{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:03:30Z","timestamp":1787792610698,"version":"build-2784847793"},"reference-count":51,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"PHAB Level 3, AHA Postdoctoral fellowship","doi-asserted-by":"publisher","award":["24POST1243617"],"award-info":[{"award-number":["24POST1243617"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sao Paulo Research Foundation","award":["2016\/11988-5"],"award-info":[{"award-number":["2016\/11988-5"]}]},{"name":"Sao Paulo Research Foundation","award":["2016\/07641-0"],"award-info":[{"award-number":["2016\/07641-0"]}]},{"name":"Sao Paulo Research Foundation","award":["2018\/05638-7"],"award-info":[{"award-number":["2018\/05638-7"]}]},{"name":"Sao Paulo Research Foundation","award":["2019\/19749-8"],"award-info":[{"award-number":["2019\/19749-8"]}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NFF130C0007739"],"award-info":[{"award-number":["NFF130C0007739"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NFF60C0023284"],"award-info":[{"award-number":["NFF60C0023284"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wilhelm Pedersen and Wife\u2019s memorial grant"},{"name":"Wilhelm Pedersen and Wife\u2019s memorial","award":["grant"],"award-info":[{"award-number":["grant"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Hypertension-induced erectile dysfunction is associated with endothelial dysfunction in the corpus cavernosum. Membrane depolarization activates the NLRP3 inflammasome, with downregulation of endothelial Ca2+-activated K+ channels type 2.3 (KCa 2.3) and upregulation of endothelin-1 (ET-1) linked to erectile dysfunction. However, underlying mechanisms remain incompletely understood. We hypothesized that activating KCa 2.2\/2.3 channels reverses erectile dysfunction and ET-1-induced NLRP3 activation in hypertensive DOCA\/salt mice. Hypertension was induced in mice using a DOCA\/salt model, with unilaterally nephrectomized mice as controls. We measured blood pressure, intracavernous pressure (ICP), and corpus cavernosum (CC) contractility, and performed immunoblots for KCa 2.3, caspase-1, and interleukin-1\u03b2 (IL-1\u03b2). DOCA\/salt mice showed impaired erectile function and increased IL-1\u03b2 activity and reduced KCa 2.3 expression. Treatment with the endothelin receptor antagonist bosentan or the KCa 2.2\/2.3 channel opener NS13001 reversed these dysfunctions and reduced ET-1-induced NLRP3 activation. NS13001 also restored decreased currents in endothelial cells exposed to ET-1. These findings establish that hypertension-induced erectile dysfunction involves an ET-1\/membrane depolarization\/NLRP3 inflammasome axis in corpus cavernosum endothelial cells, and that targeting endothelial KCa 2.2\/2.3 channels represents a promising therapeutic strategy to counteract erectile dysfunction.<\/jats:p>","DOI":"10.3390\/biom16030432","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T12:59:44Z","timestamp":1773406784000},"page":"432","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A KCa 2.2\/2.3 Opener Reverses ET-1-Induced NLRP3 Activation in Hypertensive Mice Corpora Cavernosa"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4715-7318","authenticated-orcid":false,"given":"Rafael","family":"Sobrano Fais","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14049-900, SP, Brazil"},{"name":"Department of Biomedicine, Pulmonary and Cardiovascular Pharmacology, Aarhus University, 8000 Aarhus, Denmark"},{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine, National Jewish Health, Denver, CO 80206, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6516-694X","authenticated-orcid":false,"given":"Simon Gabriel","family":"Comerma-Steffensen","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Pulmonary and Cardiovascular Pharmacology, Aarhus University, 8000 Aarhus, Denmark"},{"name":"Department of Biomedical Sciences\/Animal Physiology, Faculty of Veterinary, Central University of Venezuela, Aragua 2105, Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7852-992X","authenticated-orcid":false,"given":"Estefano","family":"Pinilla","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Pulmonary and Cardiovascular Pharmacology, Aarhus University, 8000 Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3303-1095","authenticated-orcid":false,"given":"Vladimir V.","family":"Matchkov","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Pulmonary and Cardiovascular Pharmacology, Aarhus University, 8000 Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9446-0707","authenticated-orcid":false,"given":"Rita","family":"Tostes","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14049-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Silva Carneiro","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14049-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2169-7666","authenticated-orcid":false,"given":"Ulf","family":"Simonsen","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Pulmonary and Cardiovascular Pharmacology, Aarhus University, 8000 Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1139\/Y08-031","article-title":"DOCA-salt treatment enhances responses to endothelin-1 in murine corpus cavernosum","volume":"86","author":"Carneiro","year":"2008","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3839","DOI":"10.1038\/s41598-017-04188-5","article-title":"Down-regulation of K(Ca)2.3 channels causes erectile dysfunction in mice","volume":"7","author":"Kun","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Comerma-Steffensen, S.G., Carvacho, I., Hedegaard, E.R., and Simonsen, U. (2017). Small and Intermediate Calcium-Activated Potassium Channel Openers Improve Rat Endothelial and Erectile Function. Front. Pharmacol., 8.","DOI":"10.3389\/fphar.2017.00660"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"16224","DOI":"10.1038\/s41598-019-52831-0","article-title":"The inflammasome NLRP3 plays a dual role on mouse corpora cavernosa relaxation","volume":"9","author":"Fais","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Simonsen, U., Winther, A.K., Olivan-Viguera, A., Comerma-Steffensen, S., Kohler, R., and Bek, T. (2019). Extracellular l-arginine Enhances Relaxations Induced by Opening of Calcium-Activated SKCa Channels in Porcine Retinal Arteriole. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20082032"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.vph.2017.10.001","article-title":"The influence of DOCA-salt hypertension and chronic administration of the FAAH inhibitor URB597 on K(Ca)2.3\/K(Ca)3.1-EDH-type relaxation in rat small mesenteric arteries","volume":"99","author":"Kloza","year":"2017","journal-title":"Vasc. Pharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1021\/cn400115v","article-title":"Increased catecholamine secretion from single adrenal chromaffin cells in DOCA-salt hypertension is associated with potassium channel dysfunction","volume":"4","author":"Fhaner","year":"2013","journal-title":"ACS Chem. Neurosci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.phrs.2012.02.004","article-title":"Impaired beta-adrenoceptor-induced relaxation in small mesenteric arteries from DOCA-salt hypertensive rats is due to reduced K(Ca) channel activity","volume":"65","author":"Matsumoto","year":"2012","journal-title":"Pharmacol. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1111\/j.1476-5381.2011.01649_1.x","article-title":"Guide to Receptors and Channels (GRAC), 5th edition","volume":"164","author":"Alexander","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.jacc.2011.06.024","article-title":"Erectile dysfunction and risk of cardiovascular disease: Meta-analysis of prospective cohort studies","volume":"58","author":"Dong","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.aju.2013.03.003","article-title":"Erectile dysfunction and cardiovascular disease","volume":"11","author":"Jackson","year":"2013","journal-title":"Arab. J. Urol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1111\/j.1743-6109.2008.00775.x","article-title":"C-type natriuretic peptide hyperpolarizes and relaxes human penile resistance arteries","volume":"5","author":"Kun","year":"2008","journal-title":"J. Sex. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1111\/j.1743-6109.2012.02743.x","article-title":"Flow-evoked vasodilation is blunted in penile arteries from Zucker diabetic fatty rats","volume":"9","author":"Schjorring","year":"2012","journal-title":"J. Sex. Med."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Behringer, E.J., and Hakim, M.A. (2019). Functional Interaction among K(Ca) and TRP Channels for Cardiovascular Physiology: Modern Perspectives on Aging and Chronic Disease. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20061380"},{"key":"ref_15","first-page":"L729","article-title":"ET-1 modulates KCa-channel activity and arterial tension in normoxic and hypoxic human pulmonary vasculature","volume":"275","author":"Peng","year":"1998","journal-title":"Am. J. Physiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1161\/01.HYP.24.2.183","article-title":"Effect of a nonselective endothelin antagonist on vascular remodeling in deoxycorticosterone acetate-salt hypertensive rats. Evidence for a role of endothelin in vascular hypertrophy","volume":"24","author":"Li","year":"1994","journal-title":"Hypertension"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1161\/01.CIR.103.2.319","article-title":"Myocardial fibrosis in DOCA-salt hypertensive rats: Effect of endothelin ET(A) receptor antagonism","volume":"103","author":"Ammarguellat","year":"2001","journal-title":"Circulation"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1161\/hy0202.103481","article-title":"Fibrosis, matrix metalloproteinases, and inflammation in the heart of DOCA-salt hypertensive rats: Role of ET(A) receptors","volume":"39","author":"Ammarguellat","year":"2002","journal-title":"Hypertension"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.coi.2018.03.010","article-title":"Ion homeostasis and ion channels in NLRP3 inflammasome activation and regulation","volume":"52","author":"Pelegrin","year":"2018","journal-title":"Curr. Opin. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1111\/bph.12955","article-title":"Implementing guidelines on reporting research using animals (ARRIVE etc.): New requirements for publication in BJP","volume":"172","author":"McGrath","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1111\/j.1743-6109.2008.01009.x","article-title":"Activation of the ET-1\/ETA pathway contributes to erectile dysfunction associated with mineralocorticoid hypertension","volume":"5","author":"Carneiro","year":"2008","journal-title":"J. Sex. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1124\/jpet.111.179242","article-title":"Opening of small and intermediate calcium-activated potassium channels induces relaxation mainly mediated by nitric oxide release in large arteries and endothelium-derived hyperpolarizing factor in small arteries from rat","volume":"339","author":"Stankevicius","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ucl.2005.08.007","article-title":"Physiology of penile erection and pathophysiology of erectile dysfunction","volume":"32","author":"Dean","year":"2005","journal-title":"Urol. Clin. N. Am."},{"key":"ref_24","first-page":"1","article-title":"NLRP3 activation contributes to endothelin-1-induced erectile dysfunction","volume":"27","author":"Mestriner","year":"2023","journal-title":"J. Cell. Mol. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0014-2999(01)00726-9","article-title":"Effect of sildenafil on non-adrenergic non-cholinergic neurotransmission in bovine penile small arteries","volume":"412","author":"Simonsen","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ab.2013.05.027","article-title":"Stain-Free total protein staining is a superior loading control to beta-actin for Western blots","volume":"440","author":"Gilda","year":"2013","journal-title":"Anal. Biochem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"114840","DOI":"10.1016\/j.ab.2022.114840","article-title":"Stain-Free total-protein normalization enhances the reproducibility of Western blot data","volume":"654","author":"Maloy","year":"2022","journal-title":"Anal. Biochem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ab.2012.10.010","article-title":"Stain-Free technology as a normalization tool in Western blot analysis","volume":"433","author":"Gurtler","year":"2013","journal-title":"Anal. Biochem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/j.chembiol.2012.07.013","article-title":"Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2","volume":"19","author":"Kasumu","year":"2012","journal-title":"Chem. Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1111\/j.1743-6109.2007.00733.x","article-title":"NADPH oxidase activation: A mechanism of hypertension-associated erectile dysfunction","volume":"5","author":"Jin","year":"2008","journal-title":"J. Sex. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s003950050170","article-title":"Endothelin-1 induces interleukin-6 release via activation of the transcription factor NF-kappaB in human vascular smooth muscle cells","volume":"95","author":"Browatzki","year":"2000","journal-title":"Basic Res. Cardiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1155\/S0962935193000596","article-title":"Endothelin-1 stimulates human monocytes in vitro to release TNF-alpha, IL-1beta and IL-6","volume":"2","author":"Helset","year":"1993","journal-title":"Mediat. Inflamm."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00005-014-0310-1","article-title":"The role of endothelin-1 and endothelin receptor antagonists in inflammatory response and sepsis","volume":"63","author":"Kowalczyk","year":"2015","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1093\/eurheartj\/ehn234","article-title":"Inhibition of endothelin receptors in the treatment of pulmonary arterial hypertension: Does selectivity matter?","volume":"29","author":"Opitz","year":"2008","journal-title":"Eur. Heart J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.jsxm.2022.02.021","article-title":"Erectile Dysfunction and Altered Contribution of KCa1.1 and KCa2.3 Channels in the Penile Tissue of Type-2 Diabetic db\/db Mice","volume":"19","author":"Mogensen","year":"2022","journal-title":"J. Sex. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/0006-2952(95)98500-9","article-title":"Protein kinase C-independent inhibition of the Ca(2+)-activated K+ channel by angiotensin II and endothelin-1","volume":"49","author":"Minami","year":"1995","journal-title":"Biochem. Pharmacol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1002\/glia.22419","article-title":"Activation of KCNN3\/SK3\/K(Ca)2.3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia","volume":"60","author":"Dolga","year":"2012","journal-title":"Glia"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.fct.2016.06.008","article-title":"Chemical characterization, antioxidant, anti-inflammatory and cytotoxic properties of bee venom collected in Northeast Portugal","volume":"94","author":"Sobral","year":"2016","journal-title":"Food Chem. Toxicol. Int. J. Publ. Br. Ind. Biol. Res. Assoc."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"305454","DOI":"10.1155\/2012\/305454","article-title":"The Protective Effect of Apamin on LPS\/Fat-Induced Atherosclerotic Mice","volume":"2012","author":"Kim","year":"2012","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1172\/JCI61427","article-title":"Mineralocorticoid receptor is involved in rat and human ocular chorioretinopathy","volume":"122","author":"Zhao","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"H869","DOI":"10.1152\/ajpheart.00252.2022","article-title":"Pharmacological nNOS inhibition modified small-conductance Ca2+-activated K+ channel without altering Ca(2+) dynamics","volume":"323","author":"Koya","year":"2022","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1111\/j.1469-7793.1998.835ba.x","article-title":"Apamin- and nitric oxide-sensitive biphasic non-adrenergic non-cholinergic inhibitory junction potentials in the rat anococcygeus muscle","volume":"513","author":"Selemidis","year":"1998","journal-title":"J. Physiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/0306-4522(80)90154-2","article-title":"Effect of apamin on the electrical responses of smooth muscle to adenosine 5\u2032-triphosphate and to non-adrenergic, non-cholinergic nerve stimulation","volume":"5","author":"Shuba","year":"1980","journal-title":"Neuroscience"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.cellsig.2005.01.001","article-title":"Involvement of extracellular Ca2+ influx through voltage-independent Ca2+ channels in endothelin-1 function","volume":"17","author":"Kawanabe","year":"2005","journal-title":"Cell Signal."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/S0021-9258(17)42104-1","article-title":"Coupling of endothelin B receptors to the calcium pump and phospholipase C via Gs and Gq in rat liver","volume":"269","author":"Jouneaux","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s11427-009-0046-z","article-title":"Endothelin-1 induces intracellular [Ca2+] increase via Ca2+ influx through the L-type Ca2+ channel, Ca2+-induced Ca2+ release and a pathway involving ET A receptors, PKC, PKA and AT1 receptors in cardiomyocytes","volume":"52","author":"Zeng","year":"2009","journal-title":"Sci. China Ser. C Life Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/00000542-198409000-00006","article-title":"Sympathetic efferent nerve activity in conscious and isoflurane-anesthetized dogs","volume":"61","author":"Seagard","year":"1984","journal-title":"Anesthesiology"},{"key":"ref_48","first-page":"e21","article-title":"Effects of isoflurane anesthesia on the cardiovascular function of the C57BL\/6 mouse","volume":"52","author":"Constantinides","year":"2011","journal-title":"ILAR J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1080\/19336950.2015.1071748","article-title":"Pharmacological gating modulation of small- and intermediate-conductance Ca2+-activated K+ channels (KCa2.x and KCa3.1)","volume":"9","author":"Christophersen","year":"2015","journal-title":"Channels"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0043-z","article-title":"Small-conductance Ca2+-activated K+ channels: Insights into their roles in cardiovascular disease","volume":"50","author":"Gu","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e26","DOI":"10.15420\/ecr.2024.41","article-title":"From Atrial Small-conductance Calcium-activated Potassium Channels to New Antiarrhythmics","volume":"19","author":"Saljic","year":"2024","journal-title":"Eur. Cardiol. Rev."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/3\/432\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T13:11:22Z","timestamp":1773407482000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/3\/432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,13]]},"references-count":51,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["biom16030432"],"URL":"https:\/\/doi.org\/10.3390\/biom16030432","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,13]]}}}