{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:11:16Z","timestamp":1787314276313,"version":"build-2736575974"},"reference-count":36,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007615","name":"Imam Abdulrahman Bin Faisal University","doi-asserted-by":"publisher","award":["IF-2020-012-Med"],"award-info":[{"award-number":["IF-2020-012-Med"]}],"id":[{"id":"10.13039\/501100007615","id-type":"DOI","asserted-by":"publisher"}]},{"award":["IF-2020-012-Med"],"award-info":[{"award-number":["IF-2020-012-Med"]}],"id":[{"id":"https:\/\/ror.org\/038cy8j79","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Plasma circular RNAs (circRNAs) are stable RNA molecules found in blood, which makes them potential noninvasive biomarkers for acute myocardial infarction (MI). The aim of this study was to describe the plasma circRNA profile in patients with acute MI and to identify circRNA markers that may help detect heart injury and reflect the biological processes involved. We compared plasma samples from patients with acute MI and healthy controls using total RNA sequencing with unique molecular identifiers (UMIs). After sequencing, reads were processed through quality control, alignment, duplicate removal, and circRNA detection. Differential expression was analyzed after adjusting for age, sex, smoking, and technical factors. Several circRNAs were significantly different between MI cases and controls and were able to separate the two groups in principal component and receiver operating characteristic analyses. Among the most increased circRNAs were hsa-PASK_0004, hsa-STXBP3_0002, hsa-RCAN3_0002, and hsa-RANBP9_0044, while hsa-HIF1A_0002, hsa-SUZ12_0049, hsa-PNRC1_0001, and hsa-RAB2A_0002 were decreased. Several candidates showed AUC values above 0.7. Pathway analysis linked the host genes of these circRNAs to inflammation, platelet activation, coagulation, and cardiomyocyte stress responses. Overall, these findings suggest that circulating circRNAs may serve as useful blood-based markers of MI and provide insight into the molecular changes that accompany acute MI.<\/jats:p>","DOI":"10.3390\/biom16040578","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T08:14:17Z","timestamp":1776154457000},"page":"578","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Remodeling of the circRNA Landscape in Myocardial Infarction Integrates Nuclear Regulation, DNA Damage Response, and Cardiomyocyte Structural Pathways"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3453-6340","authenticated-orcid":false,"given":"Rudaynah","family":"Alali","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Cardiology Section, King Fahd Hospital of the University, Alkhobar 34445, Saudi Arabia"},{"name":"Imam Abdulrahman bin Faisal University, Dammam 31441, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0883-7318","authenticated-orcid":false,"given":"Naif Khalid","family":"Alqannas","sequence":"additional","affiliation":[{"name":"Department of Adult Cardiology, Saud Al Babtain Cardiac Center, Dammam 32245, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5384-8764","authenticated-orcid":false,"given":"Alawi H.","family":"Habara","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Medicine, Imam Abdulrahman bin Faisal University, Dammam 31441, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Almansori","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cardiology Section, King Fahd Hospital of the University, Alkhobar 34445, Saudi Arabia"},{"name":"Imam Abdulrahman bin Faisal University, Dammam 31441, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4847-960X","authenticated-orcid":false,"given":"Ali","family":"Alsaeed","sequence":"additional","affiliation":[{"name":"Dammam Medical Complex, Dammam 32245, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3026-5520","authenticated-orcid":false,"given":"Chittibabu","family":"Vatte","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Medicine, Imam Abdulrahman bin Faisal University, Dammam 31441, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7333-6486","authenticated-orcid":false,"given":"Cyril","family":"Cyrus","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Medicine, Imam Abdulrahman bin Faisal University, Dammam 31441, Saudi 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Arabia"},{"name":"Imam Abdulrahman bin Faisal University, Dammam 31441, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal S.","family":"Alshahrani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cardiology Section, King Fahd Hospital of the University, Alkhobar 34445, Saudi Arabia"},{"name":"Imam Abdulrahman bin Faisal University, Dammam 31441, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0536-536X","authenticated-orcid":false,"given":"Moyad M.","family":"Almuslim","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Imam Abdulrahman bin Faisal University, Dammam 31441, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten T.","family":"Ven\u00f8","sequence":"additional","affiliation":[{"name":"Omics ApS, \u00c5bogade 15, 8200 Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3320-3723","authenticated-orcid":false,"given":"Brendan J.","family":"Keating","sequence":"additional","affiliation":[{"name":"Department of Surgery, NYU Grossman School of Medicine, 530 First Avenue, Suite 9V, New York, NY 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0673-3534","authenticated-orcid":false,"given":"Amein K.","family":"Al-Ali","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Medicine, Imam Abdulrahman bin Faisal University, Dammam 31441, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e146","DOI":"10.1161\/CIR.0000000000000485","article-title":"Heart Disease and Stroke Statistics-2017 Update: A Report from the 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