{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:05:53Z","timestamp":1780635953637,"version":"3.54.1"},"reference-count":46,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Epidemiological and biological evidence indicate a close connection between Alzheimer\u2019s disease (AD) and type-2 diabetes mellitus. Glucose transporter 1 (GLUT1), encoded by the SLC2A1 gene, has a major role in glucose metabolism, the dysregulation of which has been implicated in both diseases. We conducted a case-control association study in a sample of 439 non-diabetic patients with late-onset AD and 304 cognitively healthy, non-diabetic elderly controls to determine the potential risk for developing AD associated with SLC2A1 rs841847 polymorphism. The rs841847 C\/C genotype occurrence was higher in the AD group (AD: 60.4%, controls: 50.7%), while the minor T allele-containing genotypes were more frequent among controls (AD: 39.6%, controls: 49.3%). A multivariate logistic regression model adjusted for age, sex, and apolipoprotein E (APOE) \u03b54 status (\u03b54 allele carriers versus non-carriers) demonstrated that carriers of the T allele had a significantly reduced risk for AD compared to C\/C homozygotes (OR = 0.672; 95% CI: 0.493\u20130.916; p = 0.012). Although the rs841847 polymorphism has been linked to type-2 diabetes mellitus, the present study investigated this gene variant in AD for the first time. Our findings indicate a moderate protective effect for the rs841847 T allele on the susceptibility to AD. We demonstrated the rs841847 polymorphism as a candidate single nucleotide polymorphism for further examination as a predisposing genetic factor for AD.<\/jats:p>","DOI":"10.3390\/biom16060808","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T01:08:02Z","timestamp":1780535282000},"page":"808","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Variant T Allele of SLC2A1 rs841847 Confers Moderate Protection Against Late-Onset Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"16","author":[{"given":"\u00c1gnes","family":"Feh\u00e9r","sequence":"first","affiliation":[{"name":"Department of Physiology, Albert Szent-Gyorgyi Medical School, University of Szeged, D\u00f3m T\u00e9r 10, H-6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Boldizs\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Physiology, Albert Szent-Gyorgyi Medical School, University of Szeged, D\u00f3m T\u00e9r 10, H-6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdolna","family":"P\u00e1k\u00e1ski","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Albert Szent-Gyorgyi Medical School, University of Szeged, Kor\u00e1nyi Fasor 8-10, H-6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Janka","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Albert Szent-Gyorgyi Medical School, University of Szeged, Kor\u00e1nyi Fasor 8-10, H-6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5319-5639","authenticated-orcid":false,"given":"J\u00e1nos","family":"K\u00e1lm\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Albert Szent-Gyorgyi Medical School, University of Szeged, Kor\u00e1nyi Fasor 8-10, H-6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/s41467-019-14279-8","article-title":"Alzheimer\u2019s Disease Genetics Consortium. 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