{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T16:06:58Z","timestamp":1779379618599,"version":"3.53.1"},"reference-count":53,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"PROEX\u2014Programa de p\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias M\u00e9dicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Background: Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma, constituting an important public health problem. Although curable, it presents a widely variable prognosis. The main tool used for prognostic stratification in DLBCL is the International Prognostic Index (IPI), which does not consider crucial biological variables for understanding its prognostic heterogeneity. Cell adhesion molecules (CAMs) play a central role in cancer biology and can be evaluated in affected tissues or in plasma, in soluble forms (sCAMs). CAMs promote proliferation, survival, and dissemination of malignant cells. Although extensively studied in solid tumors, their role remains unclear in hematological malignancies, particularly in DLBCL. Methods: This is a prospective and longitudinal study involving 87 newly diagnosed DLBCL (ND-DLBCL) patients aiming to quantify plasma levels of sCAMs (sICAM-1, sVCAM-1, sP-selectin, and sE-cadherin) at diagnosis and assessing its potential prognostic impact, as well as establishing clinical-biological associations. Results: Plasma quantification of sICAM-1, sVCAM-1, and sP-selectin did not present prognostic impact in DLBCL. However, continuous increases in sE-cadherin levels, as well as sE-cadherin \u2265 126.55 ng\/mL were associated with lower response rates to R-CHOP regimen, higher frequency of recurrence following first-line therapy, and shortened survival. Additionally, sE-cadherin concentration \u2265 126.55 ng\/mL was an independent predictor related to decreased overall survival. Conclusion: sE-cadherin measured at diagnosis has emerged as a new prognostic biomarker able to predict response, relapse and survival in ND-DLBCL.<\/jats:p>","DOI":"10.3390\/biom16050637","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T17:26:18Z","timestamp":1777051578000},"page":"637","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Soluble E-Cadherin as a New Prognostic Biomarker Able to Predict Survival in Newly Diagnosed Diffuse Large B-Cell Lymphoma"],"prefix":"10.3390","volume":"16","author":[{"given":"Paola Carolina Rabesquini Marcelino","family":"da Silva","sequence":"first","affiliation":[{"name":"Laboratory of Medical Investigation in Pathogenesis and Directed Therapy in Immuno-Onco-Hematology (LIM-31), Faculty of Medicine, University of Sao Paulo, Sao Paulo 05430-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6266-4596","authenticated-orcid":false,"given":"Igor Cerejo Tavares da Silva","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Investigation in Pathogenesis and Directed Therapy in Immuno-Onco-Hematology (LIM-31), Faculty of Medicine, University of Sao Paulo, Sao Paulo 05430-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquim Gasparini","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hemotherapy & Cell Therapy, Faculty of Medicine, University of Sao Paulo, Sao Paulo 05430-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo Jun","family":"Otuyama","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hemotherapy & Cell Therapy, Faculty of Medicine, University of Sao Paulo, Sao Paulo 05430-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cadiele Oliana","family":"Reichert","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Investigation in Pathogenesis and Directed Therapy in Immuno-Onco-Hematology (LIM-31), Faculty of Medicine, University of Sao Paulo, Sao Paulo 05430-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hebert Fabr\u00edcio","family":"Culler","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Investigation in Pathogenesis and Directed Therapy in Immuno-Onco-Hematology (LIM-31), Faculty of Medicine, University of Sao Paulo, Sao Paulo 05430-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00e9lio C\u00e9zar","family":"de Aquino","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Investigation in Pathogenesis and Directed Therapy in Immuno-Onco-Hematology (LIM-31), Faculty of Medicine, University of Sao Paulo, Sao Paulo 05430-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian de Souza","family":"Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Investigation in Pathogenesis and Directed Therapy in Immuno-Onco-Hematology (LIM-31), Faculty of Medicine, University of Sao Paulo, Sao Paulo 05430-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila Aparecida Coelho","family":"da Siqueira","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, University of Sao Paulo, Sao Paulo 05430-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata de Oliveira","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Hematology, Faculdade de Ci\u00eancias M\u00e9dicas de Santos, Funda\u00e7\u00e3o Lus\u00edada, Santos 11050-071, Brazil"},{"name":"Department of Hematology & Oncology, Hospital Alem\u00e3o Oswaldo Cruz, Sao Paulo 01323-020, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanderson","family":"Rocha","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Investigation in Pathogenesis and Directed Therapy in Immuno-Onco-Hematology (LIM-31), Faculty of Medicine, University of Sao Paulo, Sao Paulo 05430-000, Brazil"},{"name":"Department of Hematology, Hemotherapy & Cell Therapy, Faculty of Medicine, University of Sao Paulo, Sao Paulo 05430-000, Brazil"},{"name":"Pr\u00f3-Sangue Foundation, Blood Bank of Sao Paulo, Sao Paulo 05430-000, Brazil"},{"name":"Department of Hematology, Churchill Hospital, Oxford University, Oxford OX12JD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7582-5942","authenticated-orcid":false,"given":"S\u00e9rgio Paulo","family":"Bydlowski","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hemotherapy & Cell Therapy, Faculty of Medicine, University of Sao Paulo, Sao Paulo 05430-000, Brazil"},{"name":"Laboratory of Medical Investigation in Immunology and Histocompatibility (LIM-19), Faculty of Medicine, University of Sao Paulo, Sao Paulo 05430-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7492-997X","authenticated-orcid":false,"given":"D\u00e9bora","family":"Levy","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Investigation in Immunology and Histocompatibility (LIM-19), Faculty of Medicine, University of Sao Paulo, Sao Paulo 05430-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0655-2821","authenticated-orcid":false,"given":"Juliana","family":"Pereira","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Investigation in Pathogenesis and Directed Therapy in Immuno-Onco-Hematology (LIM-31), Faculty of Medicine, University of Sao Paulo, Sao Paulo 05430-000, Brazil"},{"name":"Department of Hematology, Hemotherapy & Cell Therapy, Faculty of Medicine, University of Sao Paulo, Sao Paulo 05430-000, Brazil"},{"name":"Department of Hematology & Oncology, Hospital Alem\u00e3o Oswaldo Cruz, Sao Paulo 01323-020, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9228-3276","authenticated-orcid":false,"given":"Lu\u00eds Alberto de P\u00e1dua Covas","family":"Lage","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Investigation in Pathogenesis and Directed Therapy in Immuno-Onco-Hematology (LIM-31), Faculty of Medicine, University of Sao Paulo, Sao Paulo 05430-000, Brazil"},{"name":"Department of Hematology, Hemotherapy & Cell Therapy, Faculty of Medicine, University of Sao Paulo, Sao Paulo 05430-000, 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(2023). The epidemiological patterns of non-Hodgkin lymphoma: Global estimates of disease burden, risk factors, and temporal trends. Front. Oncol., 2.","DOI":"10.3389\/fonc.2023.1059914"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13045-022-01281-9","article-title":"Incidence, mortality, risk factors, and trends for Hodgkin lymphoma: A global data analysis","volume":"15","author":"Huang","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1097\/MNM.0000000000000553","article-title":"Interim fluorine-18 fluorodeoxyglucose PET-computed tomography and cell of origin by immunohistochemistry predicts progression-free survival and overall survival in diffuse large B-cell lymphoma patients in the rituximab era","volume":"37","author":"Costa","year":"2016","journal-title":"Nucl. Med. Commun."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1056\/NEJMra2027612","article-title":"Diffuse large B-cell lymphoma","volume":"384","author":"Sehn","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"(1993). International non-Hodgkin\u2019s Lymphoma Prognostic Factors Project. A predictive model for aggressive non-Hodgkin\u2019s lymphoma. N. Engl. J. Med., 329, 987\u2013994.","DOI":"10.1056\/NEJM199309303291402"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"607","DOI":"10.2478\/raon-2025-0028","article-title":"Are there clinically relevant prognostic factors in diffuse large B-cell lymphoma beyound International Prognostic Index?","volume":"59","author":"Miljkovic","year":"2025","journal-title":"Radiol. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/35000501","article-title":"Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling","volume":"403","author":"Alizadeh","year":"2000","journal-title":"Nature"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1056\/NEJMoa1801445","article-title":"Genetics and pathogenesis of diffuse large B-cell lymphoma","volume":"378","author":"Schmitz","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/ajh.25460","article-title":"Diffuse large B-cell lymphoma: 2019 update on diagnosis, risk stratification and treatment","volume":"94","author":"Liu","year":"2019","journal-title":"Am. J. Hematol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1182\/blood.2023020780","article-title":"The high-grade B-cell lymphomas: Double hit and more","volume":"144","author":"Davies","year":"2024","journal-title":"Blood"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1056\/NEJMoa0802885","article-title":"Stromal gene signatures in large B-cell lymphomas","volume":"359","author":"Lenz","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1038\/s41467-024-46220-z","article-title":"Spatially resolved transcriptomics reveal macrophage heterogeneity and prognostic significance in diffuse large b-cell lymphoma","volume":"15","author":"Liu","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Harjunp\u00e4\u00e4, H., Asens, M.L., Guenther, C., and Fagerholm, S.C. (2019). Cell adhesion molecules and their roles and regulation in the immune and tumor microenvironment. Front. Immunol., 22.","DOI":"10.3389\/fimmu.2019.01078"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1074\/jbc.REV119.007759","article-title":"Cell adhesion in cancer: Beyond the migration of single cells","volume":"295","author":"Janiszewska","year":"2020","journal-title":"J. Biol. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/ajh.2830500103","article-title":"Bone marrow of patients with active multiple myeloma: Angiogenesis and plasma cell adhesion molecules LFA-1, VLA-4, LAM-1, and CD44","volume":"50","author":"Vacca","year":"1995","journal-title":"Am. J. Hematol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1600-0609.2007.00902.x","article-title":"First clinical experience with simvastatin to overcome drug resistance in refractory multiple myeloma","volume":"79","author":"Schmidmaier","year":"2007","journal-title":"Eur. J. Haematol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"9281","DOI":"10.1158\/0008-5472.CAN-09-2009","article-title":"Comparative analysis of normal versus CLL B-lymphocytes reveals patient-specific variability in signaling mechanisms controlling LFA-1 activation by chemokines","volume":"69","author":"Montresor","year":"2009","journal-title":"Cancer Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1182\/blood-2003-05-1545","article-title":"Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray","volume":"103","author":"Hans","year":"2004","journal-title":"Blood"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1200\/JCO.2013.54.8800","article-title":"Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: The Lugano classification","volume":"32","author":"Cheson","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2005420","DOI":"10.1080\/21688370.2021.2005420","article-title":"Dual role of E-cadherin in cancer cells","volume":"10","author":"Rubtsova","year":"2022","journal-title":"Tissue Barriers"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.critrevonc.2017.11.010","article-title":"E-cadherin: Its dysregulation in carcinogenesis and clinical implications","volume":"121","author":"Wong","year":"2018","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_24","first-page":"871","article-title":"When E-cadherin becomes unstuck in cancer","volume":"389","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Maher, N., Maiellaro, F., Ghanej, J., Rasi, S., Moia, R., and Gaidano, G. (2025). Unraveling the epigenetic landscape of mature B cell neoplasia; mechanisms, biomarkers, and therapeutic opportunities. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26178132"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s12185-022-03461-2","article-title":"Biological and clinical significance of epigenetic alterations in B-cell lymphomas","volume":"116","author":"Ennishi","year":"2022","journal-title":"Int. J. Hematol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.it.2025.10.007","article-title":"Epigenetically programmed identity crisis to combat diffuse large B cell lymphoma","volume":"47","author":"Niccolai","year":"2026","journal-title":"Trends Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1038\/sj.jid.5701242","article-title":"ADAM10-mediated E-cadherin release is regulated by proinflammatory cytokines and modulates keratinocyte cohesion in eczematous dermatitis","volume":"128","author":"Maretzky","year":"2008","journal-title":"J. Investig. Dermatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1515\/BC.2009.055","article-title":"Cathepsin B release from rodent intestine mucosa due to mechanical injury results in extracellular matrix damage in early post-traumatic phases","volume":"390","author":"Vreemann","year":"2009","journal-title":"Biol. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.mam.2008.08.001","article-title":"The ADAM metalloproteinases","volume":"29","author":"Edwards","year":"2008","journal-title":"Mol. Asp. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.ygyno.2007.10.027","article-title":"Lysophosphatidic acid (LPA) promotes E-cadherin ectodomain shedding and OVCA429 cell invasion in an uPA-dependent manner","volume":"108","author":"Gil","year":"2008","journal-title":"Gynecol. Oncol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.2741\/4031","article-title":"Soluble E-cadherin: More than a symptom of disease","volume":"17","author":"Grabowska","year":"2014","journal-title":"Front. Biosci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"637308","DOI":"10.1155\/2014\/637308","article-title":"E-cadherin and gastric cancer: Cause, consequence, and applications","volume":"2014","author":"Liu","year":"2014","journal-title":"BioMed Res. Int."},{"key":"ref_34","first-page":"408047","article-title":"Levels of soluble E-cadherin in breast, gastric and colorectal cancers","volume":"2014","author":"Rapetto","year":"2014","journal-title":"BioMed Res. Int."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/bjc.1996.404","article-title":"Cell adhesion molecules in bladder cancer: Soluble serum E-cadherin correlates with predictors of recurrence","volume":"74","author":"Griffiths","year":"1996","journal-title":"Br. J. Cancer."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1023\/B:CLIN.0000017204.38807.22","article-title":"Soluble serum E-cadherin as a marker of tumor progression in colorectal cancer patients","volume":"21","author":"Wilmanns","year":"2004","journal-title":"Clin. Exp. Metastasis"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1002\/cncr.21260","article-title":"Early prediction of tumor recurrence after recurative resection of gastric carcinoma by measuring soluble E-cadherin","volume":"104","author":"Chan","year":"2005","journal-title":"Cancer"},{"key":"ref_38","first-page":"1390","article-title":"Significance of the serum level of soluble E-cadherin in patients with HCC","volume":"55","author":"Soyama","year":"2008","journal-title":"Hepatogastroenterology"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1038\/sj.bjc.6602599","article-title":"Assessment of a fragment of E-cadherin as a serum biomarker with predictive value for prostate cancer","volume":"92","author":"Kuefer","year":"2005","journal-title":"Br. J. Cancer"},{"key":"ref_40","first-page":"2027","article-title":"Circulating soluble E-cadherin levels are of prognostic significance in patients with multiple myeloma","volume":"24","author":"Syrigos","year":"2004","journal-title":"Anticancer Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"245","DOI":"10.12688\/f1000research.109551.1","article-title":"Negative E-cadherin expression on bone marrow myeloma cell membranes is associated with extramedullary disease","volume":"11","author":"Hirao","year":"2022","journal-title":"F1000Res"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.1182\/blood.V95.10.3208","article-title":"Hypermethylation of E-cadherin in leukemia","volume":"95","author":"Melki","year":"2000","journal-title":"Blood"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1163\/156855902760262781","article-title":"E-cadherin expression in lymph nodes of three patients with non-Hodgkin\u2019s lymphoma","volume":"32","author":"Takubo","year":"2002","journal-title":"Haematologia"},{"key":"ref_44","first-page":"29","article-title":"Relevance of some serum biomarkers (E cadherin, GAGs & MDA) in patients with diffuse large B-cell lymphoma","volume":"21","author":"Eissa","year":"2008","journal-title":"Pak. J. Pharm. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1056\/NEJMoa2115304","article-title":"Polatuzumab vedotin in previously untreated diffuse large B-cell lymphoma","volume":"386","author":"Tilly","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1007\/s00277-019-03731-w","article-title":"Absolute monocyte count is a predictor of overall survival and progression-free survival in nodal peripheral T-cell lymphoma","volume":"98","author":"Lage","year":"2019","journal-title":"Ann. Hematol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.21873\/invivo.13276","article-title":"Combination of sarcopenia and anemia predicts worse outcome in elderly patients with diffuse large B-cell lymphoma","volume":"37","author":"Liao","year":"2023","journal-title":"In Vivo"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Lage, L.A.d.P.C., De Vita, R.N., Alves, L.B.d.O., Jacomassi, M.D., Culler, H.F., Reichert, C.O., de Freitas, F.A., Rocha, V., Siqueira, S.A.C., and Costa, R.d.O. (2024). Predictors of survival, treatment modalities, and clinical outcomes of diffuse large B-cell lymphoma in patients older than 70 years\u2014Still an unmet medical need in 2024 based on real-world evidence. Cancers, 16.","DOI":"10.3390\/cancers16081459"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1002\/ajh.70229","article-title":"2026 update on the management of diffuse large B-cell lymphoma","volume":"101","author":"Chong","year":"2026","journal-title":"Am. J. Hematol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Zhou, L., Liu, Y., Lu, Y., Zhou, P., Lu, L., Lv, H., and Hai, X. (2022). Recent advances in the immunoassays based on nanozymes. Biosensors, 12.","DOI":"10.3390\/bios12121119"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-0716-2903-1_1","article-title":"Enzyme-linked immunosorbent assay: Types and applications","volume":"2612","author":"Hayrapetyan","year":"2023","journal-title":"ELISA: Methods and Protocols"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1517\/14728222.2013.827174","article-title":"Therapeutic targets associated to E-cadherin dysfunction in gastric cancer","volume":"17","author":"Carneiro","year":"2013","journal-title":"Expert. Opin. Ther. Targets"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"189466","DOI":"10.1016\/j.bbcan.2025.189466","article-title":"E-cadherin: A potential biomarker in cancer and a therapeutic target","volume":"1880","author":"Kumari","year":"2025","journal-title":"Biochim. Biophys. Acta Rev. Cancer"}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/5\/637\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:30:32Z","timestamp":1779377432000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/5\/637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,24]]},"references-count":53,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["biom16050637"],"URL":"https:\/\/doi.org\/10.3390\/biom16050637","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,24]]}}}