{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T23:09:17Z","timestamp":1770160157803,"version":"3.49.0"},"reference-count":54,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82203641"],"award-info":[{"award-number":["82203641"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"R&D Program of Beijing Municipal Education Commission","award":["KM202310025024"],"award-info":[{"award-number":["KM202310025024"]}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR053237"],"award-info":[{"award-number":["R01AR053237"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR069079"],"award-info":[{"award-number":["R01AR069079"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA196947"],"award-info":[{"award-number":["R01CA196947"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Advanced prostate cancer frequently metastasizes to bone, but no effective therapy exists. To seek a novel treatment option and identify a new drug target, we took an induced tumor-suppressing (iTS) cell-based approach and produced tumor-suppressing proteins and conditioned medium (CM). Notably, the overexpression of Lrp5 and \u03b2-catenin, as well as the pharmacological Wnt activator, converted osteocytes, Murine mesenchymal stem cells, mononuclear cells, and monocytes into iTS cells. While Lrp5 conditional knockout mice presented severe bone loss, Lrp5-overexpressing osteocyte-derived CM rescued tumor-induced bone damage. Whole-genome proteomics analysis revealed that Moesin (MSN), which acted as an oncogene in tumor cells, was enriched in CM as an extracellular tumor-suppressing protein. Its anti-tumor action was mediated primarily by the interaction with CD44. Consistently, FRET live-cell imaging demonstrated that extracellular MSN reduced Src tyrosine kinase activity and nuclear localization of \u03b2-catenin. Collectively, we demonstrated herein the iTS cell-based approach to protect bone from prostate cancer and showed MSN as a potent extracellular tumor-suppressing protein.<\/jats:p>","DOI":"10.3390\/biom16020240","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T10:03:29Z","timestamp":1770113009000},"page":"240","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Induced Tumor-Suppressing (iTS) Cell-Based Approach for Protecting the Bone from Advanced Prostate Cancer"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3286-5071","authenticated-orcid":false,"given":"Shengzhi","family":"Liu","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China"},{"name":"Weldon School of Biomedical Engineering, Purdue University Indianapolis, Indianapolis, IN 46202, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Wu","sequence":"additional","affiliation":[{"name":"Weldon School of Biomedical Engineering, Purdue University Indianapolis, Indianapolis, IN 46202, USA"},{"name":"Department of Pharmacology, School of Pharmacy, Harbin Medical University, Harbin 150081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3864-6478","authenticated-orcid":false,"given":"Kazumasa","family":"Minami","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy, Purdue University, West Lafayette, IN 47907, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4425-8906","authenticated-orcid":false,"given":"Sungsoo","family":"Na","sequence":"additional","affiliation":[{"name":"Weldon School of Biomedical Engineering, Purdue University Indianapolis, Indianapolis, IN 46202, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4543-1536","authenticated-orcid":false,"given":"Uma K.","family":"Aryal","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK 74075, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8134-0749","authenticated-orcid":false,"given":"Marxa L.","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Interdisciplinary Biomedical Sciences Program, Department of Basic Medical Sciences, Purdue University, West Lafayette, IN 47907, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander G.","family":"Robling","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA"},{"name":"Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN 46202, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1853-0216","authenticated-orcid":false,"given":"Bai-Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, Harbin Medical University, Harbin 150081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7881-8959","authenticated-orcid":false,"given":"Hiroki","family":"Yokota","sequence":"additional","affiliation":[{"name":"Weldon School of Biomedical Engineering, Purdue University Indianapolis, Indianapolis, IN 46202, USA"},{"name":"Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA"},{"name":"Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN 46202, USA"},{"name":"Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1007\/s11912-024-01614-6","article-title":"Prostate Cancer, Pathophysiology and Recent Developments in Management: A Narrative Review","volume":"26","author":"Almeeri","year":"2024","journal-title":"Curr. Oncol. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1001\/jama.2025.0228","article-title":"Prostate Cancer: A Review","volume":"333","author":"Raychaudhuri","year":"2025","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"63","DOI":"10.14740\/wjon1191","article-title":"Epidemiology of Prostate Cancer","volume":"10","author":"Rawla","year":"2019","journal-title":"World J. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e229434","DOI":"10.1136\/bcr-2019-229434","article-title":"Metastatic prostate cancer presenting as tumour-induced osteomalacia","volume":"12","author":"Layman","year":"2019","journal-title":"BMJ Case Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0140-6736(10)62344-6","article-title":"Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: A randomised, double-blind study","volume":"377","author":"Fizazi","year":"2011","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13014-021-01776-8","article-title":"Radiotherapy of oligometastatic prostate cancer: A systematic review","volume":"16","author":"Rogowski","year":"2021","journal-title":"Radiat. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"469","DOI":"10.2174\/1568009615666150506092443","article-title":"Bone Metastasis: Molecular Mechanisms Implicated in Tumour Cell Dormancy in Breast and Prostate Cancer","volume":"15","author":"Quayle","year":"2015","journal-title":"Curr. Cancer Drug Targets"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.acuro.2011.02.007","article-title":"Bone mineral density change: Comparison between prostate cancer patients with or without metastases and healthy men (a North African ethnic group)","volume":"35","author":"Janane","year":"2011","journal-title":"Actas Urol. Esp."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1002\/cncr.11132","article-title":"Mechanisms of osteolytic bone metastases in breast carcinoma","volume":"97","author":"Kakonen","year":"2003","journal-title":"Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/ocr.12282","article-title":"Osteocytes and mechanical loading: The Wnt connection","volume":"22","author":"Bullock","year":"2019","journal-title":"Orthod. Craniofac. Res."},{"key":"ref_11","first-page":"1193","article-title":"New Roles of Osteocytes in Proliferation, Migration and Invasion of Breast and Prostate Cancer Cells","volume":"36","author":"Cui","year":"2016","journal-title":"Anticancer. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4540","DOI":"10.1038\/s41388-019-0736-3","article-title":"Prostate cancer promotes a vicious cycle of bone metastasis progression through inducing osteocytes to secrete GDF15 that stimulates prostate cancer growth and invasion","volume":"38","author":"Wang","year":"2019","journal-title":"Oncogene"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1038\/onc.2016.304","article-title":"Wnt signaling in cancer","volume":"36","author":"Zhan","year":"2017","journal-title":"Oncogene"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.7150\/ijbs.79155","article-title":"Three unconventional maxims in the natural selection of cancer cells: Generation of induced tumor-suppressing cells (iTSCs)","volume":"19","author":"Li","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Esperante, D., Flisser, A., and Mendlovic, F. (2023). The many faces of parasite calreticulin. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1101390"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Xu, W., Yang, W., Wu, C., Ma, X., Li, H., and Zheng, J. (2021). Enolase 1 Correlated with Cancer Progression and Immune-Infiltrating in Multiple Cancer Types: A Pan-Cancer Analysis. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.593706"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s13577-025-01172-4","article-title":"The multifaceted roles of aldolase A in cancer: Glycolysis, cytoskeleton, translation and beyond","volume":"38","author":"Yu","year":"2025","journal-title":"Hum. Cell"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"20160284","DOI":"10.1098\/rstb.2016.0284","article-title":"The tale of a tail: Histone H4 acetylation and the repair of DNA breaks","volume":"372","author":"Dhar","year":"2017","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.bbrc.2010.06.112","article-title":"Extracellular heat shock protein HSP90beta secreted by MG63 osteosarcoma cells inhibits activation of latent TGF-beta1","volume":"398","author":"Suzuki","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1002\/cac2.70044","article-title":"Ubiquitination in cancer: Mechanisms and therapeutic opportunities","volume":"45","author":"Zhu","year":"2025","journal-title":"Cancer Commun."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.semcancer.2019.09.003","article-title":"Cell competition and tumor heterogeneity","volume":"63","author":"Parker","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/jb\/mvv050","article-title":"EDAC: Epithelial defence against cancer-cell competition between normal and transformed epithelial cells in mammals","volume":"158","author":"Kajita","year":"2015","journal-title":"J. Biochem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.7150\/thno.70549","article-title":"Counterintuitive production of tumor-suppressive secretomes from Oct4- and c-Myc-overexpressing tumor cells and MSCs","volume":"12","author":"Li","year":"2022","journal-title":"Theranostics"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nm.3074","article-title":"WNT signaling in bone homeostasis and disease: From human mutations to treatments","volume":"19","author":"Baron","year":"2013","journal-title":"Nat. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s12957-021-02229-y","article-title":"Moesin as a prognostic indicator of lung adenocarcinoma improves prognosis by enhancing immune lymphocyte infiltration","volume":"19","author":"Li","year":"2021","journal-title":"World J. Surg. Oncol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Barros, F.B.A., Assao, A., Garcia, N.G., Nonogaki, S., Carvalho, A.L., Soares, F.A., Kowalski, L.P., and Oliveira, D.T. (2018). Moesin expression by tumor cells is an unfavorable prognostic biomarker for oral cancer. BMC Cancer, 18.","DOI":"10.1186\/s12885-017-3914-0"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"5464","DOI":"10.1158\/0008-5472.CAN-21-0162","article-title":"Allosteric Inhibition of HER2 by Moesin-Mimicking Compounds Targets HER2-Positive Cancers and Brain Metastases","volume":"81","author":"Faure","year":"2021","journal-title":"Cancer Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.1158\/1078-0432.CCR-13-0495","article-title":"HMGB1 in cancer: Good, bad, or both?","volume":"19","author":"Kang","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Lin, C.Y., Song, X., Ke, Y., Raha, A., Wu, Y., Wasi, M., Wang, L., Geng, F., and You, L. (2022). Yoda1 Enhanced Low-Magnitude High-Frequency Vibration on Osteocytes in Regulation of MDA-MB-231 Breast Cancer Cell Migration. Cancers, 14.","DOI":"10.3390\/cancers14143395"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Zhang, F., Al-Amin, M.Y., Utturkar, S., Jiang, R., Cresswell, G., Alfar, R., Ophaug-Johansen, I., Bachman, G., Srinivasarao, M., and Finnell, R. (2025). Folate receptor \u03b2 performs an immune checkpoint function in activated macrophages. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1638907"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e00578","DOI":"10.1016\/j.neurot.2025.e00578","article-title":"Indole-3-propionic acid promotes Schwann cell proliferation following peripheral nerve injury by activating the PI3K\/AKT pathway","volume":"22","author":"Zhang","year":"2025","journal-title":"Neurotherapeutics"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.7150\/ijbs.58916","article-title":"Circular RNA circBCBM1 promotes breast cancer brain metastasis by modulating miR-125a\/BRD4 axis","volume":"17","author":"Fu","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"ref_33","first-page":"541","article-title":"Effects of transfection on inflammatory factor production in LPS-induced HBE cells","volume":"40","author":"Zhang","year":"2025","journal-title":"Histol. Histopathol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1016\/j.cell.2024.04.049","article-title":"Ligand binding initiates single-molecule integrin conformational activation","volume":"187","author":"Li","year":"2024","journal-title":"Cell"},{"key":"ref_35","first-page":"8946","article-title":"FRET as a biomolecular research tool\u2014Understanding its potential while avoiding pitfalls","volume":"27","author":"Algar","year":"2021","journal-title":"Chem. A Eur. J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"E271","DOI":"10.1152\/ajpendo.00092.2013","article-title":"Osteocyte-derived insulin-like growth factor I is essential for determining bone mechanosensitivity","volume":"305","author":"Lau","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"110986","DOI":"10.1016\/j.celrep.2022.110986","article-title":"Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF-\u03b2 signaling in regulatory T cells","volume":"39","author":"Gu","year":"2022","journal-title":"Cell Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41413-024-00335-7","article-title":"ATP6AP2, a regulator of LRP6\/\u03b2-catenin protein trafficking, promotes Wnt\/\u03b2-catenin signaling and bone formation in a cell type dependent manner","volume":"12","author":"Xiong","year":"2024","journal-title":"Bone Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/jbmr.3923","article-title":"Sclerostin Antibody Treatment Increases Bone Mass and Normalizes Circulating Phosphate Levels in Growing Hyp Mice","volume":"35","author":"Carpenter","year":"2020","journal-title":"J. Bone Min. Miner. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/s41419-021-04048-1","article-title":"TRAIL-receptor 2-a novel negative regulator of p53","volume":"12","author":"Willms","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.3892\/ol.2015.3498","article-title":"Role of annexin A6 in cancer","volume":"10","author":"Qi","year":"2015","journal-title":"Oncol. Lett."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.canlet.2016.12.034","article-title":"p53 mediates the suppression of cancer cell invasion by inducing LIMA1\/EPLIN","volume":"390","author":"Ohashi","year":"2017","journal-title":"Cancer Lett."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1158\/1078-0432.CCR-1323-03","article-title":"Clinical significance of cellular distribution of moesin in patients with oral squamous cell carcinoma","volume":"10","author":"Kobayashi","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1158\/1541-7786.MCR-11-0156","article-title":"Understanding the dual nature of CD44 in breast cancer progression","volume":"9","author":"Louderbough","year":"2011","journal-title":"Mol. Cancer Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s13046-021-01908-8","article-title":"Fibronectin as a multiregulatory molecule crucial in tumor matrisome: From structural and functional features to clinical practice in oncology","volume":"40","author":"Spada","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"8517","DOI":"10.7150\/thno.61006","article-title":"Generation of the tumor-suppressive secretome from tumor cells","volume":"11","author":"Liu","year":"2021","journal-title":"Theranostics"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.omto.2022.08.003","article-title":"PI3K-activated MSC proteomes inhibit mammary tumors via Hsp90ab1 and Myh9","volume":"26","author":"Sun","year":"2022","journal-title":"Mol. Ther. Oncolytics"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Li, K., Sun, X., Li, B.Y., and Yokota, H. (2021). Conversion of Osteoclasts into Bone-Protective, Tumor-Suppressing Cells. Cancers, 13.","DOI":"10.3390\/cancers13225593"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/s13287-024-03800-6","article-title":"Regenerative medicine in the treatment of specific dermatologic disorders: A systematic review of randomized controlled clinical trials","volume":"15","author":"Jafarzadeh","year":"2024","journal-title":"Stem Cell Res. Ther."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s41392-021-00544-0","article-title":"Extracellular matrix and its therapeutic potential for cancer treatment","volume":"6","author":"Huang","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.7150\/thno.80294","article-title":"Proteomes from AMPK-inhibited peripheral blood mononuclear cells suppress the progression of breast cancer and bone metastasis","volume":"13","author":"Li","year":"2023","journal-title":"Theranostics"},{"key":"ref_52","first-page":"4057","article-title":"Anticancer peptides from induced tumor-suppressing cells for inhibiting osteosarcoma cells","volume":"13","author":"Cui","year":"2023","journal-title":"Am. J. Cancer Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"186","DOI":"10.4048\/jbc.2023.26.e9","article-title":"Inhibition of Tumor Growth and Metastasis by Newcastle Disease Virus Strain P05 in a Breast Cancer Mouse Model","volume":"26","author":"Quintanar","year":"2023","journal-title":"J. Breast Cancer"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Cui, C., Huo, Q., Xiong, X., Na, S., Mitsuda, M., Minami, K., Li, B., and Yokota, H. (2024). P18: Novel Anticancer Peptide from Induced Tumor-Suppressing Cells Targeting Breast Cancer and Bone Metastasis. Cancers, 16.","DOI":"10.3390\/cancers16122230"}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/2\/240\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T10:28:45Z","timestamp":1770114525000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/2\/240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,3]]},"references-count":54,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["biom16020240"],"URL":"https:\/\/doi.org\/10.3390\/biom16020240","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,3]]}}}