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Such a complex wound microenvironment imposes more stringent requirements on multifunctional wound dressings. A multifunctional Cur Janus nanofibrous dressing is developed by integrating an electrospun poly(\u03b5-caprolactone)\/gelatin hydrophilic layer with a curcumin (Cur)-loaded PCL hydrophobic layer. Janus structure with asymmetric wettability, which exhibited unidirectional liquid transport properties both in vitro and in vivo. Its unique structure also makes it possible to carry both hydrophilic and hydrophobic drugs at the same time. The incorporation of curcumin endows the dressing with antibacterial and antioxidant functionalities, offering the potential to modulate the inflammatory microenvironment of diabetic chronic wounds. Furthermore, the wound healing ability and anti-inflammatory effects of Cur Janus nanofibers were evaluated in a diabetic mouse model. The results showed that Cur Janus nanofibers significantly reduced wound area, increased the proportion of pro-healing M2 macrophages, shortened the inflammatory phase, and ultimately accelerated diabetic wound healing. This work provides a multifunctional and scalable platform for advanced wound dressing design. Its excellent antibacterial, antioxidant (ROS scavenging) and anti-inflammatory (macrophage phenotype M1 to M2) properties, combined with the unidirectional fluid transport and dual-release potential of hydrophilic and hydrophobic drugs, demonstrate broad prospects in the management of diabetic wounds.<\/jats:p>","DOI":"10.3390\/biom16060902","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T08:59:38Z","timestamp":1781773178000},"page":"902","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multifunctional Self-Pumping Janus Dressing for Exudate Management and Diabetic Wound Healing"],"prefix":"10.3390","volume":"16","author":[{"given":"Yingnan","family":"Yue","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering, Faculty of Engineering, Graduate School, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Chado","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Faculty of Engineering, Graduate School, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rike","family":"Rachmayati","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0348-8091","authenticated-orcid":false,"given":"Rie","family":"Wakabayashi","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4898-6342","authenticated-orcid":false,"given":"Noriho","family":"Kamiya","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan"},{"name":"Division of Biotechnology, Center for Future Chemistry, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Aishima","sequence":"additional","affiliation":[{"name":"Department of Scientific Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4737-5454","authenticated-orcid":false,"given":"Hiroyuki","family":"Ijima","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Faculty of Engineering, Graduate School, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2594-3307","authenticated-orcid":false,"given":"Yasuhiro","family":"Ikegami","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Faculty of Engineering, Graduate School, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s12325-014-0140-x","article-title":"Pathogenesis and Treatment of Impaired Wound Healing in Diabetes Mellitus: New Insights","volume":"31","author":"Baltzis","year":"2014","journal-title":"Adv. Ther."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/j.1742-481X.2011.00923.x","article-title":"A Critical Review of Modern and Emerging Absorbent Dressings Used to Treat Exuding Wounds","volume":"9","author":"Sweeney","year":"2012","journal-title":"Int. Wound J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.12968\/jowc.2019.28.Sup9a.S1","article-title":"A Multipurpose Dressing: A Clinical Review of the Absorption, Debridement and Healing Properties of Aquacel Foam","volume":"28","author":"Ousey","year":"2019","journal-title":"J. Wound Care"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"198","DOI":"10.12968\/jowc.1994.3.4.198","article-title":"Criteria for Identifying Wound Infection","volume":"3","author":"Cutting","year":"1994","journal-title":"J. Wound Care"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1742-4801.2005.00131.x","article-title":"A Liquid Film-forming Acrylate for Peri-wound Protection: A Systematic Review and Meta-analysis (3MTM CavilonTM No-sting Barrier Film)","volume":"2","author":"Schuren","year":"2005","journal-title":"Int. Wound J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"62","DOI":"10.7748\/ns.19.7.62.s59","article-title":"Exudate and Care of the Peri-Wound Skin","volume":"19","author":"Cameron","year":"2004","journal-title":"Nurs. Stand."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1126\/science.abi5200","article-title":"The Spectrum of Inflammatory Responses","volume":"374","author":"Medzhitov","year":"2021","journal-title":"Science"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0039-6109(05)70572-7","article-title":"A Failure of Wound Healing Caused by an Imbalance of Bacteria","volume":"77","author":"Robson","year":"1997","journal-title":"Surg. Clin. N. Am."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"12687","DOI":"10.1021\/acsnano.1c04206","article-title":"Functional Hydrogels as Wound Dressing to Enhance Wound Healing","volume":"15","author":"Liang","year":"2021","journal-title":"ACS Nano"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2108325","DOI":"10.1002\/adma.202108325","article-title":"Endogenous Electric-Field-Coupled Electrospun Short Fiber via Collecting Wound Exudation","volume":"34","author":"Wang","year":"2022","journal-title":"Adv. Mater."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e01886","DOI":"10.1002\/adhm.202501886","article-title":"ROS-Scavenging Multifunctional Microneedle Patch Facilitating Wound Healing","volume":"14","author":"Kharaziha","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"145941","DOI":"10.1016\/j.cej.2023.145941","article-title":"ROS-Scavenging Hydrogel to Accelerate Wound Healing and Reduce Scar Formation","volume":"474","author":"Shu","year":"2023","journal-title":"Chem. Eng. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2105265","DOI":"10.1002\/adfm.202105265","article-title":"Elastic Janus Film for Wound Dressings: Unidirectional Biofluid Transport and Effectively Promoting Wound Healing","volume":"31","author":"Xu","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1804187","DOI":"10.1002\/adma.201804187","article-title":"A Self-Pumping Dressing for Draining Excessive Biofluid around Wounds","volume":"31","author":"Shi","year":"2019","journal-title":"Adv. Mater."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"5996","DOI":"10.1039\/c2sm25514f","article-title":"Unidirectional Water-Penetration Composite Fibrous Film via Electrospinning","volume":"8","author":"Wu","year":"2012","journal-title":"Soft Matter"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.1039\/D2NA00421F","article-title":"Gradient Monolayered Porous Membrane for Liquid Manipulation: From Fabrication to Application","volume":"4","author":"Zhang","year":"2022","journal-title":"Nanoscale Adv."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1601070","DOI":"10.1002\/smll.201601070","article-title":"Directional Fluid Transport in Thin Porous Materials and Its Functional Applications","volume":"13","author":"Zhao","year":"2017","journal-title":"Small"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"121040","DOI":"10.1016\/j.biomaterials.2021.121040","article-title":"Nanofibrous Composite Aerogel with Multi-Bioactive and Fluid Gating Characteristics for Promoting Diabetic Wound Healing","volume":"276","author":"Zhang","year":"2021","journal-title":"Biomaterials"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2307449","DOI":"10.1002\/adfm.202307449","article-title":"Cellulose-Based pH-Responsive Janus Dressing with Unidirectional Moisture Drainage for Exudate Management and Diabetic Wounds Healing","volume":"34","author":"Xu","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2401539","DOI":"10.1002\/adma.202401539","article-title":"A Viscous-Biofluid Self-Pumping Organohydrogel Dressing to Accelerate Diabetic Wound Healing","volume":"36","author":"Xiao","year":"2024","journal-title":"Adv. Mater."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"113276","DOI":"10.1016\/j.colsurfb.2023.113276","article-title":"Multifunctional Electrospun Membranes with Hydrophilic and Hydrophobic Gradients Property for Wound Dressing","volume":"225","author":"Ao","year":"2023","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Ji, Y., Song, W., Xu, L., Yu, D.-G., and Annie Bligh, S.W. (2022). A Review on Electrospun Poly(Amino Acid) Nanofibers and Their Applications of Hemostasis and Wound Healing. Biomolecules, 12.","DOI":"10.3390\/biom12060794"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Wang, M., Yu, D.-G., Williams, G.R., and Bligh, S.W.A. (2022). Co-Loading of Inorganic Nanoparticles and Natural Oil in the Electrospun Janus Nanofibers for a Synergetic Antibacterial Effect. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14061208"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"123464","DOI":"10.1016\/j.cej.2019.123464","article-title":"Anti-Oxidant Electroactive and Antibacterial Nanofibrous Wound Dressings Based on Poly(\u03b5-Caprolactone)\/Quaternized Chitosan-Graft-Polyaniline for Full-Thickness Skin Wound Healing","volume":"385","author":"He","year":"2020","journal-title":"Chem. Eng. J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1080\/17425247.2021.1823966","article-title":"Electrospun Nanofiber-Based Drug Delivery Platform: Advances in Diabetic Foot Ulcer Management","volume":"18","author":"Madhukiran","year":"2021","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"32104","DOI":"10.1021\/acsami.4c05967","article-title":"Bioactive Metal Ion-Coordinated Dynamic Hydrogel with Antibacterial, Immunomodulatory, and Angiogenic Activities for Infected Wound Repair","volume":"16","author":"Li","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"7944","DOI":"10.1021\/acs.biomac.5c01408","article-title":"Covalently Conjugated Synergistic Antibacterial\u2013Antioxidant Polylactic Acid Nanofiber Membranes for Chronic Infected Wound Healing","volume":"26","author":"Huang","year":"2025","journal-title":"Biomacromolecules"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"111778","DOI":"10.1016\/j.matdes.2023.111778","article-title":"Janus Amphiphilic Nanofiber Membranes Synergistically Drive Antibacterial and Anti-Inflammatory Strategies for Skin Wound Healing","volume":"227","author":"Shi","year":"2023","journal-title":"Mater. Des."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1002\/ptr.6658","article-title":"Anti-microbial Activity of Curcumin Nanoformulations: New Trends and Future Perspectives","volume":"34","author":"Sharifi","year":"2020","journal-title":"Phytother. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"46494","DOI":"10.1021\/acsomega.2c05293","article-title":"Comparison of Antibacterial Activity of Nanocurcumin with Bulk Curcumin","volume":"7","author":"Hettiarachchi","year":"2022","journal-title":"ACS Omega"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e202310061","DOI":"10.1002\/anie.202310061","article-title":"A Nanomedicine-Enabled Ion-Exchange Strategy for Enhancing Curcumin-Based Rheumatoid Arthritis Therapy","volume":"62","author":"Yang","year":"2023","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Hewlings, S., and Kalman, D. (2017). Curcumin: A Review of Its Effects on Human Health. Foods, 6.","DOI":"10.3390\/foods6100092"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"106021","DOI":"10.1016\/j.ejps.2021.106021","article-title":"Mesoporous Silica Incorporated PCL\/Curcumin Nanofiber for Wound Healing Application","volume":"167","author":"Rathinavel","year":"2021","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1111\/j.1440-1681.2009.05216.x","article-title":"Curcumin-loaded Poly(\u0395-caprolactone) Nanofibres: Diabetic Wound Dressing with Anti-oxidant and Anti-inflammatory Properties","volume":"36","author":"Merrell","year":"2009","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"6837745","DOI":"10.1155\/2022\/6837745","article-title":"Cellular Immunity of Patients with Tuberculosis Combined with Diabetes","volume":"2022","author":"Cheng","year":"2022","journal-title":"J. Immunol. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nprot.2013.002","article-title":"The Mouse Excisional Wound Splinting Model, Including Applications for Stem Cell Transplantation","volume":"8","author":"Wang","year":"2013","journal-title":"Nat. Protoc."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2103765","DOI":"10.1002\/advs.202103765","article-title":"Liquid-Assisted Single-Layer Janus Membrane for Efficient Unidirectional Liquid Penetration","volume":"9","author":"Zhao","year":"2022","journal-title":"Adv. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1904113","DOI":"10.1002\/adma.201904113","article-title":"Bioinspired Janus Textile with Conical Micropores for Human Body Moisture and Thermal Management","volume":"31","author":"Dai","year":"2019","journal-title":"Adv. Mater."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"4114","DOI":"10.1002\/adfm.201501320","article-title":"Superhydrophobic \u201cPump\u201d: Continuous and Spontaneous Antigravity Water Delivery","volume":"25","author":"Cao","year":"2015","journal-title":"Adv. Funct. Mater."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"101276","DOI":"10.1016\/j.mtcomm.2020.101276","article-title":"Efficacy of Biopolymeric PVA-AuNPs and PCL-Curcumin Loaded Electrospun Nanofibers and Their Anticancer Activity against A431 Skin Cancer Cell Line","volume":"25","author":"Balashanmugam","year":"2020","journal-title":"Mater. Today Commun."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.ijbiomac.2015.12.024","article-title":"Electrospun Curcumin Loaded Poly(\u03b5-Caprolactone)\/Gum Tragacanth Nanofibers for Biomedical Application","volume":"84","author":"Bahrami","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Di Salle, A., Viscusi, G., Di Cristo, F., Valentino, A., Gorrasi, G., Lamberti, E., Vittoria, V., Calarco, A., and Peluso, G. (2021). Antimicrobial and Antibiofilm Activity of Curcumin-Loaded Electrospun Nanofibers for the Prevention of the Biofilm-Associated Infections. Molecules, 26.","DOI":"10.3390\/molecules26164866"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"174818","DOI":"10.1016\/j.cej.2026.174818","article-title":"Photofunctionalized Commercial Nonwoven Janus Dressing for Unidirectional Exudate Clearance and Antibacterial Healing of Infected Wounds","volume":"533","author":"Cui","year":"2026","journal-title":"Chem. Eng. J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2303460","DOI":"10.1002\/adhm.202303460","article-title":"A Novel Self-Pumping Janus Dressing for Promoting Wound Immunomodulation and Diabetic Wound Healing","volume":"13","author":"Zhou","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"57644","DOI":"10.1021\/acsami.5c13577","article-title":"Enhanced Wound Healing Using Curcumin-Loaded Janus Dressings Fabricated by Femtosecond Laser-Assisted Molding","volume":"17","author":"Yang","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.2147\/IJN.S395438","article-title":"Recent Advances in Nano-Drug Delivery Systems for the Treatment of Diabetic Wound Healing","volume":"18","author":"Liu","year":"2023","journal-title":"Int. J. Nanomed."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"eabe4839","DOI":"10.1126\/scitranslmed.abe4839","article-title":"Advanced Bandages for Diabetic Wound Healing","volume":"13","author":"Matoori","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"9976912","DOI":"10.1155\/2021\/9976912","article-title":"Anti-Inflammatory Effect of Curcumin on the Mouse Model of Myocardial Infarction through Regulating Macrophage Polarization","volume":"2021","author":"Yan","year":"2021","journal-title":"Mediat. Inflamm."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.colsurfb.2015.08.029","article-title":"Polyurethane Foam Containing rhEGF as a Dressing Material for Healing Diabetic Wounds: Synthesis, Characterization, in Vitro and in Vivo Studies","volume":"135","author":"Pyun","year":"2015","journal-title":"Colloids Surf. B Biointerface"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"24596","DOI":"10.1038\/srep24596","article-title":"Controlled Water Vapor Transmission Rate Promotes Wound-Healing via Wound Re-Epithelialization and Contraction Enhancement","volume":"6","author":"Xu","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2305606","DOI":"10.1002\/adma.202305606","article-title":"High-Performance Liquid-Repellent and Thermal\u2013Wet Comfortable Membranes Using Triboelectric Nanostructured Nanofiber\/Meshes","volume":"35","author":"Gong","year":"2023","journal-title":"Adv. Mater."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Ahmad, N. (2022). In Vitro and In Vivo Characterization Methods for Evaluation of Modern Wound Dressings. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15010042"}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/6\/902\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T09:43:45Z","timestamp":1781775825000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/16\/6\/902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,18]]},"references-count":52,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["biom16060902"],"URL":"https:\/\/doi.org\/10.3390\/biom16060902","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,18]]}}}