{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:15:13Z","timestamp":1790828113331,"version":"4.1.0"},"reference-count":36,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Henan Academy of Sciences","award":["20250104"],"award-info":[{"award-number":["20250104"]}]},{"name":"Henan Academy of Sciences","award":["241802039"],"award-info":[{"award-number":["241802039"]}]},{"name":"Henan Academy of Sciences","award":["20260602001"],"award-info":[{"award-number":["20260602001"]}]},{"name":"Henan Academy of Sciences","award":["20260602003"],"award-info":[{"award-number":["20260602003"]}]},{"name":"Henan Academy of Sciences","award":["20262302001"],"award-info":[{"award-number":["20262302001"]}]},{"award":["20250104"],"award-info":[{"award-number":["20250104"]}],"id":[{"id":"https:\/\/ror.org\/00hy87220","id-type":"ROR","asserted-by":"publisher"}]},{"award":["241802039"],"award-info":[{"award-number":["241802039"]}],"id":[{"id":"https:\/\/ror.org\/00hy87220","id-type":"ROR","asserted-by":"publisher"}]},{"award":["20260602001"],"award-info":[{"award-number":["20260602001"]}],"id":[{"id":"https:\/\/ror.org\/00hy87220","id-type":"ROR","asserted-by":"publisher"}]},{"award":["20260602003"],"award-info":[{"award-number":["20260602003"]}],"id":[{"id":"https:\/\/ror.org\/00hy87220","id-type":"ROR","asserted-by":"publisher"}]},{"award":["20262302001"],"award-info":[{"award-number":["20262302001"]}],"id":[{"id":"https:\/\/ror.org\/00hy87220","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Henan Science and Technology Department","award":["252102231011"],"award-info":[{"award-number":["252102231011"]}]},{"award":["252102231011"],"award-info":[{"award-number":["252102231011"]}],"id":[{"id":"https:\/\/ror.org\/058p20n09","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Curcumin, a plant-derived polyphenolic compound, exhibits diverse pharmacological activities such as antioxidant, anti-inflammatory, anticancer, neuroprotective, and cardiovascular protective effects, and is widely used in food, medicine, and other fields. However, its poor water solubility and easy oxidative degradation limit its extensive application in biomedicine. To solve these problems, a series of biomedical polyurethanes (Cur-PU) with similar molecular weights but different PEG contents were successfully synthesized using HO-PCL-OH and HO-PEG-OH as soft segments and curcumin as a chain extender. The results indicated that increasing the PEG content reduced the T1m, T1c, and H1c of Cur-PU, along with a slower crystallization rate and lower crystallinity. More importantly, a higher PEG content decreased the water contact angle but increased water solubility and water uptake, which, combined with reduced crystallinity, enhanced hydrophilicity, swelling ratio, curcumin release rate, and degradation rate in an enzymatic solution and pH 8.0 buffer. Thus, precise regulation of Cur-PU\u2019s degradation and curcumin release was achieved by controlling the PEG content. Biocompatibility tests confirmed that Cur-PU exhibited excellent antioxidant and antibacterial activities, making it a highly promising biomedical material.<\/jats:p>","DOI":"10.3390\/biom16050640","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T17:26:18Z","timestamp":1777051578000},"page":"640","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["PEG-Dependent Tunable Degradation and Curcumin Release from Curcumin-Based Biomedical Polyurethanes"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3907-3656","authenticated-orcid":false,"given":"Man","family":"Wang","sequence":"first","affiliation":[{"name":"High & New Technology Research Center of Henan Academy of Sciences, No. 56 Hongzhuan Road, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongying","family":"Liu","sequence":"additional","affiliation":[{"name":"West China School of Nursing, Sichuan University, No. 37, Guoxue Alley, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[{"name":"High & New Technology Research Center of Henan Academy of Sciences, No. 56 Hongzhuan Road, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huafen","family":"Wang","sequence":"additional","affiliation":[{"name":"High & New Technology Research Center of Henan Academy of Sciences, No. 56 Hongzhuan Road, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwei","family":"Zhuang","sequence":"additional","affiliation":[{"name":"High & New Technology Research Center of Henan Academy of Sciences, No. 56 Hongzhuan Road, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Zhang","sequence":"additional","affiliation":[{"name":"High & New Technology Research Center of Henan Academy of Sciences, No. 56 Hongzhuan Road, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohui","family":"Liu","sequence":"additional","affiliation":[{"name":"High & New Technology Research Center of Henan Academy of Sciences, No. 56 Hongzhuan Road, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7135-2244","authenticated-orcid":false,"given":"Nengwen","family":"Ke","sequence":"additional","affiliation":[{"name":"West China School of Nursing, Sichuan University, No. 37, Guoxue Alley, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sichong","family":"Chen","sequence":"additional","affiliation":[{"name":"The Collaborative Innovation Center for Eco-Friendly and Fire-Safety Polymeric Materials (MoE), National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), College of Chemistry, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610064, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"102145","DOI":"10.1016\/j.mtbio.2025.102145","article-title":"Multifunctional Nanomedicine Targeting the \u2018Seed-and-Soil\u2019 of Hair Follicles via Simultaneous Alleviation of Oxidative Stress and Activation of Autophagy for Androgenetic Alopecia Therapy","volume":"34","author":"Chen","year":"2025","journal-title":"Mater. Today Bio"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"21571","DOI":"10.1021\/acsnano.5c03744","article-title":"Astragalus Polysaccharide Hydrogels with Drug-Carrying Super Self-Assembly from Natural Herbs Promote Wound Healing","volume":"19","author":"Zhao","year":"2025","journal-title":"ACS Nano"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.3390\/molecules20022728","article-title":"The Multifaceted Role of Curcumin in Cancer Prevention and Treatment","volume":"20","author":"Shanmugam","year":"2015","journal-title":"Molecules"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Chopra, H., Bibi, S., Singh, I., Kamal, M.A., Islam, F., Alhumaydhi, F.A., Emran, T.B., and Cavalu, S. (2022). Nanomedicines in the Management of Alzheimer\u2019s Disease: Current View and Future Prospects. Front. Aging Neurosci., 14.","DOI":"10.3389\/fnagi.2022.879114"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.ijbiomac.2022.11.233","article-title":"Self-assembled hyaluronic acid-coated nanocomplexes for targeted delivery of curcumin alleviate acute kidney injury","volume":"226","author":"Huang","year":"2023","journal-title":"Int. J. Biol. Macromil."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.1021\/acsbiomaterials.5c00006","article-title":"Nanostructuring and Antioxidant Activity of Nanotherapeutics Designed by Self-Assembly of Natural Lipids and Phytochemicals","volume":"11","author":"Akanchise","year":"2025","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2405781","DOI":"10.1002\/smll.202405781","article-title":"Intranasal Delivery of Pure Nanodrug Loaded Liposomes for Alzheimer\u2019s Disease Treatment by Efficiently Regulating Microglial Polarization","volume":"20","author":"Feng","year":"2024","journal-title":"Small"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1080\/13880209.2022.2136205","article-title":"Solid lipid nanoparticle as an effective drug delivery system of a novel curcumin derivative: Formulation, release in vitro and pharmacokinetics in vivo","volume":"60","author":"Zhao","year":"2022","journal-title":"Pharm. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/s12951-023-02045-4","article-title":"Oral hydrogel nanoemulsion co-delivery system treats infammatory bowel disease via anti-infammatory and promoting intestinal mucosa repair","volume":"21","author":"Lei","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ijbiomac.2019.06.060","article-title":"Under-standing the cellular uptake and biodistribution of a dual-targeting carrier based on redox-sensitive hyaluronic acid-ss-curcumin micelles for treating brain glioma","volume":"136","author":"Tian","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"101316","DOI":"10.1016\/j.mtphys.2023.101316","article-title":"Antibacterial and antioxidant wound dressings with pH responsive release properties accelerate chronic wound healing","volume":"40","author":"Cao","year":"2024","journal-title":"Mater. Today Phys."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e00554","DOI":"10.1002\/adhm.202500554","article-title":"Multifunctional Hydrogel Dressing Based on Glycosylated Collagen-Curcumin Nanoparticles Effectively Accelerates Wound Healing","volume":"15","author":"Fu","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"117556","DOI":"10.1016\/j.carbpol.2020.117556","article-title":"Engineering of stepwise-targeting chitosan oligosaccharide conjugate for the treatment of acute kidney injury","volume":"256","author":"Wang","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"65877","DOI":"10.1021\/acsami.4c14752","article-title":"Poly(thioctic acid) Hydrogels Integrated with Self-Healing, Bioadhesion, Antioxidation, and Antibiosis for Infected Wound Treatment","volume":"16","author":"Feng","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"110762","DOI":"10.1016\/j.colsurfb.2019.110762","article-title":"Co-delivery of curcumin and Bcl-2 siRNA by PAMAM dendrimers for enhancement of the therapeutic efficacy in HeLa cancer cells","volume":"188","author":"Ghaffari","year":"2020","journal-title":"Colloids Surf. B"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"22355","DOI":"10.1021\/acsnano.3c04556","article-title":"Exudate Absorbing and Antimicrobial Hydrogel Integrated with Multifunctional Curcumin-Loaded Magnesium Polyphenol Network for Facilitating Burn Wound Healing","volume":"17","author":"Gong","year":"2023","journal-title":"ACS Nano"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s42765-025-00592-z","article-title":"Rhizome-Inspired Liquid-Management Membrane to Promote Wound Healing","volume":"8","author":"Zhang","year":"2026","journal-title":"Adv. Fiber Mater."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1039\/c0nr00758g","article-title":"Curcumin-loaded biodegradable polymeric micelles for colon cancer therapy in vitro and in vivo","volume":"3","author":"Gou","year":"2012","journal-title":"Nanoscale"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Wang, M., Liu, H., Zhao, W., Wang, H., Zhuang, Y., Yang, J., Liu, Z., Zhu, J., Chen, S., and Cheng, J. (2025). Design and Characterization of Curcumin-Modiffed Polyurethane Material with Good Mechanical, Shape-Memory, pH-Responsive, and Biocompatible Properties. Biomolecules, 15.","DOI":"10.3390\/biom15081070"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1002\/pi.2843","article-title":"Largely improved tensile extensibility of poly(L-lactic acid) by adding poly(\u03b5-caprolactone)","volume":"59","author":"Chen","year":"2010","journal-title":"Polym. Int."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"154041","DOI":"10.1016\/j.cej.2024.154041","article-title":"Characterization of novel anthocyanins film@carbon quantum dot nanofiber intelligent active double-layer film, physicochemical properties and fresh-keeping monitoring in ictalurus punctatus fish","volume":"496","author":"Qin","year":"2024","journal-title":"Chem. Eng. J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"165793","DOI":"10.1016\/j.cej.2025.165793","article-title":"Curcumin-based antibacterial waterborne polyurethane\/gelatin composite film for pork preservation and freshness indication","volume":"520","author":"Zhong","year":"2025","journal-title":"Chem. Eng. J."},{"key":"ref_23","first-page":"29","article-title":"Glucose-Responsive Antioxidant Hydrogel Accelerates Diabetic Wound Healing","volume":"30","author":"Chen","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"5855","DOI":"10.1021\/acsbiomaterials.3c00590","article-title":"One-Pot Preparation of Skin-Inspired Multifunctional Hybrid Hydrogel with Robust Wound Healing Capacity","volume":"9","author":"Yang","year":"2023","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"6801","DOI":"10.1021\/acs.biomac.4c01019","article-title":"Negatively Charged Thermosensitive Hydrogel Loaded with Pectin Microspheres to Recover the Mucosal Barrier for Ulcerative Colitis Therapy","volume":"25","author":"Chen","year":"2024","journal-title":"Biomacromolecules"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"157808","DOI":"10.1016\/j.cej.2024.157808","article-title":"Engineering a shellfish-inspired bio-based double-layered smart packaging material with enhanced water resistance and barrier performance for universally applicable meat freshness monitoring","volume":"501","author":"Liu","year":"2024","journal-title":"Chem. Eng. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"111788","DOI":"10.1016\/j.foodhyd.2025.111788","article-title":"Smart funoran fflm incorporated with blueberry anthocyanins as a dual pH\/NH3 sensor for real-time monitoring of shrimp freshness","volume":"171","author":"Khan","year":"2026","journal-title":"Food Hydrocoll."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3164","DOI":"10.1039\/D3TB00011G","article-title":"Toward regulating biodegradation in stages of polyurethane copolymers with bicontinuous microphase separation","volume":"11","author":"Wang","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1039\/D2NR04908B","article-title":"An antioxidant and antibacterial polydopamine-modified thermo-sensitive hydrogel dressing for Staphylococcus aureus-infected wound healing","volume":"15","author":"Ge","year":"2023","journal-title":"Nanoscale"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"37563","DOI":"10.1021\/acsami.7b09395","article-title":"pH and Glucose Dual-Responsive Injectable Hydrogels with Insulin and Fibroblasts as Bioactive Dressings for Diabetic Wound Healing","volume":"9","author":"Zhao","year":"2017","journal-title":"ACS. Appl. Mater. Interfaces"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Pan, M., Zhao, C., Xu, Z., Yang, Y., Teng, T., Lin, J., and Huang, H. (2021). Radiopaque Chitosan Ducts Fabricated by Extrusion-Based 3D Printing to Promote Healing After Pancreaticoenterostomy. Front. Bioeng. Biotech., 9.","DOI":"10.3389\/fbioe.2021.686207"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"26404","DOI":"10.1021\/acsami.2c04300","article-title":"Bioactive Injectable Hydrogel Dressings for Bacteria-Infected Diabetic Wound Healing: A \u201cPull-Push\u201d Approach","volume":"14","author":"Zhang","year":"2022","journal-title":"ACS. Appl. Mater. Interfaces"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1021\/acs.biomac.7b00979","article-title":"Dual Function Injectable Hydrogel for Controlled Release of Antibiotic and Local Antibacterial Therapy","volume":"19","author":"Hoque","year":"2018","journal-title":"Biomacromolecules"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"56862","DOI":"10.1021\/acsami.4c13588","article-title":"Quaternary Ammonium Salt-Based Intrinsic Antibacterial Polyurethanes: Optimizing the Anti-bacterial Activity via Cationic Main- or Side-Chain Design in Hard Segments","volume":"16","author":"Lv","year":"2024","journal-title":"ACS. Appl. Mater. Interfaces"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1021\/acsbiomaterials.3c01644","article-title":"Fabrication of Oleophilic Polypeptide Nanoparticle from Complexing of Cross-Linked Epsilon-Poly-l-Lysine with Docusate Sodium for Preparation of Bactericidal Thermoplastic Polyurethanes","volume":"10","author":"Xu","year":"2024","journal-title":"ACS. Biomater. Sci. Eng."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2413083","DOI":"10.1002\/adfm.202413083","article-title":"Fabrication of mechanical strong supramolecular waterborne polyurethane elastomers with the inspiration of hierarchical dynamic structures of scallop Byssal threads","volume":"35","author":"Zhang","year":"2025","journal-title":"Adv. Funct. Mater."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/5\/640\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:30:37Z","timestamp":1779377437000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/5\/640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,24]]},"references-count":36,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["biom16050640"],"URL":"https:\/\/doi.org\/10.3390\/biom16050640","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,24]]}}}