journal-title":"Stroke"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1002\/jnr.22302","article-title":"Neuroprotective effects of PDGF against oxidative stress and the signaling pathway involved","volume":"88","author":"Zheng","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/jnr.490310206","article-title":"Platelet-derived growth factor and regulation of schwann cell proliferation in vivo","volume":"31","author":"Hardy","year":"1992","journal-title":"J. Neurosci. Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0165-3806(92)90246-S","article-title":"Platelet-derived growth factor B-chain-like immunoreactivity in the developing and adult rat brain","volume":"68","author":"Sasahara","year":"1992","journal-title":"Dev. Brain Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/cne.902850407","article-title":"Development of the nerve fiber layer in the olfactory bulb of mouse embryos","volume":"285","author":"Doucette","year":"1989","journal-title":"J. Comp. Neurol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0736-5748(94)90079-5","article-title":"Olfactory ensheathing glia and platelet-derived growth factor B-chain reactivity in the transplanted rat olfactory bulb","volume":"12","author":"Kott","year":"1994","journal-title":"Int. J. Dev. Neurosci."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/1098-1136(20010315)33:4<334::AID-GLIA1032>3.0.CO;2-I","article-title":"Mitogenic response of adult rat olfactory ensheathing glia to four growth factors","volume":"33","author":"Yan","year":"2001","journal-title":"Glia"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1007\/s00018-011-0630-9","article-title":"Stimulation of olfactory ensheathing cell motility enhances olfactory axon growth","volume":"68","author":"Windus","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1002\/glia.20586","article-title":"Motile membrane protrusions regulate cell\u2013cell adhesion and migration of olfactory ensheathing glia","volume":"55","author":"Windus","year":"2007","journal-title":"Glia"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.aanat.2014.10.010","article-title":"Brain-derived neurotrophic factor (BDNF) expression in normal and regenerating olfactory epithelium of Xenopus laevis","volume":"198","author":"Frontera","year":"2015","journal-title":"Ann. Anat.\u2014Anat. Anz."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0006-8993(01)02173-4","article-title":"Basic fibroblast growth factor and fibroblast growth factor receptors in adult olfactory epithelium","volume":"896","author":"Hsu","year":"2001","journal-title":"Brain Res."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1097\/WNR.0000000000001125","article-title":"Effect of intranasal administration of neurotrophic factors on regeneration of chemically degenerated olfactory epithelium in aging mice","volume":"29","author":"Fukuda","year":"2018","journal-title":"Neuroreport"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00418-025-02375-4","article-title":"Bioactive and degradable collagen-based hydrogel encapsulated with microspheres containing basic fibroblast growth factor (bFGF) and interleukin (IL)-10 promotes recovery following traumatic spinal cord injury in rats","volume":"163","author":"Hjazi","year":"2025","journal-title":"Histochem. Cell Biol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1111\/j.1460-9568.2007.05950.x","article-title":"Contrasting effects of basic fibroblast growth factor and epidermal growth factor on mouse neonatal olfactory mucosa cells","volume":"26","author":"Barraud","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0306-4522(98)00277-2","article-title":"Basic fibroblast growth factor in the primary olfactory pathway: Mitogenic effect on ensheathing cells","volume":"88","author":"Chuah","year":"1999","journal-title":"Neuroscience"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neulet.2016.04.006","article-title":"BDNF promotes the axonal regrowth after sciatic nerve crush through intrinsic neuronal capability upregulation and distal portion protection","volume":"621","author":"Zheng","year":"2016","journal-title":"Neurosci. Lett."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1002\/glia.23049","article-title":"Brain-derived Neurotrophic Factor Promotes the Migration of Olfactory Ensheathing Cells Through TRPC Channels","volume":"64","author":"Wang","year":"2016","journal-title":"Glia"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Lang, B.-C., Zhang, Z., Lv, L.-Y., Liu, J., Wang, T.-Y., Yang, L.-H., Liao, D.-Q., Zhang, W.-S., and Wang, T.-H. (2013). OECs transplantation results in neuropathic pain associated with BDNF regulating ERK activity in rats following cord hemisection. BMC Neurosci., 14.","DOI":"10.1186\/1471-2202-14-80"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.mcn.2017.08.006","article-title":"TGF-\u03b21 enhances phagocytic removal of neuron debris and neuronal survival by olfactory ensheathing cells via integrin\/MFG-E8 signaling pathway","volume":"85","author":"Li","year":"2017","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"7208","DOI":"10.1523\/JNEUROSCI.0509-07.2007","article-title":"SPARC from Olfactory Ensheathing Cells Stimulates Schwann Cells to Promote Neurite Outgrowth and Enhances Spinal Cord Repair","volume":"27","author":"Au","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.nbd.2010.02.011","article-title":"TGF-\u03b2 1 enhances neurite outgrowth via regulation of proteasome function and EFABP","volume":"38","author":"Ramljak","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1744-8069-5-16","article-title":"Transforming Growth Factor-\u03b21 Impairs Neuropathic Pain through Pleiotropic Effects","volume":"5","author":"Echeverry","year":"2009","journal-title":"Mol. Pain"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1097\/WNR.0000000000000106","article-title":"TGF\u03b21 downregulates neurite outgrowth, expression of Ca2+ transporters, and mitochondrial dynamics of in vitro cerebellar granule cells","volume":"25","author":"Jaskova","year":"2014","journal-title":"Neuroreport"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Jiang, M., Ding, Z., Huang, Y., Jiang, T., Xia, Y., Gu, D., Gu, X., Bai, H., and Yao, D. (2025). TGF-\u03b21 Improves Nerve Regeneration and Functional Recovery After Sciatic Nerve Injury by Alleviating Inflammation. Biomedicines, 13.","DOI":"10.3390\/biomedicines13040872"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1006\/exnr.1999.7290","article-title":"TGF\u03b2 Trophic Factors Differentially Modulate Motor Axon Outgrowth and Protection from Excitotoxicity","volume":"161","author":"Ho","year":"2000","journal-title":"Exp. Neurol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1111\/jcmm.16274","article-title":"Basic fibroblast growth factor accelerates myelin debris clearance through activating autophagy to facilitate early peripheral nerve regeneration","volume":"25","author":"Jiang","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.mcn.2003.11.007","article-title":"Targeted disruption of the FGF-2 gene affects the response to peripheral nerve injury","volume":"25","author":"Jungnickel","year":"2004","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"18032","DOI":"10.1016\/S0021-9258(19)37148-0","article-title":"Basic fibroblast growth factor modulates the mitogenic potency of the platelet-derived growth factor (PDGF) isoforms by specific upregulation of the PDGF alpha receptor in vascular smooth muscle cells","volume":"267","author":"Grugel","year":"1992","journal-title":"J. Biol. Chem."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/biof.46","article-title":"The function of vascular endothelial growth factor","volume":"35","author":"Nieves","year":"2009","journal-title":"BioFactors"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.4103\/1673-5374.238713","article-title":"Combined VEGF\/PDGF improves olfactory regeneration after unilateral bulbectomy in mice","volume":"13","author":"Beecher","year":"2018","journal-title":"Neural Regen. Res."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1089\/neu.2010.1423","article-title":"Combined VEGF and PDGF Treatment Reduces Secondary Degeneration after Spinal Cord Injury","volume":"29","author":"Lutton","year":"2011","journal-title":"J. Neurotrauma"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1126\/science.8493557","article-title":"GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons","volume":"260","author":"Lin","year":"1993","journal-title":"Science"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1126\/science.7973664","article-title":"GDNF: A potent survival factor for motoneurons present in peripheral nerve and muscle","volume":"266","author":"Henderson","year":"1994","journal-title":"Science"},{"key":"ref_151","first-page":"2903","article-title":"Combined effect of olfactory ensheathing cell (OEC) transplantation and glial cell line-derived neurotrophic factor (GDNF) intravitreal injection on optic nerve injury in rats","volume":"16","author":"Liu","year":"2010","journal-title":"Mol. Vis."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1089\/neu.2017.5175","article-title":"The Effects of Glial Cell Line-Derived Neurotrophic Factor after Spinal Cord Injury","volume":"34","author":"Rosich","year":"2017","journal-title":"J. Neurotrauma"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1515\/tnsci-2020-0200","article-title":"Sustained delivery of neurotrophic factors to treat spinal cord injury","volume":"12","author":"Muheremu","year":"2021","journal-title":"Transl. Neurosci."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s004010000357","article-title":"Acute up-regulation of brain-derived neurotrophic factor expression resulting from experimentally induced injury in the rat spinal cord","volume":"102","author":"Ikeda","year":"2001","journal-title":"Acta Neuropathol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.expneurol.2012.09.001","article-title":"BDNF: The career of a multifaceted neurotrophin in spinal cord injury","volume":"238","author":"Weishaupt","year":"2012","journal-title":"Exp. Neurol."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Song, X.-Y., Li, F., Zhang, F.-H., Zhong, J.-H., and Zhou, X.-F. (2008). Peripherally-Derived BDNF Promotes Regeneration of Ascending Sensory Neurons after Spinal Cord Injury. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0001707"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neures.2013.03.013","article-title":"The role of angiogenic and wound-healing factors after spinal cord injury in mammals","volume":"76","author":"Kundi","year":"2013","journal-title":"Neurosci. Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3727\/096368916X693824","article-title":"The Regulatory Effects of Transforming Growth Factor-\u03b2 on Nerve Regeneration","volume":"26","author":"Li","year":"2017","journal-title":"Cell Transplant."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1006\/exnr.2000.7372","article-title":"Localization of Transforming Growth Factor-\u03b21 and Receptor mRNA after Experimental Spinal Cord Injury","volume":"163","author":"McTigue","year":"2000","journal-title":"Exp. Neurol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1006\/exnr.1996.0149","article-title":"Increased Basic Fibroblast Growth Factor Expression Following Contusive Spinal Cord Injury","volume":"141","author":"Mocchetti","year":"1996","journal-title":"Exp. Neurol."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Fahmy, G.H., and Moftah, M.Z. (2010). FGF-2 in Astroglial Cells During Vertebrate Spinal Cord Recovery. Front. Cell. Neurosci., 4.","DOI":"10.3389\/fncel.2010.00129"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"R775","DOI":"10.1152\/ajpregu.00737.2006","article-title":"Effects on neurite outgrowth and cell survival of a secreted fibroblast growth factor binding protein upregulated during spinal cord injury","volume":"293","author":"Tassi","year":"2007","journal-title":"Am. J. Physiol.\u2014Regul. Integr. Comp. Physiol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.neuroscience.2023.03.025","article-title":"Chronic Morphine Modulates PDGFR-\u03b2 and PDGF-B Expression and Distribution in Dorsal Root Ganglia and Spinal Cord in Male Rats","volume":"519","author":"Puig","year":"2023","journal-title":"Neuroscience"},{"key":"ref_164","first-page":"24","article-title":"Neuroprotective effects of direct activation and transactivation of PDGF\u03b2 receptors","volume":"4","author":"Maryam","year":"2020","journal-title":"Vessel Plus"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1080\/08977190802025339","article-title":"The effects of inflammatory response associated with traumatic spinal cord injury in cutaneous wound healing and on expression of transforming growth factor-beta1 (TGF-\u03b21) and platelet-derived growth factor (PDGF)-A at the wound site in rats","volume":"26","author":"Konya","year":"2008","journal-title":"Growth Factors"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"13484","DOI":"10.3390\/ijms131013484","article-title":"Injury-Induced Accumulation of Glial Cell Line-Derived Neurotrophic Factor in the Rostral Part of the Injured Rat Spinal Cord","volume":"13","author":"Hara","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1172\/JCI20682","article-title":"VEGF: A critical player in neurodegeneration","volume":"113","author":"Storkebaum","year":"2004","journal-title":"J. Clin. Investig."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/cne.1380","article-title":"GDNF and NGF family members and receptors in human fetal and adult spinal cord and dorsal root ganglia","volume":"440","author":"Josephson","year":"2001","journal-title":"J. Comp. Neurol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1097\/00001756-200011270-00054","article-title":"Up-regulation of glial cell line-derived neurotrophic factor (GDNF) following traumatic spinal cord injury","volume":"11","author":"Satake","year":"2000","journal-title":"Neuroreport"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1002\/glia.20840","article-title":"GDNF-enhanced axonal regeneration and myelination following spinal cord injury is mediated by primary effects on neurons","volume":"57","author":"Zhang","year":"2009","journal-title":"Glia"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/0006-8993(91)90199-6","article-title":"Increase in nerve growth factor-like immunoreactivity and decrease in choline acetyltransferase following contusive spinal cord injury","volume":"554","author":"Bakhit","year":"1991","journal-title":"Brain Res."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0022-510X(02)00080-1","article-title":"Accumulation of nerve growth factor protein at both rostral and caudal stumps in the transected rat spinal cord","volume":"198","author":"Murakami","year":"2002","journal-title":"J. Neurol. Sci."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/1479-5876-12-130","article-title":"Nerve growth factor improves functional recovery by inhibiting endoplasmic reticulum stress-induced neuronal apoptosis in rats with spinal cord injury","volume":"12","author":"Zhang","year":"2014","journal-title":"J. Transl. Med."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jss.2019.10.033","article-title":"NT-3 Promotes Oligodendrocyte Proliferation and Nerve Function Recovery After Spinal Cord Injury by Inhibiting Autophagy Pathway","volume":"247","author":"Cong","year":"2020","journal-title":"J. Surg. Res."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1900520","DOI":"10.1002\/advs.201900520","article-title":"Adaptable Microporous Hydrogels of Propagating NGF-Gradient by Injectable Building Blocks for Accelerated Axonal Outgrowth","volume":"6","author":"Hsu","year":"2019","journal-title":"Adv. Sci."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"6772","DOI":"10.1016\/j.biomaterials.2010.05.047","article-title":"Hyaluronic acid hydrogels with controlled degradation properties for oriented bone regeneration","volume":"31","author":"Patterson","year":"2010","journal-title":"Biomaterials"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jconrel.2011.06.027","article-title":"Affinity-based growth factor delivery using biodegradable, photocrosslinked heparin-alginate hydrogels","volume":"154","author":"Jeon","year":"2011","journal-title":"J. Control. Release"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"19665","DOI":"10.1021\/acsnano.2c06393","article-title":"Injectable Drug Delivery Systems for Osteoarthritis and Rheumatoid Arthritis","volume":"16","author":"Bruno","year":"2022","journal-title":"ACS Nano"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"113851","DOI":"10.1016\/j.addr.2021.113851","article-title":"Liposome composition in drug delivery design, synthesis, characterization, and clinical application","volume":"176","author":"Large","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"100546","DOI":"10.1016\/j.mtbio.2023.100546","article-title":"Barrier-penetrating liposome targeted delivery of basic fibroblast growth factor for spinal cord injury repair","volume":"18","author":"Wu","year":"2023","journal-title":"Mater. Today Bio"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"120571","DOI":"10.1016\/j.ijpharm.2021.120571","article-title":"Design of liposomes as drug delivery system for therapeutic applications","volume":"601","author":"Nogueira","year":"2021","journal-title":"Int. J. Pharm."},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Velot, \u00c9., Elkhoury, K., Kahn, C., Kempf, H., Linder, M., Arab-Tehrany, E., and Bianchi, A. (2022). Efficient TGF-\u03b21 Delivery to Articular Chondrocytes In Vitro Using Agro-Based Liposomes. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23052864"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/jbm.a.31588","article-title":"Investigation of epidermal growth factor containing liposome formulation effects on burn wound healing","volume":"85A","author":"Degim","year":"2008","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Dirzu, N., Lucaciu, O., Dirzu, D.S., Soritau, O., Cenariu, D., Crisan, B., Tefas, L., and Campian, R.S. (2022). BMP-2 Delivery through Liposomes in Bone Regeneration. Appl. Sci., 12.","DOI":"10.3390\/app12031373"},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Doustvaghe, Y.K., Haeri, A., Sisakht, M.M., Amirkhani, M.A., and Vatanpour, H. (2024). Recombinant human epidermal growth factor-loaded liposomes and transferosomes for dermal delivery: Development, characterization, and cytotoxicity evaluation. Drug Dev. Res., 85.","DOI":"10.1002\/ddr.22234"}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/1\/86\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T16:19:38Z","timestamp":1767629978000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/1\/86"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,5]]},"references-count":185,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["biom16010086"],"URL":"https:\/\/doi.org\/10.3390\/biom16010086","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,5]]}}}