{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:33:52Z","timestamp":1787027632510,"version":"build-2736575974"},"reference-count":36,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CIBERER","award":["ACCI 2023"],"award-info":[{"award-number":["ACCI 2023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Herein, we will review the function of the NLRP3 inflammasome in hearing loss (HL), summarize the most significant experimental results described in recent years, describe the biological mechanisms involved in the role of NLRP3 inflammasome in HL, and highlight some of the most promising small NLRP3 inhibitors for its clinical therapy, showing excellent pharmacological effects and good pharmacodynamic\/pharmacokinetic profiles.<\/jats:p>","DOI":"10.3390\/biom16020186","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T11:14:07Z","timestamp":1769426047000},"page":"186","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["NLRP3 Inflammasome Role and NLRP3 Inhibitors in Sensorineural Hearing Loss"],"prefix":"10.3390","volume":"16","author":[{"given":"Mireia","family":"Toledano-Pinedo","sequence":"first","affiliation":[{"name":"Laboratory of Medicinal Chemistry, Institute of General Organic Chemistry (CSIC), C\/Juan de la Cierva 3, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Marco-Contelles","sequence":"additional","affiliation":[{"name":"Laboratory of Medicinal Chemistry, Institute of General Organic Chemistry (CSIC), C\/Juan de la Cierva 3, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7628-0465","authenticated-orcid":false,"given":"Alexey V.","family":"Dobrydnev","sequence":"additional","affiliation":[{"name":"Chemistry Department, Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, 01033 Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.4103\/1673-5374.339499","article-title":"Involvement of NLRP3-inflammasome pathway in noise-induced hearing loss","volume":"17","author":"Sai","year":"2022","journal-title":"Neural Regen. 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