{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:50:25Z","timestamp":1790970625783,"version":"4.1.0"},"reference-count":142,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008982","name":"Qatar National Research Fund","doi-asserted-by":"crossref","award":["14S-0317-210064"],"award-info":[{"award-number":["14S-0317-210064"]}],"id":[{"id":"10.13039\/100008982","id-type":"DOI","asserted-by":"crossref"}]},{"award":["14S-0317-210064"],"award-info":[{"award-number":["14S-0317-210064"]}],"id":[{"id":"https:\/\/ror.org\/01svaqq28","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Myocardial infarction (MI) is one of the prevalent cardiovascular diseases, which is caused by obstruction of one or more coronary arteries, leading to cardiac tissue ischemia and death. One of the main consequences of MI is heart failure, which is defined as dysfunction of the heart muscle to pump blood into peripheral organs. Cardiac patches have drawn a lot of interest as a potentially effective way to restore damaged cardiac tissue and enhance its functionality. They are polymer-based scaffolds designed to be implanted on the heart surface, and they have shown a significant therapeutic effect in the treatment of MI by improving cardiac function and providing mechanical support for the infarction site by the delivery of various bioactive substances or cells. Several biomaterials with specific mechanical and chemical characteristics have been widely used as a scaffold in the process of fabricating cardiac patches. In this study, we focus on the latest developments in the manufacturing of synthetic-polymer-based cardiac patches used to treat heart failure induced by myocardial infarction. We describe the mechanical and chemical characteristics of several synthetic polymers and highlight the main benefits and drawbacks of each type. An overview of the major challenges and the future development directions in the field of cardiac patches is also highlighted.<\/jats:p>","DOI":"10.3390\/biom16040580","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T10:29:08Z","timestamp":1776162548000},"page":"580","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Synthetic-Polymer-Based Cardiac Patches for MI-Induced Heart Failure Treatment: A Review"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7316-060X","authenticated-orcid":false,"given":"Ahmed","family":"Eliwa","sequence":"first","affiliation":[{"name":"College of Medicine, Qatar University, Doha P.O. Box 2713, Qatar"},{"name":"Internal Medicine Residency Program (IMRP), Division of Internal Medicine, Hamad Medical Corporation, Doha P.O. Box 3050, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4115-8264","authenticated-orcid":false,"given":"Mohamed K.","family":"Abbas","sequence":"additional","affiliation":[{"name":"Center for Advanced Materials (CAM), Qatar University, Doha P.O. Box 2713, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Al-Ejji","sequence":"additional","affiliation":[{"name":"Center for Advanced Materials (CAM), Qatar University, Doha P.O. Box 2713, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadija","family":"Zadeh","sequence":"additional","affiliation":[{"name":"Center for Advanced Materials (CAM), Qatar University, Doha P.O. Box 2713, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamda","family":"Aboujassoum","sequence":"additional","affiliation":[{"name":"Laboratory Animal Research Center (LARC), Qatar University, Doha P.O. Box 2713, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"ref_1","first-page":"e46486","article-title":"Advancements in heart failure management: A comprehensive narrative review of emerging therapies","volume":"15","author":"Sapna","year":"2023","journal-title":"Cureus"},{"key":"ref_2","unstructured":"Global Burden of Disease Collaborators (2018). Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990\u20132017: A systematic analysis for the Global Burden of Disease Study 2017. 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