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Prophylactic platelet transfusions are administered when platelet counts fall below 10 \u00d7 109 PLT\/L, to prevent severe or fatal bleeding. However, these prophylactic platelet transfusions do not always result in the prevention of bleeding. Pre- or post-transfusion acquired dysfunction of donor platelets in this respect could play a role. We previously reported intrinsic and transfusion-dependent platelet alterations in hemato-oncological patients. In particular, the expression of relevant platelet receptors was affected in donor platelets after incubation with patient\u2019s plasma, which could explain, at least in part, the variable efficacy of platelet transfusions in these patients. In the present manuscript we show that plasma from acute myeloid leukemia (AML) patients undergoing chemotherapy inhibits functionality of allogenic platelets. Further proteomic analysis allowed us to observe alterations in the composition of plasma samples, and to identify key plasma components which could be responsible for platelet function inhibition and explain bleeding in patients notwithstanding platelet transfusions. We anticipate that with the obtained results, platelet transfusion support can be further personalized in patients receiving chemotherapy and applications might expand to maximize the clinical efficacy of procedures such as bone marrow transplantation.<\/jats:p>","DOI":"10.3390\/biom16060761","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T13:12:08Z","timestamp":1779455528000},"page":"761","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Plasma Glycoprotein Milieu in the Hemato-Oncological Patient Inhibits Platelet Function"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8862-8000","authenticated-orcid":false,"given":"Iris M.","family":"De Cuyper","sequence":"first","affiliation":[{"name":"Sanquin Blood Supply Foundation, Department Research, 1066 CX Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6547-7609","authenticated-orcid":false,"given":"Graciela","family":"Carbajo-Arg\u00fcelles","sequence":"additional","affiliation":[{"name":"Platelet Research Lab, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Villa-Fajardo","sequence":"additional","affiliation":[{"name":"Department of Hematology, Instituto de Investigaci\u00f3n Sanitaria San Carlos (IdISSC), Hospital Cl\u00ednico San Carlos, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7106-3063","authenticated-orcid":false,"given":"Andrea","family":"Acebes-Huerta","sequence":"additional","affiliation":[{"name":"Platelet Research Lab, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6545-7277","authenticated-orcid":false,"given":"Rutger A.","family":"Middelburg","sequence":"additional","affiliation":[{"name":"Center for Clinical Transfusion Research, Sanquin Blood Supply Foundation, 2333 ZA Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9156-2137","authenticated-orcid":false,"given":"Johannes A.","family":"Eble","sequence":"additional","affiliation":[{"name":"Institute of Physiological Chemistry and Pathobiochemistry, University of M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7057-6257","authenticated-orcid":false,"given":"Dick H. W.","family":"Dekkers","sequence":"additional","affiliation":[{"name":"Center for Proteomics, Erasmus University Medical Center (Erasmus MC), 3015 CN Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen A. A.","family":"Demmers","sequence":"additional","affiliation":[{"name":"Center for Proteomics, Erasmus University Medical Center (Erasmus MC), 3015 CN Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis H.","family":"Kerkhoffs","sequence":"additional","affiliation":[{"name":"Center for Clinical Transfusion Research, Sanquin Blood Supply Foundation, 2333 ZA Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1228-7769","authenticated-orcid":false,"given":"Jaap Jan","family":"Zwaginga","sequence":"additional","affiliation":[{"name":"Center for Clinical Transfusion Research, Sanquin Blood Supply Foundation, 2333 ZA Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8443-900X","authenticated-orcid":false,"given":"Laura","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Platelet Research Lab, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain"},{"name":"Department of Medicine, University of Oviedo, 33006 Oviedo, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s12672-023-00616-3","article-title":"Chemotherapy-induced thrombocytopenia: Literature review","volume":"14","author":"Gao","year":"2023","journal-title":"Discov. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1159\/000546566","article-title":"Platelet Transfusion for Patients with Cancer: An Update","volume":"52","author":"Wang","year":"2025","journal-title":"Transfus. Med. Hemother."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1001\/jama.2025.7529","article-title":"Platelet Transfusion: 2025 AABB and ICTMG International Clinical Practice Guidelines","volume":"334","author":"Metcalf","year":"2025","journal-title":"JAMA"},{"key":"ref_4","first-page":"CD010981","article-title":"A therapeutic-only versus prophylactic platelet transfusion strategy for preventing bleeding in patients with haematological disorders after myelosuppressive chemotherapy or stem cell transplantation","volume":"2015","author":"Crighton","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1056\/NEJMoa1212772","article-title":"A no-prophylaxis platelet-transfusion strategy for hematologic cancers","volume":"368","author":"Stanworth","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0037-1963(00)90047-7","article-title":"Current issues with platelet transfusion in patients with cancer","volume":"37","author":"McCullough","year":"2000","journal-title":"Semin. Hematol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jtha.2023.09.031","article-title":"Management of chemotherapy-induced thrombocytopenia: Guidance from the ISTH Subcommittee on Hemostasis and Malignancy","volume":"22","author":"Soff","year":"2024","journal-title":"J. Thromb. Haemost."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"16979","DOI":"10.1038\/s41598-025-02104-w","article-title":"Coagulation profiles of breast cancer patients attending at cancer treatment centres in Northwest Ethiopia 2023: A comparative cross-sectional study","volume":"15","author":"Ayana","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_9","first-page":"e319867","article-title":"Vascular Toxicities of Cancer Therapies: 2025 Update","volume":"46","author":"Donisan","year":"2025","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/bcpt.12156","article-title":"Role of platelets in inflammation and cancer: Novel therapeutic strategies","volume":"114","author":"Dovizio","year":"2014","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1097\/CCO.0000000000000237","article-title":"Platelet function in malignant hematological disorders","volume":"27","author":"Moscardo","year":"2015","journal-title":"Curr. Opin. Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1111\/jth.13675","article-title":"Measurement of platelet aggregation, independently of patient platelet count: A flow-cytometric approach","volume":"15","author":"Vinholt","year":"2017","journal-title":"J. Thromb. Haemost."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/ajh.25512","article-title":"Platelet function tests predict bleeding in patients with acute myeloid leukemia and thrombocytopenia","volume":"94","author":"Vinholt","year":"2019","journal-title":"Am. J. Hematol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4958","DOI":"10.1182\/blood-2007-11-123620","article-title":"Inflammation induces hemorrhage in thrombocytopenia","volume":"111","author":"Goerge","year":"2008","journal-title":"Blood"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.transci.2017.08.020","article-title":"Identification of underlying and transfusion-related platelet qualitative alterations in the hemato-oncologic patient","volume":"56","author":"Papadopoulos","year":"2017","journal-title":"Transfus. Apher. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s41231-024-00189-5","article-title":"Plasma proteomes of acute myeloid leukemia patients treated with transfusions reveal signatures of inflammation and hemostatic dysregulation","volume":"9","author":"Smit","year":"2024","journal-title":"Transl. Med. Commun."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e70","DOI":"10.1182\/blood-2012-06-437723","article-title":"A novel flow cytometry-based platelet aggregation assay","volume":"121","author":"Meinders","year":"2013","journal-title":"Blood"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1046\/j.1538-7836.2003.00260.x","article-title":"Von Willebrand factor, platelets and endothelial cell interactions","volume":"1","author":"Ruggeri","year":"2003","journal-title":"J. Thromb. Haemost."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1749-6632.2001.tb03491.x","article-title":"The structure and biological features of fibrinogen and fibrin","volume":"936","author":"Mosesson","year":"2001","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/glycob\/cww086","article-title":"Biological roles of glycans","volume":"27","author":"Varki","year":"2017","journal-title":"Glycobiology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nrc3982","article-title":"Glycosylation in cancer: Mechanisms and clinical implications","volume":"15","author":"Pinho","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1146\/annurev-pathol-012414-040438","article-title":"Protein glycosylation in cancer","volume":"10","author":"Stowell","year":"2015","journal-title":"Annu. Rev. Pathol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1055\/s-0034-1370792","article-title":"The unique hemostatic dysfunction in acute promyelocytic leukemia","volume":"40","author":"Kwaan","year":"2014","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e010156","DOI":"10.1136\/bmjopen-2015-010156","article-title":"A study protocol for a randomised controlled trial evaluating clinical effects of platelet transfusion products: The Pathogen Reduction Evaluation and Predictive Analytical Rating Score (PREPAReS) trial","volume":"6","author":"Ypma","year":"2016","journal-title":"BMJ Open"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"113307","DOI":"10.1016\/j.isci.2025.113307","article-title":"Targeting synergetic endothelial inflammation by inhibiting NFKB and JAK-STAT pathways","volume":"28","author":"Groten","year":"2025","journal-title":"iScience"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/j.1365-2141.1992.tb04563.x","article-title":"Monocytes enhance endothelial von Willebrand factor release and prostacyclin production with different kinetics and dependency on intercellular contact between these two cell types","volume":"80","author":"Hakkert","year":"1992","journal-title":"Br. J. Haematol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1365-2141.1976.tb03533.x","article-title":"Immunoradiometric assay of factor VIII related antigen, with observations in 32 patients with von Willebrand\u2019s disease","volume":"33","author":"Ruggeri","year":"1976","journal-title":"Br. J. Haematol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1182\/blood.V63.6.1408.1408","article-title":"Characterization of 25 monoclonal antibodies to factor VIII-von Willebrand factor: Relationship between ristocetin-induced platelet aggregation and platelet adherence to subendothelium","volume":"63","author":"Stel","year":"1984","journal-title":"Blood"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/ng.2230","article-title":"UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair","volume":"44","author":"Schwertman","year":"2012","journal-title":"Nat. Genet."},{"key":"ref_30","unstructured":"R Core Team (2026). R: A Language and Environment for Statistical Computing, R Foundation for Statistical Computing. Available online: https:\/\/www.r-project.org\/."},{"key":"ref_31","first-page":"s89","article-title":"High-throughput fractionation of human plasma for fast enrichment of low- and high-abundance proteins","volume":"10","author":"Breen","year":"2012","journal-title":"Blood Transfus."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3608","DOI":"10.1038\/s41467-018-05806-0","article-title":"Apolipoprotein A-IV binds \u03b1IIb\u03b23 integrin and inhibits thrombosis","volume":"9","author":"Xu","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Ponomarev, E.D. (2018). Fresh Evidence for Platelets as Neuronal and Innate Immune Cells: Their Role in the Activation, Differentiation, and Deactivation of Th1, Th17, and Tregs during Tissue Inflammation. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.00406"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.3349\/ymj.2013.54.6.1305","article-title":"Association between CDH13 variants and cardiometabolic and vascular phenotypes in a Korean population","volume":"54","author":"Lee","year":"2013","journal-title":"Yonsei Med. J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1111\/j.1538-7836.2008.03179.x","article-title":"Globular adiponectin increases cGMP formation in blood platelets independently of nitric oxide","volume":"6","author":"Riba","year":"2008","journal-title":"J. Thromb. Haemost."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00395-011-0233-5","article-title":"Loss of DPP4 activity is related to a prothrombogenic status of endothelial cells: Implications for the coronary microvasculature of myocardial infarction patients","volume":"107","author":"Krijnen","year":"2012","journal-title":"Basic Res. Cardiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1182\/blood-2010-02-270876","article-title":"Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling","volume":"116","author":"Bertozzi","year":"2010","journal-title":"Blood"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1055\/s-0038-1675228","article-title":"Plasma Phospholipid Transfer Protein Promotes Platelet Aggregation","volume":"118","author":"Zhao","year":"2018","journal-title":"Thromb. Haemost."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"E1072","DOI":"10.1152\/ajpendo.00728.2009","article-title":"Adiponectin diminishes platelet aggregation and sCD40L release. Potential role in the metabolic syndrome","volume":"298","author":"Restituto","year":"2010","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13046-021-02200-5","article-title":"The essential roles of m6A RNA modification to stimulate ENO1-dependent glycolysis and tumorigenesis in lung adenocarcinoma","volume":"41","author":"Ma","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1016\/j.ejca.2010.03.018","article-title":"ENO1, a potential prognostic head and neck cancer marker, promotes transformation partly via chemokine CCL20 induction","volume":"46","author":"Tsai","year":"2010","journal-title":"Eur. J. Cancer"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Moreira, A.C., Mesquita, G., and Gomes, M.S. (2020). Ferritin: An Inflammatory Player Keeping Iron at the Core of Pathogen-Host Interactions. Microorganisms, 8.","DOI":"10.3390\/microorganisms8040589"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Smith, M.M., and Melrose, J. (2024). Lumican, a Multifunctional Cell Instructive Biomarker Proteoglycan Has Novel Roles as a Marker of the Hypercoagulative State of Long Covid Disease. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25052825"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Eriksson, O., Mohlin, C., Nilsson, B., and Ekdahl, K.N. (2019). The Human Platelet as an Innate Immune Cell: Interactions Between Activated Platelets and the Complement System. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.01590"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s13105-015-0389-9","article-title":"Orosomucoid, an acute response protein with multiple modulating activities","volume":"71","author":"Luo","year":"2015","journal-title":"J. Physiol. Biochem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1182\/blood-2002-12-3882","article-title":"Platelet-collagen interaction: Is GPVI the central receptor?","volume":"102","author":"Nieswandt","year":"2003","journal-title":"Blood"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1046\/j.1538-7836.2003.00245.x","article-title":"Activation of GPVI by collagen is regulated by \u03b12\u03b21 and secondary mediators","volume":"1","author":"Atkinson","year":"2003","journal-title":"J. Thromb. Haemost."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/978-0-387-09789-3_5","article-title":"Platelet glycoprotein VI","volume":"640","author":"Jung","year":"2008","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1080\/09537100410001710254","article-title":"Differential roles of integrins \u03b12\u03b21 and \u03b1IIb\u03b23 in collagen and CRP-induced platelet activation","volume":"15","author":"Jarvis","year":"2004","journal-title":"Platelets"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3403","DOI":"10.1182\/blood-2003-10-3664","article-title":"Signaling through GP Ib-IX-V activates \u03b1IIb\u03b23 independently of other receptors","volume":"103","author":"Cozzi","year":"2004","journal-title":"Blood"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.3324\/haematol.2017.185165","article-title":"Impaired mitochondrial activity explains platelet dysfunction in thrombocytopenic cancer patients undergoing chemotherapy","volume":"103","author":"Baaten","year":"2018","journal-title":"Haematologica"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1111\/jth.15810","article-title":"Von Willebrand factor and cancer: Another piece of the puzzle","volume":"20","author":"Denis","year":"2022","journal-title":"J. Thromb. Haemost."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1865189","DOI":"10.1155\/2022\/1865189","article-title":"Analysis of the Influence of Serum MMP-2 and vWF Levels on the Predictive Value of Risk Grade and Prognosis of Patients with Acute Myeloid Leukemia","volume":"2022","author":"Liu","year":"2022","journal-title":"Contrast Media Mol. Imaging"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Tiedemann, L., Gorantla, S.P., Ahlf, P., Schmidt, L.S., Pott, C., Litterst, M., Waetzig, V., Nagel, I., Ruemenapp, J., and von Bubnoff, N. (2025). Association of fibronectin 1 deregulation with tyrosine kinase inhibitor resistance in chronic myeloid leukemia. Front. Cell Dev. Biol., 13.","DOI":"10.3389\/fcell.2025.1725857"}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/6\/761\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T04:14:58Z","timestamp":1779596098000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/6\/761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,22]]},"references-count":54,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["biom16060761"],"URL":"https:\/\/doi.org\/10.3390\/biom16060761","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,22]]}}}