{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T18:50:03Z","timestamp":1789843803857,"version":"4.0.1"},"reference-count":226,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"2025 Provincial Natural Science Foundation Joint Fund Key Project, Heilongjiang Province, China","award":["ZL2025H018"],"award-info":[{"award-number":["ZL2025H018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Immunotherapy, especially immune checkpoint inhibitors (ICIs), has become one of the core therapeutic approaches in cancer in recent years. It demonstrates remarkable efficacy in the treatment of melanoma and lung cancer. Conversely, its use in treating gastric cancer (GC) is not associated with considerable benefits. The high heterogeneity of GC and the tumor microenvironment (TME) may directly influence this phenomenon. This review focuses on the correlation between Helicobacter pylori (H. pylori) infection, gastric physiology, and molecular subtype-specific induction pathways, with emphasis on the unique metabolic features of GC. It explores the connection of H. pylori infection, gastric physiologic functions, and molecular subtype-specific induction mechanism of GC with the special metabolism of GC. It also explains the relationship between immune metabolic reprogramming and the suppressive TME in GC. Crucially, we summarize emerging therapeutic strategies targeting metabolic vulnerabilities. Furthermore, we explore the potential of subtype-guided metabolic therapies to overcome the challenges of the immunosuppressive tumor microenvironment in GC.<\/jats:p>","DOI":"10.3390\/biom16010160","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T11:39:37Z","timestamp":1768563577000},"page":"160","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Mechanisms of Metabolic Reprogramming Regulating Immunosuppression in the Gastric Cancer Tumor Microenvironment"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0866-0962","authenticated-orcid":false,"given":"Wenting","family":"Dong","sequence":"first","affiliation":[{"name":"Institute of Chinese Materia Medica, Heilongjiang Academy of Chinese Medicine Science, Harbin 150036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6956-5957","authenticated-orcid":false,"given":"Xuepeng","family":"Qian","sequence":"additional","affiliation":[{"name":"Institute of Chinese Materia Medica, Heilongjiang Academy of Chinese Medicine Science, Harbin 150036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1567-4195","authenticated-orcid":false,"given":"Honglin","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Chinese Materia Medica, Heilongjiang Academy of Chinese Medicine Science, Harbin 150036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9714-4312","authenticated-orcid":false,"given":"Jinhai","family":"Huo","sequence":"additional","affiliation":[{"name":"Institute of Chinese Materia Medica, Heilongjiang Academy of Chinese Medicine Science, Harbin 150036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6482-426X","authenticated-orcid":false,"given":"Weiming","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Chinese Materia Medica, Heilongjiang Academy of Chinese Medicine Science, Harbin 150036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e20200219","DOI":"10.1084\/jem.20200219","article-title":"Uncovering the Dosage-Dependent Roles of Arid1a in Gastric Tumorigenesis for Combinatorial Drug Therapy","volume":"218","author":"Loe","year":"2021","journal-title":"J. Exp. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"4269781","DOI":"10.1155\/2021\/4269781","article-title":"The Clinicopathological Characteristics and Prognoses of dMMR Gastric Adenocarcinoma Patients","volume":"2021","author":"Wang","year":"2021","journal-title":"Gastroenterol. Res. Pract."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"252","DOI":"10.7704\/kjhugr.2024.0043","article-title":"Long-Term Outcomes and Risk Factors for Lymph Node Metastasis in Siewert Type II\/III Early Gastric Cancer","volume":"24","author":"Son","year":"2024","journal-title":"Korean J. Helicobacter Up. Gastrointest. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"5809","DOI":"10.2147\/OTT.S107946","article-title":"Evaluation of C-Met, HGF, and HER-2 Expressions in Gastric Carcinoma and Their Association with Other Clinicopathological Factors","volume":"9","author":"Sokmensuer","year":"2016","journal-title":"Onco Targets Ther."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2120676","DOI":"10.1080\/2162402X.2022.2120676","article-title":"Immunosuppressive Tumor Microenvironment Modulation by Chemotherapies and Targeted Therapies to Enhance Immunotherapy Effectiveness","volume":"11","author":"Barnestein","year":"2022","journal-title":"Oncoimmunology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1158\/2326-6066.CIR-24-1011","article-title":"BFAR Promotes Neutrophil Infiltration and Immunosuppressive Reprogramming through the PRP19-YBX1 Axis to Induce Immune Evasion in Gastric Cancer","volume":"13","author":"Ma","year":"2025","journal-title":"Cancer Immunol. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"649","DOI":"10.5603\/rpor.102823","article-title":"An Omics-Based Tumor Microenvironment Approach and Its Prospects","volume":"29","author":"Nema","year":"2024","journal-title":"Rep. Pract. Oncol. Radiother."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"104216","DOI":"10.1016\/j.ebiom.2022.104216","article-title":"Obstacles for T-Lymphocytes in the Tumour Microenvironment: Therapeutic Challenges, Advances and Opportunities beyond Immune Checkpoint","volume":"83","author":"Verma","year":"2022","journal-title":"EBioMedicine"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s13046-015-0221-y","article-title":"Metabolic Reprogramming: The Emerging Concept and Associated Therapeutic Strategies","volume":"34","author":"Yoshida","year":"2015","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.123.3191.309","article-title":"On the Origin of Cancer Cells","volume":"123","author":"Warburg","year":"1956","journal-title":"Science"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41467-024-55577-0","article-title":"The Protein circPETH-147aa Regulates Metabolic Reprogramming in Hepatocellular Carcinoma Cells to Remodel Immunosuppressive Microenvironment","volume":"16","author":"Lan","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1055\/s-0030-1253454","article-title":"Heterogeneity of the Tumor Vasculature","volume":"36","author":"Nagy","year":"2010","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Cui, X., Liu, X., Feng, R., Wang, X., Wei, Y., Zhu, H., Raza, A., Zhu, X., Chen, H., and Chong, W. (2024). Editorial: Tumor Microenvironment and Metabolic Reprogramming in Cancer. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1497966"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Almawash, S. (2025). Revolutionary Cancer Therapy for Personalization and Improved Efficacy: Strategies to Overcome Resistance to Immune Checkpoint Inhibitor Therapy. Cancers, 17.","DOI":"10.3390\/cancers17050880"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Menon, S., Shin, S., and Dy, G. (2016). Advances in Cancer Immunotherapy in Solid Tumors. Cancers, 8.","DOI":"10.3390\/cancers8120106"},{"key":"ref_16","first-page":"264","article-title":"Current Treatment and Recent Progress in Gastric Cancer","volume":"71","author":"Joshi","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.trecan.2024.03.008","article-title":"Gastric Cancer Immunosuppressive Microenvironment Heterogeneity: Implications for Therapy Development","volume":"10","author":"Yasuda","year":"2024","journal-title":"Trends Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3892\/or.2024.8847","article-title":"Role and Value of the Tumor Microenvironment in the Progression and Treatment Resistance of Gastric Cancer (Review)","volume":"53","author":"Yun","year":"2025","journal-title":"Oncol. Rep."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ccell.2023.01.009","article-title":"Metabolic Programming and Immune Suppression in the Tumor Microenvironment","volume":"41","author":"Arner","year":"2023","journal-title":"Cancer Cell"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Zhu, L., Zhu, X., and Wu, Y. (2022). Effects of Glucose Metabolism, Lipid Metabolism, and Glutamine Metabolism on Tumor Microenvironment and Clinical Implications. Biomolecules, 12.","DOI":"10.3390\/biom12040580"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"He, X., Guan, X.-Y., and Li, Y. (2025). Clinical Significance of the Tumor Microenvironment on Immune Tolerance in Gastric Cancer. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1532605"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Liu, Y., Li, C., Lu, Y., Liu, C., and Yang, W. (2022). Tumor Microenvironment-Mediated Immune Tolerance in Development and Treatment of Gastric Cancer. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1016817"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Kumar, R., Mishra, A., Gautam, P., Feroz, Z., Vijayaraghavalu, S., Likos, E.M., Shukla, G.C., and Kumar, M. (2022). Metabolic Pathways, Enzymes, and Metabolites: Opportunities in Cancer Therapy. Cancers, 14.","DOI":"10.3390\/cancers14215268"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cmet.2014.12.005","article-title":"Pyruvate Kinase M2 Regulates Hif-1\u03b1 Activity and IL-1\u03b2 Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages","volume":"21","author":"Curtis","year":"2015","journal-title":"Cell Metab."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e3266","DOI":"10.1002\/hon.3266","article-title":"The role of baseline 2-[18F]-FDG-PET\/CT metrics and radiomics features in predicting primary gastric lymphoma diagnosis","volume":"42","author":"Domenico","year":"2024","journal-title":"Hematol Oncol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"152409","DOI":"10.1016\/j.prp.2019.04.001","article-title":"Pyruvate Kinase M2 Contributes to Cell Growth in Gastric Cancer via Aerobic Glycolysis","volume":"215","author":"Li","year":"2019","journal-title":"Pathol. Res. Pract."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"101197","DOI":"10.1016\/j.drup.2024.101197","article-title":"N6-Methyladenosine Modification of 3\u2032tRF-AlaAGC Impairs PD-1 Blockade Efficacy by Promoting Lactic Acid Accumulation in the Tumor Microenvironment of Gastric Carcinoma","volume":"79","author":"Xu","year":"2025","journal-title":"Drug Resist. Updat."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41392-024-01839-8","article-title":"Mitochondrial Dysfunction: Mechanisms and Advances in Therapy","volume":"9","author":"Zong","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/s41556-025-01651-8","article-title":"ALDH4A1 Functions as an Active Component of the MPC Complex Maintaining Mitochondrial Pyruvate Import for TCA Cycle Entry and Tumour Suppression","volume":"27","author":"Hsu","year":"2025","journal-title":"Nat. Cell Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.molcel.2014.09.025","article-title":"Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport","volume":"56","author":"Yang","year":"2014","journal-title":"Mol. Cell"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"911","DOI":"10.15252\/embj.201490197","article-title":"Regulation of Mitochondrial Pyruvate Uptake by Alternative Pyruvate Carrier Complexes","volume":"34","author":"Bender","year":"2015","journal-title":"EMBO J."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Park, J.H., Pyun, W.Y., and Park, H.W. (2020). Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets. Cells, 9.","DOI":"10.3390\/cells9102308"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"437","DOI":"10.2478\/jtim-2022-0051","article-title":"Inhibition of Heterogeneous Nuclear Ribonucleoproteins A1 and Oxidative Stress Reduces Glycolysis via Pyruvate Kinase M2 in Chronic Thromboembolic Pulmonary Hypertension","volume":"12","author":"Liu","year":"2024","journal-title":"J. Transl. Int. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.cmet.2017.06.019","article-title":"Ancillary Activity: Beyond Core Metabolism in Immune Cells","volume":"26","author":"Puleston","year":"2017","journal-title":"Cell Metab."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"171","DOI":"10.2147\/CMAR.S405590","article-title":"Gut Microbiota-Tumor Microenvironment Interactions: Mechanisms and Clinical Implications for Immune Checkpoint Inhibitor Efficacy in Cancer","volume":"17","author":"Said","year":"2025","journal-title":"Cancer Manag. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"100077","DOI":"10.1016\/j.cellin.2023.100077","article-title":"Hexokinases in Cancer and Other Pathologies","volume":"2","author":"Guo","year":"2023","journal-title":"Cell Insight"},{"key":"ref_37","first-page":"9523071","article-title":"Pharmacological Effects and Underlying Mechanisms of Licorice-Derived Flavonoids","volume":"2022","author":"Wu","year":"2022","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Rao, G., Peng, X., Li, X., An, K., He, H., Fu, X., Li, S., and An, Z. (2023). Unmasking the Enigma of Lipid Metabolism in Metabolic Dysfunction-Associated Steatotic Liver Disease: From Mechanism to the Clinic. Front. Med., 10.","DOI":"10.3389\/fmed.2023.1294267"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"242","DOI":"10.7150\/ijbs.77304","article-title":"TREM-1 Governs NLRP3 Inflammasome Activation of Macrophages by Firing up Glycolysis in Acute Lung Injury","volume":"19","author":"Zhong","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e0211723","DOI":"10.1128\/mbio.02117-23","article-title":"Host Cell Sensing and Restoration of Mitochondrial Function and Metabolism within Helicobacter Pylori VacA Intoxicated Cells","volume":"14","author":"Seeger","year":"2023","journal-title":"mBio"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e70975","DOI":"10.1002\/cam4.70975","article-title":"Lipid Metabolism in Gastrointestinal Malignancies: Exploring Dysregulation, Biomarkers, and Treatment Strategies","volume":"14","author":"An","year":"2025","journal-title":"Cancer Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1097\/MS9.0000000000001802","article-title":"Research Progress on Molecular Mechanism of Pyroptosis Caused by Helicobacter Pylori in Gastric Cancer","volume":"86","author":"Gu","year":"2024","journal-title":"Ann. Med. Surg."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Zhou, X., Su, M., Lu, J., Li, D., Niu, X., and Wang, Y. (2024). CD36: The Bridge between Lipids and Tumors. Molecules, 29.","DOI":"10.3390\/molecules29020531"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Yang, R., Yi, M., and Xiang, B. (2022). Novel Insights on Lipid Metabolism Alterations in Drug Resistance in Cancer. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.875318"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40164-024-00482-x","article-title":"Cancer Metabolism and Carcinogenesis","volume":"13","author":"Yang","year":"2024","journal-title":"Exp. Hematol. Oncol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/978-981-13-1286-1_11","article-title":"Regulation of Lipolysis in Adipose Tissue and Clinical Significance","volume":"1090","author":"Li","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Li, J., Liu, H., Yang, P., Zhu, F., Shen, F., and Liang, G. (2025). Identifying Aberrant 1CM-Related Pathways by Multi-Omics Analysis and Validating Tumor Inhibitory Effect of One-Carbon Donor Betaine in Gastric Cancer. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26083841"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1038\/s41467-023-38360-5","article-title":"Spatially resolved multi-omics highlights cell-specific metabolic remodeling and interactions in gastric cancer","volume":"14","author":"Sun","year":"2023","journal-title":"Nat Commun."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nri2888","article-title":"Metabolism, Migration and Memory in Cytotoxic T Cells","volume":"11","author":"Finlay","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1186\/s12964-024-01760-1","article-title":"The Significant Role of Amino Acid Metabolic Reprogramming in Cancer","volume":"22","author":"Liu","year":"2024","journal-title":"Cell Commun. Signal"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1007\/s12094-021-02645-2","article-title":"Targeting GLS1 to Cancer Therapy through Glutamine Metabolism","volume":"23","author":"Yu","year":"2021","journal-title":"Clin. Transl. Oncol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1038\/s12276-020-00504-8","article-title":"Glutamine Reliance in Cell Metabolism","volume":"52","author":"Yoo","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Wang, Q., Li, K., Li, L., Li, Q., Qi, Y., Liu, K., Yuan, H., and Lin, P. (2025). The Role and Therapeutic Potential of Glucose Metabolism in Multidrug Resistance of Cancer. Front. Cell Dev. Biol., 13.","DOI":"10.3389\/fcell.2025.1584630"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e70120","DOI":"10.1002\/mco2.70120","article-title":"Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases","volume":"6","author":"Kumar","year":"2025","journal-title":"MedComm"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Daverio, Z., Balcerczyk, A., Rautureau, G.J.P., and Panthu, B. (2023). How Warburg-Associated Lactic Acidosis Rewires Cancer Cell Energy Metabolism to Resist Glucose Deprivation. Cancers, 15.","DOI":"10.3390\/cancers15051417"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Plaitakis, A., Sidiropoulou, K., Kotzamani, D., Litso, I., Zaganas, I., and Spanaki, C. (2024). Evolution of Glutamate Metabolism via GLUD2 Enhances Lactate-Dependent Synaptic Plasticity and Complex Cognition. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25105297"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev-physiol-021119-034627","article-title":"The Acidic Tumor Microenvironment as a Driver of Cancer","volume":"82","author":"Boedtkjer","year":"2020","journal-title":"Annu. Rev. Physiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"19345","DOI":"10.1073\/pnas.0709747104","article-title":"Beyond Aerobic Glycolysis: Transformed Cells Can Engage in Glutamine Metabolism That Exceeds the Requirement for Protein and Nucleotide Synthesis","volume":"104","author":"DeBerardinis","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Cui, M.-Y., Yi, X., Zhu, D.-X., and Wu, J. (2022). The Role of Lipid Metabolism in Gastric Cancer. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.916661"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1158\/2159-8290.CD-15-0507","article-title":"MYC, Metabolism, and Cancer","volume":"5","author":"Stine","year":"2015","journal-title":"Cancer Discov."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"38267","DOI":"10.1038\/srep38267","article-title":"Shikonin Induces Mitochondria-Mediated Apoptosis and Enhances Chemotherapeutic Sensitivity of Gastric Cancer through Reactive Oxygen Species","volume":"6","author":"Liang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1126\/science.aav2588","article-title":"Glutamine Blockade Induces Divergent Metabolic Programs to Overcome Tumor Immune Evasion","volume":"366","author":"Leone","year":"2019","journal-title":"Science"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"116030","DOI":"10.1016\/j.biopha.2023.116030","article-title":"Effect of Metabolic Reprogramming on the Immune Microenvironment in Gastric Cancer","volume":"170","author":"Shang","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s12672-025-01798-8","article-title":"Integrative Single-Cell and Multi-Omics Analyses Reveal Ferroptosis-Associated Gene Expression and Immune Microenvironment Heterogeneity in Gastric Cancer","volume":"16","author":"Zhang","year":"2025","journal-title":"Discov. Oncol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e002840","DOI":"10.1136\/jitc-2021-002840","article-title":"Tryptophan Potentiates CD8+ T Cells against Cancer Cells by TRIP12 Tryptophanylation and Surface PD-1 Downregulation","volume":"9","author":"Qin","year":"2021","journal-title":"J. Immunother. Cancer"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"5068701","DOI":"10.1155\/2018\/5068701","article-title":"The Protein Expression of PDL1 Is Highly Correlated with Those of eIF2\u03b1 and ATF4 in Lung Cancer","volume":"2018","author":"Chang","year":"2018","journal-title":"Dis. Markers"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"155655","DOI":"10.1016\/j.prp.2024.155655","article-title":"IDO1-Mediated Catabolism of Tryptophan in Gastric Tumors: Its Potential Role in the Axis of Histopathology, Differentiation and Metastasis","volume":"263","author":"Horozoglu","year":"2024","journal-title":"Pathol. Res. Pract."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41416-019-0664-6","article-title":"The Therapeutic Potential of Targeting Tryptophan Catabolism in Cancer","volume":"122","author":"Opitz","year":"2020","journal-title":"Br. J. Cancer"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.4161\/onci.21716","article-title":"IDO Inhibits a Tryptophan Sufficiency Signal That Stimulates mTOR: A Novel IDO Effector Pathway Targeted by D-1-Methyl-Tryptophan","volume":"1","author":"Metz","year":"2012","journal-title":"Oncoimmunology"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"6634532","DOI":"10.1155\/2021\/6634532","article-title":"The Effect of Lipid Metabolism on CD4+ T Cells","volume":"2021","author":"Cai","year":"2021","journal-title":"Mediat. Inflamm."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1007\/s12672-025-02121-1","article-title":"Mapping Growth Differentiation Factor-15 (GDF15)-Mediated Signaling Pathways in Cancer: Insights into Its Role across Different Cancer Types","volume":"16","author":"Rai","year":"2025","journal-title":"Discov. Oncol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"5359","DOI":"10.7150\/thno.34024","article-title":"Fatty Acid-Induced CD36 Expression via O-GlcNAcylation Drives Gastric Cancer Metastasis","volume":"9","author":"Jiang","year":"2019","journal-title":"Theranostics"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41392-022-01004-z","article-title":"ACSL4, PUFA, and Ferroptosis: New Arsenal in Anti-Tumor Immunity","volume":"7","author":"Gan","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"de la Cruz-L\u00f3pez, K.G., Castro-Mu\u00f1oz, L.J., Reyes-Hern\u00e1ndez, D.O., Garc\u00eda-Carranc\u00e1, A., and Manzo-Merino, J. (2019). Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches. Front. Oncol., 9.","DOI":"10.3389\/fonc.2019.01143"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"De Saedeleer, C.J., Copetti, T., Porporato, P.E., Verrax, J., Feron, O., and Sonveaux, P. (2012). Lactate Activates HIF-1 in Oxidative but Not in Warburg-Phenotype Human Tumor Cells. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0046571"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"BSR20180741","DOI":"10.1042\/BSR20180741","article-title":"Down-Regulation of HIF-1\u03b1 Inhibits the Proliferation, Migration, and Invasion of Gastric Cancer by Inhibiting PI3K\/AKT Pathway and VEGF Expression","volume":"38","author":"Zhang","year":"2018","journal-title":"Biosci. Rep."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1097\/CM9.0000000000000955","article-title":"Lactate Induces Alternative Polarization (M2) of Macrophages under Lipopolysaccharide Stimulation in Vitro through G-Protein Coupled Receptor 81","volume":"133","author":"Wang","year":"2020","journal-title":"Chin. Med. J."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"P\u00e9rez-Tom\u00e1s, R., and P\u00e9rez-Guill\u00e9n, I. (2020). Lactate in the Tumor Microenvironment: An Essential Molecule in Cancer Progression and Treatment. Cancers, 12.","DOI":"10.3390\/cancers12113244"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1159\/000534427","article-title":"Correlation of Neuroendocrine Differentiation with a Distinctively Suppressive Immune Microenvironment in Gastric Cancer","volume":"114","author":"Zou","year":"2024","journal-title":"Neuroendocrinology"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"19961","DOI":"10.1073\/pnas.1014465107","article-title":"Aryl Hydrocarbon Receptor Negatively Regulates Dendritic Cell Immunogenicity via a Kynurenine-Dependent Mechanism","volume":"107","author":"Nguyen","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41590-019-0589-5","article-title":"CD36-Mediated Metabolic Adaptation Supports Regulatory T Cell Survival and Function in Tumors","volume":"21","author":"Wang","year":"2020","journal-title":"Nat. Immunol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"114180","DOI":"10.1016\/j.biopha.2022.114180","article-title":"Targeting Regulatory T Cells in Gastric Cancer: Pathogenesis, Immunotherapy, and Prognosis","volume":"158","author":"Wang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1159\/000538659","article-title":"Association between Metabolic Reprogramming and Immune Regulation in Digestive Tract Tumors","volume":"47","author":"Liu","year":"2024","journal-title":"Oncol. Res. Treat."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"201.e9","DOI":"10.1016\/j.ccell.2022.01.001","article-title":"Lactic Acid Promotes PD-1 Expression in Regulatory T Cells in Highly Glycolytic Tumor Microenvironments","volume":"40","author":"Kumagai","year":"2022","journal-title":"Cancer Cell"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"480.e7","DOI":"10.1016\/j.ccell.2018.02.005","article-title":"Tumor-Repopulating Cells Induce PD-1 Expression in CD8+ T Cells by Transferring Kynurenine and AhR Activation","volume":"33","author":"Liu","year":"2018","journal-title":"Cancer Cell"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"e70703","DOI":"10.1002\/cam4.70703","article-title":"The Kynurenine Pathway and Indole Pathway in Tryptophan Metabolism Influence Tumor Progression","volume":"14","author":"Lu","year":"2025","journal-title":"Cancer Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/08830185.2020.1851371","article-title":"The Interplay between Aryl Hydrocarbon Receptor, H. Pylori, Tryptophan, and Arginine in the Pathogenesis of Gastric Cancer","volume":"41","author":"Pirzadeh","year":"2022","journal-title":"Int. Rev. Immunol."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Jiang, Y., Tao, Q., Qiao, X., Yang, Y., Peng, C., Han, M., Dong, K., Zhang, W., Xu, M., and Wang, D. (2025). Targeting Amino Acid Metabolism to Inhibit Gastric Cancer Progression and Promote Anti-Tumor Immunity: A Review. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1508730"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.4110\/in.2025.25.e13","article-title":"Regulatory T Cell Metabolism: A Promising Therapeutic Target for Cancer Treatment?","volume":"25","author":"Kim","year":"2025","journal-title":"Immune Netw."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/s41419-022-04821-w","article-title":"Impacts and Mechanisms of Metabolic Reprogramming of Tumor Microenvironment for Immunotherapy in Gastric Cancer","volume":"13","author":"Zhao","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"200134","DOI":"10.1183\/16000617.0134-2020","article-title":"Metabolism in Tumour-Associated Macrophages: A Quid pro Quo with the Tumour Microenvironment","volume":"29","author":"Zheng","year":"2020","journal-title":"Eur. Respir. Rev."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Chen, J., Liu, H., Mi, R., Huang, R., Li, X., Fan, F., Xie, X., and Ding, J. (2022). The Role of Histone Methylase and Demethylase in Antitumor Immunity: A New Direction for Immunotherapy. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1099892"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/s41590-024-01746-8","article-title":"Targeting JMJD1C to Selectively Disrupt Tumor Treg Cell Fitness Enhances Antitumor Immunity","volume":"25","author":"Long","year":"2024","journal-title":"Nat. Immunol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.2174\/138161210790963841","article-title":"Peptides Targeting Toll-like Receptor Signalling Pathways for Novel Immune Therapeutics","volume":"16","author":"Gomariz","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Zhao, M., Wei, F., Sun, G., Wen, Y., Xiang, J., Su, F., Zhan, L., Nian, Q., Chen, Y., and Zeng, J. (2022). Natural Compounds Targeting Glycolysis as Promising Therapeutics for Gastric Cancer: A Review. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.1004383"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"e56156","DOI":"10.15252\/embr.202256156","article-title":"Resting Natural Killer Cell Homeostasis Relies on Tryptophan\/NAD+ Metabolism and HIF-1\u03b1","volume":"24","author":"Pelletier","year":"2023","journal-title":"EMBO Rep."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"131","DOI":"10.5009\/gnl.2014.8.2.131","article-title":"Immune Response and the Tumor Microenvironment: How They Communicate to Regulate Gastric Cancer","volume":"8","author":"Lee","year":"2014","journal-title":"Gut Liver"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"6248590","DOI":"10.1155\/2018\/6248590","article-title":"Altered NKp30, NKp46, NKG2D, and DNAM-1 Expression on Circulating NK Cells Is Associated with Tumor Progression in Human Gastric Cancer","volume":"2018","author":"Han","year":"2018","journal-title":"J. Immunol. Res."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Wang, J.X., Choi, S.Y.C., Niu, X., Kang, N., Xue, H., Killam, J., and Wang, Y. (2020). Lactic Acid and an Acidic Tumor Microenvironment Suppress Anticancer Immunity. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21218363"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.yexcr.2011.01.006","article-title":"Impaired IFN-\u03b3 Production after Stimulation with Bacterial Components by Natural Killer Cells from Gastric Cancer Patients","volume":"317","author":"Lindgren","year":"2011","journal-title":"Exp. Cell Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.cell.2015.08.016","article-title":"Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression","volume":"162","author":"Chang","year":"2015","journal-title":"Cell"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/s41568-020-0273-y","article-title":"Metabolism of Immune Cells in Cancer","volume":"20","author":"Leone","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Lettieri-Barbato, D., and Aquilano, K. (2018). Pushing the Limits of Cancer Therapy: The Nutrient Game. Front. Oncol., 8.","DOI":"10.3389\/fonc.2018.00148"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/1097-0142(20010801)92:3<634::AID-CNCR1364>3.0.CO;2-X","article-title":"Expression of Glucose Transporter-1 in Human Gastric Carcinoma: Association with Tumor Aggressiveness, Metastasis, and Patient Survival","volume":"92","author":"Kawamura","year":"2001","journal-title":"Cancer"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12943-021-01316-8","article-title":"The Cancer Metabolic Reprogramming and Immune Response","volume":"20","author":"Xia","year":"2021","journal-title":"Mol. Cancer"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1186\/s12935-023-03169-1","article-title":"The Emerging Role of Glycolysis and Immune Evasion in Gastric Cancer","volume":"23","author":"Zheng","year":"2023","journal-title":"Cancer Cell Int."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Zhao, J., Jin, D., Huang, M., Ji, J., Xu, X., Wang, F., Zhou, L., Bao, B., Jiang, F., and Xu, W. (2024). Glycolysis in the Tumor Microenvironment: A Driver of Cancer Progression and a Promising Therapeutic Target. Front. Cell Dev. Biol., 12.","DOI":"10.3389\/fcell.2024.1416472"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.tcb.2020.02.005","article-title":"Nitrogen Metabolism in Cancer and Immunity","volume":"30","author":"Kurmi","year":"2020","journal-title":"Trends Cell Biol."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Lopes, C., Pereira, C., and Medeiros, R. (2021). ASCT2 and LAT1 Contribution to the Hallmarks of Cancer: From a Molecular Perspective to Clinical Translation. Cancers, 13.","DOI":"10.3390\/cancers13020203"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Scalise, M., Console, L., Rovella, F., Galluccio, M., Pochini, L., and Indiveri, C. (2020). Membrane Transporters for Amino Acids as Players of Cancer Metabolic Rewiring. Cells, 9.","DOI":"10.3390\/cells9092028"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"15330338231168498","DOI":"10.1177\/15330338231168498","article-title":"The Regulatory Mechanism and Research Progress of Ferroptosis in Gastric Cancer","volume":"22","author":"Zhang","year":"2023","journal-title":"Technol. Cancer Res. Treat."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Zhao, Y., Zhao, J., Ma, H., Han, Y., Xu, W., Wang, J., Cai, Y., Jia, X., Jia, Q., and Yang, Q. (2023). High Hepcidin Levels Promote Abnormal Iron Metabolism and Ferroptosis in Chronic Atrophic Gastritis. Biomedicines, 11.","DOI":"10.3390\/biomedicines11092338"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1258\/ebm.2011.011193","article-title":"Expression and Function of Heme Oxygenase-1 in Human Gastric Cancer","volume":"237","author":"Yin","year":"2012","journal-title":"Exp. Biol. Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"725","DOI":"10.2217\/fmb.13.43","article-title":"The Ferric Uptake Regulator of Helicobacter Pylori: A Critical Player in the Battle for Iron and Colonization of the Stomach","volume":"8","author":"Pich","year":"2013","journal-title":"Future Microbiol."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Kato, S., Gold, B.D., and Kato, A. (2022). Helicobacter Pylori-Associated Iron Deficiency Anemia in Childhood and Adolescence-Pathogenesis and Clinical Management Strategy. J. Clin. Med., 11.","DOI":"10.3390\/jcm11247351"},{"key":"ref_117","first-page":"8187235","article-title":"Potential Role of ANGPTL4 in the Cross Talk between Metabolism and Cancer through PPAR Signaling Pathway","volume":"2017","author":"Caruso","year":"2017","journal-title":"PPAR Res."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"8412","DOI":"10.7150\/thno.59092","article-title":"Targeting Iron Metabolism in Cancer Therapy","volume":"11","author":"Morales","year":"2021","journal-title":"Theranostics"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.21037\/tcr-21-655","article-title":"Aberrant Lipid Metabolism Reprogramming and Immune Microenvironment for Gastric Cancer: A Literature Review","volume":"10","author":"Cui","year":"2021","journal-title":"Transl. Cancer Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1245\/s10434-022-12465-5","article-title":"Hypoxia-Induced CD36 Expression in Gastric Cancer Cells Promotes Peritoneal Metastasis via Fatty Acid Uptake","volume":"30","author":"Aoki","year":"2023","journal-title":"Ann. Surg. Oncol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/s41568-019-0149-1","article-title":"Ferroptosis at the Crossroads of Cancer-Acquired Drug Resistance and Immune Evasion","volume":"19","author":"Krysko","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature13490","article-title":"Functional Polarization of Tumour-Associated Macrophages by Tumour-Derived Lactic Acid","volume":"513","author":"Colegio","year":"2014","journal-title":"Nature"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"112296","DOI":"10.1016\/j.isci.2025.112296","article-title":"Metabolic Alterations and Immune Heterogeneity in Gastric Cancer Metastasis","volume":"28","author":"Zeng","year":"2025","journal-title":"iScience"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"114424","DOI":"10.1016\/j.celrep.2024.114424","article-title":"Molecular Characterization and Clinical Relevance of Metabolic Signature Subtypes in Gastric Cancer","volume":"43","author":"Chen","year":"2024","journal-title":"Cell Rep."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"13804","DOI":"10.3748\/wjg.v20.i38.13804","article-title":"Pathogenetic Mechanisms in Gastric Cancer","volume":"20","author":"Shi","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13045-024-01654-2","article-title":"Helicobacter Pylori and Gastric Cancer: Mechanisms and New Perspectives","volume":"18","author":"Duan","year":"2025","journal-title":"J. Hematol. Oncol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"e70948","DOI":"10.1002\/cam4.70948","article-title":"Advances in the Study of Metabolic Reprogramming in Gastric Cancer","volume":"14","author":"Rong","year":"2025","journal-title":"Cancer Med."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1678044","DOI":"10.3389\/fcimb.2025.1678044","article-title":"Liu T, Zhao X, Cai T, Li W, Zhang M. Metabolic reprogramming in Helicobacter pylori infection: From mechanisms to therapeutics","volume":"15","author":"Liu","year":"2025","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"39839","DOI":"10.18632\/oncotarget.5674","article-title":"Inhibition of Autophagy Promotes Metastasis and Glycolysis by Inducing ROS in Gastric Cancer Cells","volume":"6","author":"Qin","year":"2015","journal-title":"Oncotarget"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1038\/s41388-020-01639-8","article-title":"The Functional Roles of TCA Cycle Metabolites in Cancer","volume":"40","author":"Eniafe","year":"2021","journal-title":"Oncogene"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/S0006-3495(99)77301-7","article-title":"Helicobacter Pylori Vacuolating Toxin Forms Anion-Selective Channels in Planar Lipid Bilayers: Possible Implications for the Mechanism of Cellular Vacuolation","volume":"76","author":"Tombola","year":"1999","journal-title":"Biophys. J."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/s41389-022-00420-8","article-title":"Lipids in Cancer: A Global View of the Contribution of Lipid Pathways to Metastatic Formation and Treatment Resistance","volume":"11","author":"Vasseur","year":"2022","journal-title":"Oncogenesis"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s12964-024-01552-7","article-title":"Tryptophan Metabolism in Digestive System Tumors: Unraveling the Pathways and Implications","volume":"22","author":"Yu","year":"2024","journal-title":"Cell Commun. Signal"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/nrgastro.2018.5","article-title":"Acid and the Basis for Cellular Plasticity and Reprogramming in Gastric Repair and Cancer","volume":"15","author":"Mills","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Lee, S.-H., and Griffiths, J.R. (2020). How and Why Are Cancers Acidic? Carbonic Anhydrase IX and the Homeostatic Control of Tumour Extracellular pH. Cancers, 12.","DOI":"10.3390\/cancers12061616"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Buczkowska, J., and Szeliga, M. (2023). Two Faces of Glutaminase GLS2 in Carcinogenesis. Cancers, 15.","DOI":"10.3390\/cancers15235566"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10120-011-0059-8","article-title":"Decreased NKG2D Expression on NK Cells Correlates with Impaired NK Cell Function in Patients with Gastric Cancer","volume":"15","author":"Saito","year":"2012","journal-title":"Gastric Cancer"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1080\/10408398.2020.1784841","article-title":"Mechanisms, Physiology, and Recent Research Progress of Gastric Emptying","volume":"61","author":"Liu","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"e50635","DOI":"10.15252\/embr.202050635","article-title":"Nutrient Metabolism and Cancer in the in Vivo Context: A Metabolic Game of Give and Take","volume":"21","author":"Cuadros","year":"2020","journal-title":"EMBO Rep."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.2147\/OTT.S189687","article-title":"Metabolic Reprogramming Results in Abnormal Glycolysis in Gastric Cancer: A Review","volume":"12","author":"Liu","year":"2019","journal-title":"Onco Targets Ther."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/s42003-021-02765-z","article-title":"CD36 Maintains the Gastric Mucosa and Associates with Gastric Disease","volume":"4","author":"Miao","year":"2021","journal-title":"Commun. Biol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1667\/RADE-21-00174.1","article-title":"CPT1 Mediated Ionizing Radiation-Induced Intestinal Injury Proliferation via Shifting FAO Metabolism Pathway and Activating the ERK1\/2 and JNK Pathway","volume":"198","author":"Liu","year":"2022","journal-title":"Radiat. Res."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1145.e9","DOI":"10.1016\/j.ccell.2022.08.016","article-title":"Ablation of the Endoplasmic Reticulum Stress Kinase PERK Induces Paraptosis and Type I Interferon to Promote Anti-Tumor T Cell Responses","volume":"40","author":"Mandula","year":"2022","journal-title":"Cancer Cell"},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Cancer Genome Atlas Research Network (2014). Comprehensive Molecular Characterization of Gastric Adenocarcinoma. Nature, 513, 202\u2013209.","DOI":"10.1038\/nature13480"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Nemtsova, M.V., Kuznetsova, E.B., and Bure, I.V. (2023). Chromosomal Instability in Gastric Cancer: Role in Tumor Development, Progression, and Therapy. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242316961"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Graziano, F., Fischer, N.W., Bagaloni, I., Di Bartolomeo, M., Lonardi, S., Vincenzi, B., Perrone, G., Fornaro, L., Ongaro, E., and Aprile, G. (2020). TP53 Mutation Analysis in Gastric Cancer and Clinical Outcomes of Patients with Metastatic Disease Treated with Ramucirumab\/Paclitaxel or Standard Chemotherapy. Cancers, 12.","DOI":"10.3390\/cancers12082049"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.3748\/wjg.v22.i6.2046","article-title":"Glucose Metabolism in Gastric Cancer: The Cutting-Edge","volume":"22","author":"Yuan","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Itahana, Y., and Itahana, K. (2018). Emerging Roles of P53 Family Members in Glucose Metabolism. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19030776"},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Wang, Y., Peng, J., Yang, D., Xing, Z., Jiang, B., Ding, X., Jiang, C., Ouyang, B., and Su, L. (2024). From Metabolism to Malignancy: The Multifaceted Role of PGC1\u03b1 in Cancer. Front. Oncol., 14.","DOI":"10.3389\/fonc.2024.1383809"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"e1217967","DOI":"10.1080\/23723556.2016.1217967","article-title":"Mutant P53-Nrf2 Axis Regulates the Proteasome Machinery in Cancer","volume":"4","author":"Lisek","year":"2017","journal-title":"Mol. Cell Oncol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"78365","DOI":"10.18632\/oncotarget.18695","article-title":"Regulation of SIRT3 Signal Related Metabolic Reprogramming in Gastric Cancer by Helicobacter Pylori Oncoprotein CagA","volume":"8","author":"Lee","year":"2017","journal-title":"Oncotarget"},{"key":"ref_152","first-page":"469","article-title":"TCGA Divides Gastric Cancer into Four Molecular Subtypes: Implications for Individualized Therapeutics","volume":"33","author":"Zhang","year":"2014","journal-title":"Chin. J. Cancer"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"111413","DOI":"10.1016\/j.jinorgbio.2021.111413","article-title":"The DpdtbA Induced EMT Inhibition in Gastric Cancer Cell Lines Was through Ferritinophagy-Mediated Activation of P53 and PHD2\/Hif-1\u03b1 Pathway","volume":"218","author":"Guan","year":"2021","journal-title":"J. Inorg. Biochem."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1101\/gad.889901","article-title":"Inhibition of Early Apoptotic Events by Akt\/PKB Is Dependent on the First Committed Step of Glycolysis and Mitochondrial Hexokinase","volume":"15","author":"Gottlob","year":"2001","journal-title":"Genes Dev."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.molcel.2004.11.014","article-title":"Hexokinase-Mitochondria Interaction Mediated by Akt Is Required to Inhibit Apoptosis in the Presence or Absence of Bax and Bak","volume":"16","author":"Majewski","year":"2004","journal-title":"Mol. Cell"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"RP92236","DOI":"10.7554\/eLife.92236","article-title":"mTORC1\/S6K1 Signaling Promotes Sustained Oncogenic Translation through Modulating CRL3IBTK-Mediated Ubiquitination of eIF4A1 in Cancer Cells","volume":"12","author":"Jiao","year":"2024","journal-title":"eLife"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.21037\/atm-21-4544","article-title":"Narrative Review of Emerging Roles for AKT-mTOR Signaling in Cancer Radioimmunotherapy","volume":"9","author":"Shen","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"11435","DOI":"10.3390\/ijms150711435","article-title":"PKM2: The Thread Linking Energy Metabolism Reprogramming with Epigenetics in Cancer","volume":"15","author":"Chen","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1111\/cas.13211","article-title":"Enhanced Expression of the M2 Isoform of Pyruvate Kinase Is Involved in Gastric Cancer Development by Regulating Cancer-Specific Metabolism","volume":"108","author":"Shiroki","year":"2017","journal-title":"Cancer Sci."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"e527","DOI":"10.1002\/mco2.527","article-title":"Tyrosine Phosphatase SHP2 Aggravates Tumor Progression and Glycolysis by Dephosphorylating PKM2 in Gastric Cancer","volume":"5","author":"Wang","year":"2024","journal-title":"MedComm"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00428-014-1588-4","article-title":"The PI3K\/AKT\/mTOR Pathway Is Activated in Gastric Cancer with Potential Prognostic and Predictive Significance","volume":"465","author":"Tapia","year":"2014","journal-title":"Virchows Arch."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00280-022-04398-3","article-title":"Disulfiram\/Copper Induces Antitumor Activity against Gastric Cancer Cells in Vitro and in Vivo by Inhibiting S6K1 and c-Myc","volume":"89","author":"Du","year":"2022","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/s41419-024-07052-3","article-title":"The NRF2-CARM1 Axis Links Glucose Sensing to Transcriptional and Epigenetic Regulation of the Pentose Phosphate Pathway in Gastric Cancer","volume":"15","author":"Ping","year":"2024","journal-title":"Cell Death Dis."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.hoc.2024.01.003","article-title":"Advances in Gastric Cancer Surgical Management","volume":"38","author":"Stroobant","year":"2024","journal-title":"Hematol. Oncol. Clin. N. Am."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"102175","DOI":"10.1016\/j.ctrv.2021.102175","article-title":"Microsatellite Instability in Gastric Cancer: Between Lights and Shadows","volume":"95","author":"Puliga","year":"2021","journal-title":"Cancer Treat. Rev."},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Liu, Y., Huang, Y., He, Q., Shen, Y., and Wang, Y. (2025). Dual Regulation of Gastrointestinal Tumor Progression by the IFN-\u03b3\/STAT1 Pathway and Prospects for Targeted Therapy. Front. Oncol., 15.","DOI":"10.3389\/fonc.2025.1598170"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/cmi.2017.143","article-title":"IDO1 in Cancer: A Gemini of Immune Checkpoints","volume":"15","author":"Zhai","year":"2018","journal-title":"Cell Mol. Immunol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"20","DOI":"10.4132\/jptm.2019.10.08","article-title":"Tumor Immune Response and Immunotherapy in Gastric Cancer","volume":"54","author":"Kwak","year":"2020","journal-title":"J. Pathol. Transl. Med."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"6099","DOI":"10.1111\/febs.16086","article-title":"Indoleamine 2,3-Dioxygenase 1 (IDO1): An up-to-Date Overview of an Eclectic Immunoregulatory Enzyme","volume":"289","author":"Pallotta","year":"2022","journal-title":"FEBS J."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1039\/D1MD00015B","article-title":"Recent Advances in the Development of AHR Antagonists in Immuno-Oncology","volume":"12","author":"Sun","year":"2021","journal-title":"RSC Med. Chem."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"115464","DOI":"10.1016\/j.bcp.2023.115464","article-title":"Glutamine Metabolism in Breast Cancer and Possible Therapeutic Targets","volume":"210","author":"Li","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"17588359241231259","DOI":"10.1177\/17588359241231259","article-title":"Adjuvant and Neoadjuvant Chemotherapy for MSI Early Gastric Cancer: A Systematic Review and Meta-Analysis","volume":"16","author":"Petrelli","year":"2024","journal-title":"Ther. Adv. Med. Oncol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s00432-018-2605-9","article-title":"Targeting of Glutamine Transporter ASCT2 and Glutamine Synthetase Suppresses Gastric Cancer Cell Growth","volume":"144","author":"Ye","year":"2018","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Kim, G.W., Lee, D.H., Jeon, Y.H., Yoo, J., Kim, S.Y., Lee, S.W., Cho, H.Y., and Kwon, S.H. (2021). Glutamine Synthetase as a Therapeutic Target for Cancer Treatment. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22041701"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.trecan.2017.01.005","article-title":"Glutamine Metabolism in Cancer: Understanding the Heterogeneity","volume":"3","author":"Cluntun","year":"2017","journal-title":"Trends Cancer"},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Wang, J., Zhang, Q., Fu, H., Han, Y., Li, X., Zou, Q., Yuan, S., and Sun, L. (2024). ASCT2 Regulates Fatty Acid Metabolism to Trigger Glutamine Addiction in Basal-like Breast Cancer. Cancers, 16.","DOI":"10.3390\/cancers16173028"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1007\/s13238-014-0082-8","article-title":"Regulation of the Pentose Phosphate Pathway in Cancer","volume":"5","author":"Jiang","year":"2014","journal-title":"Protein Cell"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.molmet.2019.11.011","article-title":"Targeting Extracellular Nutrient Dependencies of Cancer Cells","volume":"33","author":"Williams","year":"2020","journal-title":"Mol. Metab."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.canlet.2020.09.019","article-title":"Epstein-Barr Virus-Associated Gastric Cancer: A Distinct Subtype","volume":"495","author":"Yang","year":"2020","journal-title":"Cancer Lett."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1200\/JCO.2004.08.061","article-title":"EBV-Positive Gastric Adenocarcinomas: A Distinct Clinicopathologic Entity with a Low Frequency of Lymph Node Involvement","volume":"22","author":"Middeldorp","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3961\/jpmph.15.068","article-title":"Epstein-Barr Virus and Gastric Cancer Risk: A Meta-Analysis with Meta-Regression of Case-Control Studies","volume":"49","author":"Bae","year":"2016","journal-title":"J. Prev. Med. Public Health"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"e70197","DOI":"10.1002\/jmv.70197","article-title":"Metabolic Reprogramming in Epstein-Barr Virus Associated Diseases","volume":"97","author":"Yee","year":"2025","journal-title":"J. Med. Virol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1073\/pnas.1121357109","article-title":"EBV LMP1: New and Shared Pathways to NF-\u03baB Activation","volume":"109","author":"Lavorgna","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Incrocci, R., Monroy Del Toro, R., Devitt, G., Salimian, M., Braich, K., and Swanson-Mungerson, M. (2024). Epstein-Barr Virus Latent Membrane Protein 2A (LMP2A) Enhances ATP Production in B Cell Tumors through mTOR and HIF-1\u03b1. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25073944"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1038\/onc.2015.447","article-title":"Glutaminolysis as a Target for Cancer Therapy","volume":"35","author":"Jin","year":"2016","journal-title":"Oncogene"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"171","DOI":"10.2147\/JBM.S70716","article-title":"IDH1 and IDH2 Mutations as Novel Therapeutic Targets: Current Perspectives","volume":"7","author":"Mondesir","year":"2016","journal-title":"J. Blood Med."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1038\/s41418-024-01402-6","article-title":"Oncometabolites at the Crossroads of Genetic, Epigenetic and Ecological Alterations in Cancer","volume":"31","author":"Lanzetti","year":"2024","journal-title":"Cell Death Differ."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"803","DOI":"10.2217\/fvl-2018-0071","article-title":"Molecular Features and Translational Outlook for Epstein-Barr Virus-Associated Gastric Cancer","volume":"13","author":"Stanland","year":"2018","journal-title":"Future Virol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1038\/bjc.2012.197","article-title":"C-Myc and EBV-LMP1: Two Opposing Regulators of the HLA Class I Antigen Presentation Machinery in Epithelial Cells","volume":"106","author":"Tudor","year":"2012","journal-title":"Br. J. Cancer"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1002\/cncr.21784","article-title":"Down-Regulation of Locus-Specific Human Lymphocyte Antigen Class I Expression in Epstein-Barr Virus-Associated Gastric Cancer: Implication for Viral-Induced Immune Evasion","volume":"106","author":"Dutta","year":"2006","journal-title":"Cancer"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"10110","DOI":"10.1128\/JVI.01110-15","article-title":"Latent Expression of the Epstein-Barr Virus (EBV)-Encoded Major Histocompatibility Complex Class I TAP Inhibitor, BNLF2a, in EBV-Positive Gastric Carcinomas","volume":"89","author":"Strong","year":"2015","journal-title":"J. Virol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"628","DOI":"10.4251\/wjgo.v14.i3.628","article-title":"Clinical Significance of Molecular Subtypes of Gastrointestinal Tract Adenocarcinoma","volume":"14","author":"Ignatova","year":"2022","journal-title":"World J. Gastrointest. Oncol."},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Alessandrini, L., Manchi, M., De Re, V., Dolcetti, R., and Canzonieri, V. (2018). Proposed Molecular and miRNA Classification of Gastric Cancer. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19061683"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s00535-022-01879-3","article-title":"Gastric Cancer and Genomics: Review of Literature","volume":"57","author":"Onoyama","year":"2022","journal-title":"J. Gastroenterol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s40880-016-0111-5","article-title":"Emerging Molecular Classifications and Therapeutic Implications for Gastric Cancer","volume":"35","author":"Chen","year":"2016","journal-title":"Chin. J. Cancer"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"00235","DOI":"10.15406\/jcpcr.2017.07.00235","article-title":"Loss of E-Cadherin Expression and Epithelial Mesenchymal Transition (EMT) as Key Steps in Tumor Progression","volume":"7","author":"Carrizo","year":"2017","journal-title":"J. Cancer Prev. Curr. Res."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"10477","DOI":"10.2147\/CMAR.S208818","article-title":"CDH1 (E-Cadherin) Mutation and Gastric Cancer: Genetics, Molecular Mechanisms and Guidelines for Management","volume":"11","author":"Shenoy","year":"2019","journal-title":"Cancer Manag. Res."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"23198","DOI":"10.18632\/oncotarget.25269","article-title":"DGC-Specific RHOA Mutations Maintained Cancer Cell Survival and Promoted Cell Migration via ROCK Inactivation","volume":"9","author":"Nishizawa","year":"2018","journal-title":"Oncotarget"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/sj.bjc.6605561","article-title":"Inhibitory Effect of a TGFbeta Receptor Type-I Inhibitor, Ki26894, on Invasiveness of Scirrhous Gastric Cancer Cells","volume":"102","author":"Shinto","year":"2010","journal-title":"Br. J. Cancer"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"13756","DOI":"10.3748\/wjg.v20.i38.13756","article-title":"Rho\/ROCK Signaling in Motility and Metastasis of Gastric Cancer","volume":"20","author":"Matsuoka","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"a022129","DOI":"10.1101\/cshperspect.a022129","article-title":"Non-Smad Signaling Pathways of the TGF-\u03b2 Family","volume":"9","author":"Zhang","year":"2017","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"17588359221083049","DOI":"10.1177\/17588359221083049","article-title":"The Dawn of Precision Medicine in Diffuse-Type Gastric Cancer","volume":"14","author":"Ooki","year":"2022","journal-title":"Ther. Adv. Med. Oncol."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s11523-024-01097-2","article-title":"Diffuse Gastric Cancer: A Comprehensive Review of Molecular Features and Emerging Therapeutics","volume":"19","author":"Wu","year":"2024","journal-title":"Target. Oncol."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s10863-008-9165-7","article-title":"Voltage Dependent Anion Channels (VDACs): A Brief Introduction with a Focus on the Outer Mitochondrial Compartment\u2019s Roles Together with Hexokinase-2 in the \u201cWarburg Effect\u201d in Cancer","volume":"40","author":"Pedersen","year":"2008","journal-title":"J. Bioenerg. Biomembr."},{"key":"ref_205","first-page":"251","article-title":"Expression of Type 2 Hexokinase and Mitochondria-Related Genes in Gastric Carcinoma Tissues and Cell Lines","volume":"27","author":"Rho","year":"2007","journal-title":"Anticancer. Res."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.bbrc.2016.04.151","article-title":"3-Bromopyruvate and Sodium Citrate Induce Apoptosis in Human Gastric Cancer Cell Line MGC-803 by Inhibiting Glycolysis and Promoting Mitochondria-Regulated Apoptosis Pathway","volume":"475","author":"Guo","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.3892\/or.2015.4511","article-title":"3-Bromopyruvate and Sodium Citrate Target Glycolysis, Suppress Survivin, and Induce Mitochondrial-Mediated Apoptosis in Gastric Cancer Cells and Inhibit Gastric Orthotopic Transplantation Tumor Growth","volume":"35","author":"Wang","year":"2016","journal-title":"Oncol. Rep."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1158\/0008-5472.CAN-21-1820","article-title":"Disrupting Circadian Rhythm via the PER1-HK2 Axis Reverses Trastuzumab Resistance in Gastric Cancer","volume":"82","author":"Wang","year":"2022","journal-title":"Cancer Res."},{"key":"ref_209","first-page":"428","article-title":"Fenofibrate-Induced Mitochondrial Dysfunction and Metabolic Reprogramming Reversal: The Anti-Tumor Effects in Gastric Carcinoma Cells Mediated by the PPAR Pathway","volume":"12","author":"Chen","year":"2020","journal-title":"Am. J. Transl. Res."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1126\/science.1215637","article-title":"Cell Biology. Warburg Effect and Redox Balance","volume":"334","author":"Hamanaka","year":"2011","journal-title":"Science"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1002\/jcb.24122","article-title":"Reversal Effects of Pantoprazole on Multidrug Resistance in Human Gastric Adenocarcinoma Cells by Down-Regulating the V-ATPases\/mTOR\/HIF-1\u03b1\/P-Gp and MRP1 Signaling Pathway In Vitro and In Vivo","volume":"113","author":"Chen","year":"2012","journal-title":"J. Cell Biochem."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.canlet.2014.11.046","article-title":"Oxamate-Mediated Inhibition of Lactate Dehydrogenase Induces Protective Autophagy in Gastric Cancer Cells: Involvement of the Akt\u2013mTOR Signaling Pathway","volume":"358","author":"Zhao","year":"2015","journal-title":"Cancer Lett."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13046-019-1049-7","article-title":"CD36 Mediates Palmitate Acid-Induced Metastasis of Gastric Cancer via AKT\/GSK-3\u03b2\/\u03b2-Catenin Pathway","volume":"38","author":"Pan","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"e1344804","DOI":"10.1080\/2162402X.2017.1344804","article-title":"Exogenous Lipid Uptake Induces Metabolic and Functional Reprogramming of Tumor-Associated Myeloid-Derived Suppressor Cells","volume":"6","author":"Zheng","year":"2017","journal-title":"Oncoimmunology"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.18632\/aging.103985","article-title":"CD36 Upregulates DEK Transcription and Promotes Cell Migration and Invasion via GSK-3\u03b2\/\u03b2-Catenin-Mediated Epithelial-to-Mesenchymal Transition in Gastric Cancer","volume":"13","author":"Wang","year":"2020","journal-title":"Aging"},{"key":"ref_216","doi-asserted-by":"crossref","unstructured":"Zhu, T., Wang, Z., Zou, T., Xu, L., Zhang, S., Chen, Y., Chen, C., Zhang, W., Wang, S., and Ding, Q. (2021). SOAT1 Promotes Gastric Cancer Lymph Node Metastasis Through Lipid Synthesis. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.769647"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"116257","DOI":"10.1016\/j.bcp.2024.116257","article-title":"HDAC Inhibitors Activate Lipid Peroxidation and Ferroptosis in Gastric Cancer","volume":"225","author":"Jenke","year":"2024","journal-title":"Biochem. Pharmacol."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nature17412","article-title":"Potentiating the Antitumour Response of CD8+ T Cells by Modulating Cholesterol Metabolism","volume":"531","author":"Yang","year":"2016","journal-title":"Nature"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"bqz046","DOI":"10.1210\/endocr\/bqz046","article-title":"CPT1A-Mediated Fat Oxidation, Mechanisms, and Therapeutic Potential","volume":"161","author":"Schlaepfer","year":"2020","journal-title":"Endocrinology"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1186\/s13046-019-1409-3","article-title":"Targeting T Cell Metabolism in the Tumor Microenvironment: An Anti-Cancer Therapeutic Strategy","volume":"38","author":"Yin","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1089\/dna.2021.0936","article-title":"Gastric Cancer Cell-Derived Kynurenines Hyperactive Regulatory T Cells to Promote Chemoresistance via the IL-10\/STAT3\/BCL2 Signaling Pathway","volume":"41","author":"Wu","year":"2022","journal-title":"DNA Cell Biol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/s41379-018-0160-1","article-title":"Differential Expression of PD-L1 and IDO1 in Association with the Immune Microenvironment in Resected Lung Adenocarcinomas","volume":"32","author":"Zhang","year":"2019","journal-title":"Mod. Pathol."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.tips.2017.11.007","article-title":"Targeting the IDO1\/TDO2\u2013KYN\u2013AhR Pathway for Cancer Immunotherapy\u2014Challenges and Opportunities","volume":"39","author":"Cheong","year":"2018","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/s12967-025-06276-x","article-title":"IDO1 Inhibition Enhances CLDN18.2-CAR-T Cell Therapy in Gastrointestinal Cancers by Overcoming Kynurenine-Mediated Metabolic Suppression in the Tumor Microenvironment","volume":"23","author":"Wu","year":"2025","journal-title":"J. Transl. Med."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"29","DOI":"10.37796\/2211-8039.1445","article-title":"Glutaminase\u2014A Potential Target for Cancer Treatment","volume":"14","author":"Anthony","year":"2024","journal-title":"Biomedicine"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"18741","DOI":"10.1038\/s41598-025-03446-1","article-title":"Metabolomic Reprogramming of the Tumor Microenvironment by Dual Arginase Inhibitor OATD-02 Boosts Anticancer Immunity","volume":"15","author":"Grzybowski","year":"2025","journal-title":"Sci. Rep."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/1\/160\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:18:07Z","timestamp":1768565887000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/1\/160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,16]]},"references-count":226,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["biom16010160"],"URL":"https:\/\/doi.org\/10.3390\/biom16010160","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,16]]}}}