{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:21:48Z","timestamp":1777735308382,"version":"3.51.4"},"reference-count":77,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Allergic anisakiasis (AA), caused by the ingestion of fish contaminated with Anisakis larvae, has emerged as a growing global health concern due to the increasing consumption of raw or undercooked seafood. Anisakis simplex is identified as the primary etiologic species, responsible for gastrointestinal symptoms, IgE-mediated (Type I) or cell-mediated (Type IV) manifestations, and gastro-allergic anisakiasis (GAA), a unique clinical overlap between parasitic infection and acute IgE-mediated food allergy. In this review, we analyzed the epidemiology of Anisakis simplex allergy, the main diagnostic methods to confirm a diagnosis of food allergy, its clinical manifestations, and how these differ in different countries around the world. This multidisciplinary synthesis provides, for the first time, an integrated understanding of Anisakis-induced disease mechanisms across human, animal, and cellular levels. The persistence of allergenic proteins despite standard food processing underscores the need for improved diagnostic tools, public health surveillance, and preventive strategies\u2014particularly in populations with high seafood consumption or occupational exposure. A comprehensive approach combining clinical, molecular, and immunological perspectives is essential to address the expanding global burden of allergic anisakiasis.<\/jats:p>","DOI":"10.3390\/biom16050648","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:34:42Z","timestamp":1777458882000},"page":"648","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Allergic Anisakiasis: An Integrated Review of Human, Animal and Cellular Evidence"],"prefix":"10.3390","volume":"16","author":[{"given":"Stefania","family":"Isola","sequence":"first","affiliation":[{"name":"Unit and School of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6326-8547","authenticated-orcid":false,"given":"Emanuela","family":"Zumbo","sequence":"additional","affiliation":[{"name":"Unit and School of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1442-9147","authenticated-orcid":false,"given":"Francesca","family":"Dimasi","sequence":"additional","affiliation":[{"name":"Unit and School of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3010-3815","authenticated-orcid":false,"given":"Paola Lucia","family":"Minciullo","sequence":"additional","affiliation":[{"name":"Unit and School of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastiano","family":"Gangemi","sequence":"additional","affiliation":[{"name":"Unit and School of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3904\/kjim.2009.24.2.160","article-title":"The Clinical Characteristics of Anisakis Allergy in Korea","volume":"24","author":"Choi","year":"2009","journal-title":"Korean J. Intern. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0304-4017(88)90148-3","article-title":"Standardized nomenclature of animal parasitic diseases (SNOAPAD)","volume":"29","author":"Kassai","year":"1988","journal-title":"Vet. Parasitol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Nonkovi\u0107, D., Te\u0161i\u0107, V., \u0160imat, V., Karabuva, S., Medi\u0107, A., and Hrabar, J. (2025). Anisakidae and Anisakidosis: A Public Health Perspective. Pathogens, 14.","DOI":"10.3390\/pathogens14030217"},{"key":"ref_4","first-page":"e8719","article-title":"Re-evaluation of certain aspects of the EFSA Scientific Opinion of April 2010 on risk assessment of parasites in fishery products, based on new scientific data. Part 1: ToRs1\u20133","volume":"22","author":"Koutsoumanis","year":"2024","journal-title":"EFSA J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0065-308X(08)00202-9","article-title":"Chapter 2 Advances and Trends in the Molecular Systematics of Anisakid Nematodes, with Implications for their Evolutionary Ecology and Host\u2014Parasite Co-evolutionary Processes","volume":"66","author":"Mattiucci","year":"2008","journal-title":"Adv. Parasitol."},{"key":"ref_6","first-page":"D-21-00004","article-title":"Current Status of Anisakiasis and Anisakis Larvae in Tokyo, Japan","volume":"9","author":"Suzuki","year":"2021","journal-title":"Food Saf."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3347\/kjp.2001.39.2.193","article-title":"A human case of gastric infection by Pseudoterranova decipiens larva","volume":"39","author":"Yu","year":"2001","journal-title":"Korean J. Parasitol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"102794","DOI":"10.1016\/j.parint.2023.102794","article-title":"Resurrection of genus Phocanema Myers, 1959, as a genus independent from Pseudoterranova Mozgovo\u012d, 1953, for nematode species (Anisakidae) parasitic in pinnipeds and cetaceans, respectively","volume":"97","author":"Bao","year":"2023","journal-title":"Parasitol. Int."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"232","DOI":"10.2307\/3273150","article-title":"Parasitological study on the Eskimos in the Bethel area of Alaska","volume":"36","author":"Hitchcock","year":"1950","journal-title":"J. Parasitol."},{"key":"ref_10","first-page":"75","article-title":"The present state of anisakiasis and its causative worms","volume":"28","year":"1976","journal-title":"Trop. Geogr. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1007\/s00436-023-07881-9","article-title":"A critical review of anisakidosis cases occurring globally","volume":"122","author":"Shamsi","year":"2023","journal-title":"Parasitol. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3354\/dao03091","article-title":"Anisakis (Nematoda: Ascaridoidea) from Indonesia","volume":"123","author":"Palm","year":"2017","journal-title":"Dis. Aquat. Organ."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1007\/s00436-018-6018-0","article-title":"Occurrence of anisakid parasites in marine fishes and whales off New Caledonia","volume":"117","author":"Shamsi","year":"2018","journal-title":"Parasitol. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.apjtb.2015.11.011","article-title":"Anisakiasis in Southeast Asia: A story of new tropical disease?","volume":"6","author":"Wiwanitkit","year":"2016","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1017\/S0022149X17000025","article-title":"Contracaecum osculatum and other anisakid nematodes in grey seals and cod in the Baltic Sea: Molecular and ecological links","volume":"92","author":"Zuo","year":"2018","journal-title":"J. Helminthol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1007\/s00436-021-07243-3","article-title":"The occurrence of Anisakis spp. in Australian waters: Past, present, and future trends","volume":"120","author":"Shamsi","year":"2021","journal-title":"Parasitol. Res."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Anisakis, M.T.A. (2022). Something Is Moving inside the Fish. Pathogens, 11.","DOI":"10.3390\/pathogens11030326"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1034\/j.1398-9995.2001.00987.x","article-title":"Prevalence of and risk factors for IgE sensitization to Anisakis simplex in a Spanish population","volume":"56","author":"Lorenzo","year":"2001","journal-title":"Allergy"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1365-3083.2012.02670.x","article-title":"IgE sensitization to the fish parasite Anisakis simplex in a Norwegian population: A pilot study","volume":"75","author":"Lin","year":"2012","journal-title":"Scand. J. Immunol."},{"key":"ref_20","first-page":"514","article-title":"Sensitization to Anisakis simplex species in the population of northern Morocco","volume":"22","author":"Abattouy","year":"2012","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.aller.2016.06.004","article-title":"Food allergy in Catalonia: Clinical manifestations and its association with airborne allergens","volume":"45","author":"Rubira","year":"2017","journal-title":"Allergol. Immunopathol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/all.13987","article-title":"Anisakis is a major cause of anaphylaxis in seaside areas: An epidemiological study in Japan","volume":"75","author":"Morishima","year":"2020","journal-title":"Allergy"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1080\/19338244.2011.578683","article-title":"Prevalence of sensitization to Anisakis simplex among professionally exposed populations in Sicily","volume":"67","author":"Mazzucco","year":"2012","journal-title":"Arch. Environ. Occup. Health"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"AAITO-IFIACI Anisakis Consortium (2011). Anisakis hypersensitivity in Italy: Prevalence and clinical features: A multicenter study. Allergy, 66, 1563\u20131569.","DOI":"10.1111\/j.1398-9995.2011.02691.x"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.anai.2015.12.014","article-title":"High prevalence of Anisakis simplex hypersensitivity and allergy in Sicily, Italy","volume":"116","author":"Heffler","year":"2016","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S1081-1206(10)62278-8","article-title":"Incidence of sensitivity to Anisakis simplex in a risk population of fishermen\/fishmongers","volume":"84","author":"Pastorello","year":"2000","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"142","DOI":"10.18176\/jiaci.0139","article-title":"Anisakis Sensitivity in Italian Children: A Prospective Study","volume":"27","author":"Tripodi","year":"2017","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1034\/j.1398-9995.2000.00759.x","article-title":"Predictors of Anisakis simplex symptoms","volume":"55","author":"Bernardini","year":"2000","journal-title":"Allergy"},{"key":"ref_29","first-page":"253","article-title":"Immediate and cell-mediated reactions in parasitic infections by Anisakis simplex","volume":"18","author":"Ventura","year":"2008","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/bs.apar.2025.09.003","article-title":"Key discoveries from research in anisakiasis: From parasite biology to pathology in the human host","volume":"130","author":"Bellini","year":"2025","journal-title":"Adv. Parasitol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/pim.12349","article-title":"Anisakis\u2013immunology of a foodborne parasitosis","volume":"38","author":"Nieuwenhuizen","year":"2016","journal-title":"Parasite Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Carballeda-Sangiao, N., Rodr\u00edguez-Mahillo, A.I., Careche, M., Navas, A., Moneo, I., and Gonz\u00e1lez-Mu\u00f1oz, M. (2016). Changes over Time in IgE Sensitization to Allergens of the Fish Parasite Anisakis spp. PLoS Negl. Trop. Dis., 10.","DOI":"10.1371\/journal.pntd.0004864"},{"key":"ref_33","first-page":"67","article-title":"What does Anisakis simplex parasitism in gastro-allergic anisakiasis teach us about interpreting specific and total IgE values?","volume":"28","author":"Daschner","year":"2000","journal-title":"Allergol. Immunopathol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1034\/j.1398-9995.2000.00734.x","article-title":"Is tropomyosin an allergen in Anisakis?","volume":"55","author":"Asturias","year":"2000","journal-title":"Allergy"},{"key":"ref_35","first-page":"1429","article-title":"A case of immediate allergy to Anisakis following saury intake","volume":"55","author":"Kameyama","year":"2006","journal-title":"Arerugi"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1365-2249.2009.03919.x","article-title":"The Anisakis simplex Ani s 7 major allergen as an indicator of true Anisakis infections","volume":"156","author":"Escalante","year":"2009","journal-title":"Clin. Exp. Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1034\/j.1398-9995.2000.00422.x","article-title":"A double-blind, placebo-controlled oral challenge study with lyophilized larvae and antigen of the fish parasite, Anisakis simplex","volume":"55","author":"Sastre","year":"2000","journal-title":"Allergy"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00403-012-1206-8","article-title":"Ani s 1 and Ani s 7 recombinant allergens are able to differentiate distinct Anisakis simplex-associated allergic clinical disorders","volume":"304","author":"Daschner","year":"2012","journal-title":"Arch. Dermatol. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.exppara.2017.08.010","article-title":"Recombinant vs native Anisakis haemoglobin (Ani s 13): Its appraisal as a new gold standard for the diagnosis of allergy","volume":"181","author":"Rivas","year":"2017","journal-title":"Exp. Parasitol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3358\/shokueishi.56.194","article-title":"Molecular Cloning and Expression of a New Major Allergen, Ani s 14, from Anisakis simplex","volume":"56","author":"Kobayashi","year":"2015","journal-title":"Shokuhin Eiseigaku Zasshi"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Brusca, I., Barrale, M., Zarcone, M., Fruscione, S., Onida, R., De Bella, D.D., Alba, D., Belluzzo, M., Uasuf, C.G., and Cammilleri, G. (2023). Basophil Activation Test in the Diagnosis of Anisakis Allergy: An Observational Study from an Area of High Seafood Consumption in Italy. Pathogens, 12.","DOI":"10.3390\/pathogens12060777"},{"key":"ref_42","first-page":"21","article-title":"Conjunctival provocation tests in the diagnosis of Anisakis simplex hypersensitivity","volume":"12","author":"Sastre","year":"2002","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Barrale, M., Mazzucco, W., Fruscione, S., Zarcone, M., Cantisano, V., Cammilleri, G., Costa, A., Ferrantelli, V., Onida, R., and Scala, E. (2025). An Assessment of the Currently Available Molecular Assay for the Diagnosis of Anisakis Sensitization. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26073033"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e1071","DOI":"10.1016\/j.ijid.2013.05.008","article-title":"Anisakis, just think about it in an emergency!","volume":"17","author":"Bucci","year":"2013","journal-title":"Int. J. Infect. Dis."},{"key":"ref_45","first-page":"761","article-title":"Endoscopic findings and clinical manifestation of gastric anisakiasis","volume":"90","author":"Kakizoe","year":"1995","journal-title":"Am. J. Gastroenterol."},{"key":"ref_46","first-page":"90","article-title":"The mucosal changes and influencing factors in upper gastrointestinal anisakiasis: Analysis of 141 cases","volume":"53","author":"Lee","year":"2009","journal-title":"Korean J. Gastroenterol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.ajem.2014.09.010","article-title":"Anisakiasis presenting to the ED: Clinical manifestations, time course, hematologic tests, computed tomographic findings, and treatment","volume":"32","author":"Takabayashi","year":"2014","journal-title":"Am. J. Emerg. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1422.e1","DOI":"10.1016\/j.ajem.2013.05.015","article-title":"Intestinal anisakiasis as a rare cause of small bowel obstruction","volume":"31","author":"Kojima","year":"2013","journal-title":"Am. J. Emerg. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.3748\/wjg.v16.i14.1804","article-title":"Intestinal anisakiasis can cause intussusception in adults: An extremely rare condition","volume":"16","author":"Miura","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000053801","article-title":"Anaphylaxis due to hypersensitivity to Anisakis simplex","volume":"125","author":"Chamorro","year":"2001","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e601","DOI":"10.1016\/j.amjmed.2020.02.054","article-title":"A Case of Anaphylaxis with Mild Abdominal Pain Due to Gastroallergic Anisakiasis","volume":"133","author":"Seike","year":"2020","journal-title":"Am. J. Med."},{"key":"ref_52","first-page":"378","article-title":"Anisakis simplex only provokes allergic symptoms when the worm parasitises the gastrointestinal tract","volume":"93","author":"Daschner","year":"2004","journal-title":"Parasitol. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1089\/fpd.2009.0484","article-title":"Anisakiasis, an underestimated infection: Effect on intestinal permeability of Anisakis simplex-sensitized patients","volume":"7","author":"Polimeno","year":"2010","journal-title":"Foodborne Pathog. Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0301-0546(02)79145-3","article-title":"Dietary recommendations for patients allergic to Anisakis simplex","volume":"30","author":"Trujillo","year":"2002","journal-title":"Allergol. Immunopathol."},{"key":"ref_55","first-page":"49","article-title":"Freezing protects against allergy to Anisakis simplex","volume":"11","author":"Blanco","year":"2001","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S1081-1206(10)62298-3","article-title":"Anisakis simplex-sensitized patients: Should fish be excluded from their diet?","volume":"86","author":"Matheu","year":"2001","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1080\/00034983.2000.11813538","article-title":"Specific and total IgE in patients with recurrent, acute urticaria caused by Anisakis simplex","volume":"94","author":"Perteguer","year":"2000","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"ref_58","first-page":"1814","article-title":"Eosinophilic esophagitis associated with recurrent urticaria: Is the worm Anisakis simplex involved?","volume":"130","author":"Bircher","year":"2000","journal-title":"Schweiz. Med. Wochenschr."},{"key":"ref_59","first-page":"21","article-title":"Eosinophilic gastritis due to Anisakis: A case report","volume":"28","author":"Esteve","year":"2000","journal-title":"Allergol. Immunopathol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1034\/j.1398-9995.2000.03405.x","article-title":"Clinical manifestations of allergy to Anisakis simplex","volume":"55","author":"Audicana","year":"2000","journal-title":"Allergy"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1159\/000351056","article-title":"Anisakis allergy component-resolved diagnosis: Clinical and immunologic differences between patients from Italy and Spain","volume":"162","author":"Caballero","year":"2013","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1051\/parasite\/2018016","article-title":"A national retrospective survey of anisakidosis in France (2010\u20132014): Decreasing incidence, female predominance, and emerging allergic potential","volume":"25","author":"Yera","year":"2018","journal-title":"Parasite"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.alit.2023.08.002","article-title":"Effects of raw seafood on the risk of hypersensitivity reaction recurrence in patients with an Anisakis allergy: A retrospective observational study in Japan","volume":"73","author":"Hamada","year":"2024","journal-title":"Allergol. Int."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1080\/00015550252948167","article-title":"Acute allergic reactions to Anisakis simplex after ingestion of anchovies","volume":"82","author":"Foti","year":"2002","journal-title":"Acta Derm. Venereol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1157\/13070606","article-title":"Allergy and parasites reevaluated: Wide-scale induction of chronic urticaria by the ubiquitous fish-nematode Anisakis simplex in an endemic region","volume":"33","author":"Daschner","year":"2005","journal-title":"Allergol. Immunopathol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1136\/jech.2007.061572","article-title":"Anisakis simplex as a risk factor for relapsing acute urticaria: A case-control study","volume":"62","author":"Lunet","year":"2008","journal-title":"J. Epidemiol. Community Health"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00403-010-1069-9","article-title":"Anisakis simplex sensitization-associated urticaria: Short-lived immediate type or prolonged acute urticaria","volume":"302","author":"Daschner","year":"2010","journal-title":"Arch. Dermatol. Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3347\/kjp.2006.44.4.271","article-title":"Immune reactions and allergy in experimental anisakiasis","volume":"44","author":"Cho","year":"2006","journal-title":"Korean J. Parasitol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1023\/B:DDAS.0000007873.48287.f6","article-title":"Altered autonomic control in rat intestine due to both infection with Anisakis simplex and incubation with the parasite\u2019s crude extract","volume":"48","author":"Bernadina","year":"2003","journal-title":"Dig. Dis. Sci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1111\/j.1398-9995.2009.02002.x","article-title":"Differential requirements for interleukin (IL)-4 and IL-13 in protein contact dermatitis induced by Anisakis","volume":"64","author":"Nieuwenhuizen","year":"2009","journal-title":"Allergy"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/j.1365-3024.2009.01195.x","article-title":"Parasite excretory-secretory proteins elicit TRIF dependent CXCL1 and IL-6 mediated allergic inflammation","volume":"32","author":"Cho","year":"2010","journal-title":"Parasite Immunol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijfoodmicro.2014.11.019","article-title":"Genetic identification and distribution of the parasitic larvae of Anisakis pegreffii and Anisakis simplex (s. s.) in European hake Merluccius merluccius from the Tyrrhenian Sea and Spanish Atlantic coast: Implications for food safety","volume":"198","author":"Cipriani","year":"2015","journal-title":"Int. J. Food Microbiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1089\/fpd.2011.1076","article-title":"Anisakis simplex sensu stricto and Anisakis pegreffii: Biological Characteristics and Pathogenetic Potential in Human Anisakiasis","volume":"9","author":"Arizono","year":"2012","journal-title":"Foodborne Pathog. Dis."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1186\/s13071-016-1895-5","article-title":"Anisakis pegreffii (Nematoda: Anisakidae) products modulate oxidative stress and apoptosis-related biomarkers in human cell lines","volume":"9","author":"Messina","year":"2016","journal-title":"Parasit. Vectors"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Napoletano, C., Mattiucci, S., Colantoni, A., Battisti, F., Zizzari, I.G., Rahimi, H., Nuti, M., and Rughetti, A. (2018). Anisakis pegreffii impacts differentiation and function of human dendritic cells. Parasite Immunol., 40.","DOI":"10.1111\/pim.12527"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1007\/s00436-017-5551-6","article-title":"Exposure to Anisakis extracts can induce inflammation on in vitro cultured human colonic cells","volume":"116","author":"Speciale","year":"2017","journal-title":"Parasitol. Res."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Carballeda-Sangiao, N., S\u00e1nchez-Alonso, I., Navas, A., Arcos, S.C., de Palencia, P.F., Careche, M., and Gonz\u00e1lez-Mu\u00f1oz, M. (2020). Anisakis simplex products impair intestinal epithelial barrier function and occludin and zonula occludens-1 localisation in differentiated Caco-2 cells. PLoS Negl. Trop. Dis., 14.","DOI":"10.1371\/journal.pntd.0008462"}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/5\/648\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:13:22Z","timestamp":1777461202000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/5\/648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,27]]},"references-count":77,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["biom16050648"],"URL":"https:\/\/doi.org\/10.3390\/biom16050648","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,27]]}}}