{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:43:41Z","timestamp":1792457021590,"version":"4.5.0"},"reference-count":104,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019783","name":"National Agency for Research and Development","doi-asserted-by":"crossref","award":["21212100"],"award-info":[{"award-number":["21212100"]}],"id":[{"id":"10.13039\/100019783","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100019783","name":"National Agency for Research and Development","doi-asserted-by":"crossref","award":["21220031"],"award-info":[{"award-number":["21220031"]}],"id":[{"id":"10.13039\/100019783","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100019783","name":"National Agency for Research and Development","doi-asserted-by":"crossref","award":["21221512"],"award-info":[{"award-number":["21221512"]}],"id":[{"id":"10.13039\/100019783","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Polyunsaturated fatty acids (PUFAs), particularly omega-3 derivatives such as docosahexaenoic acid (DHA), are precursors of specialized pro-resolving mediators (SPMs) that actively orchestrate the resolution of inflammation. Among these, maresins (MaRs) have gathered increasing attention due to their potent immunomodulatory and tissue-regenerative properties. This review provides a comprehensive synthesis of the current knowledge on the biosynthesis, structural diversity, and biological functions of MaRs, with a focus on MaR1. We discuss the enzymatic pathways involved in the generation of MaR1, MaR2, MaRs conjugates in tissue regeneration (MCTRs), and maresin-like lipid mediators (MaR-Ls), highlighting their roles in modulating inflammatory responses, promoting phagocytosis, and restoring tissue homeostasis. Preclinical evidence from in vitro and in vivo models demonstrates that MaRs exert protective effects in a wide range of pathological contexts, including neuroinflammation, liver injury, cardiovascular dysfunction, pulmonary diseases, and metabolic disorders. Although their therapeutic promise is well-supported, key gaps remain in the understanding of MaRs biosynthesis, receptor specificity, and translational applicability. This review emphasizes the importance of advancing mechanistic and clinical research to fully harness MaRs as part of next-generation therapeutics in inflammation-driven diseases.<\/jats:p>","DOI":"10.3390\/biom16010139","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:17:32Z","timestamp":1768292252000},"page":"139","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Maresins"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1375-6223","authenticated-orcid":false,"given":"Fernanda","family":"Berrocal-Navarrete","sequence":"first","affiliation":[{"name":"Laboratory of Pharmacology and Physiology, Faculty of Health Sciences, University of Talca, Av. Lircay s\/n, Talca 3460000, Chile"},{"name":"Doctorate in Biomedical Sciences Program, Faculty of Health Sciences, University of Talca, Av. Lircay s\/n, Talca 3460000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paz","family":"Mar\u00edn-Sanhueza","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Physiology, Faculty of Health Sciences, University of Talca, Av. Lircay s\/n, Talca 3460000, Chile"},{"name":"Institute of Biological Sciences, School of Biochemistry, University of Talca, Av. Lircay s\/n, Talca 3460000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9065-7294","authenticated-orcid":false,"given":"Ram\u00f3n","family":"Norambuena-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Physiology, Faculty of Health Sciences, University of Talca, Av. Lircay s\/n, Talca 3460000, Chile"},{"name":"Doctorate in Biomedical Sciences Program, Faculty of Health Sciences, University of Talca, Av. Lircay s\/n, Talca 3460000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mat\u00edas","family":"Qui\u00f1ones San Mart\u00edn","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Physiology, Faculty of Health Sciences, University of Talca, Av. Lircay s\/n, Talca 3460000, Chile"},{"name":"Doctorate in Science Program, Mention in Research and Development of Bioactive Products, Institute of Chemistry of Natural Resources, University of Talca, Av. Lircay s\/n, Talca 3460000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Herrera-Vielma","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Physiology, Faculty of Health Sciences, University of Talca, Av. Lircay s\/n, Talca 3460000, Chile"},{"name":"Doctorate in Science Program, Mention in Research and Development of Bioactive Products, Institute of Chemistry of Natural Resources, University of Talca, Av. Lircay s\/n, Talca 3460000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3437-8998","authenticated-orcid":false,"given":"Daniel R.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Physiology, Faculty of Health Sciences, University of Talca, Av. Lircay s\/n, Talca 3460000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2930-991X","authenticated-orcid":false,"given":"Jessica","family":"Z\u00fa\u00f1iga-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Physiology, Faculty of Health Sciences, University of Talca, Av. Lircay s\/n, Talca 3460000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/S0140-6736(71)91658-8","article-title":"Plasma Lipid and Lipoprotein Pattern in Greenlandic West-Coast Eskimos","volume":"297","author":"Bang","year":"1971","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1177\/0884533611411306","article-title":"Essential Fatty Acids and Psychiatric Disorders","volume":"26","author":"Perica","year":"2011","journal-title":"Nutr. Clin. Pract."},{"key":"ref_3","first-page":"446","article-title":"Role of Diets Rich in Omega-3 and Omega-6 in the Development of Cancer","volume":"73","author":"Hankinson","year":"2016","journal-title":"Bol. Med. Hosp. Infant. 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