{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T14:09:54Z","timestamp":1774274994980,"version":"3.50.1"},"reference-count":102,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T00:00:00Z","timestamp":1774137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shaanxi Provincial Key Research and Development Program","award":["2023-ZDLSF-08"],"award-info":[{"award-number":["2023-ZDLSF-08"]}]},{"name":"Shaanxi Qinchuangyuan \u201cScientists + Engineers\u201d Team Construction Project","award":["2023KXJ-128"],"award-info":[{"award-number":["2023KXJ-128"]}]},{"name":"\u201cDouble Chain Integration\u201d Young and Middle-aged Scientific Research Innovation Team Project of Shaanxi Provincial Administration of Traditional Chinese Medicine","award":["2022-SLRH-YQ-005"],"award-info":[{"award-number":["2022-SLRH-YQ-005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Palmitoylation is a critical post-translational modification that involves the covalent binding of palmitic acid to cysteine residues within proteins. It is widely recognized that palmitoylation plays a significant role in regulating protein membrane localization, stability, and interactions. The kidney plays a key role in maintaining fluid homeostasis and excreting metabolic waste, and its normal function relies on the precise regulation of protein function. Emerging evidence reveals the crucial role of palmitoylation in renal physiological and pathological processes. However, the intricate pathways and molecular regulators in the kidney that are involved in palmitoylation remain insufficiently elucidated. This review summarizes the role and possible underlying physiological and pathological mechanism of palmitoylation in the kidney, including enzymes and inhibitors that regulate palmitoylation, the signaling pathways involved, target proteins involved in palmitoylation, and specific modification sites. Moreover, we focus on detection techniques and corresponding research strategies for palmitoylation. This review can also serve as a practical reference to improve the understanding of palmitoylation and the treatment of kidney-related diseases.<\/jats:p>","DOI":"10.3390\/biom16030473","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T13:07:06Z","timestamp":1774271226000},"page":"473","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Palmitoylation in Renal Physiology and Pathology"],"prefix":"10.3390","volume":"16","author":[{"given":"Jingru","family":"Ma","sequence":"first","affiliation":[{"name":"Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xianyang 712046, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xianyang 712046, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqi","family":"Guo","sequence":"additional","affiliation":[{"name":"Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xianyang 712046, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hu","family":"Cai","sequence":"additional","affiliation":[{"name":"Shaanxi Medical Devices Quality Testing Institute, Xixian New Area, Xianyang 712046, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2622-0215","authenticated-orcid":false,"given":"Jian","family":"Yao","sequence":"additional","affiliation":[{"name":"Division of Molecular Signaling, Department of the Advanced Biomedical Research, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo 409-3898, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dahai","family":"Yang","sequence":"additional","affiliation":[{"name":"Shaanxi Center for Technical Review of Pharmaceutical Products, 56 Gaoxin 6th Road, Yanta District, Xi\u2019an 710065, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiyuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xianyang 712046, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haijing","family":"Liu","sequence":"additional","affiliation":[{"name":"Shaanxi Institute for Food and Drug Control, High-Tech Zone, Xi\u2019an 710075, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changhe","family":"Wang","sequence":"additional","affiliation":[{"name":"Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xianyang 712046, China"},{"name":"Shaanxi Medical Devices Quality Testing Institute, Xixian New Area, Xianyang 712046, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbo","family":"Xu","sequence":"additional","affiliation":[{"name":"Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xianyang 712046, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.7150\/ijbs.72244","article-title":"Emerging roles of protein palmitoylation and its modifying enzymes in cancer cell signal transduction and cancer therapy","volume":"18","author":"Liu","year":"2022","journal-title":"Int. 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