{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:49:44Z","timestamp":1785408584897,"version":"3.56.0"},"reference-count":235,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971152"],"award-info":[{"award-number":["81971152"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["81971152"],"award-info":[{"award-number":["81971152"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018617","name":"LiaoNing Revitalization Talents Program","doi-asserted-by":"crossref","award":["XLYC2412063"],"award-info":[{"award-number":["XLYC2412063"]}],"id":[{"id":"10.13039\/501100018617","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Liaoning Province Red Cross Foundation\u2019s Research Support for Public Welfare Project","award":["2900025016"],"award-info":[{"award-number":["2900025016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>The pathological progression of Alzheimer\u2019s disease (AD) involves not only intrinsic neuronal lesions but is also closely associated with dysregulation of intercellular communication within the neuroimmune microenvironment. Glycolysis, as a central pathway in cellular energy metabolism, exhibits significant abnormalities in AD, and changes in its activity may further influence disease progression by modulating interactions between neurons. This article aims to systematically elucidate how glycolysis, as a key component of metabolic regulation, participates in the regulation of cellular interactions during the progression of AD, and to explore its potential mechanisms and therapeutic implications. Firstly, it systematically reviews the key changes in interactions between cells in AD, including microglia, astrocytes, oligodendrocytes, and neurons, and their roles in neuroinflammation, synaptic loss, and amyloid deposition. Secondly, by analysing alterations in the glycolytic metabolic profiles of various neuronal cell types in AD, we explore in depth how glycolysis regulates cellular signalling, inflammatory responses, and cellular function, thereby influencing cell\u2013cell interactions. Lastly, by combining current research on the control of the glycolytic pathway in AD with possible therapeutic methods, we propose a novel way to stop the progression of the disease by focusing on cell interactions through mediating glycolysis. By tracing the causal chain in AD through which glycolysis acts as a bridge via altered cell\u2013cell interactions, this paper aims to provide a theoretical basis for the development of disease-modifying therapies based on metabolic reprogramming.<\/jats:p>","DOI":"10.3390\/biom16060796","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T09:57:43Z","timestamp":1779962263000},"page":"796","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Glycolysis: The Bridge Between Cellular Interaction and Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"16","author":[{"given":"Qian","family":"Lei","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, The First Hospital of China Medical University, NO. 155, North Nanjing Street, Heping District, Shenyang 110001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Hospital of China Medical University, NO. 155, North Nanjing Street, Heping District, Shenyang 110001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4812-6919","authenticated-orcid":false,"given":"Bo","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Hospital of China Medical University, NO. 155, North Nanjing Street, Heping District, Shenyang 110001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer\u2019s disease: Recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"a006148","DOI":"10.1101\/cshperspect.a006148","article-title":"The clinical problem of symptomatic Alzheimer disease and mild cognitive impairment","volume":"2","author":"Tarawneh","year":"2012","journal-title":"Cold Spring Harb. 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