{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:21:44Z","timestamp":1783441304455,"version":"3.54.6"},"reference-count":30,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002704","name":"FUNDACI\u00d3N CIENT\u00cdFICA DE LA ASOCIACI\u00d3N ESPA\u00d1OLA CONTRA EL C\u00c1NCER","doi-asserted-by":"crossref","award":["CLJUN235174GARC"],"award-info":[{"award-number":["CLJUN235174GARC"]}],"id":[{"id":"10.13039\/501100002704","id-type":"DOI","asserted-by":"crossref"}]},{"name":"FUNDACI\u00d3 ONCOL\u00d2GICA DR. AMADEU PELEGR\u00cd","award":["AODAP\/2023"],"award-info":[{"award-number":["AODAP\/2023"]}]},{"DOI":"10.13039\/501100004587","name":"INSTITUTO DE SALUD CARLOS III","doi-asserted-by":"publisher","award":["PI22\/00770"],"award-info":[{"award-number":["PI22\/00770"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"DEPARTMENT OF RESEARCH AND UNIVERSITIES OF THE GENERALITAT DE CATALUNYA","award":["2023 FI-3-00065"],"award-info":[{"award-number":["2023 FI-3-00065"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Research on biomarkers reflecting tumor biology and systemic metabolism is crucial for improving the accuracy and personalization of breast cancer (BC) prognosis. We investigated circulating dodecanoic acid in 229 patients undergoing radiotherapy (RT) and assessed its association with progression-free survival and overall survival over six years. Patients were classified into two phenotypes based on post-RT changes in dodecanoic acid: The Increase Phenotype (IP) had lower baseline concentrations and showed a post-RT rise, whereas the Decrease Phenotype (DP) had higher pre-RT levels and declined after treatment. Dodecanoic acid levels were lower in tumors than in peritumoral samples, and their association with phenotypes varied by sampling region, suggesting that systemic changes reflect broader metabolic adaptations rather than local tissue concentrations. Post-RT increases in dodecanoic acid were associated with higher paraoxonase-1 activity, suggesting a link with antioxidant status. Patients in the IP group had a significantly lower risk of progression than those in the DP group, whereas no significant differences in overall survival were observed. These findings highlight the potential utility of dodecanoic acid measurement as a prognostic biomarker and suggest that modulating fatty acid metabolism could be explored as a therapeutic strategy.<\/jats:p>","DOI":"10.3390\/biom16030355","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T16:57:13Z","timestamp":1772125033000},"page":"355","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Post-Radiotherapy Changes in Circulating Dodecanoic Acid Identify Metabolic Phenotypes Associated with Recurrence in Breast Cancer"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4251-585X","authenticated-orcid":false,"given":"Andrea","family":"Jim\u00e9nez-Franco","sequence":"first","affiliation":[{"name":"Unitat de Recerca Biom\u00e8dica, Hospital Universitari de Sant Joan, Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili, Universitat Rovira i Virgili, Av. Dr. Josep Laporte 2, 43204 Reus, Spain"},{"name":"Department of Radiation Oncology, Hospital Universitari de Sant Joan, Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili, Universitat Rovira i Virgili, Av. Dr. Josep Laporte 2, 43204 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Cambra-Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Unitat de Recerca Biom\u00e8dica, Hospital Universitari de Sant Joan, Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili, Universitat Rovira i Virgili, Av. Dr. Josep Laporte 2, 43204 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9188-6593","authenticated-orcid":false,"given":"Raquel","family":"Garc\u00eda-Pablo","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Hospital Universitari de Sant Joan, Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili, Universitat Rovira i Virgili, Av. Dr. Josep Laporte 2, 43204 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0279-206X","authenticated-orcid":false,"given":"Marta","family":"Canela-Capdevila","sequence":"additional","affiliation":[{"name":"Unitat de Recerca Biom\u00e8dica, Hospital Universitari de Sant Joan, Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili, Universitat Rovira i Virgili, Av. Dr. Josep Laporte 2, 43204 Reus, Spain"},{"name":"Department of Radiation Oncology, Hospital Universitari de Sant Joan, Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili, Universitat Rovira i Virgili, Av. Dr. Josep Laporte 2, 43204 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"Benavides-Villarreal","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Hospital Universitari de Sant Joan, Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili, Universitat Rovira i Virgili, Av. Dr. Josep Laporte 2, 43204 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4159-8104","authenticated-orcid":false,"given":"Xavier","family":"Gabald\u00f3-Barrios","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory and Autoimmunity, Infection and Thrombosis Research Group (GRAIIT), Hospital Universitari de Sant Joan, Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili, Universitat Rovira i Virgili, Av. Dr. Josep Laporte 2, 43204 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6658-3603","authenticated-orcid":false,"given":"Isabel","family":"Fort-Gallifa","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Hospital Universitari Joan XXIII, Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili, Universitat Rovira i Virgili, C. 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