{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T04:03:47Z","timestamp":1779681827569,"version":"3.53.1"},"reference-count":205,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"China Rehabilitation Science Institute","award":["CRSI2025ZH-3"],"award-info":[{"award-number":["CRSI2025ZH-3"]}]},{"name":"China Rehabilitation Science Institute","award":["CRSI2026YZX-3"],"award-info":[{"award-number":["CRSI2026YZX-3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>N-methyl-D-aspartate receptors (NMDARs) play a context-dependent role in ischemic stroke (IS), contributing to acute excitotoxic injury while also supporting subsequent neuroplasticity. This functional divergence has constrained the therapeutic efficacy of non-selective NMDAR antagonists. During the acute phase, neuronal injury is associated with the redistribution of NMDARs toward extrasynaptic sites and the activation of aberrant non-ionotropic signaling pathways. As the disease progresses, NMDAR-dependent signaling becomes increasingly involved in activity-dependent plasticity, including motor engram consolidation, dendritic remodeling, and large-scale network reorganization. Post-stroke cognitive impairment and depression are increasingly recognized as potential consequences of sustained NMDAR dysregulation, involving interactions with immune signaling and metabolic processes. These observations support a shift toward activity-dependent modulation of NMDAR function, in which neurotoxic signaling is selectively dissociated from physiological receptor activity. Emerging strategies aimed at subunit-specific modulation and disruption of pathological receptor complexes provide a basis for more targeted intervention. Preservation of physiological excitation\u2013inhibition balance may therefore represent a key requirement for optimizing functional recovery after stroke.<\/jats:p>","DOI":"10.3390\/biom16060770","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T02:32:28Z","timestamp":1779676348000},"page":"770","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["NMDA Receptor Mediated Mechanisms in the Post-Stroke Brain: From Physiology to Pathology"],"prefix":"10.3390","volume":"16","author":[{"given":"Han","family":"Gong","sequence":"first","affiliation":[{"name":"Beijing Key Laboratory for Biomaterials and Neural Regeneration, National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering), School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China"},{"name":"China Rehabilitation Research Center, Beijing 100086, China"},{"name":"China Rehabilitation Science Institute, Beijing 100086, China"},{"name":"School of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences, Qingdao 266113, China"},{"name":"Beijing International Cooperation Bases for Science and Technology on Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Zheng","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Rehabilitation Medicine, Wenzhou Medical University, Wenzhou 325000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Rehabilitation, Capital Medical University, Beijing 100086, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9167-890X","authenticated-orcid":false,"given":"Wei-Jin","family":"Liu","sequence":"additional","affiliation":[{"name":"China Rehabilitation Science Institute, Beijing 100086, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8686-2236","authenticated-orcid":false,"given":"Xiao-Xia","family":"Du","sequence":"additional","affiliation":[{"name":"China Rehabilitation Research Center, Beijing 100086, China"},{"name":"China Rehabilitation Science Institute, Beijing 100086, China"},{"name":"School of Rehabilitation Medicine, Wenzhou Medical University, Wenzhou 325000, China"},{"name":"School of Rehabilitation, Capital Medical University, Beijing 100086, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Sheng","family":"Rao","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory for Biomaterials and Neural Regeneration, National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering), School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China"},{"name":"Beijing International Cooperation Bases for Science and Technology on Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.amjmed.2021.07.027","article-title":"Ischemic Stroke","volume":"134","author":"Feske","year":"2021","journal-title":"Am. 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